Ramnik J. Xavier

183.9k total citations · 46 hit papers
451 papers, 62.9k citations indexed

About

Ramnik J. Xavier is a scholar working on Molecular Biology, Immunology and Epidemiology. According to data from OpenAlex, Ramnik J. Xavier has authored 451 papers receiving a total of 62.9k indexed citations (citations by other indexed papers that have themselves been cited), including 225 papers in Molecular Biology, 165 papers in Immunology and 139 papers in Epidemiology. Recurrent topics in Ramnik J. Xavier's work include Inflammatory Bowel Disease (99 papers), Gut microbiota and health (93 papers) and Autophagy in Disease and Therapy (56 papers). Ramnik J. Xavier is often cited by papers focused on Inflammatory Bowel Disease (99 papers), Gut microbiota and health (93 papers) and Autophagy in Disease and Therapy (56 papers). Ramnik J. Xavier collaborates with scholars based in United States, Netherlands and Canada. Ramnik J. Xavier's co-authors include Dirk Gevers, Aylwin Ng, Mihai G. Netea, Agnès Gardet, Leo A. B. Joosten, Bernard Khor, Aleksandar D. Kostic, Daniel B. Graham, Hera Vlamakis and Curtis Huttenhower and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Ramnik J. Xavier

435 papers receiving 62.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

2009 2.5k citations Aylwin Ng, Ramnik J. Xavier et al. profile →
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

2012 2.0k citations Ramnik J. Xavier, Curtis Huttenhower et al. profile →
Genetics and pathogenesis of inflammatory bowel disease

2011 1.9k citations Bernard Khor, Ramnik J. Xavier et al. profile →
Trained immunity: A program of innate immune memory in health and disease

2016 1.8k citations Mihai G. Netea, Leo A. B. Joosten et al. Science profile →
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

2016 1.6k citations Ramnik J. Xavier, Luke O'neill et al. profile →
Defining trained immunity and its role in health and disease

2020 1.6k citations Mihai G. Netea, Leo A. B. Joosten et al. profile →
The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

2014 1.4k citations Aleksandar D. Kostic, Ramnik J. Xavier et al. profile →
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

2012 1.2k citations Leo A. B. Joosten, Hendrik G. Stunnenberg et al. Proceedings of the National Academy of Sciences profile →
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

2008 1.2k citations Ramnik J. Xavier, Herbert W. Virgin et al. profile →
Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

2014 1.2k citations Daniel B. Graham, Ramnik J. Xavier et al. Nature Biotechnology profile →
Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

2008 1.1k citations Abraham L. Brass, Derek M. Dykxhoorn et al. Science profile →
Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

2015 1.0k citations Gautam Goel, Clary B. Clish et al. profile →
The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

2009 1.0k citations Abraham L. Brass, Yair Benita et al. profile →
Proton pump inhibitors affect the gut microbiome

2015 935 citations Floris Imhann, Marc Jan Bonder et al. Gut profile →
Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

2012 918 citations Cisca Wijmenga, Leo A. B. Joosten et al. profile →
Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

2015 906 citations Lindsay Droit, Guoyan Zhao et al. profile →
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

2008 855 citations Ramnik J. Xavier et al. profile →
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

2016 826 citations Hera Vlamakis, Eric A. Franzosa et al. profile →
BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

2018 800 citations Ramnik J. Xavier, Cisca Wijmenga et al. profile →
Tumor Induction of VEGF Promoter Activity in Stromal Cells

1998 795 citations Ramnik J. Xavier et al. profile →
Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

2008 784 citations Aylwin Ng, Ramnik J. Xavier et al. profile →
Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability

2016 714 citations Tommi Vatanen, Heli Siljander et al. Science Translational Medicine profile →
Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

2010 672 citations Aylwin Ng, Ramnik J. Xavier et al. profile →
Microbial genes and pathways in inflammatory bowel disease

2019 634 citations Ashley Garner, Hera Vlamakis et al. profile →
Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

