Dan R. Littman

129.1k citations

345 papers · 98.4k indexed · 51 hit papers · h-index 150

Immunology top 0.01%
Molecular Biology top 0.02%
Oncology top 0.05%
Virology top 0.01%
Infectious Diseases top 0.02%

Co-authors: Steffen Jung Ivaylo I. Ivanov Liang Zhou Kenya Honda Mary Jean Sunshine Derya Unutmaz Frédéric Geissmann Andrew J. Macpherson
Topics: Immune Cell Function and Interaction (158 papers)T-cell and B-cell Immunology (146 papers)Immunotherapy and Immune Responses (76 papers)
Cited by: Immunology Virology Neurology
Journals: Nature Science Cell
Partner nations: United States Germany Japan

In The Last Decade

Dan R. Littman

342 papers receiving 97.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 4.1k citations Juan J. Lafaille, Dan R. Littman et al. Cell profile →
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

2009 3.4k citations Dan R. Littman et al. Cell profile →
Interactions Between the Microbiota and the Immune System

2012 3.1k citations Dan R. Littman et al. Science profile →
Identification of a major co-receptor for primary isolates of HIV-1

1996 3.0k citations Wilfried Ellmeier, Dan R. Littman et al. profile →
ATP mediates rapid microglial response to local brain injury in vivo

2005 3.0k citations Steffen Jung, Dan R. Littman et al. profile →
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

2003 2.7k citations Frédéric Geissmann, Steffen Jung et al. Immunity profile →
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 2.0k citations Dan R. Littman et al. profile →
Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

2000 2.0k citations Steffen Jung, Mary Jean Sunshine et al. profile →
DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells

2000 1.9k citations Dan R. Littman et al. Cell profile →
Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

2013 1.9k citations Juan J. Lafaille, Dan R. Littman et al. Cell profile →
Signal transduction by lymphocyte antigen receptors

1994 1.9k citations Dan R. Littman et al. Cell profile →
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

2007 1.7k citations Takeshi Egawa, Dan R. Littman et al. profile →
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 1.5k citations Dan R. Littman et al. profile →
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

2013 1.5k citations Dan R. Littman et al. profile →
In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

2002 1.4k citations Steffen Jung, Dan R. Littman et al. Immunity profile →
Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

2008 1.4k citations Dan R. Littman et al. profile →
The microbiota in adaptive immune homeostasis and disease

2016 1.3k citations Dan R. Littman et al. profile →
CX ₃ CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

2005 1.2k citations Jan Hendrik Niess, Stephan Brand et al. Science profile →
Control of microglial neurotoxicity by the fractalkine receptor

2006 1.2k citations Steffen Jung, Dan R. Littman et al. profile →
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

2010 1.2k citations Dan R. Littman et al. Immunity profile →
Plasticity of CD4+ T Cell Lineage Differentiation

2009 1.2k citations Dan R. Littman et al. Immunity profile →
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

2008 1.1k citations Dan R. Littman et al. profile →
Sparse and Compositionally Robust Inference of Microbial Ecological Networks

2015 1.1k citations Dan R. Littman et al. profile →
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

2006 1.0k citations Mary Jean Sunshine, Dan R. Littman et al. The Journal of Experimental Medicine profile →
Bile acid metabolites control TH17 and Treg cell differentiation

2019 956 citations Dan R. Littman, Jun R. Huh et al. profile →
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

2010 884 citations Dan R. Littman et al. profile →
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

2016 861 citations Gloria B. Choi, Yeong Shin Yim et al. Science profile →
Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

2002 809 citations Yuqing Huo, S. Bradley Forlow et al. profile →
Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

2010 805 citations Dan R. Littman et al. Cell profile →
An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

2003 786 citations Gérard Eberl, Mary Jean Sunshine et al. profile →
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 783 citations Wilfried Ellmeier, Mary Jean Sunshine et al. profile →
A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

2005 756 citations Darin K. Fogg, Claire Sibon et al. Science profile →
The Microbiome in Infectious Disease and Inflammation

2012 618 citations Dan R. Littman et al. profile →
Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

2008 607 citations Dan R. Littman et al. The Journal of Experimental Medicine profile →
Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 606 citations Ichiro Taniuchi, Takeshi Egawa et al. Cell profile →
Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease

2014 603 citations Dan R. Littman et al. profile →
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 595 citations Dan R. Littman et al. Cell profile →
Expression cloning of new receptors used by simian and human immunodeficiency viruses

1997 587 citations Dan R. Littman et al. profile →
Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development

2000 578 citations Mary Jean Sunshine, Dan R. Littman et al. Science profile →
Identification of IL-17-producing FOXP3⁺regulatory T cells in humans

