George Dubyak

19.9k total citations · 7 hit papers
198 papers, 16.5k citations indexed

About

George Dubyak is a scholar working on Molecular Biology, Physiology and Immunology. According to data from OpenAlex, George Dubyak has authored 198 papers receiving a total of 16.5k indexed citations (citations by other indexed papers that have themselves been cited), including 116 papers in Molecular Biology, 85 papers in Physiology and 34 papers in Immunology. Recurrent topics in George Dubyak's work include Adenosine and Purinergic Signaling (83 papers), Inflammasome and immune disorders (38 papers) and Neuroscience of respiration and sleep (16 papers). George Dubyak is often cited by papers focused on Adenosine and Purinergic Signaling (83 papers), Inflammasome and immune disorders (38 papers) and Neuroscience of respiration and sleep (16 papers). George Dubyak collaborates with scholars based in United States, Russia and China. George Dubyak's co-authors include Chakib El-Moatassim, Gabriel Núñez, Benjamin D. Humphreys, Yan Qu, J. Michelle Kahlenberg, Arnošt Kleinzeller, Michael Katsnelson, Luigi Franchi, Sylvia B. Kertesy and Eric Pearlman and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

George Dubyak

197 papers receiving 16.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 1.1k citations George Dubyak et al. profile →
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 518 citations George Dubyak, Gabriel Núñez et al. Proceedings of the National Academy of Sciences profile →
Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

1989 497 citations Paolo Mené, George Dubyak et al. Journal of Clinical Investigation profile →
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

2018 460 citations Joseph K. Rathkey, Junjie Zhao et al. Science Immunology profile →
The insulin-mimetic effects of vanadate in isolated rat adipocytes. Dissociation from effects of vanadate as a (Na+-K+)ATPase inhibitor.

1980 347 citations George Dubyak et al. profile →
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

2016 337 citations George Dubyak, Eric Pearlman et al. Nature Communications profile →
N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

2020 336 citations Martin Minns, Joseph K. Rathkey et al. Nature Communications profile →

Peers

Countries citing papers authored by George Dubyak

Since Specialization

Citations

This map shows the geographic impact of George Dubyak's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by George Dubyak with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites George Dubyak more than expected).

Fields of papers citing papers by George Dubyak

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by George Dubyak. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by George Dubyak. The network helps show where George Dubyak may publish in the future.

