Donald W. Nicholson

35.6k citations

140 papers · 27.3k indexed · 12 hit papers · h-index 68

Molecular Biology top 0.05%
Immunology top 0.2%
Oncology top 0.5%
Cellular and Molecular Neuroscience top 0.5%
Epidemiology top 0.5%

Co-authors: Nancy A. Thornberry Sophie Roy John P. Vaillancourt Erin P. Peterson Richard S. Hotchkiss Douglas K. Miller Dita Rasper Margarita García‐Calvo
Topics: Cell death mechanisms and regulation (60 papers)Mitochondrial Function and Pathology (24 papers)Endoplasmic Reticulum Stress and Disease (10 papers)
Cited by: Molecular Biology Immunology Cell Biology
Journals: Nature Cell Proceedings of the National Academy of Sciences
Partner nations: Canada United States Germany

In The Last Decade

Donald W. Nicholson

139 papers receiving 26.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 3.6k citations Donald W. Nicholson, Nancy A. Thornberry et al. Nature profile →
Caspases: killer proteases

1997 2.1k citations Donald W. Nicholson, Nancy A. Thornberry profile →
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 1.8k citations Nancy A. Thornberry, Dita Rasper et al. Journal of Biological Chemistry profile →
Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 1.6k citations Donald W. Nicholson, Emad S. Alnemri et al. profile →
Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors

1998 859 citations Donald W. Nicholson, Nancy A. Thornberry et al. Journal of Biological Chemistry profile →
Mitochondrial protein import

1989 706 citations F. Ulrich Hartl, Nikolaus Pfanner et al. profile →
Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

1999 673 citations François G. Gervais, Daigen Xu et al. Cell profile →
Apoptosis and caspases regulate death and inflammation in sepsis

2006 634 citations Richard S. Hotchkiss, Donald W. Nicholson Nature reviews. Immunology profile →
Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 611 citations Donald W. Nicholson et al. Nature profile →
From bench to clinic with apoptosis-based therapeutic agents

2000 566 citations Donald W. Nicholson Nature profile →
Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 563 citations Donald W. Nicholson, Nancy A. Thornberry et al. The Journal of Experimental Medicine profile →
Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin

2006 505 citations Rona K. Graham, Sophie Roy et al. Cell profile →

Peers

Countries citing papers authored by Donald W. Nicholson

Since Specialization

Citations

This map shows the geographic impact of Donald W. Nicholson's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Donald W. Nicholson with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Donald W. Nicholson more than expected).

Fields of papers citing papers by Donald W. Nicholson

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Donald W. Nicholson. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Donald W. Nicholson. The network helps show where Donald W. Nicholson may publish in the future.

