Matthias P. Wymann

18.6k total citations · 7 hit papers
138 papers, 14.6k citations indexed

About

Matthias P. Wymann is a scholar working on Molecular Biology, Immunology and Physiology. According to data from OpenAlex, Matthias P. Wymann has authored 138 papers receiving a total of 14.6k indexed citations (citations by other indexed papers that have themselves been cited), including 84 papers in Molecular Biology, 54 papers in Immunology and 19 papers in Physiology. Recurrent topics in Matthias P. Wymann's work include PI3K/AKT/mTOR signaling in cancer (49 papers), Protein Kinase Regulation and GTPase Signaling (16 papers) and Chronic Lymphocytic Leukemia Research (15 papers). Matthias P. Wymann is often cited by papers focused on PI3K/AKT/mTOR signaling in cancer (49 papers), Protein Kinase Regulation and GTPase Signaling (16 papers) and Chronic Lymphocytic Leukemia Research (15 papers). Matthias P. Wymann collaborates with scholars based in Switzerland, Italy and United Kingdom. Matthias P. Wymann's co-authors include Luciano Pirola, Alexandre Arcaro, Roger Schneiter, Emilio Hirsch, Romina Marone, Muriel Laffargue, Fiorella Altruda, Marketa Zvelebil, Marco Baggiolini and Roger Williams and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Matthias P. Wymann

137 papers receiving 14.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 1.0k citations Emilio Hirsch, Ornella Azzolino et al. profile →
Lipid signalling in disease

2008 1.0k citations Matthias P. Wymann, Roger Schneiter Nature Reviews Molecular Cell Biology profile →
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 1.0k citations Matthias P. Wymann et al. profile →
Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

2000 991 citations Matthias P. Wymann, Roger Williams et al. profile →
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

2005 650 citations Emilio Hirsch, Matthias P. Wymann et al. profile →
Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 591 citations Matthias P. Wymann et al. Molecular and Cellular Biology profile →
Structure and function of phosphoinositide 3-kinases

1998 561 citations Matthias P. Wymann et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Matthias P. Wymann Switzerland	58	9.0k	3.9k	1.9k	1.7k	1.4k	138	14.6k
Phillip T. Hawkins United Kingdom	66	12.8k 1.4×	3.7k 1.0×	2.0k 1.1×	4.5k 2.7×	1.6k 1.1×	181	18.7k
Len Stephens United Kingdom	67	13.3k 1.5×	3.9k 1.0×	2.1k 1.1×	4.7k 2.8×	1.6k 1.1×	177	19.1k
Bart Vanhaesebroeck United Kingdom	68	14.4k 1.6×	5.7k 1.5×	4.1k 2.1×	2.6k 1.6×	1.5k 1.1×	194	22.4k
Hugh Rosen United States	66	9.7k 1.1×	5.3k 1.4×	1.3k 0.7×	2.1k 1.3×	1.4k 1.0×	198	16.4k
Alex Toker United States	73	15.1k 1.7×	2.3k 0.6×	3.1k 1.6×	3.7k 2.2×	1.4k 1.0×	136	20.5k
Harvey R. Herschman United States	81	12.5k 1.4×	2.9k 0.7×	3.7k 1.9×	1.2k 0.7×	1.2k 0.9×	330	25.2k
Koiti Titani Japan	74	10.9k 1.2×	2.4k 0.6×	1.2k 0.6×	2.6k 1.5×	2.6k 1.8×	291	19.1k
Nicholas K. Tonks United States	79	20.4k 2.3×	8.4k 2.2×	2.9k 1.5×	2.8k 1.7×	1.7k 1.2×	155	24.5k
David Stokoe United States	53	11.5k 1.3×	2.1k 0.6×	3.5k 1.8×	1.6k 1.0×	753 0.5×	96	15.7k
Matthias Gaestel Germany	70	11.6k 1.3×	3.4k 0.9×	2.4k 1.2×	2.1k 1.3×	1.5k 1.0×	259	16.7k

Countries citing papers authored by Matthias P. Wymann

Since Specialization

Citations

This map shows the geographic impact of Matthias P. Wymann's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Matthias P. Wymann with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Matthias P. Wymann more than expected).

Fields of papers citing papers by Matthias P. Wymann

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Matthias P. Wymann. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Matthias P. Wymann. The network helps show where Matthias P. Wymann may publish in the future.

