Sten Orrenius

61.7k total citations · 15 hit papers
455 papers, 51.5k citations indexed

About

Sten Orrenius is a scholar working on Molecular Biology, Pharmacology and Biochemistry. According to data from OpenAlex, Sten Orrenius has authored 455 papers receiving a total of 51.5k indexed citations (citations by other indexed papers that have themselves been cited), including 253 papers in Molecular Biology, 81 papers in Pharmacology and 72 papers in Biochemistry. Recurrent topics in Sten Orrenius's work include Cell death mechanisms and regulation (125 papers), Pharmacogenetics and Drug Metabolism (60 papers) and Mitochondrial Function and Pathology (57 papers). Sten Orrenius is often cited by papers focused on Cell death mechanisms and regulation (125 papers), Pharmacogenetics and Drug Metabolism (60 papers) and Mitochondrial Function and Pathology (57 papers). Sten Orrenius collaborates with scholars based in Sweden, United States and Italy. Sten Orrenius's co-authors include Boris Zhivotovsky, Pierluigi Nicotera, Vladimir Gogvadze, David J. McConkey, Giorgio Bellomo, Hjördis Thor, Peter Moldéus, Pia Hartzell, Afshin Samali and Martin Ott and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Sten Orrenius

454 papers receiving 49.9k citations

Hit Papers

Regulation of cell death:... 1965 2026 1985 2005 2003 2007 1995 2000 1978 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Regulation of cell death: the calcium–apoptosis link
    2003 2.4k citations Sten Orrenius, Boris Zhivotovsky et al. profile →
  2. Mitochondria, oxidative stress and cell death
    2007 1.6k citations Vladimir Gogvadze, Sten Orrenius et al. profile →
  3. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
    1995 1.6k citations Boris Zhivotovsky, Sten Orrenius et al. profile →
  4. Triggering and modulation of apoptosis by oxidative stress
    2000 1.2k citations Joya Chandra, Afshin Samali et al. profile →
  5. [4] Isolation and use of liver cells
    1978 1.1k citations Sten Orrenius et al. Methods in enzymology on CD-ROM/Methods in enzymology profile →
  6. Mitochondrial Oxidative Stress: Implications for Cell Death
    2006 1.1k citations Sten Orrenius, Vladimir Gogvadze et al. profile →
  7. The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.
    1982 808 citations Hjördis Thor, Giorgio Bellomo et al. profile →
  8. Cytochrome c release from mitochondria proceeds by a two-step process
    2002 783 citations Vladimir Gogvadze, Boris Zhivotovsky et al. profile →
  9. Role of Ca2+ in toxic cell killing
    1989 733 citations Sten Orrenius, David J. McConkey et al. profile →
  10. Mitochondria in cancer cells: what is so special about them?
    2008 532 citations Vladimir Gogvadze, Sten Orrenius et al. profile →
  11. Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease
    2005 526 citations Bengt Fadeel, Sten Orrenius profile →
  12. Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis
    1982 484 citations Giorgio Bellomo, Hjördis Thor et al. profile →
  13. PHENOBARBITAL-INDUCED SYNTHESIS OF THE MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM AND ITS RELATIONSHIP TO THE PROLIFERATION OF ENDOPLASMIC MEMBRANES
    1965 463 citations Sten Orrenius, Jan L. E. Ericsson et al. profile →
  14. Calcium and mitochondria in the regulation of cell death
    2015 421 citations Sten Orrenius, Vladimir Gogvadze et al. Biochemical and Biophysical Research Communications profile →
  15. Fundamentals of drug metabolism and drug disposition
    1973 396 citations Sten Orrenius et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Sten Orrenius 28.6k 5.7k 5.3k 5.1k 4.8k 455 51.5k
Jan-Ακε Gustafsson 33.6k 1.2× 5.7k 1.0× 13.5k 2.6× 6.8k 1.3× 6.0k 1.3× 1.2k 85.2k
Helmut Sies 30.1k 1.1× 3.1k 0.5× 2.9k 0.6× 4.2k 0.8× 10.6k 2.2× 657 81.4k
David J. Mangelsdorf 40.1k 1.4× 3.0k 0.5× 17.8k 3.4× 6.0k 1.2× 7.3k 1.5× 223 70.2k
Yasutomi Nishizuka 42.1k 1.5× 1.4k 0.3× 4.3k 0.8× 5.7k 1.1× 6.8k 1.4× 255 57.7k
Steven A. Kliewer 33.0k 1.2× 8.0k 1.4× 14.4k 2.7× 3.0k 0.6× 9.1k 1.9× 168 56.3k
Bart Staels 41.5k 1.5× 2.5k 0.4× 10.3k 1.9× 7.8k 1.5× 18.2k 3.8× 789 78.9k
John R. Vane 13.2k 0.5× 4.5k 0.8× 2.9k 0.5× 4.8k 0.9× 18.4k 3.9× 468 63.3k
Joseph V. Bonventre 21.0k 0.7× 1.5k 0.3× 3.0k 0.6× 5.5k 1.1× 4.6k 1.0× 516 55.9k
Salvatore Cuzzocrea 14.0k 0.5× 2.2k 0.4× 3.7k 0.7× 5.8k 1.1× 8.6k 1.8× 923 43.4k
Marjorie B. Lees 23.2k 0.8× 1.5k 0.3× 2.1k 0.4× 6.1k 1.2× 10.0k 2.1× 110 65.3k