Co-authorship network of co-authors of Donald W. Nicholson

This figure shows the co-authorship network connecting the top 25 collaborators of Donald W. Nicholson. A scholar is included among the top collaborators of Donald W. Nicholson based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Donald W. Nicholson. Donald W. Nicholson is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection 2009 ·Proceedings of the National Academy of Sciences ·Garabet Yeretssian,Karine Doiron,Wei Shao,Blair R. Leavitt,Michael R. Hayden,Donald W. Nicholson,Maya Saleh	48
2	Hippi is essential for node cilia assembly and Sonic hedgehog signaling 2006 ·Developmental Biology ·Caroline Houde,Robin J. Dickinson,(unknown),Rebecca Cullum,Rachel Montpetit,Martina Metzler,Elizabeth M. Simpson,Sophie Roy,Michael R. Hayden,Pamela A. Hoodless,Donald W. Nicholson	77
3	Peripheral Phosphodiesterase 4 Inhibition Produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) Prevents Experimental Autoimmune Encephalomyelitis 2006 ·Journal of Pharmacology and Experimental Therapeutics ·Craig S. Moore,N. Earl,Richard Frenette,Angela Styhler,Joseph A. Mancini,Donald W. Nicholson,Andrea L.O. Hebb,Trevor Owens,George S. Robertson	14
4	Apoptosis and caspases regulate death and inflammation in sepsisbreakdown → 2006 ·Nature reviews. Immunology ·Richard S. Hotchkiss,Donald W. Nicholson	634
5	Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms 2004 ·Nature ·Maya Saleh,John P. Vaillancourt,Rona K. Graham,(unknown),Srinivasa M. Srinivasula,Emad S. Alnemri,Martin H. Steinberg,Val Nolan,Clinton T. Baldwin,Richard S. Hotchkiss,Timothy G. Buchman,Barbara A. Zehnbauer,Michael R. Hayden,Lindsay A. Farrer,Sophie Roy,Donald W. Nicholson	320
6	Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor 2004 ·Journal of Pharmacology and Experimental Therapeutics ·David Claveau,S L Chen,Stephen J. O’Keefe,Dennis M. Zaller,Angela Styhler,(unknown),Zheng Huang,Donald W. Nicholson,Joseph A. Mancini	79
7	Effects of fimbria-fornix transection on calpain and choline acetyl transferase activities in the septohippocampal pathway 2004 ·Neuroscience ·Carlos A. Ayala‐Grosso,James P. Tam,Steven Xanthoudakis,Y Bureau,Sophie Roy,Donald W. Nicholson,George S. Robertson	8
8	The Cell Adhesion Molecule CEACAM1-L Is a Substrate of Caspase-3-mediated Cleavage in Apoptotic Mouse Intestinal Cells 2003 ·Journal of Biological Chemistry ·Caroline Houde,Sophie Roy,Nelly Leung,Donald W. Nicholson,Nicole Beauchemin	25
9	Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi 2002 ·Nature Cell Biology ·François G. Gervais,Roshni R. Singaraja,Steven Xanthoudakis,Claire‐Anne Gutekunst,Blair R. Leavitt,Martina Metzler,Abigail S. Hackam,John Tam,John P. Vaillancourt,(unknown),Dita Rasper,Sophie Roy,Michael R. Hayden,Donald W. Nicholson	241
10	Molecular pharmacology of the human prostaglandin D₂ receptor, CRTH2 2002 ·British Journal of Pharmacology ·Nicole Sawyer,Elizabeth Cauchon,Anne Châteauneuf,Rani P. Cruz,Donald W. Nicholson,Kathleen M. Metters,Gary P. O’Neill,François G. Gervais	166
11	Determination of Caspase Specificities Using a Peptide Combinatorial Library 2000 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Nancy A. Thornberry,Kevin T. Chapman,Donald W. Nicholson	50
12	Cross-Talk in Cell Death Signaling 2000 ·The Journal of Experimental Medicine ·Sophie Roy,Donald W. Nicholson	213
13	Neuroprotection by the Inhibition of Apoptosis 2000 ·Brain Pathology ·George S. Robertson,Stephen J. Crocker,Donald W. Nicholson,Jörg B. Schulz	173
14	Criteria for Identifying Authentic Caspase Substrates during Apoptosis 2000 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Sophie Roy,Donald W. Nicholson	5
15	Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formationbreakdown → 1999 ·Cell ·François G. Gervais,Daigen Xu,George S. Robertson,John P. Vaillancourt,(unknown),Jingqi Huang,Andréa C. LeBlanc,David W. Smith,Michael Rigby,Mark S. Shearman,Earl E. Clarke,Hui Zheng,(unknown),(unknown),Nancy A. Thornberry,(unknown),Robert Zamboni,Sophie Roy,Donald W. Nicholson	673
16	Co-localization of the Cysteine Protease Caspase-3 with Apoptotic Myocytes afterIn VivoMyocardial Ischemia and Reperfusion in the Rat 1998 ·Journal of Molecular and Cellular Cardiology ·Shawn C. Black,Jing Huang,(unknown),(unknown),Andreas Eberhart,Donald W. Nicholson,Ian W. Rodger	127
17	Intact Cell Evidence for the Early Synthesis, and Subsequent Late Apopain-Mediated Suppression, of Poly(ADP-ribose) during Apoptosis 1997 ·Experimental Cell Research ·Dean S. Rosenthal,Ruchuang Ding,Cynthia M. Simbulan‐Rosenthal,John P. Vaillancourt,Donald W. Nicholson,Mark E. Smulson	72
18	Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract 1996 ·Nature Genetics ·Y. Paul Goldberg,Donald W. Nicholson,Dita Rasper,Michael A. Kalchman,Hiroshi Koide,Rona K. Graham,(unknown),Parsa Kazemi‐Esfarjani,Nancy A. Thornberry,(unknown),Michael R. Hayden	465
19	Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung 1993 ·European Journal of Pharmacology Molecular Pharmacology ·Elizabeth A. Frey,Donald W. Nicholson,Kathleen M. Metters	47
20	Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa 1988 ·Journal of Biological Chemistry ·Maximilian Tropschug,Donald W. Nicholson,F. Ulrich Hartl,Helmut Köhler,Nikolaus Pfanner,Elmar Wächter,Walter Neupert	40

About Donald W. Nicholson

Donald W. Nicholson is a scholar working on Molecular Biology, Cell Biology and Immunology, having authored 140 papers that have together received 27.3k indexed citations. Recurring topics across this work include Cell death mechanisms and regulation (60 papers), Mitochondrial Function and Pathology (24 papers) and Endoplasmic Reticulum Stress and Disease (10 papers). The work is most often cited by research in Molecular Biology (20.3k citations), Immunology (5.4k citations) and Cell Biology (3.0k citations). Donald W. Nicholson has collaborated with scholars based in Canada, United States and Germany. Frequent co-authors include Nancy A. Thornberry, Sophie Roy, John P. Vaillancourt, Erin P. Peterson, Richard S. Hotchkiss, Douglas K. Miller, Dita Rasper, Margarita García‐Calvo, Ting-Ting Yamin and Walter Neupert. Their work appears in journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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