2016 576 citations Floris Imhann, Arnau Vich Vila et al. Gut profile →
Ruminococcus gnavus , a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide

2019 565 citations Hera Vlamakis, Ramnik J. Xavier et al. Proceedings of the National Academy of Sciences profile →
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

2010 550 citations Aylwin Ng, Ramnik J. Xavier et al. Proceedings of the National Academy of Sciences profile →
The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids

2015 540 citations Jingyuan Fu, Marc Jan Bonder et al. profile →
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

2016 498 citations Ramnik J. Xavier, Herbert W. Virgin et al. Science profile →
Pathway paradigms revealed from the genetics of inflammatory bowel disease

2020 482 citations Daniel B. Graham, Ramnik J. Xavier profile →
Structure-based protein function prediction using graph convolutional networks

2021 467 citations Tommi Vatanen, Hera Vlamakis et al. Nature Communications profile →
Autosis is a Na ⁺ ,K ⁺ -ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia

2013 453 citations Ramnik J. Xavier et al. Proceedings of the National Academy of Sciences profile →
Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

2013 438 citations Leo A. B. Joosten, Ramnik J. Xavier et al. profile →
Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis

2019 397 citations Damian R. Plichta, Eric Brown et al. Science profile →
Image-based genome-wide siRNA screen identifies selective autophagy factors

2011 385 citations Aylwin Ng, Ramnik J. Xavier et al. profile →
BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

2014 368 citations Leo A. B. Joosten, Ramnik J. Xavier et al. profile →
Human genetic variation and the gut microbiome in disease

2017 367 citations Andrew C. Tolonen, Ramnik J. Xavier et al. profile →
The Human and Mouse Enteric Nervous System at Single-Cell Resolution

2020 337 citations Daniel B. Graham, Ramnik J. Xavier et al. profile →
Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases

2017 307 citations Ashwin N. Ananthakrishnan, Ramnik J. Xavier et al. profile →
Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

2017 279 citations Shai Bel, Mihir Pendse et al. Science profile →
Akkermansia muciniphila phospholipid induces homeostatic immune responses

2022 274 citations Hera Vlamakis, Daniel B. Graham et al. profile →
Adaptive Evolution within Gut Microbiomes of Healthy People

2019 254 citations Ramnik J. Xavier et al. profile →
Gut microbiome lipid metabolism and its impact on host physiology

2023 210 citations Eric Brown, Ramnik J. Xavier et al. profile →
Role of dietary fiber in the recovery of the human gut microbiome and its metabolome

2021 201 citations Ramnik J. Xavier, Clary B. Clish et al. profile →
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon

2023 94 citations Ariel Lefkovith, Elizabeth A. Creasey et al. Immunity profile →
Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution

2025 29 citations Ramnik J. Xavier et al. Nature Communications profile →

Peers

Countries citing papers authored by Ramnik J. Xavier

Since Specialization

Citations

This map shows the geographic impact of Ramnik J. Xavier's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ramnik J. Xavier with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ramnik J. Xavier more than expected).

Fields of papers citing papers by Ramnik J. Xavier

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ramnik J. Xavier. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ramnik J. Xavier. The network helps show where Ramnik J. Xavier may publish in the future.

