John M. Asara

60.6k total citations · 19 hit papers
293 papers, 36.4k citations indexed

About

John M. Asara is a scholar working on Molecular Biology, Cancer Research and Oncology. According to data from OpenAlex, John M. Asara has authored 293 papers receiving a total of 36.4k indexed citations (citations by other indexed papers that have themselves been cited), including 202 papers in Molecular Biology, 68 papers in Cancer Research and 36 papers in Oncology. Recurrent topics in John M. Asara's work include Cancer, Hypoxia, and Metabolism (52 papers), PI3K/AKT/mTOR signaling in cancer (36 papers) and Metabolism, Diabetes, and Cancer (32 papers). John M. Asara is often cited by papers focused on Cancer, Hypoxia, and Metabolism (52 papers), PI3K/AKT/mTOR signaling in cancer (36 papers) and Metabolism, Diabetes, and Cancer (32 papers). John M. Asara collaborates with scholars based in United States, China and Germany. John M. Asara's co-authors include Lewis C. Cantley, William S. Lane, Brendan D. Manning, William G. Kaelin, Michael Ohh, Keiichi Kondo, William Kim, Haifeng Yang, Adrian Salic and Mircea Ivan and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

John M. Asara

289 papers receiving 36.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 3.9k citations John M. Asara et al. Science profile →
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

2010 2.0k citations David B. Shackelford, Maria M. Mihaylova et al. Science profile →
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

2013 1.5k citations Costas A. Lyssiotis, Edouard Mullarky et al. profile →
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

2014 1.1k citations John M. Asara et al. profile →
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

2011 941 citations John M. Asara, Jason W. Locasale et al. Science profile →
Pyruvate kinase M2 is a phosphotyrosine-binding protein

2008 817 citations John M. Asara, Lewis C. Cantley et al. profile →
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

2016 813 citations John M. Asara, Lewis C. Cantley et al. profile →
A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

2012 808 citations Xuemei Yang, John M. Asara et al. profile →
Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation

2003 749 citations John M. Asara et al. profile →
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

2015 696 citations Jihye Yun, Edouard Mullarky et al. Science profile →
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

2016 594 citations Issam Ben‐Sahra, Gerta Hoxhaj et al. Science profile →
NRF2 regulates serine biosynthesis in non–small cell lung cancer

2015 560 citations Edouard Mullarky, John M. Asara et al. profile →
Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

2015 559 citations John M. Asara, Reuben J. Shaw et al. profile →
Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

2013 555 citations Issam Ben‐Sahra, John M. Asara et al. Science profile →
AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

2013 517 citations John M. Asara, Lewis C. Cantley et al. profile →
Evidence for an alternative glycolytic pathway in rapidly proliferating cells

2010 509 citations Jason W. Locasale, John M. Asara et al. profile →
Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylation

2012 506 citations Ng Shyh‐Chang, Jason W. Locasale et al. Science profile →
TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

2012 483 citations John M. Asara, Brendan D. Manning et al. profile →
Targeted deletion of PD-1 in myeloid cells induces antitumor immunity

2020 316 citations John M. Asara et al. profile →

Peers

Countries citing papers authored by John M. Asara

Since Specialization

Citations

This map shows the geographic impact of John M. Asara's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John M. Asara with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John M. Asara more than expected).

Fields of papers citing papers by John M. Asara

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John M. Asara. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John M. Asara. The network helps show where John M. Asara may publish in the future.

