John C. Reed

133.8k total citations · 36 hit papers
799 papers, 107.5k citations indexed

About

John C. Reed is a scholar working on Molecular Biology, Immunology and Oncology. According to data from OpenAlex, John C. Reed has authored 799 papers receiving a total of 107.5k indexed citations (citations by other indexed papers that have themselves been cited), including 587 papers in Molecular Biology, 192 papers in Immunology and 179 papers in Oncology. Recurrent topics in John C. Reed's work include Cell death mechanisms and regulation (356 papers), Cancer-related Molecular Pathways (108 papers) and RNA Interference and Gene Delivery (81 papers). John C. Reed is often cited by papers focused on Cell death mechanisms and regulation (356 papers), Cancer-related Molecular Pathways (108 papers) and RNA Interference and Gene Delivery (81 papers). John C. Reed collaborates with scholars based in United States, Germany and Japan. John C. Reed's co-authors include Douglas R. Green, Stanisław Krajewski, Quinn L. Deveraux, Shinichi Kitada, Maryla Krajewska, Shinichi Takayama, Hong‐Gang Wang, Zhihua Xie, Renata Sano and Guy S. Salvesen and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

John C. Reed

787 papers receiving 105.4k citations

Hit Papers

Mitochondria and Apoptosis 1993 2026 2004 2015 1998 1998 1999 1994 1999 2.5k 5.0k 7.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Mitochondria and Apoptosis
    1998 7.9k citations John C. Reed et al. profile →
  2. Regulation of Cell Death Protease Caspase-9 by Phosphorylation
    1998 2.6k citations John C. Reed et al. profile →
  3. IAP family proteins---suppressors of apoptosis
    1999 2.2k citations John C. Reed et al. profile →
  4. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.
    1994 1.9k citations Maryla Krajewska, John C. Reed et al. profile →
  5. Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner
    1999 1.6k citations John C. Reed et al. profile →
  6. ER stress-induced cell death mechanisms
    2013 1.6k citations Renata Sano, John C. Reed profile →
  7. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
    2008 1.5k citations John C. Reed et al. profile →
  8. Apoptosis in the Failing Human Heart
    1997 1.4k citations John C. Reed et al. profile →
  9. Bax directly induces release of cytochrome c from isolated mitochondria
    1998 1.3k citations John C. Reed et al. Proceedings of the National Academy of Sciences profile →
  10. Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype
    1997 1.1k citations John C. Reed et al. profile →
  11. Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis
    1998 1.0k citations John C. Reed et al. profile →
  12. Ca 2+ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD
    1999 972 citations John C. Reed et al. profile →
  13. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.
    1993 911 citations John C. Reed et al. profile →
  14. Anchorage dependence, integrins, and apoptosis
    1994 867 citations John C. Reed et al. profile →
  15. Dysregulation of Apoptosis in Cancer
    1999 804 citations John C. Reed Journal of Clinical Oncology profile →
  16. Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity
    1995 742 citations Shinichi Takayama, John C. Reed et al. profile →
  17. Bcl-2 family proteins and cancer
