John C. Reed

133.8k total citations · 36 hit papers
799 papers, 107.5k citations indexed

About

John C. Reed is a scholar working on Molecular Biology, Immunology and Oncology. According to data from OpenAlex, John C. Reed has authored 799 papers receiving a total of 107.5k indexed citations (citations by other indexed papers that have themselves been cited), including 587 papers in Molecular Biology, 192 papers in Immunology and 179 papers in Oncology. Recurrent topics in John C. Reed's work include Cell death mechanisms and regulation (356 papers), Cancer-related Molecular Pathways (108 papers) and RNA Interference and Gene Delivery (81 papers). John C. Reed is often cited by papers focused on Cell death mechanisms and regulation (356 papers), Cancer-related Molecular Pathways (108 papers) and RNA Interference and Gene Delivery (81 papers). John C. Reed collaborates with scholars based in United States, Germany and Japan. John C. Reed's co-authors include Douglas R. Green, Stanisław Krajewski, Quinn L. Deveraux, Shinichi Kitada, Maryla Krajewska, Shinichi Takayama, Hong‐Gang Wang, Zhihua Xie, Renata Sano and Guy S. Salvesen and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

John C. Reed

787 papers receiving 105.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mitochondria and Apoptosis

1998 7.9k citations John C. Reed et al. profile →
Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 2.6k citations John C. Reed et al. profile →
IAP family proteins---suppressors of apoptosis

1999 2.2k citations John C. Reed et al. profile →
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 1.9k citations Stanisław Krajewski, Maryla Krajewska et al. profile →
Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 1.6k citations John C. Reed et al. profile →
ER stress-induced cell death mechanisms

2013 1.6k citations Renata Sano, John C. Reed profile →
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

2008 1.5k citations John C. Reed et al. profile →
Apoptosis in the Failing Human Heart

1997 1.4k citations Stanisław Krajewski, John C. Reed et al. profile →
Bax directly induces release of cytochrome c from isolated mitochondria

1998 1.3k citations John C. Reed et al. Proceedings of the National Academy of Sciences profile →
Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 1.1k citations John C. Reed et al. profile →
Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 1.0k citations John C. Reed et al. profile →
Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 972 citations Stanisław Krajewski, John C. Reed et al. profile →
Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 911 citations Stanisław Krajewski, John C. Reed et al. profile →
Anchorage dependence, integrins, and apoptosis

1994 867 citations John C. Reed et al. profile →
Dysregulation of Apoptosis in Cancer

1999 804 citations John C. Reed Journal of Clinical Oncology profile →
Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 742 citations Shinichi Takayama, John C. Reed et al. profile →
Bcl-2 family proteins and cancer

2008 724 citations John C. Reed et al. profile →
Cytochrome c: Can't Live with It—Can't Live without It

1997 658 citations John C. Reed profile →
Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

1998 649 citations John C. Reed et al. profile →
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

2000 645 citations John C. Reed et al. profile →
Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 630 citations John C. Reed et al. profile →
FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 620 citations Shinichi Kitada, John C. Reed et al. profile →
The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 574 citations John C. Reed et al. profile →
Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3

2000 568 citations John C. Reed et al. profile →
Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

2007 563 citations Benjamin Faustin, Jean‐Marie Bruey et al. profile →
The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 561 citations John C. Reed et al. profile →
Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3

2004 560 citations John C. Reed et al. profile →
Lysosomal Protease Pathways to Apoptosis

2001 543 citations Stanisław Krajewski, John C. Reed et al. profile →
Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses

1998 534 citations Shinichi Kitada, Juan M. Zapata et al. profile →
Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.

1996 525 citations Shinichi Kitada, John C. Reed et al. profile →
Apoptosis-based therapies

2002 522 citations John C. Reed profile →
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

2000 518 citations Stanisław Krajewski, Kate Welsh et al. profile →
Channel formation by antiapoptotic protein Bcl-2

1997 516 citations John C. Reed et al. Proceedings of the National Academy of Sciences profile →
Humanin peptide suppresses apoptosis by interfering with Bax activation

2003 513 citations Dayong Zhai, Kate Welsh et al. profile →
Bcl-2-mediated alterations in endoplasmic reticulum Ca ²⁺ analyzed with an improved genetically encoded fluorescent sensor

2004 512 citations John C. Reed et al. Proceedings of the National Academy of Sciences profile →
A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

1998 507 citations Kate Welsh, John C. Reed et al. profile →

Peers

Countries citing papers authored by John C. Reed

Since Specialization

Citations

This map shows the geographic impact of John C. Reed's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John C. Reed with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John C. Reed more than expected).