Co-authorship network of co-authors of Matthias P. Wymann

This figure shows the co-authorship network connecting the top 25 collaborators of Matthias P. Wymann. A scholar is included among the top collaborators of Matthias P. Wymann based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Matthias P. Wymann. Matthias P. Wymann is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Perrotta, Marialuisa, Lorenzo Carnevale, Fabio Pallante, et al.. (2025). PI3Kγ signaling controls trafficking of CD8+ T cells between lymphoid and non-lymphoid organs and drives hypertension in a murine model. Nature Communications. 16(1). 5818–5818. 1 indexed citations

Keleş, Erhan, Luka Raguž, Thorsten Schaefer, et al.. (2024). Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling. Chemical Science. 15(48). 20274–20291. 1 indexed citations

Koumantou, Despoina, Pierre Bourdely, Erwan Boedec, et al.. (2024). Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody‐Activated, Inducible Cross‐Presentation in Murine Type 2 DCs. Advanced Science. 11(44). e2401179–e2401179. 1 indexed citations

Schaefer, Thorsten, Chiara Borsari, Saule Zhanybekova, et al.. (2023). A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα. Chemical Science. 15(2). 683–691. 15 indexed citations

Borsari, Chiara, Erhan Keleş, Jacob A. McPhail, et al.. (2022). Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα. Journal of the American Chemical Society. 144(14). 6326–6342. 40 indexed citations

Borsari, Chiara, et al.. (2021). Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood–brain barrier permeability. RSC Medicinal Chemistry. 12(4). 579–583. 8 indexed citations

Borsari, Chiara, Erhan Keleş, Denise Rageot, et al.. (2020). 4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders. Journal of Medicinal Chemistry. 63(22). 13595–13617. 18 indexed citations

Maher, Timothy J., Yu Zhang, Molly L. Bucklin, et al.. (2019). Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology. Nature Communications. 10(1). 4364–4364. 59 indexed citations

Becattini, Barbara, Claudia Sardi, Fabio Zani, et al.. (2017). PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity. Science Signaling. 10(488). 26 indexed citations

10.

Ciraolo, Elisa, Fulvio Morello, Robin M. Hobbs, et al.. (2010). Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility. Molecular Biology of the Cell. 21(5). 704–711. 51 indexed citations

11.

Marone, Romina, Thomas Bohnacker, Christian Schnell, et al.. (2009). Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors. Molecular Cancer Research. 7(4). 601–613. 92 indexed citations

12.

Gomes, Ana, Demetra Constantinidou, Joana R. Costa, et al.. (2008). The Forkhead Transcription Factor FOXO3a Increases Phosphoinositide-3 Kinase/Akt Activity in Drug-Resistant Leukemic Cells through Induction of PIK3CA Expression. Molecular and Cellular Biology. 28(19). 5886–5898. 127 indexed citations

13.

Wymann, Matthias P. & Roger Schneiter. (2008). Lipid signalling in disease. Nature Reviews Molecular Cell Biology. 9(2). 162–176. 1027 indexed citations breakdown →

14.

Nombela‐Arrieta, César, Thorsten R. Mempel, Silvia F. Soriano, et al.. (2007). A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate–mediated egress. The Journal of Experimental Medicine. 204(3). 497–510. 127 indexed citations

15.

Vetiska, Sandra, Gholamreza Ahmadian, W. Ju, et al.. (2006). GABAA receptor-associated phosphoinositide 3-kinase is required for insulin-induced recruitment of postsynaptic GABAA receptors. Neuropharmacology. 52(1). 146–155. 42 indexed citations

16.

Barber, Domingo F., Carmen Hernández, Juana M. Flores, et al.. (2006). Class IB-Phosphatidylinositol 3-Kinase (PI3K) Deficiency Ameliorates IA-PI3K-Induced Systemic Lupus but Not T Cell Invasion. The Journal of Immunology. 176(1). 589–593. 62 indexed citations

17.

Vecchione, Carmine, Enrico Patrucco, Gennaro Marino, et al.. (2005). Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ. The Journal of Experimental Medicine. 201(8). 1217–1228. 117 indexed citations

18.

Rodrı́guez-Borlado, Luis, Domingo F. Barber, Carmen Hernández, et al.. (2003). Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio. The Journal of Immunology. 170(9). 4475–4482. 70 indexed citations

19.

Barbier, M., Ronan Calvez, Muriel Laffargue, et al.. (2001). Tumor biology: mouse models of colon cancer. Nature. 796. 413–413. 1 indexed citations

20.

Follin, Per, Matthias P. Wymann, Béatrice Dewald, M. Ceska, & Cláes Dahlgren. (1991). Human neutrophil migration into skin chambers is associated with ProductionI of NAP‐1/IL8 and C5a. European Journal Of Haematology. 47(1). 71–76. 47 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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