Steven Xanthoudakis

6.8k citations

40 papers · 5.6k indexed · 2 hit papers · h-index 26

Impact in

Molecular Biology top 1%
- DNA Repair Mechanisms
- Cell death mechanisms and regulation
- Redox biology and oxidative stress
- Genomics, phytochemicals, and oxidative stress
- Mitochondrial Function and Pathology
- Heat shock proteins research
Immunology top 2%
- Immune Response and Inflammation

Papers in

Molecular Biology 34
- Cell death mechanisms and regulation 12
- Redox biology and oxidative stress 5
- DNA Repair Mechanisms 4
Oncology 10

Co-authors: Tom Curran Graham G. Miao Donald W. Nicholson Yuchun Pan J. Wallace Richard J. Smeyne Sophie Roy Carol Prives
Journals: Molecular and Cellular Biology (6 papers)Journal of Biological Chemistry (5 papers)Neuroscience (3 papers)Bioorganic & Medicinal Chemistry Letters (3 papers)Cell Death and Differentiation (3 papers)
Partner nations: United States Canada Switzerland

In The Last Decade

Steven Xanthoudakis

40 papers receiving 5.5k citations

Hit Papers

align trajectories log scale

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. 1992 · 783 citations

Peers

Countries citing papers authored by Steven Xanthoudakis

Since Specialization

Citations

This map shows the geographic impact of Steven Xanthoudakis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Steven Xanthoudakis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Steven Xanthoudakis more than expected).

