Emad S. Alnemri

70.2k total citations · 19 hit papers
166 papers, 42.0k citations indexed

About

Emad S. Alnemri is a scholar working on Molecular Biology, Immunology and Epidemiology. According to data from OpenAlex, Emad S. Alnemri has authored 166 papers receiving a total of 42.0k indexed citations (citations by other indexed papers that have themselves been cited), including 153 papers in Molecular Biology, 61 papers in Immunology and 24 papers in Epidemiology. Recurrent topics in Emad S. Alnemri's work include Cell death mechanisms and regulation (89 papers), Inflammasome and immune disorders (37 papers) and interferon and immune responses (26 papers). Emad S. Alnemri is often cited by papers focused on Cell death mechanisms and regulation (89 papers), Inflammasome and immune disorders (37 papers) and interferon and immune responses (26 papers). Emad S. Alnemri collaborates with scholars based in United States, United Kingdom and Canada. Emad S. Alnemri's co-authors include Teresa Fernandes‐Alnemri, Srinivasa M. Srinivasula, Manzoor Ahmad, Gerald Litwack, Peng Li, I. Imawati Budihardjo, Deepak Nijhawan, Xiaodong Wang, Pinaki Datta and Jianghong Wu and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Emad S. Alnemri

166 papers receiving 41.3k citations

Hit Papers

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspa... 1994 2026 2004 2015 1997 2009 1999 2015 2009 2.0k 4.0k 6.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
    1997 6.2k citations Srinivasa M. Srinivasula, Emad S. Alnemri et al. profile →
  2. Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
    2009 2.4k citations Emad S. Alnemri, Teresa Fernandes‐Alnemri et al. profile →
  3. Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner
    1999 1.6k citations Emad S. Alnemri et al. profile →
  4. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
    2015 1.6k citations Seokwon Kang, Emad S. Alnemri et al. profile →
  5. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    2009 1.5k citations Teresa Fernandes‐Alnemri, Je‐Wook Yu et al. profile →
  6. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
    2017 1.2k citations Corey Rogers, Teresa Fernandes‐Alnemri et al. Nature Communications profile →
  7. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
    1994 1.1k citations Teresa Fernandes‐Alnemri, Emad S. Alnemri et al. Journal of Biological Chemistry profile →
  8. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
    2000 1.0k citations Srinivasa M. Srinivasula, Emad S. Alnemri et al. Proceedings of the National Academy of Sciences profile →
  9. Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization
    1998 969 citations Srinivasa M. Srinivasula, Teresa Fernandes‐Alnemri et al. profile →
  10. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
    2007 831 citations Teresa Fernandes‐Alnemri, Je‐Wook Yu et al. Cell Death and Differentiation profile →
  11. Negative regulation of the Apaf-1 apoptosome by Hsp70
    2000 681 citations Srinivasa M. Srinivasula, Emad S. Alnemri et al. profile →
  12. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
    1996 660 citations Teresa Fernandes‐Alnemri, Srinivasa M. Srinivasula et al. Proceedings of the National Academy of Sciences profile →
  13. Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
    2019 619 citations Corey Rogers, Dan A. Erkes et al. Nature Communications profile →
  14. Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
    2012 616 citations Christine A. Juliana, Teresa Fernandes‐Alnemri et al. Journal of Biological Chemistry profile →
  15. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
    2010 588 citations Teresa Fernandes‐Alnemri, Je‐Wook Yu et al. Nature Immunology profile →
  16. Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction
    2002 565 citations Srinivasa M. Srinivasula, Teresa Fernandes‐Alnemri et al. Journal of Biological Chemistry profile →
  17. Mechanism of XIAP-Mediated Inhibition of Caspase-9
    2003 527 citations Srinivasa M. Srinivasula, Emad S. Alnemri et al. profile →
  18. Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome
    2010 512 citations Christine A. Juliana, Teresa Fernandes‐Alnemri et al. Journal of Biological Chemistry profile →
  19. Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis
    2019 341 citations Dan A. Erkes, Weijia Cai et al. Cancer Discovery profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Emad S. Alnemri United States 90 32.7k 12.4k 4.9k 4.6k 3.7k 166 42.0k
Jiahuai Han China 107 29.9k 0.9× 11.0k 0.9× 4.2k 0.9× 5.8k 1.3× 6.7k 1.8× 319 44.0k
Séamus J. Martin Ireland 80 20.3k 0.6× 9.6k 0.8× 3.8k 0.8× 4.5k 1.0× 4.2k 1.1× 178 31.5k
Junying Yuan United States 103 36.5k 1.1× 10.4k 0.8× 10.9k 2.2× 5.1k 1.1× 4.9k 1.3× 254 52.9k
Guy S. Salvesen United States 110 37.2k 1.1× 9.6k 0.8× 5.9k 1.2× 9.0k 1.9× 8.2k 2.2× 295 54.7k
Avi Ashkenazi United States 80 23.8k 0.7× 9.3k 0.8× 3.7k 0.8× 6.0k 1.3× 5.7k 1.5× 200 33.2k
Hao Wu United States 80 20.3k 0.6× 11.0k 0.9× 2.6k 0.5× 2.8k 0.6× 3.7k 1.0× 268 28.1k
Tatsuhiko Kodama Japan 89 20.1k 0.6× 9.3k 0.8× 3.3k 0.7× 6.7k 1.5× 4.9k 1.3× 426 36.3k
Asrar B. Malik United States 108 17.2k 0.5× 8.4k 0.7× 3.0k 0.6× 2.1k 0.5× 3.8k 1.0× 582 40.5k
Andreas Strasser Australia 120 37.3k 1.1× 18.8k 1.5× 6.0k 1.2× 13.1k 2.8× 7.5k 2.0× 483 58.4k
Klaus Schulze‐Osthoff Germany 95 17.8k 0.5× 7.3k 0.6× 3.6k 0.7× 4.6k 1.0× 4.3k 1.1× 311 29.8k

Countries citing papers authored by Emad S. Alnemri

Since Specialization
Citations

This map shows the geographic impact of Emad S. Alnemri's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Emad S. Alnemri with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Emad S. Alnemri more than expected).