Fields of papers citing papers by John C. Reed

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John C. Reed. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John C. Reed. The network helps show where John C. Reed may publish in the future.

Co-authorship network of co-authors of John C. Reed

This figure shows the co-authorship network connecting the top 25 collaborators of John C. Reed. A scholar is included among the top collaborators of John C. Reed based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John C. Reed. John C. Reed is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	PCTAIRE1 Phosphorylates p27 and Regulates Mitosis in Cancer Cells 2014 ·Cancer Research ·Teruki Yanagi, Maryla Krajewska, Shu‐ichi Matsuzawa, John C. Reed	50
2	Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs 2013 ·Molecular Cancer Therapeutics ·Darren Finlay, Mitchell Vamos, Marcos González‐López, Robert Ardecky, (unknown), Hongbin Yuan, Ying Su, (unknown), (unknown), Kate Welsh, John C. Reed, Nicholas D. P. Cosford, Kristiina Vuori	45
3	Synthetic Triterpenoid Cyano Enone of Methyl Boswellate Activates Intrinsic, Extrinsic, and Endoplasmic Reticulum Stress Cell Death Pathways in Tumor Cell Lines 2011 ·Molecular Cancer Therapeutics ·Palaniyandi Ravanan, Renata Sano, Priti Talwar, Satoshi Ogasawara, Shu‐ichi Matsuzawa, Michael Cuddy, Sanjay K. Singh, G. S. R. Subba Rao, Paturu Kondaiah, John C. Reed	18
4	Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda -7/IL-24–mediated toxicity 2011 ·Proceedings of the National Academy of Sciences ·Rupesh Dash, Belal Azab, Bridget A. Quinn, Xue‐Ning Shen, Xiangyang Wang, Swadesh K. Das, Mohamed Rahmani, Jun Wei, Michael Hedvat, Paul Dent, Igor P. Dmitriev, David T. Curiel, Steven Grant, Bainan Wu, John L. Stebbins, Maurizio Pellecchia, John C. Reed, Devanand Sarkar, Paul B. Fisher	101
5	High-Throughput Screen for the Chemical Inhibitors of Antiapoptotic Bcl-2 Family Proteins by Multiplex Flow Cytometry 2011 ·Assay and Drug Development Technologies ·Ramona Curpăn, Peter C. Simons, Dayong Zhai, Susan Young, Mark B. Carter, Cristian Bologa, Tudor I. Oprea, Arnold C. Satterthwait, John C. Reed, Bruce S. Edwards, Larry A. Sklar	21
6	Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands 2010 ·Molecular Cancer Therapeutics ·Tabitha E. Wood, Shadi Dalili, Craig D. Simpson, Mahadeo A. Sukhai, Rose Hurren, Kika Anyiwe, Xinliang Mao, Fernando Suárez, Marcela Gronda, Yanina Eberhard, Neil MacLean, Troy Ketela, John C. Reed, Jason Moffat, Mark D. Minden, Robert A. Batey, Aaron D. Schimmer	56
7	Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine 2010 ·Cancer Research ·Rupesh Dash, Joanna E. Richards, Zhao-zhong Su, Sujit K. Bhutia, Belal Azab, Mohamed Rahmani, Girija Dasmahapatra, Adly Yacoub, Paul Dent, Igor P. Dmitriev, David T. Curiel, Steven Grant, Maurizio Pellecchia, John C. Reed, Devanand Sarkar, Paul B. Fisher	65
8	Expression of p21 Protein Predicts Clinical Outcome in DLBCL Patients Older than 60 Years Treated with R-CHOP but not CHOP: A Prospective ECOG and Southwest Oncology Group Correlative Study on E4494 2010 ·Clinical Cancer Research ·Jane N. Winter, Shuli Li, (unknown), Daina Variakojis, Beverly P. Nelson, Maryla Krajewska, Lijun Zhang, Thomas M. Habermann, Richard I. Fisher, William R. Macon, Mukesh Chhanabhai, Raymond E. Felgar, Eric D. Hsi, L. Jeffrey Medeiros, James K. Weick, Edie Weller, Ari Melnick, John C. Reed, Sandra J. Horning, Randy D. Gascoyne	26
