Nico van Rooijen

104.5k citations

838 papers · 80.5k indexed · 30 hit papers · h-index 146

Immunology top 0.01%
Molecular Biology top 0.05%
Epidemiology top 0.05%
Oncology top 0.05%
Surgery top 0.1%

Co-authors: A.F. Sanders Ria van Nieuwmegen N. Kors Gwendalyn J. Randolph Wendy W. Pang Irving L. Weissman Mark P. Chao Ravindra Majeti
Topics: Immunotherapy and Immune Responses (142 papers)Immune Response and Inflammation (129 papers)Immune Cell Function and Interaction (110 papers)
Cited by: Immunology Neurology Hepatology
Journals: Nature Science Cell
Partner nations: Netherlands United States Germany

In The Last Decade

Nico van Rooijen

835 papers receiving 79.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

2007 1.5k citations Nico van Rooijen et al. The Journal of Experimental Medicine profile →
Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

1994 1.5k citations Nico van Rooijen et al. profile →
CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

2009 1.3k citations Nico van Rooijen et al. profile →
CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

2009 1.2k citations Nico van Rooijen et al. profile →
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

2007 1.1k citations Nico van Rooijen et al. profile →
Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of T _H 2 Inflammation

2011 1.0k citations Stephen J. Jenkins, Dominik Rückerl et al. Science profile →
Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response

2004 890 citations Nico van Rooijen et al. profile →
Local proliferation dominates lesional macrophage accumulation in atherosclerosis

2013 779 citations Nico van Rooijen, Ralph Weissleder et al. profile →
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

2012 757 citations Nico van Rooijen et al. Proceedings of the National Academy of Sciences profile →
Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

2011 690 citations Nico van Rooijen et al. profile →
Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation

2013 674 citations Nico van Rooijen et al. Blood profile →
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

2007 655 citations Nico van Rooijen et al. profile →
Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels

2007 633 citations Nico van Rooijen et al. profile →
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

2011 625 citations Andrew Chow, Daniel Lucas et al. The Journal of Experimental Medicine profile →
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

2010 622 citations Nico van Rooijen et al. Blood profile →
Chitin induces accumulation in tissue of innate immune cells associated with allergy

2007 597 citations Nico van Rooijen, David Voehringer et al. profile →
Microglia Promote the Death of Developing Purkinje Cells

2004 594 citations Nico van Rooijen et al. profile →
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

2012 582 citations Nico van Rooijen et al. profile →
IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

2009 579 citations Nico van Rooijen et al. profile →
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages

2005 574 citations Nico van Rooijen et al. profile →
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis

2007 567 citations Nico van Rooijen et al. profile →
Depletion of Hematogenous Macrophages Promotes Partial Hindlimb Recovery and Neuroanatomical Repair after Experimental Spinal Cord Injury

1999 566 citations Nico van Rooijen et al. profile →
Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

2013 564 citations Nico van Rooijen, Florent Ginhoux et al. profile →
The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

2010 538 citations Nico van Rooijen et al. profile →
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

2013 535 citations Yuya Kunisaki, Nico van Rooijen et al. profile →
Control of TH17 cells occurs in the small intestine

2011 505 citations Nico van Rooijen et al. profile →
NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

2007 503 citations Nico van Rooijen et al. profile →
Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

2008 500 citations Simon N. Waddington, John H. McVey et al. profile →
Macrophages in bone fracture healing: Their essential role in endochondral ossification

2015 482 citations Nico van Rooijen et al. profile →
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

2012 413 citations Nico van Rooijen et al. profile →

Peers

Countries citing papers authored by Nico van Rooijen

Since Specialization

Citations

This map shows the geographic impact of Nico van Rooijen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Nico van Rooijen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Nico van Rooijen more than expected).

Fields of papers citing papers by Nico van Rooijen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Nico van Rooijen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Nico van Rooijen. The network helps show where Nico van Rooijen may publish in the future.