Co-authorship network of co-authors of John M. Asara

This figure shows the co-authorship network connecting the top 25 collaborators of John M. Asara. A scholar is included among the top collaborators of John M. Asara based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John M. Asara. John M. Asara is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	IDH1 Inhibition Potentiates Chemotherapy Efficacy in Pancreatic Cancer 2024 ·Cancer Research ·Mehrdad Zarei, (unknown), Jonathan J. Hue, (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Ali Vaziri‐Gohar, (unknown), John M. Asara, Luke D. Rothermel, Jonathan R. Brody, Jordan M. Winter	10
2	mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency 2023 ·Journal of Autoimmunity ·Thomas Winans, Zachary Oaks, (unknown), (unknown), Nick Huang, (unknown), (unknown), James P. Nolan, Jacob S. Lewis, Sarah L. Blair, Zhi‐Wei Lai, S.K. Landas, Frank A. Middleton, John M. Asara, (unknown), (unknown), Parastoo Azadi, Katalin Bánki, András Perl	24
3	Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex 2021 ·Cancer Research ·(unknown), Andres Sanin, Kosmas Kosmas, (unknown), Ji Wang, Elie W. Akl, Krinio Giannikou, Clemens K. Probst, (unknown), (unknown), Vera P. Krymskaya, John M. Asara, Hilaire C. Lam, David J. Kwiatkowski, Elizabeth P. Henske, Harilaos Filippakis	8
4	Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells 2021 ·Proceedings of the National Academy of Sciences ·Ji Wang, Harilaos Filippakis, (unknown), Heng Du, Chenyang Ye, Heng-Jia Liu, (unknown), K.M. Hindi, (unknown), Julie Nijmeh, John M. Asara, Wei Shi, Souheil El‐Chemaly, Elizabeth P. Henske, Hilaire C. Lam	17
5	PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage 2019 ·Cancer Discovery ·Jinfang Zhang, Yu-Ru Lee, Fabin Dang, Wenjian Gan, Archita Venugopal Menon, Jesse Katon, Chih-Hung Hsu, John M. Asara, Priyanka Tibarewal, Nicholas R. Leslie, Yang Shi, Pier Paolo Pandolfi, Wenyi Wei	61
6	Direct stimulation of NADP ⁺ synthesis through Akt-mediated phosphorylation of NAD kinase 2019 ·Science ·Gerta Hoxhaj, Issam Ben‐Sahra, (unknown), Rebecca C. Timson, Vanessa Byles, (unknown), Peng Gao, Laura M. Selfors, John M. Asara, Brendan D. Manning	113
7	Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer 2017 ·Cancer Discovery ·Kristin Brown, Jessica B. Spinelli, John M. Asara, Alex Toker	142
8	A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics 2015 ·Cancer Discovery ·Anguraj Sadanandam, Stephan Wullschleger, Costas A. Lyssiotis, Carsten Grötzinger, Stefano Barbi, Samantha Bersani, (unknown), (unknown), Andrea Mafficini, Rita T. Lawlor, Michele Simbolo, John M. Asara, Hendrik Bläker, Lewis C. Cantley, Bertram Wiedenmann, Aldo Scarpa, Douglas Hanahan	139
9	Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH breakdown → 2015 ·Science ·Jihye Yun, Edouard Mullarky, (unknown), Kaitlyn Bosch, Adam Kavalier, Keith Rivera, Jatin Roper, Iok In Christine Chio, Ευγενία Γιαννοπούλου, Carlo Rago, Ashlesha Muley, John M. Asara, Jihye Paik, Olivier Elemento, Zhengming Chen, Darryl Pappin, Lukas E. Dow, Nickolas Papadopoulos, Steven S. Gross, Lewis C. Cantley	696
10	Metabolic Signature Identifies Novel Targets for Drug Resistance in Multiple Myeloma 2015 ·Cancer Research ·Patricia Maiso, Daisy Huynh, Michele Moschetta, Antonio Sacco, Yosra Aljawai, Yuji Mishima, John M. Asara, Aldo M. Roccaro, Alec C. Kimmelman, Irene M. Ghobrial	166
