Gabriel Núñez

123.7k total citations · 47 hit papers
383 papers, 82.2k citations indexed

About

Gabriel Núñez is a scholar working on Molecular Biology, Immunology and Infectious Diseases. According to data from OpenAlex, Gabriel Núñez has authored 383 papers receiving a total of 82.2k indexed citations (citations by other indexed papers that have themselves been cited), including 210 papers in Molecular Biology, 190 papers in Immunology and 51 papers in Infectious Diseases. Recurrent topics in Gabriel Núñez's work include Immune Response and Inflammation (90 papers), Inflammasome and immune disorders (74 papers) and Cell death mechanisms and regulation (66 papers). Gabriel Núñez is often cited by papers focused on Immune Response and Inflammation (90 papers), Inflammasome and immune disorders (74 papers) and Cell death mechanisms and regulation (66 papers). Gabriel Núñez collaborates with scholars based in United States, Japan and Spain. Gabriel Núñez's co-authors include Naohiro Inohara, Grace Chen, Luigi Franchi, Raúl Muñoz-Planillo, Yuan He, Yasunori Ogura, Nobuhiko Kamada, Stanley J. Korsmeyer, David M. Hockenbery and Hideki Hara and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Gabriel Núñez

377 papers receiving 80.9k citations

Hit Papers

A frameshift mutation in NOD2 associated with susceptibil... 1989 2026 2001 2013 2001 1990 1993 2010 2016 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    2001 3.7k citations Naohiro Inohara, Gabriel Núñez et al. profile →
  2. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    1990 3.3k citations Gabriel Núñez et al. profile →
  3. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
    1993 2.7k citations Gabriel Núñez et al. profile →
  4. Sterile inflammation: sensing and reacting to damage
    2010 2.4k citations Grace Chen, Gabriel Núñez profile →
  5. Mechanism and Regulation of NLRP3 Inflammasome Activation
    2016 2.2k citations Yuan He, Hideki Hara et al. profile →
  6. Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
    1997 1.9k citations Gabriel Núñez et al. Science profile →
  7. Role of the gut microbiota in immunity and inflammatory disease
    2013 1.7k citations Nobuhiko Kamada, Sang‐Uk Seo et al. profile →
  8. K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
    2013 1.7k citations Gabriel Núñez et al. profile →
  9. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
    2009 1.5k citations Luigi Franchi, Gabriel Núñez et al. Nature Immunology profile →
  10. Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
    1999 1.4k citations Gabriel Núñez et al. profile →
  11. Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
    2005 1.4k citations Mathias Chamaillard, Naohiro Inohara et al. Science profile →
  12. Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2
    2003 1.3k citations Naohiro Inohara, Gabriel Núñez et al. Journal of Biological Chemistry profile →
  13. Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
    2017 1.2k citations Joseph M. Pickard, Roberta Caruso et al. profile →
  14. Control of pathogens and pathobionts by the gut microbiota
    2013 1.2k citations Nobuhiko Kamada, Grace Chen et al. Nature Immunology profile →
  15. Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB
    2001 1.1k citations Naohiro Inohara, Gabriel Núñez et al. Journal of Biological Chemistry profile →
  16. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid
    2003 1.0k citations Mathias Chamaillard, Gabriel Núñez et al. Nature Immunology profile →
  17. bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
    1989 1.0k citations Gabriel Núñez et al. profile →
  18. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    2009 1.0k citations Yun‐Gi Kim, Gabriel Núñez et al. Nature Immunology profile →
  19. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
    2016 979 citations Yuan He, Gabriel Núñez et al. profile →
  20. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages
    2006 949 citations Luigi Franchi, Naohiro Inohara et al. Nature Immunology profile →
  21. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    2006 935 citations Luigi Franchi, Gabriel Núñez et al. profile →
  22. Caspases: the proteases of the apoptotic pathway
    1998 929 citations Gabriel Núñez, Mary Benedict et al. profile →
  23. Sensing and reacting to microbes through the inflammasomes
    2012 858 citations Luigi Franchi, Gabriel Núñez et al. Nature Immunology profile →
  24. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.
