William C. Comb

2.7k citations

16 papers · 2.1k indexed · 2 hit papers · h-index 12

Impact in

Aging top 5%
Physiology top 2%

Papers in

Cancer Research 6
- NF-κB Signaling Pathways 4
- Cancer, Hypoxia, and Metabolism 2
Cell Biology 5
- Cellular transport and secretion 3
- Muscle metabolism and nutrition 2

Co-authors: David M. Sabatini Alejo Efeyan Liron Bar‐Peled Patricia C. Cogswell Zhi-Yang Tsun Bernardo L. Sabatini Gregory A. Wyant Molly Plovanich
Journals: Science (2 papers)Molecular Cancer Therapeutics (1 paper)Nature Communications (1 paper)Cell Reports (1 paper)Clinical and Translational Gastroenterology (1 paper)
Partner nations: United States Australia Singapore

In The Last Decade

William C. Comb

16 papers receiving 2.1k citations

Hit Papers

align trajectories log scale

Nutrient-sensing mechanisms and pathways 2015 · 825 citations

Peers

Countries citing papers authored by William C. Comb

Since Specialization

Citations

This map shows the geographic impact of William C. Comb's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William C. Comb with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William C. Comb more than expected).

Fields of papers citing papers by William C. Comb

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William C. Comb. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William C. Comb. The network helps show where William C. Comb may publish in the future.

Co-authors

The 25 scholars most cited alongside William C. Comb, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William C. Comb Line = papers co-authored together William C. Comb links everyone, so they are left out of the graph.

