David E. Root

69.9k citations

223 papers · 24.9k indexed · 11 hit papers · h-index 68

Aging top 0.2%
Molecular Biology top 0.1%
- CRISPR and Genetic Engineering 29
- Advanced biosensing and bioanalysis techniques 14
- Epigenetics and DNA Methylation 13
- Protein Degradation and Inhibitors 13
Cancer Research top 0.2%
Business and International Management top 0.5%
Oncology top 0.5%
Electrical and Electronic Engineering
- Radio Frequency Integrated Circuit Design 56
- Advanced Power Amplifier Design 23
- Silicon Carbide Semiconductor Technologies 22
- Advancements in Semiconductor Devices and Circuit Design 18

Co-authors: John G. Doench Benjamin L. Ebert Ella Hartenian Mudra Hegde Meagan E. Sullender William C. Hahn Tarjei S. Mikkelsen David Scott
Cited by: Aging Molecular Biology Cancer Research
Journals: Proceedings of the National Academy of Sciences (11 papers)Blood (10 papers)Nature Communications (7 papers)
Partner nations: United States Germany United Kingdom

In The Last Decade

David E. Root

216 papers receiving 24.5k citations

Hit Papers

11 papers align trajectories log scale

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2021 Genome biology
2018 Nature Communications
2017 Nature
2016 Nature Biotechnology
2014 Cell
2014 Nature Biotechnology
2013 Science
2013 Science
2011 Nature
2008 Nature
2006 Cell

Peers

Countries citing papers authored by David E. Root

Since Specialization

Citations

This map shows the geographic impact of David E. Root's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David E. Root with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David E. Root more than expected).

Fields of papers citing papers by David E. Root

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David E. Root. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David E. Root. The network helps show where David E. Root may publish in the future.