    1990 818 citations Gabriel Núñez et al. profile →
  25. Intracellular NOD-like Receptors in Host Defense and Disease
    2007 809 citations Gabriel Núñez et al. profile →
  26. NODs: intracellular proteins involved in inflammation and apoptosis
    2003 803 citations Naohiro Inohara, Gabriel Núñez profile →
  27. NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease
    2005 768 citations Naohiro Inohara, Mathias Chamaillard et al. profile →
  28. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    2002 731 citations Naohiro Inohara, Gabriel Núñez et al. profile →
  29. Function of Nod‐like receptors in microbial recognition and host defense
    2008 678 citations Luigi Franchi, Neil Warner et al. profile →
  30. Negative Regulation of the Forkhead Transcription Factor FKHR by Akt
    1999 656 citations Gabriel Núñez et al. Journal of Biological Chemistry profile →
  31. NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease
    2014 620 citations Roberta Caruso, Neil Warner et al. profile →
  32. Mechanisms of inflammation-driven bacterial dysbiosis in the gut
    2016 606 citations Naohiro Inohara, Gabriel Núñez et al. profile →
  33. Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB
    1999 606 citations Naohiro Inohara, Gabriel Núñez et al. Journal of Biological Chemistry profile →
  34. NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease
    2008 588 citations Grace Chen, Michael H. Shaw et al. profile →
  35. Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
    2019 571 citations Gabriel Núñez et al. profile →
  36. Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA
    2006 568 citations Luigi Franchi, Naohiro Inohara et al. Journal of Biological Chemistry profile →
  37. Host–microbiota interactions in inflammatory bowel disease
    2020 538 citations Roberta Caruso, Bernard C. Lo et al. profile →
  38. Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome
    2011 532 citations Luigi Franchi, Gabriel Núñez et al. profile →
  39. Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.
    1994 518 citations George Dubyak, Gabriel Núñez et al. Proceedings of the National Academy of Sciences profile →
  40. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
    1999 512 citations Gabriel Núñez et al. profile →
  41. Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut Microbiota
    2012 499 citations Nobuhiko Kamada, Yun‐Gi Kim et al. Science profile →
  42. Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock
    2015 496 citations Yuan He, Gabriel Núñez et al. profile →
  43. NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
    2013 453 citations Aurélie Couturier-Maillard, Thomas Sécher et al. Journal of Clinical Investigation profile →
  44. Staphylococcus δ-toxin induces allergic skin disease by activating mast cells
    2013 409 citations Naohiro Inohara, Gabriel Núñez et al. profile →
  45. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
    2017 377 citations Stephanie A. Conos, Kaiwen Chen et al. Proceedings of the National Academy of Sciences profile →
  46. The NLRP3 inflammasome: activation and regulation
    2022 336 citations Jie Xu, Gabriel Núñez profile →
  47. Microbiota-mediated colonization resistance: mechanisms and regulation
    2022 204 citations Joseph M. Pickard, Gabriel Núñez et al. profile →

Peers

Gabriel Núñez
Comparison fields: 5 of 187
  • Molecular Biology 46.9k
  • Immunology 33.2k
  • Epidemiology 10.6k
  • Oncology 8.9k
  • Genetics 8.4k
Replace Jürg Tschopp with:
Jürg Tschopp Switzerland
Charles A. Dinarello United States
Kiyoshi Takeda Japan
Ruslan Medzhitov United States
Dan R. Littman United States
Nico van Rooijen Netherlands
Ramnik J. Xavier United States
Josef Penninger Austria
Katherine A. Fitzgerald United States
Yoichiro Iwakura Japan
Jürg Tschopp Switzerland View profile →
Citations per field, relative to Gabriel Núñez
Gabriel Núñez · 1×
Citations per year, relative to Gabriel Núñez
Gabriel Núñez · 1×

Countries citing papers authored by Gabriel Núñez

Since Specialization
Citations

This map shows the geographic impact of Gabriel Núñez's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gabriel Núñez with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gabriel Núñez more than expected).

Fields of papers citing papers by Gabriel Núñez

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gabriel Núñez. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gabriel Núñez. The network helps show where Gabriel Núñez may publish in the future.