Countries citing papers authored by Sten Orrenius

Since Specialization
Citations

This map shows the geographic impact of Sten Orrenius's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sten Orrenius with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sten Orrenius more than expected).

Fields of papers citing papers by Sten Orrenius

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sten Orrenius. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sten Orrenius. The network helps show where Sten Orrenius may publish in the future.

Co-authorship network of co-authors of Sten Orrenius

This figure shows the co-authorship network connecting the top 25 collaborators of Sten Orrenius. A scholar is included among the top collaborators of Sten Orrenius based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Sten Orrenius. Sten Orrenius is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Orrenius, Sten, Pierluigi Nicotera, & Boris Zhivotovsky. (2010). Cell Death Mechanisms and Their Implications in Toxicology. Toxicological Sciences. 119(1). 3–19. 315 indexed citations
2.
Gogvadze, Vladimir, Sten Orrenius, & Boris Zhivotovsky. (2006). Multiple pathways of cytochrome c release from mitochondria in apoptosis. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1757(5-6). 639–647. 384 indexed citations
3.
Kagan, Valerian E., Yulia Y. Tyurina, Vladimir A. Tyurin, et al.. (2002). A Role for Oxidative Stress in Apoptosis: Oxidation and Externalization of Phosphatidylserine Is Required for Macrophage Clearance of Cells Undergoing Fas-Mediated Apoptosis. The Journal of Immunology. 169(1). 487–499. 209 indexed citations
4.
Håkansson, Anders, et al.. (1999). Multimeric α-Lactalbumin from Human Milk Induces Apoptosis through a Direct Effect on Cell Nuclei. Experimental Cell Research. 246(2). 451–460. 71 indexed citations
5.
Pörn-Ares, M. Isabella, Afshin Samali, & Sten Orrenius. (1998). Cleavage of the calpain inhibitor, calpastatin, during apoptosis. Cell Death and Differentiation. 5(12). 1028–1033. 174 indexed citations
6.
Dobbelsteen, Diels J. van den, Stefan Nobel, Andrew F.G. Slater, & Sten Orrenius. (1997). Regulation and Mechanisms of Apoptosis in T Lymphocytes. Archives of toxicology. Supplement. 19. 77–85. 2 indexed citations
7.
Zhivotovsky, Boris, Annie Gahm, & Sten Orrenius. (1997). Two Different Proteases Are Involved in the Proteolysis of Lamin during Apoptosis. Biochemical and Biophysical Research Communications. 233(1). 96–101. 51 indexed citations
8.
Schlegel, Jürgen, et al.. (1995). Isolation and partial characterization of a protease involved in Fas‐induced apoptosis. FEBS Letters. 364(2). 139–142. 37 indexed citations
9.
Tinton, Sandrine A., Sek C. Chow, Pedro Buc Calderón, George E.N. Kass, & Sten Orrenius. (1995). Adenosine Inhibits Protein Synthesis in Isolated Rat Hepatocytes. European Journal of Biochemistry. 229(2). 419–425. 14 indexed citations
10.