Co-authorship network of co-authors of Nico van Rooijen

This figure shows the co-authorship network connecting the top 25 collaborators of Nico van Rooijen. A scholar is included among the top collaborators of Nico van Rooijen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Nico van Rooijen. Nico van Rooijen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	CD68 acts as a major gateway for malaria sporozoite liver infection 2015 ·The Journal of Experimental Medicine ·Sung‐Jae Cha,Kiwon Park,P. Srinivasan,Christian Schindler,Nico van Rooijen,Monique F. Stins,Marcelo Jacobs‐Lorena	45
2	Twist1 Induces CCL2 and Recruits Macrophages to Promote Angiogenesis 2013 ·Cancer Research ·Janine M. Low-Marchelli,Veronica C. Ardi,Edward A. Vizcarra,Nico van Rooijen,James P. Quigley,Jing Yang	157
3	Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell nichebreakdown → 2011 ·The Journal of Experimental Medicine ·Andrew Chow,Daniel Lucas,Andrés Hidalgo,Simón Méndez‐Ferrer,Daigo Hashimoto,Christoph Scheiermann,Michela Battista,Marylène Leboeuf,Colette Prophete,Nico van Rooijen,Masato Tanaka,Miriam Mérad,Paul S. Frenette	625
4	Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation 2011 ·The Journal of Experimental Medicine ·Daigo Hashimoto,Andrew Chow,Melanie Greter,Yvonne M. Saenger,W. H. Kwan,Marylène Leboeuf,Florent Ginhoux,Jordi Ochando,Yuya Kunisaki,Nico van Rooijen,Chen Liu,Takanori Teshima,Peter S. Heeger,E. Richard Stanley,Paul S. Frenette,Miriam Mérad	122
5	Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of T _H 2 Inflammationbreakdown → 2011 ·Science ·Stephen J. Jenkins,Dominik Rückerl,Peter C. Cook,Lucy H. Jackson‐Jones,Fred D. Finkelman,Nico van Rooijen,Andrew S. MacDonald,Judith E. Allen	1049
6	Monocytes control natural killer cell differentiation to effector phenotypes 2011 ·Blood ·Katrina Soderquest,Nick Powell,Carmelo Luci,Nico van Rooijen,Andrés Hidalgo,Frédéric Geissmann,Thierry Walzer,Graham M. Lord,Alfonso Martin‐Fontecha	72
7	Mononuclear Phagocyte System Depletion Blocks Interstitial Tonicity-Responsive Enhancer Binding Protein/Vascular Endothelial Growth Factor C Expression and Induces Salt-Sensitive Hypertension in Rats 2010 ·Hypertension ·(unknown),Anke Dahlmann,Christoph Kopp,Jennifer Goss,Hubertus Wagner,Nico van Rooijen,Kai‐Uwe Eckardt,Dominik N. Müller,Joon-Keun Park,Friedrich C. Luft,Dontscho Kerjaschki,Jens Titze	161
8	Blockade of Tumor Necrosis Factor α Signaling in Tumor-Associated Macrophages as a Radiosensitizing Strategy 2010 ·Cancer Research ·Yuru Meng,Michael A. Beckett,Hua Liang,Helena J. Mauceri,Nico van Rooijen,Kenneth S. Cohen,Ralph R. Weichselbaum	144
9	Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus 2010 ·Proceedings of the National Academy of Sciences ·Jae-Min Song,Nico van Rooijen,Jadranka Bozja,Richard W. Compans,Sang‐Moo Kang	129
10	The EGF/CSF-1 Paracrine Invasion Loop Can Be Triggered by Heregulin β1 and CXCL12 2009 ·Cancer Research ·Lorena Hernandez,Т. А. Смирнова,Dmitriy Kedrin,Jeffrey Wyckoff,Liyin Zhu,E. Richard Stanley,Dianne Cox,William J. Muller,Jeffrey W. Pollard,Nico van Rooijen,Jeffrey E. Segall	96
11	Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP 2008 ·Blood ·Jonas Byström,Ian Evans,Justine Newson,Melanie Stables,Iqbal Toor,Nico van Rooijen,Mark Crawford,Paul Colville‐Nash,Stuart Farrow,Derek W. Gilroy	259
