John P. Vaillancourt

9.9k total citations · 3 hit papers
24 papers, 8.3k citations indexed

About

John P. Vaillancourt is a scholar working on Molecular Biology, Cell Biology and Oncology. According to data from OpenAlex, John P. Vaillancourt has authored 24 papers receiving a total of 8.3k indexed citations (citations by other indexed papers that have themselves been cited), including 24 papers in Molecular Biology, 6 papers in Cell Biology and 5 papers in Oncology. Recurrent topics in John P. Vaillancourt's work include Cell death mechanisms and regulation (15 papers), Endoplasmic Reticulum Stress and Disease (5 papers) and PARP inhibition in cancer therapy (3 papers). John P. Vaillancourt is often cited by papers focused on Cell death mechanisms and regulation (15 papers), Endoplasmic Reticulum Stress and Disease (5 papers) and PARP inhibition in cancer therapy (3 papers). John P. Vaillancourt collaborates with scholars based in Canada, United States and Japan. John P. Vaillancourt's co-authors include Donald W. Nicholson, Nancy A. Thornberry, Sophie Roy, Marc Labelle, Michel Gallant, Yves Gareau, Ambereen Ali, Douglas K. Miller, Ting-Ting Yamin and Violeta Yu and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

John P. Vaillancourt

24 papers receiving 8.1k citations

Hit Papers

3 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 3.6k citations Donald W. Nicholson, Ambereen Ali et al. Nature profile →
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 1.8k citations Nancy A. Thornberry, Thomas A. Rano et al. Journal of Biological Chemistry profile →
Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

1999 673 citations François G. Gervais, Daigen Xu et al. Cell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
John P. Vaillancourt Canada	19	6.4k	1.6k	1.2k	941	844	24	8.3k
Gregory D. Cuny United States	50	6.9k 1.1×	1.9k 1.2×	1.3k 1.0×	856 0.9×	1.4k 1.7×	165	11.5k
Robert V. Talanian United States	33	5.8k 0.9×	2.1k 1.3×	880 0.7×	956 1.0×	796 0.9×	55	8.2k
Christoph Borner Germany	50	6.1k 1.0×	1.6k 1.0×	1.3k 1.0×	959 1.0×	1.2k 1.4×	119	8.8k
Bruno Antonsson Switzerland	49	9.8k 1.5×	1.2k 0.8×	1.3k 1.0×	1.2k 1.3×	1.3k 1.6×	92	12.2k
Kevin J. Tomaselli United States	31	4.8k 0.8×	1.3k 0.8×	864 0.7×	558 0.6×	812 1.0×	42	6.6k
Beni B. Wolf United States	26	5.3k 0.8×	1.2k 0.8×	1.3k 1.1×	840 0.9×	801 0.9×	53	7.6k
Ruth M. Kluck Australia	38	9.4k 1.5×	1.7k 1.1×	1.6k 1.3×	832 0.9×	1.3k 1.6×	66	11.9k
Tomomi Kuwana United States	28	7.9k 1.2×	1.2k 0.8×	1.6k 1.3×	1.0k 1.1×	1.2k 1.4×	46	10.0k
Deepak Nijhawan United States	19	6.8k 1.1×	1.2k 0.7×	1.4k 1.1×	749 0.8×	981 1.2×	28	9.1k

Countries citing papers authored by John P. Vaillancourt

Since Specialization

Citations

This map shows the geographic impact of John P. Vaillancourt's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John P. Vaillancourt with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John P. Vaillancourt more than expected).

Fields of papers citing papers by John P. Vaillancourt

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John P. Vaillancourt. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John P. Vaillancourt. The network helps show where John P. Vaillancourt may publish in the future.