11	High-Throughput Drug Screen Identifies Chelerythrine as a Selective Inducer of Death in a TSC2-null Setting 2014 ·Molecular Cancer Research ·Doug Medvetz, Yang Sun, Chenggang Li, Damir Khabibullin, Murugabaskar Balan, Andrey A. Parkhitko, Carmen Priolo, John M. Asara, Soumitro Pal, Jane Yu, Elizabeth P. Henske	21
12	Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain 2014 ·Cancer Research ·Jinyu Chen, Ho-Jeong Lee, Xuefeng Wu, Lei Huo, Sun-Jin Kim, (unknown), Yan Wang, (unknown), Lakshmi Reddy Bollu, Guang Gao, Fei Su, James M. Briggs, Xiaojing Liu, Tamar Melman, John M. Asara, Isaiah J. Fidler, Lewis C. Cantley, Jason W. Locasale, Weihua Zhang	136
13	Vulnerabilities of PTEN – TP53 -Deficient Prostate Cancers to Compound PARP–PI3K Inhibition 2014 ·Cancer Discovery ·Enrique González‐Billalabeitia, Nina Seitzer, Su Jung Song, Min Sup Song, Akash Patnaik, Xuesong Liu, Mirjam T. Epping, Antonella Papa, Robin M. Hobbs, Ming Chen, Andrea Lunardi, Christopher Ng, Kaitlyn A. Webster, Sabina Signoretti, Massimo Loda, John M. Asara, Caterina Nardella, John G. Clohessy, Lewis C. Cantley, Pier Paolo Pandolfi	80
14	Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide 2013 ·Molecular Cancer Research ·Andrey A. Parkhitko, Carmen Priolo, Jonathan L. Coloff, Jihye Yun, Julia Wu, Kenji Mizumura, Wenping Xu, Izabela A. Malinowska, Jane Yu, David J. Kwiatkowski, Jason W. Locasale, John M. Asara, Augustine M.K. Choi, Toren Finkel, Elizabeth P. Henske	50
15	MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors 2012 ·Cancer Research ·Alexa B. Turke, Youngchul Song, Carlotta Costa, Rebecca S. Cook, Carlos L. Arteaga, John M. Asara, Jeffrey A. Engelman	285
16	Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylation breakdown → 2012 ·Science ·Ng Shyh‐Chang, Jason W. Locasale, Costas A. Lyssiotis, Yu-Xiang Zheng, (unknown), Sutheera Ratanasirintrawoot, Jin Zhang, Tamer T. Önder, Juli Unternaehrer, Hao Zhu, John M. Asara, George Q. Daley, Lewis C. Cantley	506
17	Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer 2012 ·Cancer Discovery ·Ashish Juvekar, Laura N. Burga, Hai Hu, Elaine P. Lunsford, Yasir H. Ibrahim, Judith Balmañà, Anbazhagan Rajendran, Antonella Papa, Katherine Spencer, Costas A. Lyssiotis, Caterina Nardella, Pier Paolo Pandolfi, José Baselga, Ralph Scully, John M. Asara, Lewis C. Cantley, Gerburg M. Wulf	336
18	Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI3K in Cancer 2011 ·Cancer Research ·Xuemei Yang, Alexa B. Turke, Jie Qi, Youngchul Song, Brent N. Rexer, Todd W. Miller, Pasi A. Jänne, Carlos L. Arteaga, Lewis C. Cantley, Jeffrey A. Engelman, John M. Asara	9
19	Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy breakdown → 2010 ·Science ·(unknown), David B. Shackelford, Maria M. Mihaylova, Sara Gelino, Rebecca A. Kohnz, William B. Mair, Debbie S. Vasquez, Aashish Joshi, Dana M. Gwinn, Rebecca C. Taylor, John M. Asara, James A. J. Fitzpatrick, Andrew Dillin, Benoı̂t Viollet, Mondira Kundu, Malene Hansen, Reuben J. Shaw	2048
20	Protein Sequences from Mastodon and Tyrannosaurus Rex Revealed by Mass Spectrometry 2007 ·Science ·John M. Asara, Mary H. Schweitzer, Lisa M. Freimark, Matthew J. Phillips, Lewis C. Cantley	216

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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