John P. Vaillancourt

9.9k citations

24 papers · 8.3k indexed · 3 hit papers · h-index 19

Molecular Biology top 0.5%
Immunology top 1%
Oncology top 2%
Cell Biology top 1%
Epidemiology top 5%

Co-authors: Donald W. Nicholson Nancy A. Thornberry Sophie Roy Marc Labelle Michel Gallant Yves Gareau Ambereen Ali Ting-Ting Yamin
Topics: Cell death mechanisms and regulation (15 papers)Endoplasmic Reticulum Stress and Disease (5 papers)PARP inhibition in cancer therapy (3 papers)
Cited by: Molecular Biology Immunology Cell Biology
Journals: Nature Cell Proceedings of the National Academy of Sciences
Partner nations: Canada United States Japan

In The Last Decade

John P. Vaillancourt

24 papers receiving 8.1k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 3.6k citations Donald W. Nicholson, Ambereen Ali et al. Nature profile →
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 1.8k citations Nancy A. Thornberry, Thomas A. Rano et al. Journal of Biological Chemistry profile →
Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

1999 673 citations François G. Gervais, Daigen Xu et al. Cell profile →

Peers

Countries citing papers authored by John P. Vaillancourt

Since Specialization

Citations

This map shows the geographic impact of John P. Vaillancourt's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John P. Vaillancourt with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John P. Vaillancourt more than expected).

Fields of papers citing papers by John P. Vaillancourt

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John P. Vaillancourt. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John P. Vaillancourt. The network helps show where John P. Vaillancourt may publish in the future.

