Steven P. Gygi

170.4k citations
695 papers · 121.5k indexed · 65 hit papers · h-index 166
Co-authors
Joshua E. EliasJudit VillénRuedi AebersoldScott A. GerberWilhelm HaasJ. Wade HarperMark P. JedrychowskiMathew E. Sowa
Topics
Advanced Proteomics Techniques and Applications (153 papers)Ubiquitin and proteasome pathways (134 papers)Mass Spectrometry Techniques and Applications (95 papers)
Cited by
AgingMolecular BiologyGeriatrics and Gerontology
Journals
NatureScienceCell
Partner nations
United StatesUnited KingdomCanada

In The Last Decade

Steven P. Gygi

684 papers receiving 119.9k citations

Hit Papers

A PGC1-α-dependent myokine that drives brown...19992026200820172012199920071999200810002.0k3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    2012 3.7k citations Mark P. Jedrychowski, Steven P. Gygi et al. profile →
  2. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
    1999 3.6k citations Steven P. Gygi, Scott A. Gerber et al. profile →
  3. Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
    2007 3.1k citations Joshua E. Elias, Steven P. Gygi profile →
  4. Correlation between Protein and mRNA Abundance in Yeast
    1999 3.0k citations Steven P. Gygi et al. profile →
  5. The impact of microRNAs on protein output
    2008 2.9k citations Judit Villén, Steven P. Gygi et al. profile →
  6. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
    2004 2.7k citations Anne Brunet, Lora B. Sweeney et al. Science profile →
  7. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
    2005 2.6k citations Steven P. Gygi et al. profile →
  8. ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
    2007 2.4k citations Kristen E. Hurov, Corey E. Bakalarski et al. Science profile →
  9. Identification of a unique TGF-β–dependent molecular and functional signature in microglia
    2013 1.9k citations Mark P. Jedrychowski, Steven P. Gygi et al. profile →
  10. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
    2014 1.5k citations Steven P. Gygi, J. Wade Harper et al. profile →
  11. Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS
    2003 1.4k citations Scott A. Gerber, A. John Rush et al. Proceedings of the National Academy of Sciences profile →
  12. Evaluation of Multidimensional Chromatography Coupled with Tandem Mass Spectrometry (LC/LC−MS/MS) for Large-Scale Protein Analysis:  The Yeast Proteome
    2002 1.4k citations Joshua E. Elias, Steven P. Gygi et al. Journal of Proteome Research profile →
  13. A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression
    2010 1.3k citations Edward L. Huttlin, Mark P. Jedrychowski et al. profile →
  14. A quantitative atlas of mitotic phosphorylation
    2008 1.3k citations Noah Dephoure, Chunshui Zhou et al. Proceedings of the National Academy of Sciences profile →
  15. A proteomics approach to understanding protein ubiquitination
    2003 1.3k citations Daniel Schwartz, Joshua E. Elias et al. profile →
  16. Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
    2011 1.3k citations Edward L. Huttlin, Ramin Rad et al. profile →
  17. A probability-based approach for high-throughput protein phosphorylation analysis and site localization
    2006 1.3k citations Sean A. Beausoleil, Judit Villén et al. profile →
  18. Network organization of the human autophagy system
    2010 1.2k citations Steven P. Gygi, J. Wade Harper et al. profile →
  19. Defining the Human Deubiquitinating Enzyme Interaction Landscape
    2009 1.2k citations Steven P. Gygi, J. Wade Harper et al. profile →
  20. Large-scale characterization of HeLa cell nuclear phosphoproteins
    2004 1.2k citations Sean A. Beausoleil, Mark P. Jedrychowski et al. Proceedings of the National Academy of Sciences profile →
  21. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
    1999 1.1k citations Steven P. Gygi et al. profile →
  22. Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology
    2000 1.0k citations Steven P. Gygi et al. Proceedings of the National Academy of Sciences profile →
  23. mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events
    2005 962 citations Steven P. Gygi et al. profile →
  24. RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
    2004 937 citations André Verdel, Songtao Jia et al. Science profile →
  25. MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes
    2014 896 citations Mark P. Jedrychowski, Martin Wühr et al. profile →
  26. Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
    2013 826 citations Edward L. Huttlin, Steven P. Gygi et al. profile →
  27. MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics
    2011 769 citations Ramin Rad, Steven P. Gygi et al. profile →
  28. Enhancement of proteasome activity by a small-molecule inhibitor of USP14
    2010 760 citations Carlos A. Gartner, Steven P. Gygi et al. profile →
  29. Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation
    2011 758 citations Judit Villén, Steven P. Gygi et al. profile →
  30. Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis
    2014 737 citations Mark P. Jedrychowski, Steven P. Gygi et al. profile →
  31. An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets
    2005 730 citations Daniel Schwartz, Steven P. Gygi profile →
  32. Comprehensive proteomic analysis of the human spliceosome
    2002 726 citations Steven P. Gygi et al. profile →
  33. Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution
    2009 716 citations Judit Villén, Steven P. Gygi et al. Science profile →
