Ruth M. Kluck

14.8k total citations · 4 hit papers
66 papers, 11.9k citations indexed

About

Ruth M. Kluck is a scholar working on Molecular Biology, Oncology and Epidemiology. According to data from OpenAlex, Ruth M. Kluck has authored 66 papers receiving a total of 11.9k indexed citations (citations by other indexed papers that have themselves been cited), including 56 papers in Molecular Biology, 12 papers in Oncology and 10 papers in Epidemiology. Recurrent topics in Ruth M. Kluck's work include Cell death mechanisms and regulation (46 papers), Mitochondrial Function and Pathology (22 papers) and RNA Interference and Gene Delivery (21 papers). Ruth M. Kluck is often cited by papers focused on Cell death mechanisms and regulation (46 papers), Mitochondrial Function and Pathology (22 papers) and RNA Interference and Gene Delivery (21 papers). Ruth M. Kluck collaborates with scholars based in Australia, United States and United Kingdom. Ruth M. Kluck's co-authors include Donald D. Newmeyer, Douglas R. Green, Ella Bossy‐Wetzel, Grant Dewson, Dana Westphal, Peter E. Czabotar, Jerry M. Adams, Beni B. Wolf, Donald W. Nicholson and John C. Reed and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Ruth M. Kluck

66 papers receiving 11.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 4.1k citations Ruth M. Kluck, Donald D. Newmeyer et al. profile →
Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 1.6k citations Ruth M. Kluck, Donald D. Newmeyer et al. profile →
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

2007 883 citations Peter E. Czabotar, Andreas Strasser et al. profile →
Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

2013 444 citations Peter E. Czabotar, Dana Westphal et al. profile →

Peers

Ruth M. Kluck

IMMUN

ONCOL

EPIDE

Isabel Marzo Spain

Manzoor Ahmad United States

I. Imawati Budihardjo United States

Hua Zou United States

Atan Gross Israel

Tomomi Kuwana United States

Reiner U. Jänicke Germany

Henning R. Stennicke Denmark

Deepak Nijhawan United States

Bruno Antonsson Switzerland

Isabel Marzo Spain

Ruth M. Kluck

8.5k ×0.9

1.8k ×1.0

IMMUN

2.1k ×1.3

ONCOL

1.2k ×0.9

EPIDE

975 ×0.9

Citations per year, relative to Ruth M. Kluck Ruth M. Kluck (= 1×) peers Isabel Marzo

Countries citing papers authored by Ruth M. Kluck

Since Specialization

Citations

This map shows the geographic impact of Ruth M. Kluck's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ruth M. Kluck with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ruth M. Kluck more than expected).

Fields of papers citing papers by Ruth M. Kluck

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ruth M. Kluck. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ruth M. Kluck. The network helps show where Ruth M. Kluck may publish in the future.

Co-authorship network of co-authors of Ruth M. Kluck

This figure shows the co-authorship network connecting the top 25 collaborators of Ruth M. Kluck. A scholar is included among the top collaborators of Ruth M. Kluck based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ruth M. Kluck. Ruth M. Kluck is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Iyer, Sweta, Agnes W. Wong, Ahmad Z. Wardak, et al.. (2024). A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells. Cell Death and Differentiation. 31(6). 711–721. 1 indexed citations

Diepstraten, Sarah T., et al.. (2023). Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs. Cell Death and Differentiation. 30(4). 1005–1017. 14 indexed citations

Robin, A.Y., Michelle S. Miller, Sweta Iyer, et al.. (2022). Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation. Cell Death and Differentiation. 29(9). 1757–1768. 6 indexed citations

Uren, Rachel T., Agnes W. Wong, Melissa H. Little, et al.. (2022). The BCL ‐2 family member BID plays a role during embryonic development in addition to its BH3 ‐only protein function by acting in parallel to BAX , BAK and BOK. The EMBO Journal. 41(15). e110300–e110300. 33 indexed citations

Uren, Rachel T., et al.. (2022). NAb-seq: an accurate, rapid, and cost-effective method for antibody long-read sequencing in hybridoma cell lines and single B cells. mAbs. 14(1). 2106621–2106621. 13 indexed citations

Birkinshaw, Richard W., Sweta Iyer, Daisy Lio, et al.. (2021). Structure of detergent-activated BAK dimers derived from the inert monomer. Molecular Cell. 81(10). 2123–2134.e5. 27 indexed citations

Iyer, Sweta, Rachel T. Uren, Michael A. Dengler, et al.. (2020). Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target. Cell Death and Disease. 11(4). 268–268. 28 indexed citations

Hockings, Colin, Sweta Iyer, Rachel T. Uren, & Ruth M. Kluck. (2019). Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation. Cell Death and Differentiation. 26(5). 794–795. 3 indexed citations

Robin, A.Y., Sweta Iyer, Richard W. Birkinshaw, et al.. (2018). Ensemble Properties of Bax Determine Its Function. Structure. 26(10). 1346–1359.e5. 36 indexed citations

10.

Iyer, Sweta, Rachel T. Uren, & Ruth M. Kluck. (2018). Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage. Methods in molecular biology. 1877. 201–216. 13 indexed citations

11.

Uren, Rachel T., Sweta Iyer, & Ruth M. Kluck. (2017). Pore formation by dimeric Bak and Bax: an unusual pore?. Philosophical Transactions of the Royal Society B Biological Sciences. 372(1726). 20160218–20160218. 64 indexed citations

12.

Uren, Rachel T., Martin O’Hely, Sweta Iyer, et al.. (2017). Disordered clusters of Bak dimers rupture mitochondria during apoptosis. eLife. 6. 82 indexed citations

13.

Brouwer, Jason M., Dana Westphal, Grant Dewson, et al.. (2014). Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers. Molecular Cell. 55(6). 938–946. 128 indexed citations

14.

Bartolo, Ray C., et al.. (2013). Bak apoptotic function is not directly regulated by phosphorylation. Cell Death and Disease. 4(1). e452–e452. 12 indexed citations

15.

Dewson, Grant, Stephen Ma, Colin Hockings, et al.. (2011). Bax dimerizes via a symmetric BH3:groove interface during apoptosis. Cell Death and Differentiation. 19(4). 661–670. 149 indexed citations

16.

Westphal, Dana, Grant Dewson, Peter E. Czabotar, & Ruth M. Kluck. (2010). Molecular biology of Bax and Bak activation and action. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1813(4). 521–531. 430 indexed citations

17.

Smith, Danielle, et al.. (2008). The mitochondrial gateway to cell death. IUBMB Life. 60(6). 383–389. 65 indexed citations

18.

Kaspar, Allan, Satoshi Okada, Jayant Kumar, et al.. (2001). A Distinct Pathway of Cell-Mediated Apoptosis Initiated by Granulysin. The Journal of Immunology. 167(1). 350–356. 120 indexed citations

19.

Kluck, Ruth M., et al.. (1996). Loss and shedding of surface markers from the leukemic myeloid monocytic line THP-1 induced to undergo apoptosis. Journal of Cellular Biochemistry. 60(2). 246–259. 10 indexed citations

20.

Kluck, Ruth M., et al.. (1994). Calcium chelators induce apoptosis — evidence that raised intracellular ionised calcium is not essential for apoptosis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1223(2). 247–254. 50 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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