2009 559 citations Dan R. Littman et al. profile →
Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 552 citations Dan R. Littman et al. Cell profile →
Intravascular Immune Surveillance by CXCR6+ NKT Cells Patrolling Liver Sinusoids

2005 532 citations Frédéric Geissmann, Michael L. Dustin et al. profile →
Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype

1997 525 citations Dan R. Littman et al. profile →
In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression

1997 519 citations Dan R. Littman et al. profile →
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring

2017 508 citations Hyunju Kim, Yeong Shin Yim et al. profile →
A Coordinated Change in Chemokine Responsiveness Guides Plasma Cell Movements

2001 506 citations Dan R. Littman et al. The Journal of Experimental Medicine profile →
An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

2015 440 citations Dan R. Littman et al. Cell profile →
Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis

2012 351 citations Dan R. Littman et al. profile →
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease

2019 335 citations Lina Kroehling, Hernandez Moura Silva et al. Cell profile →
Feeding-dependent VIP neuron–ILC3 circuit regulates the intestinal barrier

2020 243 citations Lina Kroehling, Dan R. Littman et al. profile →
TH17 cell heterogeneity and its role in tissue inflammation

2023 133 citations Dan R. Littman et al. profile →

Peers

Countries citing papers authored by Dan R. Littman

Since Specialization

Citations

This map shows the geographic impact of Dan R. Littman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dan R. Littman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dan R. Littman more than expected).

Fields of papers citing papers by Dan R. Littman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dan R. Littman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dan R. Littman. The network helps show where Dan R. Littman may publish in the future.

