Ruslan Medzhitov

128.9k total citations · 61 hit papers
227 papers, 97.2k citations indexed

About

Ruslan Medzhitov is a scholar working on Immunology, Molecular Biology and Epidemiology. According to data from OpenAlex, Ruslan Medzhitov has authored 227 papers receiving a total of 97.2k indexed citations (citations by other indexed papers that have themselves been cited), including 154 papers in Immunology, 54 papers in Molecular Biology and 25 papers in Epidemiology. Recurrent topics in Ruslan Medzhitov's work include Immune Response and Inflammation (99 papers), Immune Cell Function and Interaction (60 papers) and T-cell and B-cell Immunology (31 papers). Ruslan Medzhitov is often cited by papers focused on Immune Response and Inflammation (99 papers), Immune Cell Function and Interaction (60 papers) and T-cell and B-cell Immunology (31 papers). Ruslan Medzhitov collaborates with scholars based in United States, Germany and France. Ruslan Medzhitov's co-authors include Charles A. Janeway, Akiko Iwasaki, Gregory M. Barton, Chandrashekhar Pasare, Richard A. Flavell, Paula Preston‐Hurlburt, Seth Rakoff-Nahoum, Tiffany Horng, Lena Alexopoulou and Daniel B. Stetson and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Ruslan Medzhitov

