William C. Comb

2.7k total citations · 2 hit papers
16 papers, 2.1k citations indexed

About

William C. Comb is a scholar working on Molecular Biology, Cancer Research and Cell Biology. According to data from OpenAlex, William C. Comb has authored 16 papers receiving a total of 2.1k indexed citations (citations by other indexed papers that have themselves been cited), including 11 papers in Molecular Biology, 6 papers in Cancer Research and 5 papers in Cell Biology. Recurrent topics in William C. Comb's work include NF-κB Signaling Pathways (4 papers), Cellular transport and secretion (3 papers) and PI3K/AKT/mTOR signaling in cancer (3 papers). William C. Comb is often cited by papers focused on NF-κB Signaling Pathways (4 papers), Cellular transport and secretion (3 papers) and PI3K/AKT/mTOR signaling in cancer (3 papers). William C. Comb collaborates with scholars based in United States, Australia and Singapore. William C. Comb's co-authors include David M. Sabatini, Alejo Efeyan, Liron Bar‐Peled, Patricia C. Cogswell, Molly Plovanich, Bernardo L. Sabatini, Rachel L. Wolfson, Lynne Chantranupong, Roberto Zoncu and Gregory A. Wyant and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

William C. Comb

16 papers receiving 2.1k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Nutrient-sensing mechanisms and pathways

2015 825 citations Alejo Efeyan, William C. Comb et al. Nature profile →
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

2015 618 citations Shuyu Wang, Zhi-Yang Tsun et al. PubMed profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
William C. Comb United States	12	1.2k	394	334	332	289	16	2.1k
Sonia M. Scaria United States	8	2.1k 1.7×	448 1.1×	622 1.9×	316 1.0×	396 1.4×	12	2.9k
Mitsugu Shimobayashi Switzerland	13	1.5k 1.3×	478 1.2×	318 1.0×	290 0.9×	420 1.5×	20	2.3k
Stephen G. Dann United States	16	1.8k 1.5×	322 0.8×	410 1.2×	220 0.7×	434 1.5×	20	2.6k
Jeffrey A. Porter United States	9	1.2k 1.0×	240 0.6×	247 0.7×	422 1.3×	193 0.7×	10	1.8k
Pankuri Goraksha-Hicks United States	8	1.5k 1.3×	542 1.4×	378 1.1×	366 1.1×	331 1.1×	9	2.5k
Elaine A. Dunlop United Kingdom	18	1.3k 1.1×	629 1.6×	310 0.9×	185 0.6×	296 1.0×	28	2.0k
Xin Gu United States	21	1.5k 1.3×	211 0.5×	273 0.8×	208 0.6×	228 0.8×	34	2.1k
Pawan Gulati United Kingdom	14	1.7k 1.4×	337 0.9×	318 1.0×	313 0.9×	286 1.0×	14	2.2k
Yimin Fang United States	24	1.7k 1.4×	290 0.7×	379 1.1×	208 0.6×	765 2.6×	59	2.8k
Kazuyuki Kitatani Japan	29	2.1k 1.7×	304 0.8×	641 1.9×	191 0.6×	735 2.5×	76	2.9k

Countries citing papers authored by William C. Comb

Since Specialization

Citations

This map shows the geographic impact of William C. Comb's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William C. Comb with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William C. Comb more than expected).

Fields of papers citing papers by William C. Comb

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William C. Comb. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William C. Comb. The network helps show where William C. Comb may publish in the future.