Co-authorship network of co-authors of George Dubyak

This figure shows the co-authorship network connecting the top 25 collaborators of George Dubyak. A scholar is included among the top collaborators of George Dubyak based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with George Dubyak. George Dubyak is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Neutrophil KLF2 regulates inflammasome-dependent neonatal mortality from endotoxemia 2025 ·Journal of Leukocyte Biology ·(unknown), (unknown), (unknown), Stefano Piero Bernardo Cioffi, Yuexin Li, E. Ricky Chan, (unknown), Alex Y. Huang, Mukesh K. Jain, George Dubyak, Lalitha Nayak	2
2	ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D 2025 ·Proceedings of the National Academy of Sciences ·(unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Gregory Brubaker, (unknown), Chandrasekhar R. Kothapalli, George Dubyak, Jonathan D. Smith, Kailash Gulshan	1
3	A T _H 17-intrinsic IL-1β–STAT5 axis drives steroid resistance in autoimmune neuroinflammation 2024 ·Science Immunology ·William A. Miller-Little, Xing Chen, Vanessa Salazar, Caini Liu, Katarzyna Bulek, Julie Y. Zhou, Li Xiao, Olaf Stüve, Thaddeus S. Stappenbeck, George Dubyak, Junjie Zhao, Xiaoxia Li	4
4	Neutrophils use a novel NLRP3 inflammasome-independent mechanism to release bioactive IL-1β in response to lysosomal disruption 2023 ·The Journal of Immunology ·Brandon A. Miller, Eric Pearlman, George Dubyak	0
5	Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways 2023 ·Immunological Reviews ·George Dubyak, Brandon A. Miller, Eric Pearlman	38
6	NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity 2023 ·Nature Communications ·Martin Minns, (unknown), Tatiane S. Lima, Serena Abbondante, Brandon A. Miller, Michaela Marshall, (unknown), (unknown), Arne Rietsch, George Dubyak, Eric Pearlman	33
7	TH17 cells promote CNS inflammation by sensing danger signals via Mincle 2022 ·Nature Communications ·(unknown), Weiwei Liu, Han Wang, Hao Zhou, Katarzyna Bulek, Xing Chen, Cun‐Jin Zhang, Junjie Zhao, Renliang Zhang, Caini Liu, Zizhen Kang, Robert A Bermel, George Dubyak, Derek W. Abbott, Tsan Sam Xiao, Laura E. Nagy, Xiaoxia Li	17
8	Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis 2020 ·Journal of Clinical Investigation ·Katarzyna Bulek, Junjie Zhao, Yun Liao, Nitish Rana, Daniele Corridoni, Agne Antanaviciute, Xing Chen, Han Wang, Qian Wen, William A. Miller-Little, Shadi Swaidani, Fangqiang Tang, Belinda Willard, Keith R. McCrae, Zizhen Kang, George Dubyak, Fabio Cominelli, Alison Simmons, Theresa T. Pizarro, Xiaoxia Li	129
9	Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor 2018 ·Proceedings of the National Academy of Sciences ·Jie Yang, Liu Z, Chuanping Wang, Rui Yang, Joseph K. Rathkey, Otis Pinkard, Wuxian Shi, Yinghua Chen, George Dubyak, Derek W. Abbott, Tsan Sam Xiao	150
10	Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis breakdown → 2018 ·Science Immunology ·Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah Kondolf, Bryan L. Benson, Steven M. Chirieleison, Alex Y. Huang, George Dubyak, Tsan Sam Xiao, Xiaoxia Li, Derek W. Abbott	460
11	Stealth filaments: Polymer chain length and conformation affect the in vivo fate of PEGylated potato virus X 2015 ·Acta Biomaterialia ·Karin L. Lee, Sourabh Shukla, (unknown), Nadia Ayat, Caroline El Sanadi, Amy M. Wen, (unknown), Jonathan K. Pokorski, Ulrich Commandeur, George Dubyak, Nicole F. Steinmetz	77
12	IKKα negatively regulates ASC-dependent inflammasome activation 2014 ·Nature Communications ·Bradley N. Martin, Chenhui Wang, Jami Willette‐Brown, Tomasz Herjan, Muhammet F. Gülen, Hao Zhou, Katarzyna Bulek, Luigi Franchi, Takashi Sato, Emad S. Alnemri, Goutham Narla, Xiao-Ping Zhong, James A. Thomas, Dennis M. Klinman, Katherine A. Fitzgerald, Michael Karin, Gabriel Núñez, George Dubyak, Yinling Hu, Xiaoxia Li	88
13	P2X7 Receptor-dependent Secretion of IL-1beta is Mediated by Exocytosis of Secretory Lysosomes 2007 ·The FASEB Journal ·Yan Qu, Luigi Franchi, Gabriel Núñez, George Dubyak	2
14	Inhibitory Effects of Chloride on the Activation of Caspase-1, IL-1β Secretion, and Cytolysis by the P2X7 Receptor 2005 ·The Journal of Immunology ·Philip A. Verhoef, Sylvia B. Kertesy, Kathleen C. Lundberg, J. Michelle Kahlenberg, George Dubyak	101
15	Potentiation of Caspase-1 Activation by the P2X7 Receptor Is Dependent on TLR Signals and Requires NF-κB-Driven Protein Synthesis 2005 ·The Journal of Immunology ·J. Michelle Kahlenberg, Kathleen C. Lundberg, Sylvia B. Kertesy, Yan Qu, George Dubyak	177
16	Maitotoxin induces biphasic interleukin-1beta secretion and membrane blebbing in murine macrophages. 2004 ·PubMed ·Philip A. Verhoef, Sylvia B. Kertesy, Mark Estación, William P. Schilling, George Dubyak	44
17	P2X7 Receptor-Dependent Blebbing and the Activation of Rho-Effector Kinases, Caspases, and IL-1β Release 2003 ·The Journal of Immunology ·Philip A. Verhoef, Mark Estación, William P. Schilling, George Dubyak	154
18	Cutting Edge: The Nucleotide Receptor P2X7 Contains Multiple Protein- and Lipid-Interaction Motifs Including a Potential Binding Site for Bacterial Lipopolysaccharide 2001 ·The Journal of Immunology ·Loren C. Denlinger, Philip L. Fisette, Julie A. Sommer, Jyoti J. Watters, Usha Prabhu, George Dubyak, Richard A. Proctor, Paul J. Bertics	163
19	Endotoxin Activation of Macrophages Does Not Induce ATP Release and Autocrine Stimulation of P2 Nucleotide Receptors 2000 ·The Journal of Immunology ·(unknown), George Dubyak	43
20	Modulation of cytosolic free calcium by serum and phorbol myristate acetate in cultured rat mesangial cells 1987 ·Clinical research ·Paolo Mené, George Dubyak, (unknown), (unknown)	1

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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