Co-authorship network of co-authors of Gabriel Núñez

This figure shows the co-authorship network connecting the top 25 collaborators of Gabriel Núñez. A scholar is included among the top collaborators of Gabriel Núñez based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Gabriel Núñez. Gabriel Núñez is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
# Work Indexed citations
1
NEK7 phosphorylation amplifies NLRP3 inflammasome activation downstream of potassium efflux and gasdermin D
2025 ·Science Immunology ·Jie Xu, Lingzhi Zhang, Yanhui Duan, Fangyuan Sun, (unknown), Yuan He, Gabriel Núñez
11
2
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
2025 ·Science Immunology ·Manuel M. Gómez de las Heras, Elisa Carrasco, (unknown), Naohiro Inohara, (unknown), (unknown), (unknown), Isaac Francos-Quijorna, Carolina Simó, Virginia García‐Cañas, (unknown), Juan Aranda, Gonzalo Soto‐Heredero, Enrique Gabandé‐Rodríguez, Eva María Blanco, (unknown), Gabriel Núñez, Marı́a Mittelbrunn
0
3
Reactive oxygen species regulate early development of the intestinal macrophage-microbiome interface
2025 ·Blood ·(unknown), (unknown), Céline Raynaud, Valentina Strohmeier, Jana Neuber, (unknown), Sonia Qureshi, Vitka Gres, (unknown), Sebastian Baasch, Christoph Schell, Klaus Warnatz, Naohiro Inohara, Gabriel Núñez, Thomas Clavel, Stephan P. Rosshart, Julia Kolter, Philipp Henneke
0
4
FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation
2024 ·Cell Reports ·Jie Xu, Joseph M. Pickard, Gabriel Núñez
27
5
Microbiota-dependent activation of CD4 + T cells induces CTLA-4 blockade–associated colitis via Fcγ receptors
2024 ·Science ·Bernard C. Lo, Ilona Kryczek, Jiali Yu, Linda Vatan, Roberta Caruso, Masanori Matsumoto, Yosuke Sato, Michael H. Shaw, Naohiro Inohara, Yuying Xie, Yu L. Lei, Weiping Zou, Gabriel Núñez
40
6
Prevention and cure of murine C. difficile infection by a Lachnospiraceae strain
2024 ·Gut Microbes ·(unknown), William A. Walters, Yanling Wang, Melissa C. Kordahi, Benoît Chassaing, Joseph M. Pickard, Gabriel Núñez, Ruth E. Ley, Andrew T. Gewirtz
6
7
Altering the Microbiome Inhibits Tumorigenesis in a Mouse Model of Oviductal High-Grade Serous Carcinoma
2021 ·Cancer Research ·Lixing Chen, Yali Zhai, Yisheng Wang, Eric R. Fearon, Gabriel Núñez, Naohiro Inohara, Kathleen R. Cho
27
8
Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL‐1β
2019 ·Allergy ·Christian Schwartz, Tara Moran, Sean P. Saunders, (unknown), Achilleas Floudas, Joana Bom, Gabriel Núñez, Yoichiro Iwakura, Luke O'neill, Alan D. Irvine, Andrew N. J. McKenzie, Graham S. Ogg, Patrick Walsh, Jocelyne Demengeot, Padraic G. Fallon
60
9
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner breakdown →
2017 ·Proceedings of the National Academy of Sciences ·Stephanie A. Conos, Kaiwen Chen, Dominic De Nardo, Hideki Hara, Lachlan Whitehead, Gabriel Núñez, Seth L. Masters, James M. Murphy, Kate Schroder, David L. Vaux, Kate E. Lawlor, Lisa Lindqvist, James E. Vince
377
10
Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens
2017 ·Science ·Yun‐Gi Kim, (unknown), Sang‐Uk Seo, Joseph M. Pickard, Merritt Gillilland, Nicholas A. Pudlo, Matthew J. Hoostal, Xue Li, Thomas D. Wang, Taylor Feehley, Andrew Stefka, Thomas M. Schmidt, Eric C. Martens, Shinji Fukuda, Naohiro Inohara, Cathryn R. Nagler, Gabriel Núñez
191
11
IKKα negatively regulates ASC-dependent inflammasome activation