12	MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries 2008 ·The Journal of Experimental Medicine ·Paul C. Tang,Lingfeng Qin,Jacek Zielonka,(unknown),Catherine Matte-Martone,Sonia Bergaya,Nico van Rooijen,Warren D. Shlomchik,Min Wang,William C. Sessa,Jordan S. Pober,George Tellides	53
13	Immediate Mineralocorticoid Receptor Blockade Improves Myocardial Infarct Healing by Modulation of the Inflammatory Response 2008 ·Hypertension ·Daniela Fraccarollo,Paolo Galuppo,(unknown),Susanne Kneitz,Nico van Rooijen,Georg Ertl,Johann Bauersachs	96
14	Ly6c+ “inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis 2008 ·The Journal of Experimental Medicine ·Daniel R. Getts,Rachael Terry,Meghann Teague Getts,Marcus Müller,Sabita Rana,Bimmi Shrestha,Jane Radford,Nico van Rooijen,Iain L. Campbell,Nicholas J. C. King	271
15	Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues 2008 ·Science ·Linda M. Wakim,Jason Waithman,Nico van Rooijen,William R. Heath,Francis R. Carbone	357
16	Effect of Neutralizing Sera on Factor X-Mediated Adenovirus Serotype 5 Gene Transfer 2008 ·Journal of Virology ·Alan L. Parker,Simon N. Waddington,Suzanne M. K. Buckley,Jerome Custers,Menzo Havenga,Nico van Rooijen,Jaap Goudsmit,John H. McVey,Stuart A. Nicklin,Andrew H. Baker	66
17	Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages 2007 ·Journal of Leukocyte Biology ·David Voehringer,Nico van Rooijen,Richard M. Locksley	127
18	Depletion of Peripheral Macrophages and Brain Microglia Increases Brain Tumor Titers of Oncolytic Viruses 2007 ·Cancer Research ·Giulia Fulci,Nina Dmitrieva,Davide Gianni,(unknown),Xiaogang Pan,(unknown),Claire Kaufman,Balveen Kaur,Sean Lawler,Robert J. Lee,Clay B. Marsh,Daniel J. Brat,Nico van Rooijen,(unknown),Fred H. Hochberg,Ralph Weissleder,Robert L. Martuza,E. Antonio Chiocca	135
19	Macrophages Mediate Inflammation-Enhanced Metastasis of Ovarian Tumors in Mice 2007 ·Cancer Research ·Toni M. Robinson-Smith,Idit Isaacsohn,Carol A. Mercer,Mingfu Zhou,Nico van Rooijen,Nader Husseinzadeh,Molly M. McFarland-Mancini,Angela F. Drew	165
20	A1 Adenosine Receptors in Microglia Control Glioblastoma-Host Interaction 2006 ·Cancer Research ·Michael Synowitz,Rainer Glaß,Katrin Färber,Darko Marković,Golo Kronenberg,(unknown),(unknown),Christiané Nolte,Nico van Rooijen,Juergen Kiwit,Helmut Kettenmann	70

About Nico van Rooijen

Nico van Rooijen is a scholar working on Immunology, Neurology and Immunology and Allergy, having authored 838 papers that have together received 80.5k indexed citations. Recurring topics across this work include Immunotherapy and Immune Responses (142 papers), Immune Response and Inflammation (129 papers) and Immune Cell Function and Interaction (110 papers). The work is most often cited by research in Immunology (38.1k citations), Neurology (7.0k citations) and Hepatology (3.6k citations). Nico van Rooijen has collaborated with scholars based in Netherlands, United States and Germany. Frequent co-authors include A.F. Sanders, Ria van Nieuwmegen, N. Kors, Gwendalyn J. Randolph, Wendy W. Pang, Irving L. Weissman, Mark P. Chao, Ravindra Majeti, Siddhartha Jaiswal and Georg Kraal. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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