Earl E. Clarke

2.4k citations

30 papers · 2.0k indexed · 1 hit paper · h-index 19

Impact in

Physiology top 2%
- Alzheimer's disease research and treatments
Pharmacology top 2%
- Cholinesterase and Neurodegenerative Diseases

Papers in

Physiology 17
- Alzheimer's disease research and treatments 16
Cellular and Molecular Neuroscience 11
- Nerve injury and regeneration 6
- Neuroscience and Neuropharmacology Research 4

Co-authors: Mark S. Shearman Dirk Beher Alan Nadin Jonathan D.J. Wrigley Huw D. Lewis José L. Castro Jonathan Corcoran Ian Churcher
Journals: Bioorganic & Medicinal Chemistry Letters (8 papers)Journal of Biological Chemistry (4 papers)Journal of Neuroscience (2 papers)European Journal of Neuroscience (2 papers)Journal of Medicinal Chemistry (2 papers)
Partner nations: United Kingdom United States France

In The Last Decade

Earl E. Clarke

29 papers receiving 1.9k citations

Hit Papers

align trajectories log scale

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation 1999 · 673 citations

Peers

Countries citing papers authored by Earl E. Clarke

Since Specialization

Citations

This map shows the geographic impact of Earl E. Clarke's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Earl E. Clarke with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Earl E. Clarke more than expected).

