Daigen Xu

3.5k citations

36 papers · 2.8k indexed · 1 hit paper · h-index 23

Impact in

Pharmacology top 1%
- Inflammatory mediators and NSAID effects
Cellular and Molecular Neuroscience top 5%
- Neuroscience and Neuropharmacology Research

Papers in ⓘ

Pharmacology 12
- Inflammatory mediators and NSAID effects 11
Genetics 6
- Estrogen and related hormone effects 4
- Chronic Lymphocytic Leukemia Research 3

Co-authors: George S. Robertson (12 shared papers)Donald W. Nicholson (7 shared papers)Patsy Clark (10 shared papers)Sophie Roy (4 shared papers)John P. Vaillancourt (2 shared papers)Robert G. Korneluk (5 shared papers)Robert Zamboni (2 shared papers)Steven Xanthoudakis (3 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (6 papers)Journal of Pharmacology and Experimental Therapeutics (5 papers)Neuroscience (2 papers)Journal of Neuroscience (2 papers)The Journal of Comparative Neurology (2 papers)
Partner nations: Canada United States Italy

In The Last Decade

Daigen Xu

36 papers receiving 2.7k citations

Hit Papers

align trajectories log scale

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation 1999 · 673 citations

Peers

Countries citing papers authored by Daigen Xu

Since Specialization

Citations

This map shows the geographic impact of Daigen Xu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Daigen Xu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Daigen Xu more than expected).

Fields of papers citing papers by Daigen Xu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Daigen Xu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Daigen Xu. The network helps show where Daigen Xu may publish in the future.