Co-authorship network of co-authors of Ramnik J. Xavier

This figure shows the co-authorship network connecting the top 25 collaborators of Ramnik J. Xavier. A scholar is included among the top collaborators of Ramnik J. Xavier based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ramnik J. Xavier. Ramnik J. Xavier is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation 2024 ·Science Advances ·(unknown), (unknown), Zher Yin Tan, Bihua Li, Partha P. Nag, (unknown), (unknown), Kimberly L. Carey, Daniel B. Graham, Ramnik J. Xavier	4
2	Spatial host–microbiome sequencing reveals niches in the mouse gut 2023 ·Nature Biotechnology ·Britta Lötstedt, Martin Stražar, Ramnik J. Xavier, Aviv Regev, Sanja Vicković	64
3	Annotating metabolite mass spectra with domain-inspired chemical formula transformers 2023 ·Nature Machine Intelligence ·Samuel Goldman, Jeremy Wohlwend, Martin Stražar, (unknown), Ramnik J. Xavier, Connor W. Coley	39
4	HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery 2023 ·Immunity ·Martin Stražar, Jihye Park, Jennifer G. Abelin, (unknown), (unknown), Damian R. Plichta, Eric Brown, Basak Eraslan, (unknown), (unknown), Karl R. Clauser, Steven A. Carr, Ramnik J. Xavier, Daniel B. Graham	20
5	The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain 2022 ·Molecular Psychiatry ·Robert G. Mealer, Sarah Williams, Maxence Noël, Bo Yang, Alexandria K. D’Souza, Toru Nakata, Daniel B. Graham, Elizabeth A. Creasey, Murat Çetinbaş, Ruslan I. Sadreyev, Edward M. Scolnick, Christina M. Woo, Jordan W. Smoller, Ramnik J. Xavier, Richard D. Cummings	24
6	Publisher Correction: Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations 2021 ·Nature Communications ·Martin Stražar, Godfrey S. Temba, Hera Vlamakis, Vesla Kullaya, Furaha S. Lyamuya, Blandina T. Mmbaga, Leo A. B. Joosten, André van der Ven, Mihai G. Netea, Quirijn de Mast, Ramnik J. Xavier	5
7	QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis 2020 ·Science ·(unknown), Lingfei Wang, Chih‐Hung Chou, Kai Liu, Toru Nakata, Alok Jaiswal, Junmei Yao, Ariel Lefkovith, (unknown), Jacqueline Perrigoue, Jennifer E. Towne, Aviv Regev, Daniel B. Graham, Ramnik J. Xavier	89
8	Growth effects of N-acylethanolamines on gut bacteria reflect altered bacterial abundances in inflammatory bowel disease 2020 ·Nature Microbiology ·Nadine Fornelos, Eric A. Franzosa, Jason Bishai, John W. Annand, Akihiko Oka, Jason Lloyd‐Price, Timothy D. Arthur, Ashley Garner, Julián Ávila-Pacheco, Henry J. Haiser, Andrew C. Tolonen, Jeffrey A. Porter, Clary B. Clish, R. Balfour Sartor, Curtis Huttenhower, Hera Vlamakis, Ramnik J. Xavier	74
9	Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1 2019 ·The Journal of Immunology ·Bernard Khor, Kara L. Conway, (unknown), Moshe Biton, Adam L. Haber, Noga Rogel, Leigh A. Baxt, Jakob Begun, Petric Kuballa, John D Gagnon, Kara G. Lassen, Aviv Regev, Ramnik J. Xavier	19
10	The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response 2019 ·eLife ·Sydney Lavoie, Kara L. Conway, Kara G. Lassen, Humberto Jijon, Hui Pan, Eunyoung Chun, Monia Michaud, Jessica Lang, (unknown), Jonathan M. Dreyfuss, Jonathan N. Glickman, Hera Vlamakis, Ashwin N. Ananthakrishnan, Aleksandar D. Kostic, Wendy S. Garrett, Ramnik J. Xavier	98