Fields of papers citing papers by Earl E. Clarke

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Earl E. Clarke. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Earl E. Clarke. The network helps show where Earl E. Clarke may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Earl E. Clarke, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Earl E. Clarke Line = papers co-authored together Earl E. Clarke links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	C286, an orally available retinoic acid receptor β agonist drug, regulates multiple pathways to achieve spinal cord injury repair Frontiers in Molecular Neuroscience ·Maria B. Goncalves, Yue Wu, Earl E. Clarke, John Grist, Paul Adepoju, Marco Antonio Mendoza-Parra, Carl Hobbs, Roberto Quezada Calvillo, Henry Fok, Adrian Mander, Hana Hassanin, D Payne, Jörg Täubel, Tim Mant, Thomas Carlstedt, Julian Jack, Jonathan Corcoran	2024	0
2	Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL‐286, a novel retinoic acid receptor‐β agonist for treatment of spinal cord injury, in male healthy participants British Journal of Clinical Pharmacology ·Maria B. Goncalves, Tim Mant, Jörg Täubel, Earl E. Clarke, Hana Hassanin, D Payne, Henry Fok, John Posner, Jane Holmes, Adrian Mander, Jonathan Corcoran	2023	4
3	Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells Journal of Neuroscience ·Maria B. Goncalves, Yue Wu, Earl E. Clarke, John Grist, Carl Hobbs, Diogo Trigo, Julian Jack, Jonathan Corcoran	2019	35
4	RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms iScience ·Maria B. Goncalves, Paul Adepoju, Earl E. Clarke, John Grist, Carl Hobbs, Antony M. Carr, Julian Jack, Marco Antonio Mendoza-Parra, Jonathan Corcoran	2019	12
5	Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury Bioorganic & Medicinal Chemistry Letters ·Maria B. Goncalves, Earl E. Clarke, Christopher I Jarvis, S. Barret Kalindjian, Thomas Pitcher, John Grist, Carl Hobbs, Thomas Carlstedt, Julian Jack, 紀夫高田, م. أحمد مصطفى البحيرى, Enora Le Questel, Alan D. Borthwick, Jonathan Corcoran	2019	5
6	Drug repurposing for Alzheimer’s disease based on transcriptional profiling of human iPSC-derived cortical neurons Translational Psychiatry ·Gareth Williams, Ariana Gatt, Earl E. Clarke, Jonathan Corcoran, Patrick Doherty, David Chambers, Clive Ballard	2019	35
7	Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist Bioorganic & Medicinal Chemistry ·Earl E. Clarke, Christopher I Jarvis, Maria B. Goncalves, S. Barret Kalindjian, David R. Adams, 紀夫高田, Patricia C. Martínez, Carlos Tiago Garantizado, Pahlawan Pahlawan, Stephan Lippold, P. P. Novikov, محسن حداد سبزوار, Alan D. Borthwick, Jonathan Corcoran	2017	9
8	Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth Neurobiology of Disease ·Maria B. Goncalves, Yue Wu, Diogo Trigo, Earl E. Clarke, Maria da Conceição Sanches, John Grist, Carl Hobbs, Thomas Carlstedt, Jonathan Corcoran	2017	30
9	Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration Journal of Neuroscience ·Maria B. Goncalves, Maria da Conceição Sanches, Earl E. Clarke, S.F.H. Jellinghaus, John Grist, Carl Hobbs, Diogo Trigo, Mårten Risling, Maria Angéria, Peter Damberg, Thomas Carlstedt, Jonathan Corcoran	2015	82
10	Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist European Journal of Neuroscience ·Maria B. Goncalves, Earl E. Clarke, Carl Hobbs, Maria da Conceição Sanches, Robert M. J. Deacon, Julian Jack, Jonathan Corcoran	2013	60
11	Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Tim Sparey, Earl E. Clarke, Willis R. Heath, Timothy Harrison, Andrew Madin, Mark S. Shearman, Bindi Sohal	2007	7
12	3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity Bioorganic & Medicinal Chemistry Letters ·Richard A. Jelley, Jason Elliott, Karl R. Gibson, Timothy Harrison, Dirk Beher, Earl E. Clarke, Huw D. Lewis, Mark S. Shearman, Jonathan D.J. Wrigley	2006	14
13	Intra- or Intercomplex Binding to the γ-Secretase Enzyme Journal of Biological Chemistry ·Earl E. Clarke, Ian Churcher, Amss Cas, Jonathan D.J. Wrigley, Huw D. Lewis, Timothy Harrison, Mark S. Shearman, Dirk Beher	2006	30
14	Cyclic sulfamide γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Tim Sparey, Dirk Beher, Jonathan D. Best, Mirlinda Biba, José L. Castro, Earl E. Clarke, Willis R. Heath, Timothy Harrison, Huw D. Lewis, Andrew Madin, Mark S. Shearman, Bindi Sohal, Nancy N. Tsou, Christopher J. Welch, Jonathan D.J. Wrigley	2005	44
15	A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core Bioorganic & Medicinal Chemistry Letters ·Stephen J. Lewis, Adrian L. Smith, Joseph G. Neduvelil, Graeme I. Stevenson, Matthew Lindon, A. Brian Jones, Mark S. Shearman, Dirk Beher, Earl E. Clarke, Jonathan D. Best, Samuel Njoroge, Timothy Harrison, José L. Castro	2004	35
16	Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site Journal of Biological Chemistry ·Dirk Beher, Earl E. Clarke, Jonathan D.J. Wrigley, Agnés C. L. Martin, Alan Nadin, Ian Churcher, Mark S. Shearman	2004	144
17	Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity Journal of Biological Chemistry ·Jonathan D.J. Wrigley, Irina Schurov, Ren Can, Agnés C. L. Martin, Earl E. Clarke, Amss Cas, Timothy P. Bonnert, Mark S. Shearman, Dirk Beher	2004	35
18	Conserved residues within the putative active site of γ‐secretase differentially influence enzyme activity and inhibitor binding Journal of Neurochemistry ·Jonathan D.J. Wrigley, Ren Can, Omar Nyabi, Earl E. Clarke, Peter Hunt, Alan Nadin, Bart De Strooper, Mark S. Shearman, Dirk Beher	2004	18
19	High affinity, bioavailable 3-Amino-1,4-benzodiazepine-Based γ-Secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Andrew P. Owens, Alan Nadin, Adam C. Talbot, Earl E. Clarke, Timothy Harrison, Huw D. Lewis, Michael Reilly, Jonathan D.J. Wrigley, José L. Castro	2003	25
20	Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation Cell ·François G. Gervais, Daigen Xu, George S. Robertson, John P. Vaillancourt, Julia Sieß, Jingqi Huang, Andréa C. LeBlanc, David W. Smith, Michael Rigby, Mark S. Shearman, Earl E. Clarke, Hui Zheng, 龍子佐藤, Абдусаттар Ахатович Насиров, Nancy A. Thornberry, Amer Mohioddin Shashi Kumar P Srinu, Robert Zamboni, Sophie Roy, Donald W. Nicholson Hit paper breakdown →	1999	673

About Earl E. Clarke

Earl E. Clarke is a scholar working on Physiology, Cellular and Molecular Neuroscience, Computational Theory and Mathematics, Developmental Neuroscience and Biological Psychiatry, having authored 30 papers that have together received 2.0k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (16 papers), Computational Drug Discovery Methods (9 papers), Nerve injury and regeneration (6 papers), Retinoids in leukemia and cellular processes (6 papers), Cholinesterase and Neurodegenerative Diseases (5 papers), Neuroscience and Neuropharmacology Research (4 papers), Chemical Synthesis and Analysis (3 papers) and Protein Structure and Dynamics (3 papers). The work is most often cited by research in Physiology (1.0k citations), Pharmacology (402 citations), Cellular and Molecular Neuroscience (392 citations), Computational Theory and Mathematics (292 citations) and Developmental Neuroscience (67 citations). Earl E. Clarke has collaborated with scholars based in United Kingdom, United States and France. Frequent co-authors include Mark S. Shearman, Dirk Beher, Alan Nadin, Jonathan D.J. Wrigley, Huw D. Lewis, José L. Castro, Jonathan Corcoran, Ian Churcher, Jingqi Huang and Michael Rigby. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Biological Chemistry, Journal of Neuroscience, European Journal of Neuroscience and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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