Hidde L. Ploegh

79.8k citations

607 papers · 62.0k indexed · 19 hit papers · h-index 133

Molecular Biology top 0.02%
Immunology top 0.01%
Epidemiology top 0.05%
Oncology top 0.1%
Cell Biology top 0.02%

Co-authors: Eric Spooner Jacques Neefjes Brendan N. Lilley Domenico Tortorella Benedikt M. Kessler Jessica R. Ingram Matthew Bogyo Annemarthe G. van der Veen
Topics: Immunotherapy and Immune Responses (158 papers)Immune Cell Function and Interaction (142 papers)T-cell and B-cell Immunology (140 papers)
Cited by: Immunology Cell Biology Molecular Biology
Journals: Nature Science Cell
Partner nations: United States Netherlands Germany

In The Last Decade

Hidde L. Ploegh

599 papers receiving 60.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

2014 1.9k citations Hidde L. Ploegh et al. profile →
CX ₃ CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

2005 1.2k citations Jan Hendrik Niess, Stephan Brand et al. Science profile →
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 910 citations Domenico Tortorella, Hidde L. Ploegh et al. profile →
The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 904 citations Hidde L. Ploegh et al. profile →
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

2015 860 citations Stephanie K. Dougan, Matthias C. Truttmann et al. profile →
Empty MHC class I molecules come out in the cold

1990 810 citations Hidde L. Ploegh et al. profile →
Herpes simplex virus turns off the TAP to evade host immunity

1995 668 citations Hidde L. Ploegh et al. profile →
Viral Subversion of the Immune System

2000 664 citations Domenico Tortorella, Hidde L. Ploegh et al. profile →
Viral Strategies of Immune Evasion

1998 634 citations Hidde L. Ploegh Science profile →
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 605 citations Hidde L. Ploegh et al. profile →
Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 560 citations Hidde L. Ploegh et al. Science profile →
A membrane protein required for dislocation of misfolded proteins from the ER

2004 552 citations Brendan N. Lilley, Hidde L. Ploegh profile →
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

2008 528 citations You‐Me Kim, Hidde L. Ploegh et al. profile →
Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

2011 513 citations Hidde L. Ploegh et al. Science profile →
Multiple Associated Proteins Regulate Proteasome Structure and Function

2002 506 citations Hidde L. Ploegh et al. profile →
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase

1987 502 citations Hidde L. Ploegh et al. profile →
Major histocompatibility antigens: The human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules

1981 444 citations Hidde L. Ploegh et al. profile →
A guide to antigen processing and presentation

2022 412 citations Novalia Pishesha, Thibault J. Harmand et al. profile →
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

2007 354 citations Eric Spooner, Hidde L. Ploegh et al. profile →

Peers

Countries citing papers authored by Hidde L. Ploegh

Since Specialization

Citations

This map shows the geographic impact of Hidde L. Ploegh's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hidde L. Ploegh with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hidde L. Ploegh more than expected).

Fields of papers citing papers by Hidde L. Ploegh

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hidde L. Ploegh. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hidde L. Ploegh. The network helps show where Hidde L. Ploegh may publish in the future.