Fields of papers citing papers by Emad S. Alnemri

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Emad S. Alnemri. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Emad S. Alnemri. The network helps show where Emad S. Alnemri may publish in the future.

Co-authorship network of co-authors of Emad S. Alnemri

This figure shows the co-authorship network connecting the top 25 collaborators of Emad S. Alnemri. A scholar is included among the top collaborators of Emad S. Alnemri based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Emad S. Alnemri. Emad S. Alnemri is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Varney, Scott, Dan A. Erkes, Vivian Chua, et al.. (2024). Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma. Molecular Cancer Research. 23(4). 350–362. 4 indexed citations
2.
Vernon, Mégane, Nicole A. Wilski, Weijia Cai, et al.. (2022). Raptinal Induces Gasdermin E–Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma. Molecular Cancer Research. 20(12). 1811–1821. 22 indexed citations
3.
Xie, Jian, Chou‐Long Huang, Robert Köchl, et al.. (2021). Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis. Nature Communications. 12(1). 4546–4546. 66 indexed citations
4.
Erkes, Dan A., Weijia Cai, Ileine M. Sanchez, et al.. (2019). Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis. Cancer Discovery. 10(2). 254–269. 341 indexed citations breakdown →
5.
Rodrigue‐Gervais, Ian Gaël, Karine Doiron, Claudia Champagne, et al.. (2018). The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. Scientific Reports. 8(1). 8446–8446. 20 indexed citations
6.
Ratner, Dmitry, Pontus Ørning, Megan K. Proulx, et al.. (2016). The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. PLoS Pathogens. 12(12). e1006035–e1006035. 92 indexed citations
7.
Martin, Bradley N., Chenhui Wang, Jami Willette‐Brown, et al.. (2014). IKKα negatively regulates ASC-dependent inflammasome activation. Nature Communications. 5(1). 4977–4977. 88 indexed citations
8.
Fernandes‐Alnemri, Teresa, Je‐Wook Yu, Christine A. Juliana, et al.. (2010). The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nature Immunology. 11(5). 385–393. 588 indexed citations breakdown →
9.
Jéru, Isabelle, Sandrine Marlin, Emmanuelle Cochet, et al.. (2010). Functional consequences of a germline mutation in the leucine‐rich repeat domain of NLRP3 identified in an atypical autoinflammatory disorder. Arthritis & Rheumatism. 62(4). 1176–1185. 25 indexed citations
10.
Fernandes‐Alnemri, Teresa, Je‐Wook Yu, Jianghong Wu, Pinaki Datta, & Emad S. Alnemri. (2009). AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. The Medicine Forum. 458(7237). 509–513. 29 indexed citations
11.
Jéru, Isabelle, Philippe Duquesnoy, Teresa Fernandes‐Alnemri, et al.. (2008). Mutations in NALP12 cause hereditary periodic fever syndromes. Proceedings of the National Academy of Sciences. 105(5). 1614–1619. 288 indexed citations
12.
Zeuner, Ann, Adriana Eramo, Ugo Testa, et al.. (2003). Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1. Cell Death and Differentiation. 10(8). 905–913. 43 indexed citations
13.
Chang, David, Dara Ditsworth, Hongtu Liu, et al.. (2003). Oligomerization Is a General Mechanism for the Activation of Apoptosis Initiator and Inflammatory Procaspases. Journal of Biological Chemistry. 278(19). 16466–16469. 57 indexed citations
14.
Giampietri, Claudia, Simonetta Petrungaro, Pierpaolo Coluccia, et al.. (2003). FLIP is expressed in mouse testis and protects germ cells from apoptosis. Cell Death and Differentiation. 10(2). 175–184. 26 indexed citations
15.
Guo, Yin, Srinivasa M. Srinivasula, Anne Druilhe, Teresa Fernandes‐Alnemri, & Emad S. Alnemri. (2002). Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria. Journal of Biological Chemistry. 277(16). 13430–13437. 430 indexed citations
16.
Srinivasula, Srinivasa M., Jean‐Luc Poyet, Marjaneh Razmara, et al.. (2002). The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1. Journal of Biological Chemistry. 277(24). 21119–21122. 485 indexed citations
17.
Kelsey, Stephen M., et al.. (2001). c-IAP1 Blocks TNFα-Mediated Cytotoxicity Upstream of Caspase-Dependent and -Independent Mitochondrial Events in Human Leukemic Cells. Biochemical and Biophysical Research Communications. 287(1). 181–189. 18 indexed citations
18.
Wu, Gen Sheng, et al.. (1999). Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.. PubMed. 59(12). 2770–5. 204 indexed citations
19.
Harvey, Kieran F., Natasha L. Harvey, Gayathri Parasivam, et al.. (1998). Caspase-mediated Cleavage of the Ubiquitin-protein Ligase Nedd4 during Apoptosis. Journal of Biological Chemistry. 273(22). 13524–13530. 61 indexed citations
20.
Takahashi, Atsushi, Pascal J. Goldschmidt‐Clermont, Emad S. Alnemri, et al.. (1997). Inhibition of ICE-Related Proteases (Caspases) and Nuclear Apoptosis by Phenylarsine Oxide. Experimental Cell Research. 231(1). 123–131. 38 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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