Charles A. Dinarello

144.9k total citations · 41 hit papers
873 papers, 108.0k citations indexed

About

Charles A. Dinarello is a scholar working on Immunology, Molecular Biology and Oncology. According to data from OpenAlex, Charles A. Dinarello has authored 873 papers receiving a total of 108.0k indexed citations (citations by other indexed papers that have themselves been cited), including 515 papers in Immunology, 320 papers in Molecular Biology and 120 papers in Oncology. Recurrent topics in Charles A. Dinarello's work include Immune Response and Inflammation (234 papers), Inflammasome and immune disorders (199 papers) and Immune Cell Function and Interaction (132 papers). Charles A. Dinarello is often cited by papers focused on Immune Response and Inflammation (234 papers), Inflammasome and immune disorders (199 papers) and Immune Cell Function and Interaction (132 papers). Charles A. Dinarello collaborates with scholars based in United States, Netherlands and Germany. Charles A. Dinarello's co-authors include Giamila Fantuzzi, Jos W.M. van der Meer, Mihai G. Netea, Leo A. B. Joosten, Sheldon Wolff, Joseph G. Cannon, Franklin H. Epstein, Cecília Garlanda, Alberto Mantovani and Soohyun Kim and has published in prestigious journals such as Science, New England Journal of Medicine and Cell.