2014 ·Nature Communications ·Bradley N. Martin, Chenhui Wang, Jami Willette‐Brown, Tomasz Herjan, Muhammet F. Gülen, Hao Zhou, Katarzyna Bulek, Luigi Franchi, Takashi Sato, Emad S. Alnemri, Goutham Narla, Xiao-Ping Zhong, James A. Thomas, Dennis M. Klinman, Katherine A. Fitzgerald, Michael Karin, Gabriel Núñez, George Dubyak, Yinling Hu, Xiaoxia Li
88
12
Gut Microbiota Protects against Gastrointestinal Tumorigenesis Caused by Epithelial Injury
2013 ·Cancer Research ·Yu Zhan, Po-Ju Chen, W. David Sadler, Fuyuan Wang, Sara Poe, Gabriel Núñez, Kathryn A. Eaton, Grace Chen
82
13
NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer breakdown →
2013 ·Journal of Clinical Investigation ·Aurélie Couturier-Maillard, Thomas Sécher, Ateequr Rehman, Sylvain Normand, Adèle De Arcangelis, Robert Haesler, Ludovic Huot, Teddy Grandjean, Aude Bressenot, (unknown), Olivier Gaillot, Stefan Schreiber, Yves Lemoine, Bernhard Ryffel, David Hot, Gabriel Núñez, Grace Chen, Philip Rosenstiel, Mathias Chamaillard
453
14
Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut Microbiota breakdown →
2012 ·Science ·Nobuhiko Kamada, Yun‐Gi Kim, Ho Pan Sham, Bruce A. Vallance, José L. Puente, Eric C. Martens, Gabriel Núñez
499
15
Influence of Donor Microbiota on the Severity of Experimental Graft-versus-Host-Disease
2012 ·Biology of Blood and Marrow Transplantation ·Isao Tawara, Chen Liu, Hiroya Tamaki, Tomomi Toubai, Yaping Sun, Rebecca Evers, Evelyn Nieves, Nathan D. Mathewson, Gabriel Núñez, Pavan Reddy
28
16
Interleukin-10 Ablation Promotes Tumor Development, Growth, and Metastasis
2011 ·Cancer Research ·Takashi Tanikawa, Cailin Moira Wilke, Ilona Kryczek, Grace Chen, John Y. Kao, Gabriel Núñez, Weiping Zou
119
17
Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation
2011 ·Journal of Biological Chemistry ·Jenny Barthson, Carla Maria Ramos Germano, Fabrice Moore, Adriano Maida, Daniel J. Drucker, Piero Marchetti, Conny Gysemans, Chantal Mathieu, Gabriel Núñez, Andrea Jurisicova, Décio L. Eizirik, Esteban N. Gurzov
97
18
T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii
2009 ·Nature Immunology ·Michael H. Shaw, Thornik Reimer, (unknown), Neil Warner, Yun‐Gi Kim, Manuel Fresno, Gabriel Núñez
149
19
CD95 (APO-1/Fas)- and p53-independent apoptosis by betulinic acid involves mitochondrial alterations and activation of caspases.
1997 ·Blood ·Simone Fulda, Claudia Friesen, Marek Łoś, Mary Benedict, Gabriel Núñez, Marcus E. Peter, Klaus‐Michael Debatin
2
20
Survey of workshop monoclonal antibodies by inhibition of fluorescein-labelled reference monoclonal reagents, double labelling studies on monocytes and inhibition of T cell recognition of class II antigens
1984 ·Disease Markers ·Peter Šťastný, Gabriel Núñez, Linda K. Myers, Edward J. Ball
3

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Jürg Tschopp Breakdown of academic impact, for papers by Charles A. Dinarello Breakdown of academic impact, for papers by Kiyoshi Takeda Breakdown of academic impact, for papers by Ruslan Medzhitov Breakdown of academic impact, for papers by Dan R. Littman Breakdown of academic impact, for papers by Nico van Rooijen Breakdown of academic impact, for papers by Ramnik J. Xavier Breakdown of academic impact, for papers by Josef Penninger Breakdown of academic impact, for papers by Katherine A. Fitzgerald Breakdown of academic impact, for papers by Yoichiro Iwakura
Rankless by CCL
2026