Co-authorship network of co-authors of Hidde L. Ploegh

This figure shows the co-authorship network connecting the top 25 collaborators of Hidde L. Ploegh. A scholar is included among the top collaborators of Hidde L. Ploegh based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hidde L. Ploegh. Hidde L. Ploegh is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Nanobodies as in vivo , non-invasive, imaging agents 2021 ·RSC Chemical Biology ·Thibault J. Harmand,Ashraful Islam,Novalia Pishesha,Hidde L. Ploegh	41
2	Improved Antitumor Efficacy of Chimeric Antigen Receptor T Cells that Secrete Single-Domain Antibody Fragments 2020 ·Cancer Immunology Research ·Yushu Joy Xie,Michael Dougan,Jessica R. Ingram,Novalia Pishesha,Tao Fang,Noor Momin,Hidde L. Ploegh	82
3	Nanobody–Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses 2018 ·Cancer Immunology Research ·Andrew W. Woodham,Ross W. Cheloha,Jingjing Ling,Mohammad Rashidian,(unknown),(unknown),João N. Duarte,(unknown),Joseph G. Skeate,Diane M. Da Silva,W. Martin Kast,Hidde L. Ploegh	24
4	Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs 2018 ·Cancer Immunology Research ·Michael Dougan,Jessica R. Ingram,Hee‐Jin Jeong,Munir M. Mosaheb,Patrick T. Bruck,Lestat R. Ali,Novalia Pishesha,Olga Blomberg,Paul Tyler,(unknown),Mohammad Rashidian,Quang‐Dé Nguyen,Ulrich H. von Andrian,Hidde L. Ploegh,Stephanie K. Dougan	71
5	Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides 2018 ·Proceedings of the National Academy of Sciences ·Matthias C. Truttmann,David Pincus,Hidde L. Ploegh	30
6	Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas 2017 ·Cancer Research ·Anushka Dongre,Mohammad Rashidian,Ferenc Reinhardt,(unknown),Zuzana Keckesova,Hidde L. Ploegh,Robert A. Weinberg	295
7	Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose 2016 ·Proceedings of the National Academy of Sciences ·Jasdave S. Chahal,Omar F. Khan,Christopher L. Cooper,Justine S. McPartlan,Jonathan K. Tsosie,Lucas D. Tilley,Saima Sidik,Sebastian Lourido,Róbert Langer,Sina Bavari,Hidde L. Ploegh,Daniel G. Anderson	330
8	Epithelial-to-Mesenchymal Transition Activates PERK–eIF2α and Sensitizes Cells to Endoplasmic Reticulum Stress 2014 ·Cancer Discovery ·Yuxiong Feng,Ethan S. Sokol,Catherine Del Vecchio Fitz,Sandhya Sanduja,Jasper H.L. Claessen,Theresa A. Proia,Dexter X. Jin,Ferenc Reinhardt,Hidde L. Ploegh,Qiu Wang,Piyush B. Gupta	240
9	Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier 2011 ·Proceedings of the National Academy of Sciences ·Annemarthe G. van der Veen,Kenji Schorpp,Christian Schlieker,Ludovico Buti,(unknown),Eric Spooner,Hidde L. Ploegh,Stefan Jentsch	87
10	Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host 2011 ·Proceedings of the National Academy of Sciences ·Ludovico Buti,Eric Spooner,Annemarthe G. van der Veen,Rino Rappuoli,Antonello Covacci,Hidde L. Ploegh	190
11	Transnuclear Mice with Predefined T Cell Receptor Specificities Against Toxoplasma gondii Obtained via SCNT 2010 ·Science ·Oktay Kirak,Eva‐Maria Frickel,Gijsbert M. Grotenbreg,Heikyung Suh,Rudolf Jaenisch,Hidde L. Ploegh	46
12	Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity 2007 ·Proceedings of the National Academy of Sciences ·(unknown),Benedikt M. Kessler,Hidde L. Ploegh,Christophe Benoıst,Diane Mathis	74
13	A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation 2007 ·Proceedings of the National Academy of Sciences ·Keith W. Jarosinski,Lisa Kattenhorn,Benedikt B. Kaufer,Hidde L. Ploegh,Nikolaus Osterrieder	67
14	Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum 2006 ·Molecular Microbiology ·Katerina Artavanis‐Tsakonas,Shahram Misaghi,Christy Comeaux,André Catic,Eric Spooner,Manoj T. Duraisingh,Hidde L. Ploegh	68
15	Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation 2006 ·Proceedings of the National Academy of Sciences ·You‐Me Kim,Jennifer Pan,Gregory A. Korbel,Victor Peperzak,Marianne Boes,Hidde L. Ploegh	98
16	CX ₃ CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearancebreakdown → 2005 ·Science ·Jan Hendrik Niess,Stephan Brand,Xiubin Gu,Limor Landsman,Steffen Jung,Beth A. McCormick,Jatin M. Vyas,Marianne Boes,Hidde L. Ploegh,James G. Fox,Dan R. Littman,Hans-Christian Reinecker	1232
17	Cotranslational endoplasmic reticulum assembly of FcεRI controls the formation of functional IgE-binding receptors 2005 ·The Journal of Experimental Medicine ·Edda Fiebiger,Domenico Tortorella,Marie-Hélène Jouvin,Jean‐Pierre Kinet,Hidde L. Ploegh	35
18	Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane 2005 ·Proceedings of the National Academy of Sciences ·Brendan N. Lilley,Hidde L. Ploegh	271
19	Differential dependence of CD4 ⁺ CD25 ⁺ regulatory and natural killer-like T cells on signals leading to NF-κB activation 2004 ·Proceedings of the National Academy of Sciences ·Marc Schmidt‐Supprian,Jane Tian,Ethan Grant,Manolis Pasparakis,René Maehr,Huib Ovaa,Hidde L. Ploegh,Anthony J. Coyle,Klaus Rajewsky	202
20	Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-K ^b molecules 2002 ·Proceedings of the National Academy of Sciences ·Eckart Schott,Nicolas Bertho,Qing Ge,Madelon M. Maurice,Hidde L. Ploegh	52

About Hidde L. Ploegh

Hidde L. Ploegh is a scholar working on Immunology, Parasitology and Radiology, Nuclear Medicine and Imaging, having authored 607 papers that have together received 62.0k indexed citations. Recurring topics across this work include Immunotherapy and Immune Responses (158 papers), Immune Cell Function and Interaction (142 papers) and T-cell and B-cell Immunology (140 papers). The work is most often cited by research in Immunology (25.9k citations), Cell Biology (8.0k citations) and Molecular Biology (30.3k citations). Hidde L. Ploegh has collaborated with scholars based in United States, Netherlands and Germany. Frequent co-authors include Eric Spooner, Jacques Neefjes, Brendan N. Lilley, Domenico Tortorella, Benedikt M. Kessler, Jessica R. Ingram, Matthew Bogyo, Annemarthe G. van der Veen, Emmanuel J. H. J. Wiertz and Maximilian W. Popp. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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