In The Last Decade

Charles A. Dinarello

863 papers receiving 105.0k citations

Hit Papers

Immunological and Inflamm... 1983 2026 1997 2011 2009 1986 2011 2000 1989 500 1000 1.5k 2.0k 2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Immunological and Inflammatory Functions of the Interleukin-1 Family
    2009 2.7k citations Charles A. Dinarello profile →
  2. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
    1986 2.2k citations Charles A. Dinarello et al. The Journal of Immunology profile →
  3. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
    2011 1.7k citations Charles A. Dinarello Blood profile →
  4. Proinflammatory Cytokines
    2000 1.6k citations Charles A. Dinarello profile →
  5. The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells
    1989 1.6k citations Charles A. Dinarello et al. profile →
  6. The Interleukin-1 Family: Back to the Future
    2013 1.5k citations Charles A. Dinarello et al. profile →
  7. Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration
    1988 1.4k citations Charles A. Dinarello et al. profile →
  8. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
    2012 1.3k citations Charles A. Dinarello et al. profile →
  9. Biology of interleukin 1
    1988 1.3k citations Charles A. Dinarello profile →
  10. Overview of the IL‐1 family in innate inflammation and acquired immunity
    2017 1.3k citations Charles A. Dinarello profile →
  11. Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
    1986 1.2k citations Charles A. Dinarello et al. profile →
  12. Interleukin-1 and Its Biologically Related Cytokines
    1989 1.0k citations Charles A. Dinarello profile →
  13. Interleukin-1 and the Pathogenesis of the Acute-Phase Response
    1984 935 citations Charles A. Dinarello et al. profile →
  14. Anti-inflammatory Agents: Present and Future
    2010 846 citations Charles A. Dinarello profile →
  15. IL-1 is required for tumor invasiveness and angiogenesis
    2003 814 citations Charles A. Dinarello et al. Proceedings of the National Academy of Sciences profile →
  16. The Role of Interleukin-1 in Disease
    1993 809 citations Charles A. Dinarello et al. profile →
  17. Cytokine-Induced Expression of HIV-1 in a Chronically Infected Promonocyte Cell Line
    1987 795 citations Charles A. Dinarello et al. profile →
  18. Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity
    2019 735 citations Charles A. Dinarello et al. profile →
  19. Interleukin-18 and IL-18 Binding Protein
    2013 692 citations Charles A. Dinarello, Daniela Novick et al. Frontiers in Immunology profile →
  20. IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family
    1999 685 citations Charles A. Dinarello profile →
  21. IL-37 is a fundamental inhibitor of innate immunity
    2010 676 citations Marcel F. Nold, Claudia A. Nold‐Petry et al. profile →
  22. Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages
    2008 660 citations Mihai G. Netea, Claudia A. Nold‐Petry et al. Blood profile →
  23. Interleukin-18 Binding Protein
    1999 646 citations Daniela Novick, Leonid L. Reznikov et al. profile →
  24. A clinical perspective of IL‐1β as the gatekeeper of inflammation
    2011 642 citations Charles A. Dinarello profile →
  25. The interleukin‐1 family: 10 years of discovery 1
    1994 642 citations Charles A. Dinarello profile →
  26. Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro
    1991 611 citations Charles A. Dinarello et al. profile →
  27. Inflammatory Markers and Risk of Heart Failure in Elderly Subjects Without Prior Myocardial Infarction
    2003 607 citations Charles A. Dinarello et al. profile →
  28. Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome
    2015 599 citations Bita Shakoory, Joseph A. Carcillo et al. Critical Care Medicine profile →
  29. Inflammasome activation and IL-1β and IL-18 processing during infection
    2011 558 citations Mihai G. Netea, Charles A. Dinarello et al. profile →
  30. Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.
    1986 542 citations Charles A. Dinarello et al. profile →
  31. Stimulation of Muscle Protein Degradation and Prostaglandin E2Release by Leukocytic Pyrogen (Interleukin-1)
    1983 529 citations Charles A. Dinarello et al. profile →
  32. Interleukins in cancer: from biology to therapy
    2021 528 citations Charles A. Dinarello et al. profile →
  33. Interleukin-1
    1997 519 citations Charles A. Dinarello profile →
  34. Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease
    2020 508 citations Carlo Marchetti, Charles A. Dinarello et al. profile →
  35. Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.
    1986 495 citations Charles A. Dinarello et al. profile →
  36. Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling
    1988 485 citations Charles A. Dinarello et al. profile →
  37. Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial
    2014 472 citations Charles A. Dinarello et al. profile →
  38. Cytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans
    1986 458 citations Thomas Mandrup‐Poulsen, Charles A. Dinarello et al. profile →
  39. Treating inflammation by blocking interleukin-1 in humans
    2013 431 citations Charles A. Dinarello et al. profile →
  40. Targeting innate immune mediators in type 1 and type 2 diabetes
    2019 299 citations Marc Y. Donath, Charles A. Dinarello et al. profile →
  41. Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases
    2021 214 citations Giulio Cavalli, Serena Colafrancesco et al. Autoimmunity Reviews profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Charles A. Dinarello United States 174 47.0k 36.8k 15.9k 11.9k 10.8k 873 108.0k
Nico van Rooijen Netherlands 146 38.1k 0.8× 21.4k 0.6× 13.1k 0.8× 10.0k 0.8× 8.1k 0.7× 838 80.5k
Jürg Tschopp Switzerland 131 43.3k 0.9× 52.0k 1.4× 11.9k 0.7× 7.7k 0.6× 6.5k 0.6× 283 87.3k
Peter Libby United States 197 48.9k 1.0× 36.2k 1.0× 25.3k 1.6× 11.8k 1.0× 39.4k 3.7× 768 148.1k
Richard A. Flavell United States 219 86.8k 1.8× 75.7k 2.1× 19.7k 1.2× 23.1k 1.9× 11.7k 1.1× 1.2k 179.2k
Dan R. Littman United States 150 56.0k 1.2× 30.6k 0.8× 8.0k 0.5× 13.8k 1.2× 5.6k 0.5× 345 98.4k
Alberto Mantovani Italy 173 91.5k 1.9× 42.5k 1.2× 13.7k 0.9× 45.1k 3.8× 11.2k 1.0× 1.1k 157.6k
Gabriel Núñez United States 131 33.2k 0.7× 46.9k 1.3× 10.6k 0.7× 8.9k 0.7× 7.4k 0.7× 383 82.2k
Douglas R. Green United States 178 35.3k 0.8× 80.9k 2.2× 18.8k 1.2× 18.8k 1.6× 4.7k 0.4× 613 125.1k
Kiyoshi Takeda Japan 118 57.1k 1.2× 27.9k 0.8× 14.7k 0.9× 9.7k 0.8× 5.4k 0.5× 463 92.8k
Anthony Cerami United States 135 20.7k 0.4× 18.8k 0.5× 10.8k 0.7× 6.5k 0.5× 4.7k 0.4× 514 76.7k

Countries citing papers authored by Charles A. Dinarello

Since Specialization
Citations

This map shows the geographic impact of Charles A. Dinarello's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Charles A. Dinarello with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Charles A. Dinarello more than expected).

Fields of papers citing papers by Charles A. Dinarello

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Charles A. Dinarello. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Charles A. Dinarello. The network helps show where Charles A. Dinarello may publish in the future.