222 papers receiving 95.2k citations

Hit Papers

Innate Immune Recognition 1997 2026 2006 2016 2002 2001 2008 1997 2001 2.0k 4.0k 6.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Innate Immune Recognition
    2002 6.3k citations Ruslan Medzhitov et al. profile →
  2. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
    2001 4.9k citations Ruslan Medzhitov et al. Nature profile →
  3. Origin and physiological roles of inflammation
    2008 4.8k citations Ruslan Medzhitov Nature profile →
  4. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    1997 4.2k citations Ruslan Medzhitov et al. Nature profile →
  5. Toll-like receptors and innate immunity
    2001 3.4k citations Ruslan Medzhitov Nature reviews. Immunology profile →
  6. Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
    2004 3.3k citations Seth Rakoff-Nahoum, Ruslan Medzhitov et al. Cell profile →
  7. Toll-like receptor control of the adaptive immune responses
    2004 3.3k citations Akiko Iwasaki, Ruslan Medzhitov profile →
  8. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
    2014 2.2k citations Ruslan Medzhitov et al. Nature profile →
  9. Recognition of microorganisms and activation of the immune response
    2007 2.1k citations Ruslan Medzhitov Nature profile →
  10. Innate Immunity: The Virtues of a Nonclonal System of Recognition
    1997 1.9k citations Ruslan Medzhitov et al. Cell profile →
  11. Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells
    2003 1.7k citations Chandrashekhar Pasare, Ruslan Medzhitov Science profile →
  12. Decoding the Patterns of Self and Nonself by the Innate Immune System
    2002 1.6k citations Ruslan Medzhitov et al. Science profile →
  13. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    2014 1.6k citations Ruslan Medzhitov et al. Proceedings of the National Academy of Sciences profile →
  14. Regulation of Adaptive Immunity by the Innate Immune System
    2010 1.6k citations Akiko Iwasaki, Ruslan Medzhitov Science profile →
  15. Innate Immunity
    2000 1.5k citations Ruslan Medzhitov et al. profile →
  16. Control of adaptive immunity by the innate immune system
    2015 1.4k citations Akiko Iwasaki, Ruslan Medzhitov profile →
  17. Inflammation 2010: New Adventures of an Old Flame
    2010 1.4k citations Ruslan Medzhitov Cell profile →
  18. MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
    1998 1.3k citations Ruslan Medzhitov, Elizabeth B. Kopp et al. profile →
  19. Disease Tolerance as a Defense Strategy
    2012 1.2k citations Ruslan Medzhitov et al. Science profile →
  20. Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    2005 1.2k citations Shuang Yu, Robert Homer et al. profile →
  21. Innate immunity: impact on the adaptive immune response
    1997 1.1k citations Ruslan Medzhitov et al. profile →
  22. Toll-like receptors control activation of adaptive immune responses
    2001 1.1k citations Ruslan Medzhitov et al. profile →
  23. Innate immune recognition: mechanisms and pathways
    2000 1.1k citations Ruslan Medzhitov et al. profile →
  24. IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling
    2002 1.1k citations Ruslan Medzhitov et al. Cell profile →
  25. Toll-Like Receptor Signaling Pathways
    2003 1.1k citations Ruslan Medzhitov et al. Science profile →
  26. Gene-specific control of inflammation by TLR-induced chromatin modifications
    2007 1.0k citations Ruslan Medzhitov et al. Nature profile →
  27. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages
    2017 1.0k citations Wai‐Ki Ip, Namiko Hoshi et al. Science profile →
  28. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
    2008 1.0k citations Ruslan Medzhitov et al. profile →
  29. Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity
    2008 974 citations Ruslan Medzhitov et al. Cell profile →
  30. Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
    2003 969 citations Ayuko Sato, Ruslan Medzhitov et al. The Journal of Experimental Medicine profile →
  31. Type I Interferons in Host Defense
    2006 937 citations Ruslan Medzhitov et al. Immunity profile →
  32. Homeostasis, Inflammation, and Disease Susceptibility
    2015 898 citations Ruslan Medzhitov et al. Cell profile →
  33. Transcriptional control of the inflammatory response
    2009 826 citations Ruslan Medzhitov et al. Nature reviews. Immunology profile →
  34. Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response
    2006 821 citations Ruslan Medzhitov et al. Immunity profile →