Co-authorship network of co-authors of John P. Vaillancourt

This figure shows the co-authorship network connecting the top 25 collaborators of John P. Vaillancourt. A scholar is included among the top collaborators of John P. Vaillancourt based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John P. Vaillancourt. John P. Vaillancourt is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	High-frequency transposition for determining antibacterial mode of action 2011 ·Nature Chemical Biology ·Hao Wang,David Claveau,John P. Vaillancourt,Terry Roemer,Timothy C. Meredith	45
2	Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones 2007 ·Bioorganic & Medicinal Chemistry Letters ·Élise Isabel,Renée Aspiotis,W. Cameron Black,John Colucci,Réjean Fortin,André Giroux,Erich L. Grimm,Yongxin Han,Christophe Mellon,Donald W. Nicholson,Dita Rasper,Johanne Renaud,Sophie Roy,John Tam,Paul Tawa,John P. Vaillancourt,Steven Xanthoudakis,Robert Zamboni	9
3	Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors 2005 ·Bioorganic & Medicinal Chemistry Letters ·Yongxin Han,André Giroux,John Colucci,Christopher I. Bayly,Daniel J. McKay,Sophie Roy,(unknown),John P. Vaillancourt,Dita Rasper,John Tam,Paul Tawa,Donald W. Nicholson,Robert Zamboni	25
4	Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors 2005 ·Bioorganic & Medicinal Chemistry Letters ·Christophe Mellon,Renée Aspiotis,(unknown),Christopher I. Bayly,Erich L. Grimm,André Giroux,Yongxin Han,Élise Isabel,Daniel J. McKay,Donald W. Nicholson,Dita Rasper,Sophie Roy,John Tam,Nancy A. Thornberry,John P. Vaillancourt,Steven Xanthoudakis,Robert Zamboni	10
5	Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms 2004 ·Nature ·Maya Saleh,John P. Vaillancourt,Rona K. Graham,(unknown),Srinivasa M. Srinivasula,Emad S. Alnemri,Martin H. Steinberg,Val Nolan,Clinton T. Baldwin,Richard S. Hotchkiss,Timothy G. Buchman,Barbara A. Zehnbauer,Michael R. Hayden,Lindsay A. Farrer,Sophie Roy,Donald W. Nicholson	320
6	Solid phase synthesis of selective caspase-3 peptide inhibitors 2004 ·Bioorganic & Medicinal Chemistry ·Erich L. Grimm,Bruno Roy,Renée Aspiotis,Christopher I. Bayly,Donald W. Nicholson,Dita Rasper,Johanne Renaud,Sophie Roy,John Tam,Paul Tawa,John P. Vaillancourt,Steven Xanthoudakis,Robert Zamboni	12
7	Differential Efficacy of Caspase Inhibitors on Apoptosis Markers during Sepsis in Rats and Implication for Fractional Inhibition Requirements for Therapeutics 2004 ·The Journal of Experimental Medicine ·Nathalie Méthot,Jingqi Huang,Nathalie Coulombe,John P. Vaillancourt,Dita Rasper,John Tam,Yongxin Han,John Colucci,Robert Zamboni,Steven Xanthoudakis,Sylvie Toulmond,Donald W. Nicholson,Sophie Roy	49
8	A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation 2004 ·Journal of Biological Chemistry ·Nathalie Méthot,John P. Vaillancourt,Jingqi Huang,John Colucci,Yongxin Han,(unknown),Robert Zamboni,Sylvie Toulmond,Donald W. Nicholson,Sophie Roy	22
9	Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors 2003 ·Bioorganic & Medicinal Chemistry Letters ·Yongxin Han,André Giroux,Erich L. Grimm,Renée Aspiotis,(unknown),Christopher I. Bayly,Daniel J. McKay,Sophie Roy,(unknown),John P. Vaillancourt,Dita Rasper,John Tam,Paul Tawa,Nancy A. Thornberry,(unknown),Margarita García‐Calvo,Joseph W. Becker,J. Rotonda,Donald W. Nicholson,Robert Zamboni	23
10	Nicotinyl aspartyl ketones as inhibitors of caspase-3 2003 ·Bioorganic & Medicinal Chemistry Letters ·Élise Isabel,W. Cameron Black,Christopher I. Bayly,Erich L. Grimm,(unknown),Daniel J. McKay,Donald W. Nicholson,Dita Rasper,Johanne Renaud,Sophie Roy,John Tam,Nancy A. Thornberry,John P. Vaillancourt,Steven Xanthoudakis,Robert Zamboni	18
11	Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi 2002 ·Nature Cell Biology ·François G. Gervais,Roshni R. Singaraja,Steven Xanthoudakis,Claire‐Anne Gutekunst,Blair R. Leavitt,Martina Metzler,Abigail S. Hackam,John Tam,John P. Vaillancourt,(unknown),Dita Rasper,Sophie Roy,Michael R. Hayden,Donald W. Nicholson	241
12	Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury 2002 ·Journal of Biological Chemistry ·Byung Hee Han,Daigen Xu,Junjeong Choi,Yongxin Han,Steven Xanthoudakis,Sophie Roy,John Tam,John P. Vaillancourt,John Colucci,Robert Siman,André Giroux,George S. Robertson,Robert Zamboni,Donald W. Nicholson,David M. Holtzman	141
13	Huntingtin Interacting Protein 1 Induces Apoptosis via a Novel Caspase-dependent Death Effector Domain 2000 ·Journal of Biological Chemistry ·Abigail S. Hackam,(unknown),Roshni R. Singaraja,Martina Metzler,(unknown),Lu Gan,Simon C. Warby,Cheryl L. Wellington,John P. Vaillancourt,Nansheng Chen,François G. Gervais,Lynn A. Raymond,Donald W. Nicholson,Michael R. Hayden	110
14	Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formationbreakdown → 1999 ·Cell ·François G. Gervais,Daigen Xu,George S. Robertson,John P. Vaillancourt,(unknown),Jingqi Huang,Andréa C. LeBlanc,David W. Smith,Michael Rigby,Mark S. Shearman,Earl E. Clarke,Hui Zheng,(unknown),(unknown),Nancy A. Thornberry,(unknown),Robert Zamboni,Sophie Roy,Donald W. Nicholson	673
15	Cell death attenuation by `Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex 1998 ·Cell Death and Differentiation ·Dita Rasper,John P. Vaillancourt,(unknown),(unknown),(unknown),Sabina Keen,Paul Tawa,(unknown),Jamal Nasir,Duane W. Martindale,Ben F. Koop,Erin P. Peterson,Nancy A. Thornberry,(unknown),David MacPherson,Shawn C. Black,Felicita Hornung,Michael J. Lenardo,Michael R. Hayden,Sophie Roy,Donald W. Nicholson	271
16	Intact Cell Evidence for the Early Synthesis, and Subsequent Late Apopain-Mediated Suppression, of Poly(ADP-ribose) during Apoptosis 1997 ·Experimental Cell Research ·Dean S. Rosenthal,Ruchuang Ding,Cynthia M. Simbulan‐Rosenthal,John P. Vaillancourt,Donald W. Nicholson,Mark E. Smulson	72
17	A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme Bbreakdown → 1997 ·Journal of Biological Chemistry ·Nancy A. Thornberry,Thomas A. Rano,Erin P. Peterson,Dita Rasper,(unknown),Margarita García‐Calvo,(unknown),(unknown),Sophie Roy,John P. Vaillancourt,Kevin T. Chapman,Donald W. Nicholson	1802
18	Interleukin-1α-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3 1997 ·Mammalian Genome ·Jamal Nasir,Jane Theilmann,John P. Vaillancourt,(unknown),Ambereen Ali,Stephen W. Scherer,Barbara Beatty,Donald W. Nicholson,Michael R. Hayden	8
19	Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases 1995 ·Journal of Biological Chemistry ·(unknown),John P. Vaillancourt,Ambereen Ali,(unknown),Douglas K. Miller,Susan M. Molineaux,Ting-Ting Yamin,Violeta Yu,Donald W. Nicholson	247
20	Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisbreakdown → 1995 ·Nature ·Donald W. Nicholson,Ambereen Ali,Nancy A. Thornberry,John P. Vaillancourt,(unknown),Michel Gallant,Yves Gareau,Patrick R. Griffin,Marc Labelle,Yuri Lazebnik,(unknown),(unknown),Mark E. Smulson,Ting-Ting Yamin,Violeta Yu,Douglas K. Miller	3612

About John P. Vaillancourt

John P. Vaillancourt is a scholar working on Cell Biology, Molecular Biology and Toxicology, having authored 24 papers that have together received 8.3k indexed citations. Recurring topics across this work include Cell death mechanisms and regulation (15 papers), Endoplasmic Reticulum Stress and Disease (5 papers) and PARP inhibition in cancer therapy (3 papers). The work is most often cited by research in Molecular Biology (6.4k citations), Immunology (1.6k citations) and Cell Biology (941 citations). John P. Vaillancourt has collaborated with scholars based in Canada, United States and Japan. Frequent co-authors include Donald W. Nicholson, Nancy A. Thornberry, Sophie Roy, Marc Labelle, Michel Gallant, Yves Gareau, Ambereen Ali, Ting-Ting Yamin, Violeta Yu and Douglas K. Miller. Their work appears in journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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