Irene E. Karl

16.4k citations

129 papers · 13.0k indexed · 3 hit papers · h-index 53

Impact in

Critical Care and Intensive Care Medicine top 0.2%
- Intensive Care Unit Cognitive Disorders
Immunology top 0.2%
- Immune Response and Inflammation
- Immune Cell Function and Interaction

Papers in

Clinical Biochemistry 17
- Metabolism and Genetic Disorders 15
Immunology 33
- Immune Response and Inflammation 30

Co-authors: Richard S. Hotchkiss Timothy G. Buchman Paul E. Swanson Kevin W. Tinsley David Kipnis J. Perren Cobb Katherine Chang Bradley D. Freeman
Journals: Shock (17 papers)Critical Care Medicine (12 papers)The Journal of Immunology (8 papers)Journal of Clinical Investigation (7 papers)American Journal of Physiology-Endocrinology and Metabolism (7 papers)
Partner nations: United States China Germany

In The Last Decade

Irene E. Karl

129 papers receiving 12.5k citations

Hit Papers

align trajectories log scale

The Pathophysiology and Treatment of Sepsis 2003 · 3.1k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2003 New England Journal of Medicine
2001 The Journal of Immunology
1999 Critical Care Medicine

Peers

Countries citing papers authored by Irene E. Karl

Since Specialization

Citations

This map shows the geographic impact of Irene E. Karl's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Irene E. Karl with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Irene E. Karl more than expected).

Fields of papers citing papers by Irene E. Karl

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Irene E. Karl. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Irene E. Karl. The network helps show where Irene E. Karl may publish in the future.

