David E. Root

69.9k total citations · 11 hit papers
223 papers, 24.9k citations indexed

About

David E. Root is a scholar working on Molecular Biology, Electrical and Electronic Engineering and Oncology. According to data from OpenAlex, David E. Root has authored 223 papers receiving a total of 24.9k indexed citations (citations by other indexed papers that have themselves been cited), including 107 papers in Molecular Biology, 71 papers in Electrical and Electronic Engineering and 22 papers in Oncology. Recurrent topics in David E. Root's work include Radio Frequency Integrated Circuit Design (56 papers), CRISPR and Genetic Engineering (29 papers) and Advanced Power Amplifier Design (23 papers). David E. Root is often cited by papers focused on Radio Frequency Integrated Circuit Design (56 papers), CRISPR and Genetic Engineering (29 papers) and Advanced Power Amplifier Design (23 papers). David E. Root collaborates with scholars based in United States, Germany and United Kingdom. David E. Root's co-authors include John G. Doench, Benjamin L. Ebert, Ella Hartenian, Meagan E. Sullender, Mudra Hegde, William C. Hahn, Tarjei S. Mikkelsen, Neville E. Sanjana, David Scott and Dirk Heckl and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

David E. Root

216 papers receiving 24.5k citations

Hit Papers

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells 2006 2026 2012 2019 2013 2016 2011 2006 2014 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
    2013 3.7k citations Ophir Shalem, Neville E. Sanjana et al. Science profile →
  2. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
    2016 2.6k citations John G. Doench, David E. Root et al. profile →
  3. lincRNAs act in the circuitry controlling pluripotency and differentiation
    2011 1.5k citations David E. Root et al. profile →
  4. A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
    2006 1.4k citations Biao Luo, William C. Hahn et al. Cell profile →
  5. Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
    2014 1.2k citations John G. Doench, Ella Hartenian et al. profile →
  6. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
    2017 774 citations Eliezer M. Van Allen, David E. Root et al. profile →
  7. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
    2008 629 citations Benjamin L. Ebert, Pablo Tamayo et al. profile →
  8. KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
    2014 573 citations Federica Piccioni, Xiaoxing Wang et al. Cell profile →
  9. ( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
    2013 533 citations Ryan Looper, Peppi Koivunen et al. Science profile →
  10. Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities
    2018 505 citations Amy Goodale, David E. Root et al. profile →
  11. Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects
    2021 204 citations Joshua M. Dempster, Francisca Vázquez et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
David E. Root United States 68 17.0k 4.1k 3.6k 2.4k 2.2k 223 24.9k
Olivier Elemento United States 80 16.5k 1.0× 4.3k 1.0× 6.4k 1.8× 3.0k 1.2× 909 0.4× 440 25.9k
Steven A. Carr United States 108 31.7k 1.9× 5.4k 1.3× 4.0k 1.1× 3.5k 1.5× 641 0.3× 372 44.4k
Sarah A. Teichmann United Kingdom 87 23.6k 1.4× 3.8k 0.9× 3.8k 1.0× 6.4k 2.7× 365 0.2× 264 32.5k
John N. Weinstein United States 85 22.9k 1.3× 6.9k 1.7× 7.1k 1.9× 2.2k 0.9× 449 0.2× 322 34.9k
Peter K. Sorger United States 90 20.8k 1.2× 4.2k 1.0× 1.9k 0.5× 1.7k 0.7× 541 0.2× 299 28.5k
Jos Jonkers Netherlands 74 13.7k 0.8× 10.3k 2.5× 4.1k 1.1× 3.0k 1.3× 347 0.2× 237 21.4k
Douglas A. Lauffenburger United States 98 19.9k 1.2× 6.1k 1.5× 2.6k 0.7× 4.2k 1.7× 396 0.2× 561 39.2k
Akhilesh Pandey United States 89 20.8k 1.2× 3.2k 0.8× 3.6k 1.0× 2.8k 1.2× 205 0.1× 502 31.6k
John D. Pfeifer United States 49 12.7k 0.7× 2.2k 0.5× 1.7k 0.5× 2.3k 1.0× 241 0.1× 176 20.8k
Santosh Kesari United States 63 7.6k 0.4× 4.3k 1.0× 4.4k 1.2× 1.5k 0.6× 331 0.1× 440 18.1k

Countries citing papers authored by David E. Root

Since Specialization
Citations

This map shows the geographic impact of David E. Root's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David E. Root with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David E. Root more than expected).