Fields of papers citing papers by Steven Xanthoudakis

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Steven Xanthoudakis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Steven Xanthoudakis. The network helps show where Steven Xanthoudakis may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Steven Xanthoudakis, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Steven Xanthoudakis Line = papers co-authored together Steven Xanthoudakis links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Caspase-3 cleaved spectrin colocalizes with neurofilament-immunoreactive neurons in Alzheimer’s disease Neuroscience ·Carlos A. Ayala‐Grosso, James P. Tam, Sophie Roy, Steven Xanthoudakis, David Da Costa, Donald W. Nicholson, George S. Robertson	2006	27
2	Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors Bioorganic & Medicinal Chemistry Letters ·Christophe Mellon, Renée Aspiotis, Nestor Casubha, Christopher I. Bayly, Erich L. Grimm, André Giroux, Yongxin Han, Élise Isabel, Daniel J. McKay, Donald W. Nicholson, Dita Rasper, Sophie Roy, John Tam, Nancy A. Thornberry, John P. Vaillancourt, Steven Xanthoudakis, Robert Zamboni	2005	10
3	Gob-5 Is Not Essential for Mucus Overproduction in Preclinical Murine Models of Allergic Asthma American Journal of Respiratory Cell and Molecular Biology ·Annette Robichaud, Stephanie A. Tuck, Stacia Kargman, John Tam, Elizabeth Wong, Mark Abramovitz, James R. Mortimer, Helen E. Burston, P. Masson, Jeremy A. Hirota, Deborah Slipetz, Brian P. Kennedy, Gary P. O’Neill, Steven Xanthoudakis	2005	43
4	Effects of fimbria-fornix transection on calpain and choline acetyl transferase activities in the septohippocampal pathway Neuroscience ·Carlos A. Ayala‐Grosso, James P. Tam, Steven Xanthoudakis, Y Bureau, Sophie Roy, Donald W. Nicholson, George S. Robertson	2004	8
5	Solid phase synthesis of selective caspase-3 peptide inhibitors Bioorganic & Medicinal Chemistry ·Erich L. Grimm, Bruno Roy, Renée Aspiotis, Christopher I. Bayly, Donald W. Nicholson, Dita Rasper, Johanne Renaud, Sophie Roy, John Tam, Paul Tawa, John P. Vaillancourt, Steven Xanthoudakis, Robert Zamboni	2004	12
6	Differential Efficacy of Caspase Inhibitors on Apoptosis Markers during Sepsis in Rats and Implication for Fractional Inhibition Requirements for Therapeutics The Journal of Experimental Medicine ·Nathalie Méthot, Jingqi Huang, Nathalie Coulombe, John P. Vaillancourt, Dita Rasper, John Tam, Yongxin Han, John Colucci, Robert Zamboni, Steven Xanthoudakis, Sylvie Toulmond, Donald W. Nicholson, Sophie Roy	2004	49
7	Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors Cell Death and Differentiation ·Paul Tawa, Kai Hell, André Giroux, Erich L. Grimm, Yongxin Han, Donald W. Nicholson, Steven Xanthoudakis	2004	91
8	Nicotinyl aspartyl ketones as inhibitors of caspase-3 Bioorganic & Medicinal Chemistry Letters ·Élise Isabel, W. Cameron Black, Christopher I. Bayly, Erich L. Grimm, Connie Zsembik, Daniel J. McKay, Donald W. Nicholson, Dita Rasper, Johanne Renaud, Sophie Roy, John Tam, Nancy A. Thornberry, John P. Vaillancourt, Steven Xanthoudakis, Robert Zamboni	2003	18
9	Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi Nature Cell Biology ·François G. Gervais, Roshni R. Singaraja, Steven Xanthoudakis, Claire‐Anne Gutekunst, Blair R. Leavitt, Martina Metzler, Abigail S. Hackam, John Tam, John P. Vaillancourt, Claudia Klein, Dita Rasper, Sophie Roy, Michael R. Hayden, Donald W. Nicholson	2002	241
10	Immunohistochemical and biochemical assessment of caspase-3 activation and DNA fragmentation following transient focal ischemia in the rat Neuroscience ·Maria Antonietta Davoli, Alaíde Paulino Machado de Oliveira, James P. Tam, Steven Xanthoudakis, Donald W. Nicholson, George S. Robertson, Gordon Ng, Daigen Xu	2002	114
11	Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis Cell Death and Differentiation ·Birgit Schwab, Danilo Guerini, Claire Didszun, Daniele Bano, Elisa Ferrando‐May, Eugenio Fava, James P. Tam, Daigen Xu, Steven Xanthoudakis, Donald W. Nicholson, Ernesto Carafoli, Pierluigi Nicotera	2002	221
12	Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury Journal of Biological Chemistry ·Byung Hee Han, Daigen Xu, Junjeong Choi, Yongxin Han, Steven Xanthoudakis, Sophie Roy, John Tam, John P. Vaillancourt, John Colucci, Robert Siman, André Giroux, George S. Robertson, Robert Zamboni, Donald W. Nicholson, David M. Holtzman	2002	141
13	NRAGE, a p75 Neurotrophin Receptor-interacting Protein, Induces Caspase Activation and Cell Death through a JNK-dependent Mitochondrial Pathway Journal of Biological Chemistry ·Amir H. Salehi, Steven Xanthoudakis, Philip Barker	2002	119
14	Quantitative analysis of fluorescent caspase substrate cleavage in intact cells and identification of novel inhibitors of apoptosis Cell Death and Differentiation ·Paul Tawa, James P. Tam, Atsuo Takanishii, Donald W. Nicholson, Steven Xanthoudakis	2001	51
15	Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte Nature Immunology ·Richard S. Hotchkiss, K. Chang, Paul E. Swanson, Kevin W. Tinsley, Jiaojiao Hui, Díaz Restrepo, Steven Xanthoudakis, Sophie Roy, Cheryl A. Black, Erich L. Grimm, Renée Aspiotis, Yongxin Han, Donald W. Nicholson, Irene E. Karl	2000	452
16	Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis The EMBO Journal ·Steven Xanthoudakis	1999	256
17	Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. The EMBO Journal ·Steven Xanthoudakis, Graham G. Miao, 孙文昭, Yuchun Pan, Tom Curran Hit paper breakdown →	1992	783
18	UV cross-linking of distinct proteins to the PRDII domain of the interferon-β promoter Biochemical and Biophysical Research Communications ·Steven Xanthoudakis, John Hiscott	1990	7
19	trans Activation of Type 1 Interferon Promoters by Simian Virus 40 T Antigen Molecular and Cellular Biology ·John Hiscott, Nilesh Sudam Navagale, O Ha-Yeong, Steven Xanthoudakis	1988	7
20	Transient Expression of the Beta Interferon Promoter in Human Cells Molecular and Cellular Biology ·Steven Xanthoudakis, O Ha-Yeong, John Hiscott	1987	11

About Steven Xanthoudakis

Steven Xanthoudakis is a scholar working on Molecular Biology, Oncology, Cancer Research, Immunology and Cellular and Molecular Neuroscience, having authored 40 papers that have together received 5.6k indexed citations. Recurring topics across this work include Cell death mechanisms and regulation (12 papers), interferon and immune responses (5 papers), Redox biology and oxidative stress (5 papers), DNA Repair Mechanisms (4 papers), Immune Response and Inflammation (4 papers), Virus-based gene therapy research (3 papers), Neuroscience and Neuropharmacology Research (3 papers) and Trace Elements in Health (3 papers). The work is most often cited by research in Molecular Biology (4.2k citations), Immunology (1.0k citations), Cancer Research (722 citations), Oncology (865 citations) and Aging (47 citations). Steven Xanthoudakis has collaborated with scholars based in United States, Canada and Switzerland. Frequent co-authors include Tom Curran, Graham G. Miao, Donald W. Nicholson, Yuchun Pan, J. Wallace, Richard J. Smeyne, Sophie Roy, Carol Prives, L. Jayaraman and Kanneganti Murthy. Their work appears in journals such as Molecular and Cellular Biology, Journal of Biological Chemistry, Neuroscience, Bioorganic & Medicinal Chemistry Letters and Cell Death and Differentiation.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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