  34. Hierarchical phosphorylation of the translation inhibitor 4E-BP1
    2001 707 citations Steven P. Gygi et al. profile →
  35. A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span
    2006 696 citations Judit Villén, Steven P. Gygi et al. profile →
  36. The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor
    2007 677 citations Steven P. Gygi, Anne Brunet et al. profile →
  37. Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
    2011 672 citations Yonghao Yu, Judit Villén et al. Science profile →
  38. A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila , and Humans
    2012 644 citations Eric B. Taylor, John C. Schell et al. Science profile →
  39. An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans
    2007 624 citations Judit Villén, Steven P. Gygi et al. profile →
  40. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
    2004 611 citations Steven P. Gygi et al. Proceedings of the National Academy of Sciences profile →
  41. The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
    2016 607 citations Sonia M. Scaria, J. Wade Harper et al. profile →
  42. Large-scale phosphorylation analysis of mouse liver
    2007 606 citations Judit Villén, Sean A. Beausoleil et al. Proceedings of the National Academy of Sciences profile →
  43. Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
    2017 593 citations Steven P. Gygi et al. The Journal of Cell Biology profile →
  44. Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations
    2005 590 citations Joshua E. Elias, Steven P. Gygi et al. profile →
  45. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
    2003 581 citations Michael E. Greenberg, Steven P. Gygi et al. profile →
  46. Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex
    2009 576 citations Kazuishi Kubota, Steven P. Gygi et al. profile →
  47. Quantitative Proteomics of the Cancer Cell Line Encyclopedia
    2020 574 citations Devin K. Schweppe, Mark P. Jedrychowski et al. profile →
  48. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis
    2007 567 citations Steven P. Gygi et al. The EMBO Journal profile →
  49. Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response
    2007 561 citations Steven P. Gygi, Stephen J. Elledge et al. Science profile →
  50. Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair
    2007 552 citations Kristen E. Hurov, Steven P. Gygi et al. profile →
  51. Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
    2014 545 citations Mark P. Jedrychowski, Sean A. Beausoleil et al. profile →
  52. SDH5 , a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
    2009 541 citations Huai‐Xiang Hao, Oleh Khalimonchuk et al. Science profile →
  53. SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
    2011 537 citations Steven P. Gygi et al. profile →
  54. Complementary Profiling of Gene Expression at the Transcriptome and Proteome Levels in Saccharomyces cerevisiae
    2002 534 citations Steven P. Gygi, Jimmy K. Eng et al. profile →
  55. The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry
    2008 508 citations Judit Villén, Steven P. Gygi profile →
  56. Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin
    2011 497 citations Kunhong Xiao, Seungkirl Ahn et al. Science Signaling profile →
  57. Increasing the Multiplexing Capacity of TMTs Using Reporter Ion Isotopologues with Isobaric Masses
    2012 464 citations Edward L. Huttlin, Mark P. Jedrychowski et al. profile →
  58. Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry
    2015 448 citations Mark P. Jedrychowski, João A. Paulo et al. profile →
  59. SAMTOR is an S -adenosylmethionine sensor for the mTORC1 pathway
    2017 413 citations Xin Gu, Jose M. Orozco et al. Science profile →
  60. iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis
    2014 406 citations Steven P. Gygi et al. profile →
  61. Accumulation of succinate controls activation of adipose tissue thermogenesis
    2018 376 citations Mark P. Jedrychowski, Steven P. Gygi et al. profile →
  62. The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
    2014 374 citations Jose M. Orozco, Sonia M. Scaria et al. profile →
  63. TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples
    2020 297 citations Jonathan G. Van Vranken, Devin K. Schweppe et al. profile →
  64. A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging
    2020 260 citations Mark P. Jedrychowski, Devin K. Schweppe et al. profile →
  65. Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance
    2021 188 citations Steven P. Gygi et al. profile →

Peers

Steven P. Gygi
Comparison fields: 5 of 205
  • Molecular Biology 88.4k
  • Spectroscopy 19.2k
  • Cell Biology 18.1k
  • Physiology 15.6k
  • Epidemiology 14.5k
Replace Matthias Mann with:
Matthias Mann Germany
John R. Yates United States
Lewis C. Cantley United States
Ruedi Aebersold Switzerland
Craig B. Thompson United States
Guido Kroemer France
Paul Tempst United States
David M. Sabatini United States
Robert A. Weinberg United States
Toren Finkel United States
Steven P. Gygi relative to Matthias Mann Germany Matthias Mann's profile →
Citations per field
00.5×1.5×
Matthias Mann · 1×
Citations per year

Countries citing papers authored by Steven P. Gygi

Since Specialization
Citations

This map shows the geographic impact of Steven P. Gygi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Steven P. Gygi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Steven P. Gygi more than expected).