9	BCIRG 001 Molecular Analysis: Prognostic Factors in Node-Positive Breast Cancer Patients Receiving Adjuvant Chemotherapy 2010 ·Clinical Cancer Research ·Charles Dumontet, Maryla Krajewska, Isabelle Treilleux, John R. Mackey, Miguel Martín, (unknown), Laurence Lafanéchère, John C. Reed	33
10	Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins 2009 ·Molecular Cancer Therapeutics ·Jun Wei, Shinichi Kitada, Michele F. Rega, Aras Emdadi, Hongbin Yuan, Jason Cellitti, John L. Stebbins, Dayong Zhai, Jiazhi Sun, Li Yang, Russell Dahl, Ziming Zhang, Bainan Wu, Si Wang, (unknown), Nicholas J. Lawrence, Saı̈d M. Sebti, John C. Reed, Maurizio Pellecchia	51
11	Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins 2008 ·Molecular Cancer Therapeutics ·Dayong Zhai, Chaofang Jin, Chung-Wai Shiau, Shinichi Kitada, Arnold C. Satterthwait, John C. Reed	70
12	Apoptotic Activity and Mechanism of 2-Cyano-3,12-Dioxoolean-1,9-Dien-28-Oic-Acid and Related Synthetic Triterpenoids in Prostate Cancer 2008 ·Cancer Research ·Marc L. Hyer, Ranxin Shi, Maryla Krajewska, Colin J. Meyer, Irina V. Lebedeva, Paul B. Fisher, John C. Reed	52
13	BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments 2008 ·Proceedings of the National Academy of Sciences ·Sungho Maeng, Joshua Hunsberger, Brandon L. Pearson, Peixiong Yuan, Yun Wang, Yanling Wei, (unknown), Robert J. Schloesser, Rulun Zhou, Jing Du, Guang Chen, Bruce S. McEwen, John C. Reed, Husseini K. Manji	52
14	Mice Lacking bi-1 Gene Show Accelerated Liver Regeneration 2007 ·Cancer Research ·Béatrice Bailly‐Maitre, Emilie A. Bard-Chapeau, Frédéric Luciano, Nathalie Droin, Jean‐Marie Bruey, Benjamin Faustin, Christina Kress, Juan M. Zapata, John C. Reed	25
15	Comprehensive Assessment of Genetic and Molecular Features Predicting Outcome in Patients With Chronic Lymphocytic Leukemia: Results From the US Intergroup Phase III Trial E2997 2007 ·Journal of Clinical Oncology ·Michael R. Grever, David Lucas, Gordon W. Dewald, Donna Neuberg, John C. Reed, Shinichi Kitada, Ian W. Flinn, Martin S. Tallman, Frederick R. Appelbaum, Richard A. Larson, Elisabeth Paietta, Diane F. Jelinek, John G. Gribben, John C. Byrd	256
16	BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells 2007 ·Cancer Research ·Masahiro Iwasaki, Sachiko Homma, Akinori Hishiya, (unknown), John C. Reed, Shinichi Takayama	90
17	Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors 2006 ·Cancer Research ·Aaron D. Schimmer, Michael P. Thomas, Rose Hurren, Marcela Gronda, Maurizio Pellecchia, Gregory R. Pond, Marina Konopleva, Debbie Gurfinkel, Imtiaz A. Mawji, Ewan Brown, John C. Reed	59
18	Structure–activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid 2006 ·Proceedings of the National Academy of Sciences ·Barbara Becattini, Carsten Culmsee, Marilisa Leone, Dayong Zhai, Xiyun Zhang, Kevin Crowell, Michele F. Rega, Stefan Landshamer, John C. Reed, Nikolaus Plesnila, Maurizio Pellecchia	67
19	Predicting chemoresistance in human malignant glioma cells: The role of molecular genetic analyses 1998 ·International Journal of Cancer ·Michael Weller, Johannes Rieger, Cornelia Grimmel, Erwin G. Van Meir, Nicolas de Tribolet, Stanisław Krajewski, John C. Reed, Andreas von Deimling, J. Dichgans	152
20	Recombinant Interleukin 2 Regulates Levels of c- myc mRNA in a Cloned Murine T Lymphocyte 1985 ·Molecular and Cellular Biology ·John C. Reed, Daniel E. Sabath, R G Hoover, Michael B. Prystowsky	21

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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