Co-authors

The 25 scholars most cited alongside Irene E. Karl, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Irene E. Karl Line = papers co-authored together Irene E. Karl links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Surviving sepsis:bcl-2 overexpression modulates splenocyte transcriptional responses in vivo American Journal of Physiology-Regulatory, Integrative and Comparative Physiology ·Tracey H. Wagner, Anne M. Drewry, Sandra MacMillan, William M. Dunne, Katherine Chang, Irene E. Karl, Richard S. Hotchkiss, J. Perren Cobb	2007	17
2	TAT-BH4 and TAT-Bcl-xL Peptides Protect against Sepsis-Induced Lymphocyte Apoptosis In Vivo The Journal of Immunology ·Richard S. Hotchkiss, Kevin W. McConnell, Florian Sebastian Reiff, Christopher G. Davis, Katherine Chang, Steven J. Schwulst, Jeffrey C. Dunne, Gunnar P.H. Dietz, Mathias Bähr, Jonathan E. McDunn, Irene E. Karl, Tracey H. Wagner, J. Perren Cobb, Craig M. Coopersmith, David Piwnica‐Worms	2006	92
3	BOTH GRAM-NEGATIVE AND GRAM-POSITIVE EXPERIMENTAL PNEUMONIA INDUCE PROFOUND LYMPHOCYTE BUT NOT RESPIRATORY EPITHELIAL CELL APOPTOSIS Shock ·Torsten Schreiber, Paul E. Swanson, Katherine Chang, Christophér C. Davis, William M. Dunne, Irene E. Karl, Konrad Reinhart, Richard S. Hotchkiss	2006	14
4	Molecular Diagnostics in Sepsis: From Bedside to Bench Journal of the American College of Surgeons ·T. Philip Chung, Jason M. Laramie, Donald J. Meyer, Thomas J. Downey, 雅章古川, エドワード H. リッピー, Timothy G. Buchman, Irene E. Karl, Gary D. Stormo, Richard S. Hotchkiss, J. Perren Cobb	2006	28
5	Accelerated Lymphocyte Death in Sepsis Occurs by both the Death Receptor and Mitochondrial Pathways The Journal of Immunology ·Richard S. Hotchkiss, Stephen Osmon, Katherine Chang, Tracey H. Wagner, Craig M. Coopersmith, Irene E. Karl	2005	271
6	Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury* Critical Care Medicine ·Mejias-Alpizar Maria Jose, Paul E. Stromberg, Cheryl A. Woolsey, Isaiah R. Turnbull, William M. Dunne, J. Dyduch, Timothy G. Buchman, Irene E. Karl, Richard S. Hotchkiss, Craig M. Coopersmith	2005	16
7	Akt Decreases Lymphocyte Apoptosis and Improves Survival in Sepsis The Journal of Immunology ·Ursula Bommhardt, Katherine Chang, Paul E. Swanson, Tracey H. Wagner, Kevin W. Tinsley, Irene E. Karl, Richard S. Hotchkiss	2004	113
8	THE ADAPTIVE IMMUNE SYSTEM MEDIATES GUT EPITHELIAL APOPTOSIS FOLLOWING CECAL LIGATION AND PUNCTURE Shock ·Cheryl A. Woolsey, Paul E. Stromberg, J. Dyduch, W Budding, K. Chang, R. S. Hotchkiss, Irene E. Karl, Timothy G. Buchman, Craig M. Coopersmith	2004	2
9	Sepsis Induces Apoptosis and Profound Depletion of Splenic Interdigitating and Follicular Dendritic Cells The Journal of Immunology ·Kevin W. Tinsley, Mitchell H. Grayson, Paul E. Swanson, Anne M. Drewry, Katherine Chang, Irene E. Karl, Richard S. Hotchkiss	2003	136
10	Sepsis gene expression profiling: Murine splenic compared with hepatic responses determined by using complementary DNA microarrays Critical Care Medicine ·J. Perren Cobb, Jason M. Laramie, Gary D. Stormo, 滋之水口, William D. Shannon, Yuyu Qiu, Irene E. Karl, Timothy G. Buchman, Richard S. Hotchkiss	2002	39
11	Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans The Journal of Immunology ·Richard S. Hotchkiss, Kevin W. Tinsley, Paul E. Swanson, Robert E. Schmieg, デートリッチバレッツ, Katherine Chang, Dale F. Osborne, Bradley D. Freeman, J. Perren Cobb, Timothy G. Buchman, Irene E. Karl Hit paper breakdown →	2001	713
12	Rapid Onset of Hepatocyte Apoptosis in a Patient with Trauma PubMed ·Robert E. Schmieg, Kevin W. Tinsley, Paul E. Swanson, Irene E. Karl, Rebecca Aft, Timothy G. Buchman, Richard S. Hotchkiss	2000	3
13	Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte Nature Immunology ·Richard S. Hotchkiss, K. Chang, Paul E. Swanson, Kevin W. Tinsley, Jiaojiao Hui, Díaz Restrepo, Steven Xanthoudakis, Sophie Roy, Cheryl A. Black, Erich L. Grimm, Renée Aspiotis, Yongxin Han, Donald W. Nicholson, Irene E. Karl	2000	452
14	CASPASES -2, -3, -6, AND -9, BUT NOT CASPASE-1, ARE ACTIVATED IN SEPSIS-INDUCED THYMOCYTE APOPTOSIS Shock ·Kevin W. Tinsley, Pitri Balgis, Timothy G. Buchman, Amanda Bennis, デートリッチバレッツ, Paul E. Swanson, Irene E. Karl, Richard S. Hotchkiss	2000	40
15	Reversal of Hypocalcemia and Decreased Afterload in Sepsis: Effect on Myocardial Systolic and Diastolic Function American Journal of Respiratory and Critical Care Medicine ·Attila Kovács, Michael Courtois, Benico Barzilai, Irene E. Karl, Philip A. Ludbrook, Richard S. Hotchkiss	1998	23
16	CALCIUM ANTAGONISTS INHIBIT OXIDATIVE BURST AND NITRITE FORMATION IN LIPOPOLYSACCHARIDE-STIMULATED RAT PERITONEAL MACROPHAGES Shock ·Richard S. Hotchkiss, William M. Bowling, Irene E. Karl, Dale F. Osborne, P Osusky	1997	41
17	Mechanisms of cell injury and death British Journal of Anaesthesia ·Justin Cobb, Richard S. Hotchkiss, Irene E. Karl, Timothy G. Buchman	1996	79
18	EFFECT OF ETHANOL AND SODIUM ARSENITE ON HSP-72 FORMATION AND ON SURVIVAL IN A MURINE ENDOTOXIN MODEL Shock ·George Lappas, Irene E. Karl, Richard S. Hotchkiss	1994	25
19	Dietary Supplementation With l-Arginine Ameliorates the Progression of Renal Disease in Rats With Subtotal Nephrectomy American Journal of Kidney Diseases ·Alvaro A. Reyes, Mabel L. Purkerson, Irene E. Karl, Saulo Klahr	1992	97
20	Transient neonatal diabetes: Delayed maturation of the pancreatic beta cell The Journal of Pediatrics ·Anthony S. Pagliara, Irene E. Karl, Juan Manuel Mascarós Martínez	1973	25

About Irene E. Karl

Irene E. Karl is a scholar working on Clinical Biochemistry, Immunology, Endocrinology, Diabetes and Metabolism, Cell Biology and Physiology, having authored 129 papers that have together received 13.0k indexed citations. Recurring topics across this work include Immune Response and Inflammation (30 papers), Muscle metabolism and nutrition (19 papers), Cell death mechanisms and regulation (17 papers), Diet and metabolism studies (16 papers), Metabolism and Genetic Disorders (15 papers), Sepsis Diagnosis and Treatment (14 papers), Adipose Tissue and Metabolism (8 papers) and Hyperglycemia and glycemic control in critically ill and hospitalized patients (7 papers). The work is most often cited by research in Critical Care and Intensive Care Medicine (1.4k citations), Immunology (4.6k citations), Clinical Biochemistry (899 citations), Epidemiology (4.3k citations) and Nephrology (812 citations). Irene E. Karl has collaborated with scholars based in United States, China and Germany. Frequent co-authors include Richard S. Hotchkiss, Timothy G. Buchman, Paul E. Swanson, Kevin W. Tinsley, David Kipnis, J. Perren Cobb, Katherine Chang, Bradley D. Freeman, Dale F. Osborne and A. J. Garber. Their work appears in journals such as Shock, Critical Care Medicine, The Journal of Immunology, Journal of Clinical Investigation and American Journal of Physiology-Endocrinology and Metabolism.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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