Co-authorship network of co-authors of Dan R. Littman

This figure shows the co-authorship network connecting the top 25 collaborators of Dan R. Littman. A scholar is included among the top collaborators of Dan R. Littman based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Dan R. Littman. Dan R. Littman is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Antigen-presenting cells as specialized drivers of intestinal T cell functions 2024 ·Immunity ·Ranit Kedmi,Dan R. Littman	27
2	Transmembrane domain–driven PD-1 dimers mediate T cell inhibition 2024 ·Science Immunology ·(unknown),Jia Liu,Audun Kvalvaag,(unknown),Anna S. Tocheva,Charles Ng,(unknown),Ian M. Ahearn,(unknown),Christina C. Luo,Alexander Leithner,(unknown),Yong Zhou,Antonio García‐España,Adam Mor,Dan R. Littman,Michael L. Dustin,Jun Wang,Xiang‐Peng Kong	17
3	c-MAF–dependent perivascular macrophages regulate diet-induced metabolic syndrome 2021 ·Science Immunology ·Hernandez Moura Silva,Jamil Z. Kitoko,(unknown),Lina Kroehling,Fanny Matheis,Katharine Yang,Bernardo Sgarbi Reis,Christine Ren‐Fielding,Dan R. Littman,Marcelo T. Bozza,Daniel Mucida,Juan J. Lafaille	36
4	The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspringbreakdown → 2016 ·Science ·Gloria B. Choi,Yeong Shin Yim,Helen Wong,(unknown),Hyunju Kim,Sangwon V. Kim,Charles A. Hoeffer,Dan R. Littman,Jun R. Huh	861
5	SIRT1 deacetylates RORγt and enhances Th17 cell generation 2015 ·The Journal of Experimental Medicine ·Hyung W. Lim,Seung Goo Kang,Jae Kyu Ryu,Birgit Schilling,Mingjian Fei,(unknown),(unknown),Kotaro Shirakawa,Masaru Yokoyama,Martina Schnölzer,Herbert G. Kasler,Hye‐Sook Kwon,Bradford W. Gibson,Hironori Sato,Katerina Akassoglou,Changchun Xiao,Dan R. Littman,Mélanie Ott,Eric Verdin	124
6	Releasing the Brakes on Cancer Immunotherapy 2015 ·Cell ·Dan R. Littman	133
7	Nonredundant Function of Soluble LTα ₃ Produced by Innate Lymphoid Cells in Intestinal Homeostasis 2013 ·Science ·Andrey Kruglov,Sergei I. Grivennikov,Dmitry V. Kuprash,(unknown),(unknown),Gitta Seleznik,Gérard Eberl,Dan R. Littman,Mathias Heikenwälder,Alexei V. Tumanov,Sergei A. Nedospasov	203
8	A Genomic Regulatory Element That Directs Assembly and Function of Immune-Specific AP-1–IRF Complexes 2012 ·Science ·Elke Glasmacher,Smita Agrawal,Anne B. Chang,Theresa L. Murphy,Wenwen Zeng,Bryan Vander Lugt,Aly A. Khan,Maria Ciofani,Chauncey J. Spooner,Sascha Rutz,Jason A. Hackney,Roza Nurieva,Carlos Escalante,Wenjun Ouyang,Dan R. Littman,Kenneth M. Murphy,Harinder Singh	260
9	NK cell–activating receptors require PKC-θ for sustained signaling, transcriptional activation, and IFN-γ secretion 2008 ·Blood ·Ilaria Tassi,Marina Cella,Rachel M. Presti,(unknown),Susan Gilfillan,Dan R. Littman,Marco Colonna	60
10	Relief of Preintegration Inhibition and Characterization of Additional Blocks for HIV Replication in Primary Mouse T Cells 2008 ·PLoS ONE ·Jing-xin Zhang,Gretchen E. Diehl,Dan R. Littman	29
11	CX ₃ CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearancebreakdown → 2005 ·Science ·Jan Hendrik Niess,Stephan Brand,Xiubin Gu,Limor Landsman,Steffen Jung,Beth A. McCormick,Jatin M. Vyas,Marianne Boes,Hidde L. Ploegh,James G. Fox,Dan R. Littman,Hans-Christian Reinecker	1232
12	A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cellsbreakdown → 2005 ·Science ·Darin K. Fogg,Claire Sibon,Chaouki Miled,Steffen Jung,Pièrre Aucouturier,Dan R. Littman,Ana Cumano,Frédéric Geissmann	756
13	Runx3 Regulates Integrin αE/CD103 and CD4 Expression during Development of CD4−/CD8+ T Cells 2005 ·The Journal of Immunology ·(unknown),Michaela Petter,Takeshi Egawa,Kirsten Laule-Kilian,(unknown),(unknown),Yvonne Ludwig,Hidehiro Fukuyama,Hedda Wardemann,(unknown),Tarik Möröy,Ichiro Taniuchi,Viktor Steimle,Dan R. Littman,Marc Ehlers	107
14	Runx3 regulates integrin αE/CD103 and CD4 expression during development of CD4−/CD8+ T cells 2005 ·The Journal of Immunology ·(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),Tarik Möröy,(unknown),(unknown),Dan R. Littman,Marc Ehlers	3
15	CD8αα-Mediated Survival and Differentiation of CD8 Memory T Cell Precursors 2004 ·Science ·Loui Madakamutil,Urs Christen,Christopher J. Lena,Yiran Wang-Zhu,Antoine Attinger,(unknown),Wilfried Ellmeier,Matthias G. von Herrath,Peter E. Jensen,Dan R. Littman,Hilde Cheroutre	155
16	Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt ⁺ Cells 2004 ·Science ·Gérard Eberl,Dan R. Littman	404
17	PKC-θ knockout mice are protected from fat-induced insulin resistance 2004 ·Journal of Clinical Investigation ·Jason K. Kim,Jonathan J. Fillmore,Mary Jean Sunshine,(unknown),Takamasa Higashimori,Dong‐Wook Kim,Zhenxiang Liu,Timothy Soos,Gary W. Cline,(unknown),Dan R. Littman,Gerald I. Shulman	371
18	PKC-θ knockout mice are protected from fat-induced insulin resistance 2004 ·Journal of Clinical Investigation ·Jason K. Kim,Jonathan J. Fillmore,Mary Jean Sunshine,(unknown),Takamasa Higashimori,Dongwook Kim,Zhenxiang Liu,Timothy Soos,Gary W. Cline,(unknown),Dan R. Littman,Gerald I. Shulman	341
19	The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium 2001 ·Journal of Clinical Investigation ·Yuqing Huo,Christian Weber,(unknown),Markus Sperandio,Jayant Thatte,Matthias Mack,Steffen Jung,Dan R. Littman,Klaus Ley	17
20	The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium 2001 ·Journal of Clinical Investigation ·Yuqing Huo,Christian Weber,S. Bradley Forlow,Markus Sperandio,Jayant Thatte,Matthias Mack,Steffen Jung,Dan R. Littman,Klaus Ley	226

About Dan R. Littman

Dan R. Littman is a scholar working on Virology, Immunology and Immunology and Allergy, having authored 345 papers that have together received 98.4k indexed citations. Recurring topics across this work include Immune Cell Function and Interaction (158 papers), T-cell and B-cell Immunology (146 papers) and Immunotherapy and Immune Responses (76 papers). The work is most often cited by research in Immunology (56.0k citations), Virology (11.2k citations) and Neurology (8.3k citations). Dan R. Littman has collaborated with scholars based in United States, Germany and Japan. Frequent co-authors include Steffen Jung, Ivaylo I. Ivanov, Liang Zhou, Kenya Honda, Mary Jean Sunshine, Derya Unutmaz, Frédéric Geissmann, Andrew J. Macpherson, Lora V. Hooper and Arthur Weiss. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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