Michael E. Pacold

9.6k citations

36 papers · 5.2k indexed · 3 hit papers · h-index 23

Impact in

Cancer Research top 1%
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
Molecular Biology top 1%
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- Cancer-related gene regulation
- RNA Research and Splicing
- Epigenetics and DNA Methylation

Papers in ⓘ

Biochemistry 4
Molecular Biology 30
- Protein Kinase Regulation and GTPase Signaling 8
- PI3K/AKT/mTOR signaling in cancer 7
- Epigenetics and DNA Methylation 4
- RNA modifications and cancer 3
- Glycosylation and Glycoproteins Research 3
- Melanoma and MAPK Pathways 2

Co-authors: Phillip T. Hawkins (4 shared papers)Len Stephens (4 shared papers)Olga Perišić (4 shared papers)Roger Williams (4 shared papers)Edward H. Walker (2 shared papers)Matthias P. Wymann (1 shared paper)David M. Sabatini (9 shared papers)Timothy C. Wang (3 shared papers)
Journals: Cell (4 papers)Nature (3 papers)Science (3 papers)Molecular Cell (2 papers)Journal of Clinical Oncology (2 papers)
Partner nations: United States United Kingdom South Korea

In The Last Decade

Michael E. Pacold

35 papers receiving 5.1k citations

Hit Papers

align trajectories log scale

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites 2014 · 978 citations

Peers

Countries citing papers authored by Michael E. Pacold

Since Specialization

Citations

This map shows the geographic impact of Michael E. Pacold's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael E. Pacold with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael E. Pacold more than expected).

Fields of papers citing papers by Michael E. Pacold

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael E. Pacold. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael E. Pacold. The network helps show where Michael E. Pacold may publish in the future.