    2008 724 citations John C. Reed et al. profile →
  18. Cytochrome c: Can't Live with It—Can't Live without It
    1997 658 citations John C. Reed profile →
  19. Pro-caspase-3 Is a Major Physiologic Target of Caspase-8
    1998 649 citations John C. Reed et al. profile →
  20. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis
    2000 645 citations John C. Reed et al. profile →
  21. Identification of a p53-dependent negative response element in the bcl-2 gene.
    1994 630 citations John C. Reed et al. profile →
  22. FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas
    1995 620 citations Shinichi Kitada, John C. Reed et al. profile →
  23. The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins
    1998 574 citations John C. Reed et al. profile →
  24. Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3
    2000 568 citations John C. Reed et al. profile →
  25. Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation
    2007 563 citations Benjamin Faustin, Jean‐Marie Bruey et al. profile →
  26. The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis
    1997 561 citations John C. Reed et al. profile →
  27. Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3
    2004 560 citations John C. Reed et al. profile →
  28. Lysosomal Protease Pathways to Apoptosis
    2001 543 citations John C. Reed et al. profile →
  29. Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses
    1998 534 citations Shinichi Kitada, Juan M. Zapata et al. profile →
  30. Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.
    1996 525 citations Shinichi Kitada, John C. Reed et al. profile →
  31. Apoptosis-based therapies
    2002 522 citations John C. Reed profile →
  32. Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.
    2000 518 citations Kate Welsh, Shinichi Kitada et al. profile →
  33. Channel formation by antiapoptotic protein Bcl-2
    1997 516 citations John C. Reed et al. Proceedings of the National Academy of Sciences profile →
  34. Humanin peptide suppresses apoptosis by interfering with Bax activation
    2003 513 citations Dayong Zhai, Kate Welsh et al. profile →
  35. Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
    2004 512 citations John C. Reed et al. Proceedings of the National Academy of Sciences profile →
  36. A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases
    1998 507 citations Kate Welsh, John C. Reed et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
John C. Reed 73.3k 21.4k 20.4k 12.2k 10.6k 799 107.5k
Stanley J. Korsmeyer 59.5k 0.8× 15.3k 0.7× 15.2k 0.7× 7.6k 0.6× 8.0k 0.7× 230 84.0k
Douglas R. Green 80.9k 1.1× 18.8k 0.9× 35.3k 1.7× 15.1k 1.2× 18.8k 1.8× 613 125.1k
Roger J. Davis 62.3k 0.9× 15.6k 0.7× 13.6k 0.7× 11.6k 1.0× 7.5k 0.7× 572 92.6k
Tak W. Mak 49.6k 0.7× 22.6k 1.1× 34.0k 1.7× 17.0k 1.4× 7.3k 0.7× 710 96.1k
Lewis C. Cantley 104.9k 1.4× 27.4k 1.3× 16.8k 0.8× 29.7k 2.4× 8.7k 0.8× 710 150.4k
Ronald A. DePinho 56.0k 0.8× 23.0k 1.1× 9.8k 0.5× 13.7k 1.1× 6.1k 0.6× 417 86.1k
David M. Sabatini 71.6k 1.0× 9.5k 0.4× 10.4k 0.5× 12.9k 1.1× 13.8k 1.3× 257 101.0k
Peter Carmeliet 53.1k 0.7× 15.0k 0.7× 11.7k 0.6× 27.4k 2.2× 5.5k 0.5× 729 100.0k
George D. Yancopoulos 55.1k 0.8× 14.3k 0.7× 16.0k 0.8× 11.9k 1.0× 4.5k 0.4× 430 103.1k
Roderick T. Bronson 46.0k 0.6× 23.2k 1.1× 11.5k 0.6× 11.6k 1.0× 4.2k 0.4× 544 77.8k