Co-authorship network of co-authors of William C. Comb

This figure shows the co-authorship network connecting the top 25 collaborators of William C. Comb. A scholar is included among the top collaborators of William C. Comb based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William C. Comb. William C. Comb is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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16 of 16 papers shown

Gera, Nimish, Vijay Ramesh, Deepak Kanojia, et al.. (2024). MYTX-011: A pH-Dependent Anti–c-MET Antibody–Drug Conjugate Designed for Enhanced Payload Delivery to c-MET–Expressing Tumor Cells. Molecular Cancer Therapeutics. 23(9). 1282–1293. 8 indexed citations

Spira, Alexander I., Melissa L. Johnson, George R. Blumenschein, et al.. (2023). Phase 1 multicenter dose escalation and dose expansion study of antibody-drug conjugate (ADC) MYTX-011 in subjects with non-small cell lung cancer.. Journal of Clinical Oncology. 41(16_suppl). TPS9147–TPS9147. 2 indexed citations

Gera, Nimish, Vijay Ramesh, Purvi Patel, et al.. (2023). Abstract 5000: MYTX-011: A novel cMET-targeting antibody drug conjugate (ADC) engineered to increase on-target uptake in and efficacy against cMET expressing tumors. Cancer Research. 83(7_Supplement). 5000–5000. 4 indexed citations

Cangelosi, Andrew L., Anna M. Puszynska, Justin M. Roberts, et al.. (2022). Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine. Science. 377(6601). 47–56. 49 indexed citations

Gauthier-Coles, Gregory, et al.. (2021). Quantitative modelling of amino acid transport and homeostasis in mammalian cells. Nature Communications. 12(1). 5282–5282. 76 indexed citations

Chakravarthy, Manu V., Joel Neutel, Peng Zhao, et al.. (2020). Safety, Tolerability, and Physiological Effects of AXA1665, a Novel Composition of Amino Acids, in Subjects With Child–Pugh A and B Cirrhosis. Clinical and Translational Gastroenterology. 11(8). e00222–e00222. 11 indexed citations

Holloway, Tanya M., Chris McGlory, Sean McKellar, et al.. (2019). A Novel Amino Acid Composition Ameliorates Short-Term Muscle Disuse Atrophy in Healthy Young Men. Frontiers in Nutrition. 6. 105–105. 28 indexed citations

Tsun, Zhi-Yang, Rachel L. Wolfson, Kuang Shen, et al.. (2015). Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 347(6218). 188–194. 17 indexed citations

Efeyan, Alejo, William C. Comb, & David M. Sabatini. (2015). Nutrient-sensing mechanisms and pathways. Nature. 517(7534). 302–310. 825 indexed citations breakdown →

10.

Schweitzer, Lawrence D., William C. Comb, Liron Bar‐Peled, & David M. Sabatini. (2015). Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1. Cell Reports. 12(9). 1445–1455. 26 indexed citations

11.

Wang, Shuyu, Zhi-Yang Tsun, Rachel L. Wolfson, et al.. (2015). Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.. PubMed. 347(6218). 188–94. 618 indexed citations breakdown →

12.

Shaul, Yoav D., Elizaveta Freinkman, William C. Comb, et al.. (2014). Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition. Cell. 158(5). 1094–1109. 172 indexed citations

13.

Comb, William C., Jessica E. Hutti, Patricia C. Cogswell, Lewis C. Cantley, & A S Baldwin. (2012). p85α SH2 Domain Phosphorylation by IKK Promotes Feedback Inhibition of PI3K and Akt in Response to Cellular Starvation. Molecular Cell. 45(6). 719–730. 60 indexed citations

14.

Comb, William C., Patricia C. Cogswell, Raquel Sitcheran, & Albert S. Baldwin. (2010). IKK-dependent, NF-κB-independent control of autophagic gene expression. Oncogene. 30(14). 1727–1732. 89 indexed citations

15.

Comb, William C., et al.. (2008). Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347. Biochemical and Biophysical Research Communications. 367(1). 103–108. 67 indexed citations

16.

Sitcheran, Raquel, William C. Comb, Patricia C. Cogswell, & Albert S. Baldwin. (2008). Essential Role for Epidermal Growth Factor Receptor in Glutamate Receptor Signaling to NF-κB. Molecular and Cellular Biology. 28(16). 5061–5070. 23 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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