Fields of papers citing papers by David E. Root

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David E. Root. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David E. Root. The network helps show where David E. Root may publish in the future.

Co-authorship network of co-authors of David E. Root

This figure shows the co-authorship network connecting the top 25 collaborators of David E. Root. A scholar is included among the top collaborators of David E. Root based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David E. Root. David E. Root is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Jain, Neha, Anna-Marie Marsh, Julie Boucau, et al.. (2025). VPS18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis –infected macrophages. Science Advances. 11(5). eadr6166–eadr6166. 4 indexed citations
2.
Schneider, Constanze, Gabriela Alexe, Yara Rodríguez, et al.. (2024). Posttranslational Changes in Histone Modification Driven By USP48 Loss Increase Sensitivity to Hypomethylating Agents in Acute Myeloid Leukemia. Blood. 144(Supplement 1). 205–205. 1 indexed citations
3.
Abu‐Remaileh, Muhannad, Nicole S. Persky, Yenarae Lee, David E. Root, & William G. Kaelin. (2024). Total loss of VHL gene function impairs neuroendocrine cancer cell fitness due to excessive HIF2α activity. Proceedings of the National Academy of Sciences. 121(40). e2410356121–e2410356121. 4 indexed citations
4.
Malone, Clare F., Neekesh V. Dharia, Guillaume Kugener, et al.. (2021). Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. Cancer Discovery. 11(9). 2282–2299. 23 indexed citations
5.
Self, Annette J., Paul A. Clarke, Udai Banerji, et al.. (2020). A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer. Molecular Cancer Therapeutics. 19(7). 1423–1435. 13 indexed citations
6.
Shen, Yu J., Yuji Mishima, Jiantao Shi, et al.. (2020). Progression signature underlies clonal evolution and dissemination of multiple myeloma. Blood. 137(17). 2360–2372. 32 indexed citations
7.
Hayes, Tikvah K., Flora Luo, Ofir Cohen, et al.. (2019). A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma. Cancer Research. 79(9). 2352–2366. 30 indexed citations
8.
Durbin, Adam D., Mark W. Zimmerman, Neekesh V. Dharia, et al.. (2018). Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nature Genetics. 50(9). 1240–1246. 145 indexed citations
9.
Wheeler, Douglas B., Roberto Zoncu, David E. Root, David M. Sabatini, & Charles L. Sawyers. (2015). Identification of an oncogenic RAB protein. Science. 350(6257). 211–217. 95 indexed citations
10.
Whittaker, Steven R., Glenn S. Cowley, Steve Wagner, et al.. (2015). Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors. Molecular Cancer Therapeutics. 14(12). 2700–2711. 55 indexed citations
11.
Shalem, Ophir, Neville E. Sanjana, Ella Hartenian, et al.. (2013). Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells. Science. 343(6166). 84–87. 3656 indexed citations breakdown →
12.
Looper, Ryan, Peppi Koivunen, Sung-Woo Lee, et al.. (2013). ( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible. Science. 339(6127). 1621–1625. 533 indexed citations breakdown →
13.
Whittaker, Steven R., Jean‐Philippe Theurillat, Eliezer M. Van Allen, et al.. (2013). A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition. Cancer Discovery. 3(3). 350–362. 260 indexed citations
14.
Ren, Yin, Hiu Wing Cheung, Amit Agrawal, et al.. (2012). Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4. Science Translational Medicine. 4(147). 147ra112–147ra112. 134 indexed citations
15.
Ren, Yin, Amit Agrawal, Jill P. Mesirov, et al.. (2012). Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Target ID4. DSpace@MIT (Massachusetts Institute of Technology). 2 indexed citations
16.
Nijhawan, Deepak, Travis Zack, Yin Ren, et al.. (2012). Cancer Vulnerabilities Unveiled by Genomic Loss. Cell. 150(4). 842–854. 161 indexed citations
17.
Cheung, Hiu Wing, Jinyan Du, Jesse S. Boehm, et al.. (2011). Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers. Cancer Discovery. 1(7). 608–625. 110 indexed citations
18.
Gohil, Vishal M., et al.. (2010). Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression. Journal of Biological Chemistry. 285(18). 13742–13747. 68 indexed citations
19.
Verspecht, Jan, et al.. (2009). Extension of X-parameters to include long-term dynamic memory effects. 741–744. 48 indexed citations
20.
Kramer, P. L., David E. Root, & S. Gancher. (1994). A gene for nystagmus-associated episodic ataxia maps to chromosome 19p. The American Journal of Human Genetics. 55(3). 536–47. 4 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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