  35. Regulation of Phagosome Maturation by Signals from Toll-Like Receptors
    2004 795 citations Ruslan Medzhitov et al. Science profile →
  36. TIRAP: an adapter molecule in the Toll signaling pathway
    2001 793 citations Ruslan Medzhitov et al. profile →
  37. A mechanism for the initiation of allergen-induced T helper type 2 responses
    2007 755 citations Ruslan Medzhitov et al. profile →
  38. Toll-like receptors and cancer
    2008 738 citations Seth Rakoff-Nahoum, Ruslan Medzhitov profile →
  39. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    2002 731 citations Ruslan Medzhitov et al. Nature profile →
  40. Harnessing innate immunity in cancer therapy
    2019 702 citations Ruslan Medzhitov et al. Nature profile →
  41. Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling
    2006 698 citations Ruslan Medzhitov et al. Cell profile →
  42. Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages
    2014 679 citations Yasutaka Okabe, Ruslan Medzhitov Cell profile →
  43. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
    2002 663 citations Ruslan Medzhitov et al. Nature profile →
  44. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
    2000 658 citations Ruslan Medzhitov et al. Nature profile →
  45. Toll-dependent selection of microbial antigens for presentation by dendritic cells
    2006 656 citations Ruslan Medzhitov et al. Nature profile →
  46. Control of B-cell responses by Toll-like receptors
    2005 594 citations Chandrashekhar Pasare, Ruslan Medzhitov Nature profile →
  47. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
    1999 556 citations Ruslan Medzhitov et al. profile →
  48. The Toll-receptor family and control of innate immunity
    1999 549 citations Elizabeth B. Kopp, Ruslan Medzhitov profile →
  49. Pattern recognition receptors and control of adaptive immunity
    2008 540 citations Noah W. Palm, Ruslan Medzhitov profile →
  50. Stress, Inflammation, and Defense of Homeostasis
    2014 530 citations Ruslan Medzhitov et al. profile →
  51. The Toll receptor family and microbial recognition
    2000 527 citations Ruslan Medzhitov et al. profile →
  52. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    2005 526 citations Ruslan Medzhitov et al. profile →
  53. Toll-Like Receptors: Linking Innate and Adaptive Immunity
    2005 518 citations Chandrashekhar Pasare, Ruslan Medzhitov profile →
  54. Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation
    2009 516 citations Ruslan Medzhitov et al. Cell profile →
  55. Tissue biology perspective on macrophages
    2015 490 citations Yasutaka Okabe, Ruslan Medzhitov profile →
  56. The spectrum of inflammatory responses
    2021 403 citations Ruslan Medzhitov Science profile →
  57. Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation
    2016 388 citations Andrew Wang, Shuang Yu et al. Cell profile →
  58. GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance
    2019 342 citations Andrew Wang, Shuang Yu et al. Cell profile →
  59. Tissue Homeostasis and Inflammation
    2021 216 citations Matthew L. Meizlish, Ruth A. Franklin et al. profile →
  60. An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis
    2023 92 citations Miri Adler, Ruslan Medzhitov et al. profile →
  61. Immune sensing of food allergens promotes avoidance behaviour
    2023 86 citations Jaime L. Cullen, Cuiling Zhang et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Ruslan Medzhitov United States 114 61.3k 27.9k 13.4k 8.9k 7.3k 227 97.2k
Kiyoshi Takeda Japan 118 57.1k 0.9× 27.9k 1.0× 14.7k 1.1× 10.5k 1.2× 8.4k 1.1× 463 92.8k
Osamu Takeuchi Japan 109 55.9k 0.9× 24.1k 0.9× 15.3k 1.1× 10.0k 1.1× 8.7k 1.2× 352 81.5k
Taro Kawai Japan 83 46.7k 0.8× 20.2k 0.7× 12.5k 0.9× 8.7k 1.0× 7.0k 0.9× 177 67.0k
Bruce Beutler United States 112 38.1k 0.6× 17.2k 0.6× 10.8k 0.8× 6.0k 0.7× 3.8k 0.5× 406 64.5k
Gabriel Núñez United States 131 33.2k 0.5× 46.9k 1.7× 10.6k 0.8× 6.3k 0.7× 6.8k 0.9× 383 82.2k
Charles A. Dinarello United States 174 47.0k 0.8× 36.8k 1.3× 15.9k 1.2× 5.5k 0.6× 5.8k 0.8× 873 108.0k
Katherine A. Fitzgerald United States 119 39.7k 0.6× 37.7k 1.4× 12.3k 0.9× 6.9k 0.8× 6.7k 0.9× 334 69.4k
Siamon Gordon United Kingdom 133 41.2k 0.7× 22.0k 0.8× 10.6k 0.8× 3.6k 0.4× 7.7k 1.0× 455 78.1k
Luke O'neill Ireland 124 32.5k 0.5× 23.7k 0.8× 8.3k 0.6× 11.2k 1.2× 3.4k 0.5× 392 61.3k
Jürg Tschopp Switzerland 131 43.3k 0.7× 52.0k 1.9× 11.9k 0.9× 8.1k 0.9× 4.1k 0.6× 283 87.3k