Co-authors

The 25 scholars most cited alongside Michael E. Pacold, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Michael E. Pacold Line = papers co-authored together Michael E. Pacold links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 36 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine Molecular Cell ·Edward H. Walker, Michael E. Pacold, Olga Perišić, Len Stephens, Phillip T. Hawkins, Matthias P. Wymann, Roger Williams Hit paper breakdown →	2000	991
2	Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites Cell Reports ·Schraga Schwartz, Maxwell R. Mumbach, Marko Jovanović, Timothy C. Wang, Karolina Maciag, G. Guy Bushkin, Philipp Mertins, Dmitry Ter‐Ovanesyan, Naomi Habib, Davide Cacchiarelli, Neville E. Sanjana, Elizaveta Freinkman, Michael E. Pacold, Rahul Satija, Tarjei S. Mikkelsen, Nir Hacohen, Feng Zhang, Steven A. Carr, Eric S. Lander, Aviv Regev Hit paper breakdown →	2014	978
3	Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ Cell ·Michael E. Pacold, Sabine Suire, Olga Perišić, Samuel Lara‐González, Colin Davis, Edward H. Walker, Phillip T. Hawkins, Len Stephens, John F. Eccleston, Roger Williams Hit paper breakdown →	2000	504
4	Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway Science ·Robert A. Saxton, Kevin E. Knockenhauer, Rachel L. Wolfson, Lynne Chantranupong, Michael E. Pacold, Timothy C. Wang, Thomas Schwartz, David M. Sabatini	2015	356
5	mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin DSpace@MIT (Massachusetts Institute of Technology) ·Christopher Cervantes, Daniel Lim, Seong A. Kang, Michael E. Pacold, Hua Jane Lou, Kathleen Ottina, Nathanael S. Gray, Benjamin E. Turk, Michael B. Yaffe, David M. Sabatini	2013	349
6	SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance Nature ·Do‐Hoon Kim, Brian P. Fiske, Kıvanç Birsoy, Elizaveta Freinkman, Kenjiro Kami, Richard Possemato, Yakov Chudnovsky, Michael E. Pacold, Walter W. Chen, Jason R. Cantor, Laura M. Shelton, Dan Y. Gui, Manjae Kwon, Shakti Ramkissoon, Keith L. Ligon, Seong Woo Kang, Matija Snuderl, Matthew G. Vander Heiden, David M. Sabatini	2015	273
7	Therapeutic Targeting of Oncogenic K‐Ras by a Covalent Catalytic Site Inhibitor Angewandte Chemie International Edition ·Sang Min Lim, Kenneth D. Westover, Scott B. Ficarro, Rane A. Harrison, Hwan Geun Choi, Michael E. Pacold, Martin A. Carrasco, John C. Hunter, Nam Doo Kim, Ting Xie, Taebo Sim, Pasi A. Jänne, Matthew Meyerson, Jarrod A. Marto, John R. Engen, Nathanael S. Gray	2013	246
8	The Crystal Structure of the PX Domain from p40phox Bound to Phosphatidylinositol 3-Phosphate Molecular Cell ·Jerónimo Bravo, Dimitrios Karathanassis, Christine M Pacold, Michael E. Pacold, Chris D. Ellson, Karen E. Anderson, P.J.G. Butler, Isabelle Lavenir, Olga Perišić, Phillip T. Hawkins, Len Stephens, Roger Williams	2001	227
9	Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer Cell ·Robert S. Banh, Douglas E. Biancur, Keisuke Yamamoto, Albert S.W. Sohn, Beth Walters, Miljan Kuljanin, Ajami Gikandi, Huamin Wang, Joseph D. Mancias, Robert J. Schneider, Michael E. Pacold, Alec C. Kimmelman	2020	185
10	Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition Cell ·Yoav D. Shaul, Elizaveta Freinkman, William C. Comb, Jason R. Cantor, Wai Leong Tam, Prathapan Thiru, Do‐Hoon Kim, Naama Kanarek, Michael E. Pacold, Walter W. Chen, Brian Bierie, Richard Possemato, Ferenc Reinhardt, Robert A. Weinberg, Michael B. Yaffe, David M. Sabatini	2014	172
11	SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism Science ·Nora Kory, Gregory A. Wyant, Gyan Prakash, Jelmi uit de Bos, Francesca Bottanelli, Michael E. Pacold, Sze Ham Chan, Caroline A. Lewis, Timothy C. Wang, Heather R. Keys, Yang Guo, David M. Sabatini	2018	169
12	Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery Proceedings of the National Academy of Sciences ·Shrirang Karve, Michael E. Werner, Rohit Sukumar, Natalie D. Cummings, Jonathan A. Copp, Edina C. Wang, Chenxi Li, Manish Sethi, Ronald C. Chen, Michael E. Pacold, Andrew Z. Wang	2012	106
13	Using a Small Molecule Inhibitor of Peptide: N-Glycanase to Probe Its Role in Glycoprotein Turnover Chemistry & Biology ·Shahram Misaghi, Michael E. Pacold, Daniël Blom, Hidde L. Ploegh, Gregory A. Korbel	2004	100
14	Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy Cell ·Lin Wu, Kate E.R. Hollinshead, Yuhan Hao, Christy Au, Lina Kroehling, Charles Ng, Woan-Yu Lin, Dayi Li, Hernandez Moura Silva, Jong Shin, Juan J. Lafaille, Richard Possemato, Michael E. Pacold, Thales Papagiannakopoulos, Alec C. Kimmelman, Rahul Satija, Dan R. Littman	2020	83
15	Extracellular RNAs Are Associated With Insulin Resistance and Metabolic Phenotypes Diabetes Care ·Ravi V. Shah, Venkatesh L. Murthy, Michael E. Pacold, Kirsty Danielson, Kahraman Tanrıverdi, Martin G. Larson, Kristina Hanspers, Alexander R. Pico, Eric Mick, Jared P. Reis, Sarah D. de Ferranti, Elizaveta Freinkman, Daniel Levy, Udo Hoffmann, Stavroula K. Osganian, Saumya Das, Jane E. Freedman	2017	79
16	Yeast N ‐glycanase distinguishes between native and non‐native glycoproteins EMBO Reports ·Christian Hirsch, Shahram Misaghi, Daniël Blom, Michael E. Pacold, Hidde L. Ploegh	2004	47
17	The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase Advances in Enzyme Regulation ·Olga Perišić, Michael Wilson, Dimitrios Karathanassis, Jerónimo Bravo, Michael E. Pacold, Chris D. Ellson, Phillip T. Hawkins, Len Stephens, Roger Williams	2004	41
18	The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway Nature ·Robert S. Banh, Esther Kim, Quentin Spillier, Douglas E. Biancur, Keisuke Yamamoto, Albert S.W. Sohn, Guangbin Shi, Drew R. Jones, Alec C. Kimmelman, Michael E. Pacold	2021	37
19	PIK3CA mutant tumors depend on oxoglutarate dehydrogenase Proceedings of the National Academy of Sciences ·Nina Ilić, Kıvanç Birsoy, Andrew J. Aguirre, Nora Kory, Michael E. Pacold, Shambhavi Singh, Susan E. Moody, Joseph D. DeAngelo, Nicole A. Spardy, Elizaveta Freinkman, Barbara A. Weir, Aviad Tsherniak, Glenn S. Cowley, David E. Root, John M. Asara, Francisca Vázquez, Hans R. Widlund, David M. Sabatini, William C. Hahn	2017	36
20	Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors Bioorganic & Medicinal Chemistry ·Jason M. Rohde, Kyle R. Brimacombe, Li Liu, Michael E. Pacold, Adam Yasgar, Dorian M. Cheff, Tobie D. Lee, Ganesha Rai, Bolormaa Baljinnyam, Zhuyin Li, Anton Simeonov, Matthew D. Hall, Min Shen, David M. Sabatini, Matthew B. Boxer	2018	35

About Michael E. Pacold

Michael E. Pacold is a scholar working on Biochemistry, Molecular Biology, Cancer Research, Clinical Biochemistry and Geriatrics and Gerontology, having authored 36 papers that have together received 5.2k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (8 papers), PI3K/AKT/mTOR signaling in cancer (7 papers), Cancer, Hypoxia, and Metabolism (5 papers), Epigenetics and DNA Methylation (4 papers), Endoplasmic Reticulum Stress and Disease (3 papers), RNA modifications and cancer (3 papers), Glycosylation and Glycoproteins Research (3 papers) and Melanoma and MAPK Pathways (2 papers). The work is most often cited by research in Cancer Research (1.1k citations), Molecular Biology (4.1k citations), Cell Biology (655 citations), Physiology (113 citations) and Biochemistry (174 citations). Michael E. Pacold has collaborated with scholars based in United States, United Kingdom and South Korea. Frequent co-authors include Phillip T. Hawkins, Len Stephens, Olga Perišić, Roger Williams, Edward H. Walker, Matthias P. Wymann, David M. Sabatini, Timothy C. Wang, Elizaveta Freinkman and Rahul Satija. Their work appears in journals such as Cell, Nature, Science, Molecular Cell and Journal of Clinical Oncology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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