Fields of papers citing papers by Steven P. Gygi

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Steven P. Gygi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Steven P. Gygi. The network helps show where Steven P. Gygi may publish in the future.

Co-authorship network of co-authors of Steven P. Gygi

This figure shows the co-authorship network connecting the top 25 collaborators of Steven P. Gygi. A scholar is included among the top collaborators of Steven P. Gygi based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Steven P. Gygi. Steven P. Gygi is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
#WorkIndexed citations
1
Enhanced Sample Multiplexing-Based Targeted Proteomics with Intelligent Data Acquisition
2024 ·Journal of the American Society for Mass Spectrometry ·Ka Yang,(unknown),Steven P. Gygi,Qing Yu
0
2
Proteomic analysis identifies the E3 ubiquitin ligase Pdzrn3 as a regulatory target of Wnt5a-Ror signaling
2021 ·Proceedings of the National Academy of Sciences ·Sara E. Konopelski,Michael W. Susman,Ryan C. Kunz,Jia Tan,(unknown),Michael D. Cohen,Kyoko Okada,(unknown),S. S. Choi,(unknown),Michael K. Scales,Steven P. Gygi,Michael E. Greenberg,Hsin‐Yi Henry Ho
10
3
Targeting the cyclin-dependent kinase 5 in metastatic melanoma
2020 ·Proceedings of the National Academy of Sciences ·Samanta Sharma,Tian Zhang,Wojciech Michowski,Vito W. Rebecca,Min Xiao,Roberta Ferretti,Jan M. Suski,Roderick T. Bronson,João A. Paulo,Dennie T. Frederick,Anne Fassl,Genevieve M. Boland,Yan Geng,Jacqueline A. Lees,René H. Medema,Meenhard Herlyn,Steven P. Gygi,Piotr Siciński
17
4
O-GlcNAc regulates gene expression by controlling detained intron splicing
2020 ·Nucleic Acids Research ·(unknown),(unknown),João A. Paulo,Stanislav Bellaousov,Sara E. Martin,Damien Duveau,Craig J. Thomas,Steven P. Gygi,Paul L. Boutz,Suzanne Walker
76
5
Full-Featured, Real-Time Database Searching Platform Enables Fast and Accurate Multiplexed Quantitative Proteomics
2020 ·Journal of Proteome Research ·Devin K. Schweppe,Jimmy K. Eng,Qing Yu,Derek J. Bailey,Ramin Rad,José Navarrete-Perea,Edward L. Huttlin,Brian K. Erickson,João A. Paulo,Steven P. Gygi
177
6
Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg
2017 ·Proceedings of the National Academy of Sciences ·Marc Presler,Elizabeth Van Itallie,Allon M. Klein,Ryan C. Kunz,Margaret Coughlin,Leonid Peshkin,Steven P. Gygi,Martin Wühr,Marc W. Kirschner
38
7
SAMTOR is an S -adenosylmethionine sensor for the mTORC1 pathwaybreakdown →
2017 ·Science ·Xin Gu,Jose M. Orozco,Robert A. Saxton,Kendall J. Condon,Grace Y. Liu,Patrycja A. Krawczyk,Sonia M. Scaria,J. Wade Harper,Steven P. Gygi,David M. Sabatini
413
8
S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction
2015 ·Science ·Ling Yang,Ediz S. Calay,Jason Fan,Alessandro Arduini,Ryan C. Kunz,Steven P. Gygi,Abdullah Yalçın,Suneng Fu,Gökhan S. Hotamışlıgil
186
9
M sp1/ ATAD 1 maintains mitochondrial function by facilitating the degradation of mislocalized tail‐anchored proteins
2014 ·The EMBO Journal ·Yuchan Chen,George K. E. Umanah,Noah Dephoure,(unknown),Steven P. Gygi,Ted M. Dawson,Valina L. Dawson,Jared Rutter
167
10
A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila , and Humansbreakdown →
2012 ·Science ·(unknown),Eric B. Taylor,John C. Schell,(unknown),Audrey Boutron,(unknown),James E. Cox,(unknown),Jonathan G. Van Vranken,Noah Dephoure,Claire Redin,Sihem Boudina,Steven P. Gygi,M. Brivet,Carl S. Thummel,Jared Rutter
644
11
Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestinbreakdown →
2011 ·Science Signaling ·(unknown),Kunhong Xiao,Seungkirl Ahn,Arun K. Shukla,(unknown),Sudarshan Rajagopal,Ryan T. Strachan,Teng‐Yi Huang,(unknown),Makoto R. Hara,Sudha K. Shenoy,Steven P. Gygi,Robert J. Lefkowitz
497
12
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
2010 ·Proceedings of the National Academy of Sciences ·Danny M. Chou,Britt Adamson,Noah Dephoure,Xu Tan,Amanda C. Nottke,Kristen E. Hurov,Steven P. Gygi,Mónica P. Colaiácovo,Stephen J. Elledge
440
13
Oxygen-Regulated β 2 -Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL
2009 ·Science Signaling ·Liang Xie,Kunhong Xiao,Erin J. Whalen,Michael T. Forrester,Robert S. Freeman,Guo‐Hua Fong,Steven P. Gygi,Robert J. Lefkowitz,Jonathan S. Stamler
125
14
A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry
2009 ·Proceedings of the National Academy of Sciences ·Yonghao Yu,Rana Anjum,Kazuishi Kubota,A. John Rush,Judit Villén,Steven P. Gygi
62
15
During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation
2009 ·The Journal of Cell Biology ·Shenhav Cohen,Jeffrey J. Brault,Steven P. Gygi,David J. Glass,David M. Valenzuela,Carlos A. Gartner,Esther Latres,Alfred L. Goldberg
472
16
SDH5 , a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paragangliomabreakdown →
2009 ·Science ·Huai‐Xiang Hao,Oleh Khalimonchuk,Margit Schraders,Noah Dephoure,Jean‐Pierre Bayley,Henricus P. M. Kunst,Peter Devilee,Cor W. R. J. Cremers,Joshua D. Schiffman,Brandon G. Bentz,Steven P. Gygi,Dennis R. Winge,Hannie Kremer,Jared Rutter
541
17
A quantitative atlas of mitotic phosphorylationbreakdown →
2008 ·Proceedings of the National Academy of Sciences ·Noah Dephoure,Chunshui Zhou,Judit Villén,Sean A. Beausoleil,Corey E. Bakalarski,Stephen J. Elledge,Steven P. Gygi
1303
18
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylasebreakdown →
2004 ·Science ·Anne Brunet,Lora B. Sweeney,James Fitzhugh Sturgill,Katrin F. Chua,Paul L. Greer,Yingxi Lin,Hien Tran,Sarah E. Ross,Raúl Mostoslavsky,Haim Cohen,Linda Hu,Hwei-Ling Cheng,Mark P. Jedrychowski,Steven P. Gygi,David Sinclair,Frederick W. Alt,Michael E. Greenberg
2730
19
Large-scale characterization of HeLa cell nuclear phosphoproteinsbreakdown →
2004 ·Proceedings of the National Academy of Sciences ·Sean A. Beausoleil,Mark P. Jedrychowski,Daniel Schwartz,Joshua E. Elias,Judit Villén,Jiaxu Li,Martin A. Cohn,Lewis C. Cantley,Steven P. Gygi
1190
20
RNAi-Mediated Targeting of Heterochromatin by the RITS Complexbreakdown →
2004 ·Science ·André Verdel,Songtao Jia,Scott A. Gerber,Tomoyasu Sugiyama,Steven P. Gygi,Shiv I. S. Grewal,Danesh Moazed
937

About Steven P. Gygi

Steven P. Gygi is a scholar working on Spectroscopy, Cell Biology and Molecular Biology, having authored 695 papers that have together received 121.5k indexed citations. Recurring topics across this work include Advanced Proteomics Techniques and Applications (153 papers), Ubiquitin and proteasome pathways (134 papers) and Mass Spectrometry Techniques and Applications (95 papers). The work is most often cited by research in Aging (2.8k citations), Molecular Biology (88.4k citations) and Geriatrics and Gerontology (4.9k citations). Steven P. Gygi has collaborated with scholars based in United States, United Kingdom and Canada. Frequent co-authors include Joshua E. Elias, Judit Villén, Ruedi Aebersold, Scott A. Gerber, Wilhelm Haas, J. Wade Harper, Mark P. Jedrychowski, Mathew E. Sowa, Sean A. Beausoleil and Yvan Rochon. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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