Countries citing papers authored by Ruslan Medzhitov

Since Specialization
Citations

This map shows the geographic impact of Ruslan Medzhitov's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ruslan Medzhitov with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ruslan Medzhitov more than expected).

Fields of papers citing papers by Ruslan Medzhitov

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ruslan Medzhitov. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ruslan Medzhitov. The network helps show where Ruslan Medzhitov may publish in the future.

Co-authorship network of co-authors of Ruslan Medzhitov

This figure shows the co-authorship network connecting the top 25 collaborators of Ruslan Medzhitov. A scholar is included among the top collaborators of Ruslan Medzhitov based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ruslan Medzhitov. Ruslan Medzhitov is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Medzhitov, Ruslan. (2026). On the balance of knowledge. Nature reviews. Immunology. 26(3). 163–165.
2.
Cullen, Jaime L., et al.. (2026). Environmentally driven immune imprinting protects against allergy. Nature. 650(8103). 987–996.
3.
Zhou, Xu, Ruth A. Franklin, Miri Adler, et al.. (2022). Microenvironmental sensing by fibroblasts controls macrophage population size. Proceedings of the National Academy of Sciences. 119(32). e2205360119–e2205360119. 53 indexed citations
4.
Lim, Jaechul, et al.. (2022). Induction of natural IgE by glucocorticoids. The Journal of Experimental Medicine. 219(10). 17 indexed citations
5.
Sullivan, Zuri A., William Khoury-Hanold, Jaechul Lim, et al.. (2021). γδ T cells regulate the intestinal response to nutrient sensing. Science. 371(6535). 82 indexed citations
6.
Ye, Jessica, Xin Bian, Jaechul Lim, & Ruslan Medzhitov. (2020). Adiponectin and related C1q/TNF-related proteins bind selectively to anionic phospholipids and sphingolipids. Proceedings of the National Academy of Sciences. 117(29). 17381–17388. 36 indexed citations
7.
Wang, Andrew, Scott D. Pope, Jason S. Weinstein, et al.. (2019). Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice. Proceedings of the National Academy of Sciences. 116(6). 2200–2209. 47 indexed citations
8.
Ip, Wai‐Ki, Namiko Hoshi, Dror S. Shouval, Scott B. Snapper, & Ruslan Medzhitov. (2017). Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 356(6337). 513–519. 1026 indexed citations breakdown →
9.
Medzhitov, Ruslan. (2017). Ruslan Medzhitov. Current Biology. 27(12). R577–R578. 2 indexed citations
10.
Okabe, Yasutaka & Ruslan Medzhitov. (2014). Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages. Cell. 157(4). 832–844. 679 indexed citations breakdown →
11.
Jamieson, A. M., Lesley Pasman, Shuang Yu, et al.. (2013). Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection. Science. 340(6137). 1230–1234. 212 indexed citations
12.
Sultana, Hameeda, Girish Neelakanta, Harald G. Foellmer, et al.. (2012). Semaphorin 7A Contributes to West Nile Virus Pathogenesis through TGF-β1/Smad6 Signaling. The Journal of Immunology. 189(6). 3150–3158. 32 indexed citations
13.
Abraham, Clara & Ruslan Medzhitov. (2011). Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease. Gastroenterology. 140(6). 1729–1737. 421 indexed citations
14.
Kopp, Elizabeth B. & Ruslan Medzhitov. (2009). PERSPECTIVE: Infection and inflammation in somatic maintenance, growth and longevity. Evolutionary Applications. 2(1). 132–141. 19 indexed citations
15.
Medzhitov, Ruslan & Dan R. Littman. (2008). HIV immunology needs a new direction. Nature. 455(7213). 591–591. 21 indexed citations
16.
Rakoff-Nahoum, Seth & Ruslan Medzhitov. (2008). Innate immune recognition of the indigenous microbial flora. Mucosal Immunology. 1. S10–S14. 79 indexed citations
17.
Rakoff-Nahoum, Seth & Ruslan Medzhitov. (2007). Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88. Science. 317(5834). 124–127. 468 indexed citations
18.
Soderberg, Kelly A., Geoffrey W. Payne, Ayuko Sato, et al.. (2005). Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proceedings of the National Academy of Sciences. 102(45). 16315–16320. 114 indexed citations
19.
Pasare, Chandrashekhar & Ruslan Medzhitov. (2004). Toll-Dependent Control Mechanisms of CD4 T Cell Activation. Immunity. 21(5). 733–741. 294 indexed citations
20.
Pasare, Chandrashekhar & Ruslan Medzhitov. (2003). Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells. Science. 299(5609). 1033–1036. 1673 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Kiyoshi Takeda Breakdown of academic impact, for papers by Osamu Takeuchi Breakdown of academic impact, for papers by Taro Kawai Breakdown of academic impact, for papers by Bruce Beutler Breakdown of academic impact, for papers by Gabriel Núñez Breakdown of academic impact, for papers by Charles A. Dinarello Breakdown of academic impact, for papers by Katherine A. Fitzgerald Breakdown of academic impact, for papers by Siamon Gordon Breakdown of academic impact, for papers by Luke O'neill Breakdown of academic impact, for papers by Jürg Tschopp
Rankless by CCL
2026