Co-authorship network of co-authors of Charles A. Dinarello

This figure shows the co-authorship network connecting the top 25 collaborators of Charles A. Dinarello. A scholar is included among the top collaborators of Charles A. Dinarello based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Charles A. Dinarello. Charles A. Dinarello is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Mack, Douglas G., Tabrez A. Mohammad, Arlan D. Martin, et al.. (2025). Interleukin-1 signaling and CD4+ T cells control B cell recruitment to the lungs in chronic beryllium disease. Frontiers in Immunology. 16. 1479348–1479348. 1 indexed citations
2.
Dinarello, Alberto, Jesús Amo‐Aparicio, Tania Azam, et al.. (2023). IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1β secretion. Proceedings of the National Academy of Sciences. 120(45). e2306476120–e2306476120. 4 indexed citations
3.
Cavalli, Giulio, Serena Colafrancesco, Giacomo Emmi, et al.. (2021). Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases. Autoimmunity Reviews. 20(3). 102763–102763. 214 indexed citations breakdown →
4.
Powers, Nicholas E., Benjamin J. Swartzwelter, Carlo Marchetti, et al.. (2019). PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis. Journal of Biological Chemistry. 295(3). 868–882. 15 indexed citations
5.
Hayashi, Masahiro, Ying Jin, Daniel Yorgov, et al.. (2016). Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo. Proceedings of the National Academy of Sciences. 113(5). 1357–1362. 43 indexed citations
6.
Cavalli, Giulio, Masahiro Hayashi, Ying Jin, et al.. (2016). MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo. Proceedings of the National Academy of Sciences. 113(5). 1363–1368. 72 indexed citations
7.
Shakoory, Bita, Joseph A. Carcillo, W. Winn Chatham, et al.. (2015). Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome. Critical Care Medicine. 44(2). 275–281. 599 indexed citations breakdown →
8.
Rider, Peleg, Yaron Carmi, Rami Yossef, et al.. (2015). IL-1 Receptor Antagonist Chimeric Protein: Context-Specific and Inflammation-Restricted Activation. The Journal of Immunology. 195(4). 1705–1712. 10 indexed citations
9.
Choi, Sung Won, Erin Gatza, Guoqing Hou, et al.. (2014). Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans. Blood. 125(5). 815–819. 86 indexed citations
10.
Cavelti‐Weder, Claudia, Cornelia Keller, Marc Stahel, et al.. (2012). Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes. Diabetes Care. 35(8). 1654–1662. 229 indexed citations
11.
McNamee, Eóin N., Joanne C. Masterson, Paul Jedlicka, et al.. (2011). Interleukin 37 expression protects mice from colitis. Proceedings of the National Academy of Sciences. 108(40). 16711–16716. 271 indexed citations
12.
Dinarello, Charles A.. (2011). Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood. 117(14). 3720–3732. 1690 indexed citations breakdown →
13.
Glauben, Rainer, A Batra, Thomas Stroh, et al.. (2008). Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice. Gut. 57(5). 613–622. 86 indexed citations
14.
Calabrese, Fiorella, Simonetta Baraldo, Erica Bazzan, et al.. (2008). IL-32, a Novel Proinflammatory Cytokine in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. 178(9). 894–901. 137 indexed citations
15.
Arcaroli, John J., John E. Hokanson, Edward Abraham, et al.. (2008). Extracellular Superoxide Dismutase Haplotypes Are Associated with Acute Lung Injury and Mortality. American Journal of Respiratory and Critical Care Medicine. 179(2). 105–112. 42 indexed citations
16.
Novick, Daniela, et al.. (2007). Antiviral and immunoregulatory activities of IFN-γ depend on constitutively expressed IL-1α. Proceedings of the National Academy of Sciences. 104(12). 5044–5049. 47 indexed citations
17.
Novick, Daniela, Menachem Rubinstein, Tania Azam, et al.. (2006). Proteinase 3 is an IL-32 binding protein. Proceedings of the National Academy of Sciences. 103(9). 3316–3321. 125 indexed citations
18.
Joosten, Leo A. B., Mihai G. Netea, Soohyun Kim, et al.. (2006). IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proceedings of the National Academy of Sciences. 103(9). 3298–3303. 277 indexed citations
19.
Reddy, Pavan, Yoshinobu Maeda, Kevin B. Hotary, et al.. (2004). Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect. Proceedings of the National Academy of Sciences. 101(11). 3921–3926. 213 indexed citations
20.
Dinarello, Charles A.. (2004). The IL-1 family and inflammatory diseases.. PubMed. 20(5 Suppl 27). S1–13. 493 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Nico van Rooijen Breakdown of academic impact, for papers by Jürg Tschopp Breakdown of academic impact, for papers by Peter Libby Breakdown of academic impact, for papers by Richard A. Flavell Breakdown of academic impact, for papers by Dan R. Littman Breakdown of academic impact, for papers by Alberto Mantovani Breakdown of academic impact, for papers by Gabriel Núñez Breakdown of academic impact, for papers by Douglas R. Green Breakdown of academic impact, for papers by Kiyoshi Takeda Breakdown of academic impact, for papers by Anthony Cerami
Rankless by CCL
2026