Co-authorship network

The 25 scholars most cited alongside David E. Root, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David E. Root Line = papers co-authored together David E. Root links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma Acta Neuropathologica Communications ·李嘉竹,Z. O. Poduholnikova,P. Mühlhahn,Federica Piccioni,Xuesong Zhao,Charles S. Xuereb,David E. Root,Luca Tiberi,Marcel Kool,Jens Schittenhelm,Pratiti Bandopadhayay,Rosalind A. Segal,Ghazaleh Tabatabai,Riche Aryana	2024	4
2	Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries Nature Communications ·Sean A. Misek,Sandro Castelli,Jérémie Kalfon,Javad Noorbakhsh,Isabella Boyle,Yuejiao Lian,Joshua M. Dempster,L Petronio,Katherine Huang,Alham Saadat,Thomas Green,Adam Brown,John G. Doench,David E. Root,James M. McFarland,Rameen Beroukhim,Jesse S. Boehm	2024	4
3	Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer Cancer Research ·秋美野村,Timothy D. Martin,Haley E. Manchester,Desti Emiliani,SHANE STEVEN SMITS,PATRICIA A. BALEY,喻德华,Nausikaä El-Mecky,Nicole S. Persky,David E. Root,Myles Brown,Karen Cichowski,Stephen J. Elledge,Taru Muranen,(unknown),Simon T. Barry,John G. Clohessy,Ralitsa R. Madsen,Alex Toker	2024	12
4	Systematic identification of biomarker-driven drug combinations to overcome resistance Nature Chemical Biology ·Matthew G. Rees,Lisa Brenan,Samantha A Beebe,Patrick Duggan,Besnik Bajrami,Else M. de Vries,Andrew S. Boghossian,Emma W Vaimberg,Steven Ferrara,Timothy A. Lewis,Danny Rosenberg,光司佐々木,Jennifer A. Roth,Virendar K. Kaushik,Federica Piccioni,John G. Doench,David E. Root,Cory M. Johannessen	2022	9
5	Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer Cancer Discovery ·Clare F. Malone,Neekesh V. Dharia,Guillaume Kugener,Christian Lindström,Michael Rothberg,Mai Abdusamad,Alfredo González,Miljan Kuljanin,Amanda L. Robichaud,Amy Saur Conway,Joshua M. Dempster,Brenton R. Paolella,Nancy Dumont,Volker Hovestadt,Joseph D. Mancias,Scott T. Younger,David E. Root,Todd R. Golub,Francisca Vázquez,Kimberly Stegmaier	2021	23
6	Progression signature underlies clonal evolution and dissemination of multiple myeloma Blood ·Yu J. Shen,Yuji Mishima,Jiantao Shi,Romanos Sklavenitis‐Pistofidis,Robert Redd,Michele Moschetta,Salomon Manier,Aldo M. Roccaro,Antonio Sacco,Yu‐Tzu Tai,François Mercier,Yawara Kawano,Nang Kham Su,Brianna Berrios,John G. Doench,David E. Root,Franziska Michor,David T. Scadden,Irene M. Ghobrial	2020	32
7	Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer Clinical Cancer Research ·Pingping Mao,Ofir Cohen,Kailey J. Kowalski,G. Kehrer,Jorge E. Buendia-Buendia,Michael S. Cuoco,Pedro Exman,Seth A. Wander,Adrienne G. Waks,Utthara Nayar,Jon Chung,Samuel S. Freeman,Orit Rozenblatt–Rosen,Vincent A. Miller,Federica Piccioni,David E. Root,Aviv Regev,Eric P. Winer,Nancy U. Lin,Nikhil Wagle	2020	90
8	A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma Cancer Research ·Tikvah K. Hayes,Flora Luo,Ofir Cohen,Amy Goodale,Yenarae Lee,Sasha Pantel,Mukta Bagul,Federica Piccioni,David E. Root,Levi A. Garraway,Matthew Meyerson,Cory M. Johannessen	2019	30
9	Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry Nature Genetics ·Adam D. Durbin,Mark W. Zimmerman,Neekesh V. Dharia,Brian J. Abraham,Amanda Balboni Iniguez,Nina Weichert‐Leahey,Shuning He,John M. Krill-Burger,David E. Root,Francisca Vázquez,Aviad Tsherniak,William C. Hahn,Todd R. Golub,Richard A. Young,A. Thomas Look,Kimberly Stegmaier	2018	145
10	The Canonical Wnt Pathway Drives Macropinocytosis in Cancer Cancer Research ·Gil Redelman‐Sidi,王金亭,Isabella Gaeta,Wilhelm Palm,Craig B. Thompson,Paul B. Romesser,Scott W. Lowe,Mukta Bagul,John G. Doench,David E. Root,Michael S. Glickman	2018	78
11	CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors Cell Host & Microbe ·Yijie Ma,Michael J. Walsh,Katharina Bernhardt,崔高生,Stephen J. Trudeau,Luis Carlos Alipio de Souza,Sizun Jiang,Chang Jiang,Bo Zhao,David E. Root,John G. Doench,Benjamin E. Gewurz	2017	104
12	HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase Science Translational Medicine ·Abhishek A. Chakraborty,Eijiro Nakamura,Jun Qi,Amanda L. Creech,Jacob D. Jaffe,Joshiawa Paulk,Jesse Novak,Kshithija Nagulapalli,Samuel K. McBrayer,Glenn S. Cowley,Javier Pineda,Jiaxi Song,Yaoyu E. Wang,Steven A. Carr,David E. Root,Sabina Signoretti,James E. Bradner,William G. Kaelin	2017	36
13	Identification of an oncogenic RAB protein Science ·Douglas B. Wheeler,Roberto Zoncu,David E. Root,David M. Sabatini,Charles L. Sawyers	2015	95
14	Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors Molecular Cancer Therapeutics ·Steven R. Whittaker,Glenn S. Cowley,Steve Wagner,Flora Luo,David E. Root,Levi A. Garraway	2015	55
15	( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversiblebreakdown → Science ·Michael Herb,Ryan Looper,Peppi Koivunen,Sung-Woo Lee,Rebekka K. Schneider,Christine M. McMahon,Glenn S. Cowley,David E. Root,Benjamin L. Ebert,William G. Kaelin	2013	533
16	A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition Cancer Discovery ·Steven R. Whittaker,Jean‐Philippe Theurillat,Eliezer M. Van Allen,Nikhil Wagle,Jessica Hsiao,Glenn S. Cowley,Dirk Schadendorf,David E. Root,Levi A. Garraway	2013	260
17	Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cellsbreakdown → Science ·Ophir Shalem,Neville E. Sanjana,Ella Hartenian,Xi Shi,David Scott,Tarjei S. Mikkelsen,Dirk Heckl,Benjamin L. Ebert,David E. Root,John G. Doench,Feng Zhang	2013	3656
18	Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4 Science Translational Medicine ·Yin Ren,Hiu Wing Cheung,Mohammad Bagha,Amit Agrawal,Glenn S. Cowley,Barbara A. Weir,Jesse S. Boehm,Pablo Tamayo,Alison M. Karst,Joyce F. Liu,Michelle S. Hirsch,Jill P. Mesirov,Ronny Drapkin,David E. Root,Justin H. Lo,Valentina Fogal,Erkki Ruoslahti,William C. Hahn,Sangeeta N. Bhatia	2012	134
19	Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers Cancer Discovery ·Hiu Wing Cheung,Jinyan Du,Jesse S. Boehm,Frank He,Barbara A. Weir,Xiaoxing Wang,Mohit Butaney,Lecia V. Sequist,Biao Luo,Jeffrey A. Engelman,David E. Root,Matthew Meyerson,Todd R. Golub,Pasi A. Jänne,William C. Hahn	2011	110
20	Extension of X-parameters to include long-term dynamic memory effects Jan Verspecht,Jason Horn,Wiwiek Fatmawati,Daniel Gunyan,R.D. Pollard,Ida Ahlin,David E. Root	2009	48

About David E. Root

David E. Root is a scholar working on Molecular Biology, Cancer Research, Electrical and Electronic Engineering, Biophysics and Hematology, having authored 223 papers that have together received 24.9k indexed citations. Recurring topics across this work include Radio Frequency Integrated Circuit Design (56 papers), CRISPR and Genetic Engineering (29 papers), Advanced Power Amplifier Design (23 papers), Silicon Carbide Semiconductor Technologies (22 papers), Advancements in Semiconductor Devices and Circuit Design (18 papers), Advanced biosensing and bioanalysis techniques (14 papers), Epigenetics and DNA Methylation (13 papers) and Protein Degradation and Inhibitors (13 papers). The work is most often cited by research in Aging (559 citations), Molecular Biology (17.0k citations), Cancer Research (3.6k citations), Business and International Management (390 citations) and Oncology (4.1k citations). David E. Root has collaborated with scholars based in United States, Germany and United Kingdom. Frequent co-authors include John G. Doench, Benjamin L. Ebert, Ella Hartenian, Mudra Hegde, Meagan E. Sullender, William C. Hahn, Tarjei S. Mikkelsen, David Scott, Neville E. Sanjana and Feng Zhang. Their work appears in journals such as Proceedings of the National Academy of Sciences, Blood, Nature Communications, Cell and Nature.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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