Tinton, Sandrine A., Sek C. Chow, Pedro Buc Calderón, George E.N. Kass, & Sten Orrenius. (1995). Adenosine Inhibits Protein Synthesis in Isolated Rat Hepatocytes. Evidence for a Lack of Involvement of Intracellular Calcium in the Mechanism of Inhibition. European Journal of Biochemistry. 229(2). 419–425. 2 indexed citations
11.
Slater, Andrew F.G., Christopher J. Stefan, Stefan Nobel, & Sten Orrenius. (1995). The role of intracellular oxidants in apoptosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1271(1). 59–62. 252 indexed citations
12.
Ernster, Lars, Rolf Luft, & Sten Orrenius. (1995). Preface. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1271(1). ix–x. 1 indexed citations
13.
McCabe, Michael J. & Sten Orrenius. (1993). Genistein Induces Apoptosis in Immature Human Thymocytes by Inhibiting Topoisomerase-II. Biochemical and Biophysical Research Communications. 194(2). 944–950. 100 indexed citations
14.
Zhivotovsky, Boris, Pierluigi Nicotera, Giorgio Bellomo, K.P. Hanson, & Sten Orrenius. (1993). Ca2+ and Endonuclease Activation in Radiation-Induced Lymphoid Cell Death. Experimental Cell Research. 207(1). 163–170. 43 indexed citations
15.
Bellomo, Giorgio, Hjördis Thor, & Sten Orrenius. (1990). [66] Modulation of cellular glutathione and protein thiol status during quinone metabolism. Methods in enzymology on CD-ROM/Methods in enzymology. 186. 627–635. 31 indexed citations
16.
Nicotera, Pierluigi, Giorgio Bellomo, & Sten Orrenius. (1990). The role of calcium in cell killing. Chemical Research in Toxicology. 3(6). 484–494. 176 indexed citations
17.
Moore, Gregory, David J. McConkey, Georges Kass, Peter J. O’Brien, & Sten Orrenius. (1987). 2,5‐Di(tert‐butyl)‐1,4‐benzohydroquinone — a novel inhibitor of liver microsomal Ca2+ sequestration. FEBS Letters. 224(2). 331–336. 195 indexed citations
18.
Jernström, Bengt, et al.. (1978). Fluorescence study of DNA-binding metabolites of benzo(a)pyrene formed in hepatocytes isolated from 3-methylcholanthrene-treated rats.. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich). 38(8). 2600–7. 53 indexed citations
19.
Kupfer, David, Ingela Jansson, & Sten Orrenius. (1972). Spectral interactions of marihuana constituents (cannabinoids) with rat liver microsomal monooxygenase system. Chemico-Biological Interactions. 5(3). 201–206. 14 indexed citations
20.
Ericsson, Jan L. E., Sten Orrenius, & Ingemar Holm. (1966). Effects of protein deficiency on hepatic parenchymal cells. Electron microscopic observations.. 132. 106–111. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Jan-Ακε Gustafsson Breakdown of academic impact, for papers by Helmut Sies Breakdown of academic impact, for papers by David J. Mangelsdorf Breakdown of academic impact, for papers by Yasutomi Nishizuka Breakdown of academic impact, for papers by Steven A. Kliewer Breakdown of academic impact, for papers by Bart Staels Breakdown of academic impact, for papers by John R. Vane Breakdown of academic impact, for papers by Joseph V. Bonventre Breakdown of academic impact, for papers by Salvatore Cuzzocrea Breakdown of academic impact, for papers by Marjorie B. Lees
Rankless by CCL
2026