Countries citing papers authored by John C. Reed

Since Specialization
Citations

This map shows the geographic impact of John C. Reed's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John C. Reed with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John C. Reed more than expected).

Fields of papers citing papers by John C. Reed

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John C. Reed. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John C. Reed. The network helps show where John C. Reed may publish in the future.

Co-authorship network of co-authors of John C. Reed

This figure shows the co-authorship network connecting the top 25 collaborators of John C. Reed. A scholar is included among the top collaborators of John C. Reed based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John C. Reed. John C. Reed is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Yanagi, Teruki, Maryla Krajewska, Shu‐ichi Matsuzawa, & John C. Reed. (2014). PCTAIRE1 Phosphorylates p27 and Regulates Mitosis in Cancer Cells. Cancer Research. 74(20). 5795–5807. 50 indexed citations
2.
Finlay, Darren, Mitchell Vamos, Marcos González‐López, et al.. (2013). Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs. Molecular Cancer Therapeutics. 13(1). 5–15. 45 indexed citations
3.
Ravanan, Palaniyandi, Renata Sano, Priti Talwar, et al.. (2011). Synthetic Triterpenoid Cyano Enone of Methyl Boswellate Activates Intrinsic, Extrinsic, and Endoplasmic Reticulum Stress Cell Death Pathways in Tumor Cell Lines. Molecular Cancer Therapeutics. 10(9). 1635–1643. 18 indexed citations
4.
Curpăn, Ramona, Peter C. Simons, Dayong Zhai, et al.. (2011). High-Throughput Screen for the Chemical Inhibitors of Antiapoptotic Bcl-2 Family Proteins by Multiplex Flow Cytometry. Assay and Drug Development Technologies. 9(5). 465–474. 21 indexed citations
5.
Dash, Rupesh, Belal Azab, Bridget A. Quinn, et al.. (2011). Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda -7/IL-24–mediated toxicity. Proceedings of the National Academy of Sciences. 108(21). 8785–8790. 101 indexed citations
6.
Wood, Tabitha E., Shadi Dalili, Craig D. Simpson, et al.. (2010). Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands. Molecular Cancer Therapeutics. 9(1). 246–256. 56 indexed citations
7.
Dash, Rupesh, Joanna E. Richards, Zhao-zhong Su, et al.. (2010). Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine. Cancer Research. 70(12). 5034–5045. 65 indexed citations
8.
9.
Dumontet, Charles, Maryla Krajewska, Isabelle Treilleux, et al.. (2010). BCIRG 001 Molecular Analysis: Prognostic Factors in Node-Positive Breast Cancer Patients Receiving Adjuvant Chemotherapy. Clinical Cancer Research. 16(15). 3988–3997. 33 indexed citations
10.
Wei, Jun, Shinichi Kitada, Michele F. Rega, et al.. (2009). Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Molecular Cancer Therapeutics. 8(4). 904–913. 51 indexed citations
11.
Zhai, Dayong, Chaofang Jin, Chung-Wai Shiau, et al.. (2008). Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins. Molecular Cancer Therapeutics. 7(6). 1639–1646. 70 indexed citations
12.
Hyer, Marc L., Ranxin Shi, Maryla Krajewska, et al.. (2008). Apoptotic Activity and Mechanism of 2-Cyano-3,12-Dioxoolean-1,9-Dien-28-Oic-Acid and Related Synthetic Triterpenoids in Prostate Cancer. Cancer Research. 68(8). 2927–2933. 52 indexed citations
13.
Maeng, Sungho, Joshua Hunsberger, Brandon L. Pearson, et al.. (2008). BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments. Proceedings of the National Academy of Sciences. 105(25). 8766–8771. 52 indexed citations
14.
Iwasaki, Masahiro, et al.. (2007). BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells. Cancer Research. 67(21). 10252–10259. 90 indexed citations
15.
Bailly‐Maitre, Béatrice, Emilie A. Bard-Chapeau, Frédéric Luciano, et al.. (2007). Mice Lacking bi-1 Gene Show Accelerated Liver Regeneration. Cancer Research. 67(4). 1442–1450. 25 indexed citations
16.
Grever, Michael R., David Lucas, Gordon W. Dewald, et al.. (2007). Comprehensive Assessment of Genetic and Molecular Features Predicting Outcome in Patients With Chronic Lymphocytic Leukemia: Results From the US Intergroup Phase III Trial E2997. Journal of Clinical Oncology. 25(7). 799–804. 256 indexed citations
17.
Schimmer, Aaron D., Michael P. Thomas, Rose Hurren, et al.. (2006). Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors. Cancer Research. 66(4). 2367–2375. 59 indexed citations
18.
Becattini, Barbara, Carsten Culmsee, Marilisa Leone, et al.. (2006). Structure–activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid. Proceedings of the National Academy of Sciences. 103(33). 12602–12606. 67 indexed citations
19.
Reed, John C.. (2001). The Survivin saga goes in vivo. Journal of Clinical Investigation. 108(7). 965–969. 19 indexed citations
20.
Reed, John C.. (1997). Bcl-2 Family Proteins: Strategies for Overcoming Chemoresistance in Cancer. Advances in pharmacology. 41. 501–532. 109 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Stanley J. Korsmeyer Breakdown of academic impact, for papers by Douglas R. Green Breakdown of academic impact, for papers by Roger J. Davis Breakdown of academic impact, for papers by Tak W. Mak Breakdown of academic impact, for papers by Lewis C. Cantley Breakdown of academic impact, for papers by Ronald A. DePinho Breakdown of academic impact, for papers by David M. Sabatini Breakdown of academic impact, for papers by Peter Carmeliet Breakdown of academic impact, for papers by George D. Yancopoulos Breakdown of academic impact, for papers by Roderick T. Bronson
Rankless by CCL
2026