All Works

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16 of 16 papers shown

#	Work
1	MYTX-011: A pH-Dependent Anti–c-MET Antibody–Drug Conjugate Designed for Enhanced Payload Delivery to c-MET–Expressing Tumor Cells Molecular Cancer Therapeutics ·Nimish Gera, Kyle M. Fitzgerald, Vijay Ramesh, Purvi Patel, Deepak Kanojia, Federico Colombo, Lena Kien, Simon Aoyama, Lihui Xu, Jussekia Jean, Amit M. Deshpande, William C. Comb, Thomas Chittenden, Brian P. Fiske	2024	8
2	Phase 1 multicenter dose escalation and dose expansion study of antibody-drug conjugate (ADC) MYTX-011 in subjects with non-small cell lung cancer. Journal of Clinical Oncology ·Alexander I. Spira, Melissa L. Johnson, George R. Blumenschein, Timothy F. Burns, Jonathan R. Thompson, Amit Deshpande, William C. Comb, Brian Fiske, Gilles Gallant, Rebecca S. Heist	2023	2
3	Abstract 5000: MYTX-011: A novel cMET-targeting antibody drug conjugate (ADC) engineered to increase on-target uptake in and efficacy against cMET expressing tumors Cancer Research ·Nimish Gera, Kyle M. Fitzgerald, Vijay Ramesh, Purvi Patel, Lena Kien, Deepak Kanojia, Simon Aoyama, Federico Colombo, Amit Deshpande, William C. Comb, Thomas W. Chittenden, Brian Fiske	2023	4
4	Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine Science ·Andrew L. Cangelosi, Anna M. Puszynska, Justin M. Roberts, Andrea Armani, Thao P. Nguyen, Jessica B. Spinelli, Tenzin Kunchok, Brianna Wang, Sze Ham Chan, Caroline A. Lewis, William C. Comb, George W. Bell, Aharon Helman, David M. Sabatini	2022	49
5	Quantitative modelling of amino acid transport and homeostasis in mammalian cells Nature Communications ·Gregory Gauthier-Coles, Jade Vennitti, Zhiduo Zhang, William C. Comb, Shuran Xing, Kiran Javed, Angelika Bröer, Stefan Bröer	2021	76
6	Safety, Tolerability, and Physiological Effects of AXA1665, a Novel Composition of Amino Acids, in Subjects With Child–Pugh A and B Cirrhosis Clinical and Translational Gastroenterology ·Manu V. Chakravarthy, Joel Neutel, Scharmen Confer, Peng Zhao, Noriaki Tatsuta, Sam Rebello, William C. Comb, Michael J. Hamill, Tony Tramontin, Sean Carroll, Raffi Afeyan, Arun J. Sanyal	2020	11
7	A Novel Amino Acid Composition Ameliorates Short-Term Muscle Disuse Atrophy in Healthy Young Men Frontiers in Nutrition ·Tanya M. Holloway, Chris McGlory, Sean McKellar, Adrienne K Morgan, Michael J. Hamill, Raffi Afeyan, William C. Comb, Scharmen Confer, Peng Zhao, M. Hinton, Olga Kubassova, Manu V. Chakravarthy, Stuart M. Phillips	2019	28
8	Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 Science ·S. Wang, Zhi-Yang Tsun, Rachel L. Wolfson, Kuang Shen, Gregory A. Wyant, Molly Plovanich, E. D. Yuan, Tony D. Jones, Lynne Chantranupong, William C. Comb, Ting Ching Wang, Liron Bar‐Peled, Roberto Zoncu, C. Straub, C. Kim, J. Park, Bernardo L. Sabatini, David M. Sabatini	2015	17
9	Nutrient-sensing mechanisms and pathways Nature ·Alejo Efeyan, William C. Comb, David M. Sabatini Hit paper breakdown →	2015	825
10	Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1 Cell Reports ·Lawrence D. Schweitzer, William C. Comb, Liron Bar‐Peled, David M. Sabatini	2015	26
11	Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. PubMed ·Shuyu Wang, Zhi-Yang Tsun, Rachel L. Wolfson, Kuang Shen, Gregory A. Wyant, Molly Plovanich, Elizabeth D. Yuan, Tony D. Jones, Lynne Chantranupong, William C. Comb, Timothy C. Wang, Liron Bar‐Peled, Roberto Zoncu, Christoph Straub, Choah Kim, Jiwon V. Park, Bernardo L. Sabatini, David M. Sabatini Hit paper breakdown →	2015	618
12	Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition Cell ·Yoav D. Shaul, Elizaveta Freinkman, William C. Comb, Jason R. Cantor, Wai Leong Tam, Prathapan Thiru, Do‐Hoon Kim, Naama Kanarek, Michael E. Pacold, Walter W. Chen, Brian Bierie, Richard Possemato, Ferenc Reinhardt, Robert A. Weinberg, Michael B. Yaffe, David M. Sabatini	2014	172
13	p85α SH2 Domain Phosphorylation by IKK Promotes Feedback Inhibition of PI3K and Akt in Response to Cellular Starvation Molecular Cell ·William C. Comb, Jessica E. Hutti, Patricia C. Cogswell, Lewis C. Cantley, A S Baldwin	2012	60
14	IKK-dependent, NF-κB-independent control of autophagic gene expression Oncogene ·William C. Comb, Patricia C. Cogswell, Raquel Sitcheran, Albert S. Baldwin	2010	89
15	Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347 Biochemical and Biophysical Research Communications ·Melanie Herscovitch, William C. Comb, Thomas Ennis, Kate Coleman, Sheila T. Yong, Brinda Armstead, Demetrios Kalaitzidis, Sushil Chandani, Thomas D. Gilmore	2008	67
16	Essential Role for Epidermal Growth Factor Receptor in Glutamate Receptor Signaling to NF-κB Molecular and Cellular Biology ·Raquel Sitcheran, William C. Comb, Patricia C. Cogswell, Albert S. Baldwin	2008	23

About William C. Comb

William C. Comb is a scholar working on Cancer Research, Cell Biology, Physiology, Pharmaceutical Science and Molecular Biology, having authored 16 papers that have together received 2.1k indexed citations. Recurring topics across this work include NF-κB Signaling Pathways (4 papers), Cellular transport and secretion (3 papers), PI3K/AKT/mTOR signaling in cancer (3 papers), Cancer, Hypoxia, and Metabolism (2 papers), Fibroblast Growth Factor Research (2 papers), Immune Response and Inflammation (2 papers), Muscle metabolism and nutrition (2 papers) and Retinal Development and Disorders (2 papers). The work is most often cited by research in Aging (82 citations), Physiology (163 citations), Biochemistry (219 citations), Cancer Research (332 citations) and Cell Biology (334 citations). William C. Comb has collaborated with scholars based in United States, Australia and Singapore. Frequent co-authors include David M. Sabatini, Alejo Efeyan, Liron Bar‐Peled, Patricia C. Cogswell, Zhi-Yang Tsun, Bernardo L. Sabatini, Gregory A. Wyant, Molly Plovanich, Roberto Zoncu and Kuang Shen. Their work appears in journals such as Science, Molecular Cancer Therapeutics, Nature Communications, Cell Reports and Clinical and Translational Gastroenterology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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