Co-authorship network of co-authors of John P. Vaillancourt

This figure shows the co-authorship network connecting the top 25 collaborators of John P. Vaillancourt. A scholar is included among the top collaborators of John P. Vaillancourt based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John P. Vaillancourt. John P. Vaillancourt is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Wang, Hao, David Claveau, John P. Vaillancourt, Terry Roemer, & Timothy C. Meredith. (2011). High-frequency transposition for determining antibacterial mode of action. Nature Chemical Biology. 7(10). 720–729. 45 indexed citations

Isabel, Élise, Renée Aspiotis, W. Cameron Black, et al.. (2007). Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones. Bioorganic & Medicinal Chemistry Letters. 17(6). 1671–1674. 9 indexed citations

Han, Yongxin, André Giroux, John Colucci, et al.. (2005). Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 15(4). 1173–1180. 25 indexed citations

Mellon, Christophe, Renée Aspiotis, Christopher I. Bayly, et al.. (2005). Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 15(17). 3886–3890. 10 indexed citations

Méthot, Nathalie, Jingqi Huang, Nathalie Coulombe, et al.. (2004). Differential Efficacy of Caspase Inhibitors on Apoptosis Markers during Sepsis in Rats and Implication for Fractional Inhibition Requirements for Therapeutics. The Journal of Experimental Medicine. 199(2). 199–207. 49 indexed citations

Saleh, Maya, John P. Vaillancourt, Rona K. Graham, et al.. (2004). Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature. 429(6987). 75–79. 320 indexed citations

Méthot, Nathalie, John P. Vaillancourt, Jingqi Huang, et al.. (2004). A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation. Journal of Biological Chemistry. 279(27). 27905–27914. 22 indexed citations

Grimm, Erich L., Bruno Roy, Renée Aspiotis, et al.. (2004). Solid phase synthesis of selective caspase-3 peptide inhibitors. Bioorganic & Medicinal Chemistry. 12(5). 845–851. 12 indexed citations

Han, Yongxin, André Giroux, Erich L. Grimm, et al.. (2003). Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 14(3). 805–808. 23 indexed citations

10.

Isabel, Élise, W. Cameron Black, Christopher I. Bayly, et al.. (2003). Nicotinyl aspartyl ketones as inhibitors of caspase-3. Bioorganic & Medicinal Chemistry Letters. 13(13). 2137–2140. 18 indexed citations

11.

Han, Byung Hee, Daigen Xu, Junjeong Choi, et al.. (2002). Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury. Journal of Biological Chemistry. 277(33). 30128–30136. 141 indexed citations

12.

Gervais, François G., Roshni R. Singaraja, Steven Xanthoudakis, et al.. (2002). Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nature Cell Biology. 4(2). 95–105. 241 indexed citations

13.

Hackam, Abigail S., Roshni R. Singaraja, Martina Metzler, et al.. (2000). Huntingtin Interacting Protein 1 Induces Apoptosis via a Novel Caspase-dependent Death Effector Domain. Journal of Biological Chemistry. 275(52). 41299–41308. 110 indexed citations

14.

Gervais, François G., Daigen Xu, George S. Robertson, et al.. (1999). Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation. Cell. 97(3). 395–406. 673 indexed citations breakdown →

15.

Rasper, Dita, John P. Vaillancourt, Sabina Keen, et al.. (1998). Cell death attenuation by `Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. Cell Death and Differentiation. 5(4). 271–288. 271 indexed citations

16.

Nasir, Jamal, Jane Theilmann, John P. Vaillancourt, et al.. (1997). Interleukin-1α-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3. Mammalian Genome. 8(8). 611–613. 8 indexed citations

17.

Thornberry, Nancy A., Thomas A. Rano, Erin P. Peterson, et al.. (1997). A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B. Journal of Biological Chemistry. 272(29). 17907–17911. 1802 indexed citations breakdown →

18.

Rosenthal, Dean S., Ruchuang Ding, Cynthia M. Simbulan‐Rosenthal, et al.. (1997). Intact Cell Evidence for the Early Synthesis, and Subsequent Late Apopain-Mediated Suppression, of Poly(ADP-ribose) during Apoptosis. Experimental Cell Research. 232(2). 313–321. 72 indexed citations

19.

Nicholson, Donald W., Ambereen Ali, Nancy A. Thornberry, et al.. (1995). Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 376(6535). 37–43. 3612 indexed citations breakdown →

20.

Vaillancourt, John P., Ambereen Ali, Douglas K. Miller, et al.. (1995). Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases. Journal of Biological Chemistry. 270(26). 15870–15876. 247 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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