Co-authors

The 25 scholars most cited alongside Daigen Xu, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Daigen Xu Line = papers co-authored together Daigen Xu links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 36 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation Cell ·François G. Gervais, Daigen Xu, George S. Robertson, John P. Vaillancourt, Yanxia Zhu, Jingqi Huang, Andréa C. LeBlanc, David W. Smith, Michael Rigby, Mark S. Shearman, Earl E. Clarke, Hui Zheng, Leonardus H.T. Van Der Ploeg, Salvatore C. Ruffolo, Nancy A. Thornberry, Steve Xanthoudakis, Robert Zamboni, Sophie Roy, Donald W. Nicholson Hit paper breakdown →	1999	673
2	Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis Cell Death and Differentiation ·Birgit Schwab, Danilo Guerini, Claire Didszun, Daniele Bano, Elisa Ferrando‐May, Eugenio Fava, James P. Tam, Daigen Xu, Steven Xanthoudakis, Donald W. Nicholson, Ernesto Carafoli, Pierluigi Nicotera	2002	221
3	Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus Nature Medicine ·Daigen Xu, Stephen J. Crocker, J. P. Doucet, Martine St-Jean, Katsuyuki Tamai, A. M. Hakim, J. Ikeda, Peter Liston, Charlie S. Thompson, Robert G. Korneluk, Alex MacKenzie, George S. Robertson	1997	209
4	Attenuation of Ischemia-Induced Cellular and Behavioral Deficits by X Chromosome-Linked Inhibitor of Apoptosis Protein Overexpression in the Rat Hippocampus Journal of Neuroscience ·Daigen Xu, Y Bureau, Dan McIntyre, Donald W. Nicholson, Peter Liston, Yanxia Zhu, Wei Gin Fong, Stephen J. Crocker, Robert G. Korneluk, George S. Robertson	1999	176
5	Genetic Deletion of mPGES-1 Suppresses Intestinal Tumorigenesis Cancer Research ·Masako Nakanishi, David C. Montrose, Patsy Clark, Prashant R. Nambiar, Glenn S. Belinsky, Kevin P. Claffey, Daigen Xu, Daniel W. Rosenberg	2008	142
6	Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury Journal of Biological Chemistry ·Byung Hee Han, Daigen Xu, Junjeong Choi, Yongxin Han, Steven Xanthoudakis, Sophie Roy, John Tam, John P. Vaillancourt, John Colucci, Robert Siman, André Giroux, George S. Robertson, Robert Zamboni, Donald W. Nicholson, David M. Holtzman	2002	141
7	MF63 [2-(6-Chloro-1 H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation Journal of Pharmacology and Experimental Therapeutics ·Daigen Xu, Steven E. Rowland, Patsy Clark, André Giroux, Bernard Côté, Sébastien Guiral, Myriam Salem, Yves Ducharme, Richard W. Friesen, Nathalie Méthot, Joseph A. Mancini, Laurent Audoly, Denis Riendeau	2008	129
8	Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors Bioorganic & Medicinal Chemistry Letters ·Bernard Côté, Louise Boulet, Christine Brideau, David Claveau, Diane Ethier, Richard Frenette, Marc Gagnon, André Giroux, Jocelyne Guay, Sébastien Guiral, Joseph A. Mancini, Evelyn Martins, Frédéric Massé, Nathalie Méthot, Denis Riendeau, Joel Rubin, Daigen Xu, Hongping Yu, Yves Ducharme, Richard W. Friesen	2007	116
9	Immunohistochemical and biochemical assessment of caspase-3 activation and DNA fragmentation following transient focal ischemia in the rat Neuroscience ·Maria Antonietta Davoli, Jimmy Fourtounis, James P. Tam, Steven Xanthoudakis, Donald W. Nicholson, George S. Robertson, Gordon Ng, Daigen Xu	2002	114
10	RN486, a Selective Bruton's Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents Journal of Pharmacology and Experimental Therapeutics ·Daigen Xu, Yong Kim, Jennifer Postelnek, Minh Diem Vu, Dong‐Qing Hu, Cheng Liao, Mike Bradshaw, Jonathan C. Hsu, Jun Zhang, Achal Pashine, Dinesh Srinivasan, John Woods, Anita Levin, Alison O’Mahony, Timothy D. Owens, Yan Lou, Ronald J. Hill, Satwant K. Narula, Julie A. DeMartino, Jay S. Fine	2012	105
11	Prostacyclin Antagonism Reduces Pain and Inflammation in Rodent Models of Hyperalgesia and Chronic Arthritis Journal of Pharmacology and Experimental Therapeutics ·Anne-Marie Pulichino, Steve Rowland, Tom Wu, Patsy Clark, Daigen Xu, Marie‐Claude Mathieu, Denis Riendeau, Laurent Audoly	2006	94
12	MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7 H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis Journal of Pharmacology and Experimental Therapeutics ·Patsy Clark, Steven E. Rowland, Danielle Denis, Marie‐Claude Mathieu, Rino Stocco, Hugo Poirier, Jason D. Burch, Yongxin Han, Laurent Audoly, Alex G. Therien, Daigen Xu	2008	78
13	Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models Scientific Reports ·Justin Komguep Nono, Kai Fu, Thabo Mpotje, Georgianna Varrone, Nada Abdel Aziz, Paballo Mosala, Lerato Hlaka, Séverin Donald Kamdem, Daigen Xu, Thomas Spangenberg, Frank Brombacher	2020	70
14	Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody‐driven K/BxN serum–transfer arthritis Arthritis & Rheumatism ·Mei Chen, Éric Boilard, Peter A. Nigrović, Patsy Clark, Daigen Xu, Garret A. FitzGerald, Laurent Audoly, David M. Lee	2008	62
15	NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6‐OHDA rat model of Parkinson's disease European Journal of Neuroscience ·Stephen J. Crocker, N. Wigle, Peter Liston, Charlie S. Thompson, Christopher J. Lee, Daigen Xu, Sophie Roy, Donald W. Nicholson, David S. Park, Alex MacKenzie, Robert G. Korneluk, George S. Robertson	2001	59
16	Btk inhibition treats TLR7/IFN driven murine lupus Clinical Immunology ·Andrew T. Bender, Albertina Pereira, Kai Fu, Eileen T. Samy, Yin Wu, Lesley Liu‐Bujalski, Richard D. Caldwell, Yi‐Ying Chen, Hui Tian, Federica Morandi, Jared Head, Ursula Koehler, Melinda Genest, Shinji L. Okitsu, Daigen Xu, Roland Grenningloh	2016	38
17	Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy Arthritis Research & Therapy ·Cheng Liao, Jonathan Hsu, Yong Kim, Dong‐Qing Hu, Daigen Xu, Jun Zhang, Achal Pashine, John G. Menke, Toni Whittard, Natasha Romero, Theresa Truitt, Michelle Slade, Christine Lukacs, Johannes C. Hermann, Mingyan Zhou, Matthew C. Lucas, Satwant K. Narula, Julie A. DeMartino, Seng‐Lai Tan	2013	35
18	Distribution of neuronal apoptosis inhibitory protein-like immunoreactivity in the rat central nervous system The Journal of Comparative Neurology ·Daigen Xu, Robert G. Korneluk, Katsuyuki Tamai, N. Wigle, A. M. Hakim, Alex MacKenzie, George S. Robertson	1997	35
19	Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain Bioorganic & Medicinal Chemistry Letters ·John Colucci, Michael J. Boyd, Carl Berthelette, Jean-François Chiasson, Zhaoyin Wang, Yves Ducharme, R. W. Friesen, Mark Wrona, Jean-François Lévesque, Danielle Denis, Marie‐Claude Mathieu, Rino Stocco, Alex G. Therien, Patsy Clarke, Steve Rowland, Daigen Xu, Yongxin Han	2010	29
20	Development of a homogeneous immunoassay for the detection of angiotensin I in plasma using AlphaLISA acceptor beads technology Analytical Biochemistry ·Elizabeth Cauchon, Susana Liu, M. David Percival, Steve E. Rowland, Daigen Xu, Christoph A. Binkert, Panja Strickner, Jean‐Pierre Falgueyret	2009	29

About Daigen Xu

Daigen Xu is a scholar working on Pharmacology, Genetics, Developmental Neuroscience, Cellular and Molecular Neuroscience and Cancer Research, having authored 36 papers that have together received 2.8k indexed citations. Recurring topics across this work include Inflammatory mediators and NSAID effects (11 papers), Cell death mechanisms and regulation (7 papers), Synthesis of β-Lactam Compounds (4 papers), Estrogen and related hormone effects (4 papers), Monoclonal and Polyclonal Antibodies Research (4 papers), Chronic Lymphocytic Leukemia Research (3 papers), Neuroscience and Neuropharmacology Research (3 papers) and Nerve injury and regeneration (2 papers). The work is most often cited by research in Pharmacology (668 citations), Cellular and Molecular Neuroscience (474 citations), Developmental Neuroscience (95 citations), Physiology (556 citations) and Biochemistry (147 citations). Daigen Xu has collaborated with scholars based in Canada, United States and Italy. Frequent co-authors include George S. Robertson, Donald W. Nicholson, Patsy Clark, Sophie Roy, John P. Vaillancourt, Robert G. Korneluk, Robert Zamboni, Steven Xanthoudakis, Stephen J. Crocker and Peter Liston. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Pharmacology and Experimental Therapeutics, Neuroscience, Journal of Neuroscience and The Journal of Comparative Neurology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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