11	Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine breakdown → 2017 ·Science ·Shai Bel, Mihir Pendse, Yuhao Wang, Yun Li, Kelly A. Ruhn, Brian Hassell, (unknown), Sebastian Winter, Ramnik J. Xavier, Lora V. Hooper	279
12	Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children 2017 ·Proceedings of the National Academy of Sciences ·Guoyan Zhao, Tommi Vatanen, Lindsay Droit, Arnold Park, Aleksandar D. Kostic, Tiffany Poon, Hera Vlamakis, Heli Siljander, Taina Härkönen, (unknown), Aleksandr Peet, Vallo Tillmann, Jorma Ilonen, David Wang, Mikael Knip, Ramnik J. Xavier, Herbert W. Virgin	212
13	Allergic asthma is distinguished by sensitivity of allergen-specific CD4 ⁺ T cells and airway structural cells to type 2 inflammation 2016 ·Science Translational Medicine ·(unknown), Morris Ling, David C. Adams, Lucas Faustino, Sabina A. Islam, Roshi Afshar, Jason W. Griffith, R. Scott Harris, Aylwin Ng, Giorgia Radicioni, Amina A. Ford, (unknown), Ramnik J. Xavier, William W. Kwok, Richard C. Boucher, James Moon, Daniel L. Hamilos, Mehmet Kesımer, Melissa J. Suter, Benjamin D. Medoff, Andrew D. Luster	46
14	Trained immunity: A program of innate immune memory in health and disease breakdown → 2016 ·Science ·Mihai G. Netea, Leo A. B. Joosten, Eicke Latz, Kingston H. G. Mills, Gioacchino Natoli, Hendrik G. Stunnenberg, Luke O'neill, Ramnik J. Xavier	1772
15	Impaired autophagy in macrophages promotes inflammatory eye disease 2016 ·Autophagy ·Andrea Santeford, Luke A. Wiley, Sunmin Park, (unknown), Rei Nakamura, Abdelaziz Gdoura, Thomas A. Ferguson, P. Kumar Rao, Jun‐Lin Guan, Tatsuya Saitoh, Shizuo Akira, Ramnik J. Xavier, Herbert W. Virgin, Rajendra S. Apte	56
16	Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples 2015 ·Science ·Tal Korem, David Zeevi, Jotham Suez, Adina Weinberger, Tali Avnit-Sagi, (unknown), (unknown), Ghil Jona, Alon Harmelin, Nadav Cohen, Alexandra Sirota‐Madi, Christoph A. Thaiss, Meirav Pevsner‐Fischer, Rotem Sorek, Ramnik J. Xavier, Eran Elinav, Eran Segal	310
17	Proton pump inhibitors affect the gut microbiome breakdown → 2015 ·Gut ·Floris Imhann, Marc Jan Bonder, Arnau Vich Vila, Jingyuan Fu, Zlatan Mujagic, Lisa Vork, Ettje F. Tigchelaar, Soesma A. Jankipersadsing, María Carmen Cénit, Hermie J. M. Harmsen, Gerard Dijkstra, Lude Franke, Ramnik J. Xavier, Daisy Jonkers, Cisca Wijmenga, Rinse K. Weersma, Alexandra Zhernakova	935
18	Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 ( DLG1 ) Revealed in a Murine Model of Pediatric B-ALL 2013 ·Cancer Immunology Research ·Gabriel J. Sandoval, Daniel B. Graham, Grzegorz B. Gmyrek, (unknown), Keiko Fujikawa, Bénédicte Sammut, Deepta Bhattacharya, (unknown), Alfred H.J. Kim, Andréy S. Shaw, Katherine Yang‐Iott, Craig H. Bassing, Eric J. Duncavage, Ramnik J. Xavier, Wojciech Swat	19
19	Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer 2013 ·Clinical Cancer Research ·Erin M. Coffee, Anthony C. Faber, Jatin Roper, Mark J. Sinnamon, Gautam Goel, (unknown), (unknown), Loredana Vecchione, Veerle de Vriendt, Barbara Weinstein, Roderick T. Bronson, Sabine Tejpar, Ramnik J. Xavier, Jeffrey A. Engelman, Eric S. Martin, Kenneth E. Hung	70
20	Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen breakdown → 2008 ·Science ·Abraham L. Brass, Derek M. Dykxhoorn, Yair Benita, Nan Yan, Alan Engelman, Ramnik J. Xavier, Judy Lieberman, Stephen J. Elledge	1149

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact