René H. Medema

38.2k total citations · 11 hit papers
235 papers, 29.6k citations indexed

About

René H. Medema is a scholar working on Molecular Biology, Cell Biology and Oncology. According to data from OpenAlex, René H. Medema has authored 235 papers receiving a total of 29.6k indexed citations (citations by other indexed papers that have themselves been cited), including 203 papers in Molecular Biology, 117 papers in Cell Biology and 81 papers in Oncology. Recurrent topics in René H. Medema's work include Microtubule and mitosis dynamics (113 papers), Cancer-related Molecular Pathways (72 papers) and DNA Repair Mechanisms (62 papers). René H. Medema is often cited by papers focused on Microtubule and mitosis dynamics (113 papers), Cancer-related Molecular Pathways (72 papers) and DNA Repair Mechanisms (62 papers). René H. Medema collaborates with scholars based in Netherlands, United Kingdom and United States. René H. Medema's co-authors include Boudewijn Burgering, Geert J.P.L. Kops, Johannes L. Bos, Susanne M.A. Lens, Paul J. Coffer, Veronique A. J. Smits, Marvin E. Tanenbaum, Marcel A.T.M. van Vugt, Rob Klompmaker and Aniek Janssen and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

René H. Medema

232 papers receiving 29.3k citations

Hit Papers

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Ph... 2000 2026 2008 2017 2002 2002 2000 2004 2000 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
    2002 1.6k citations René H. Medema et al. profile →
  2. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
    2002 1.3k citations Geert J.P.L. Kops, Paul J. Coffer et al. profile →
  3. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    2000 1.2k citations René H. Medema, Geert J.P.L. Kops et al. profile →
  4. Cell death by mitotic catastrophe: a molecular definition
    2004 973 citations René H. Medema et al. profile →
  5. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
    2000 814 citations Pascale F. Dijkers, René H. Medema et al. profile →
  6. FoxM1 is required for execution of the mitotic programme and chromosome stability
    2005 672 citations René H. Medema et al. profile →
  7. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
    2008 563 citations Libor Macůrek, Arne Lindqvist et al. profile →
  8. cell cycle and death control: long live Forkheads
    2002 537 citations Boudewijn Burgering, René H. Medema et al. profile →
  9. Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27KIP1
    2000 525 citations Pascale F. Dijkers, René H. Medema et al. profile →
  10. The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension
    2017 519 citations René H. Medema et al. profile →
  11. FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis
    2011 473 citations Wen‐Tai Chiu, Jianfei Xue et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
René H. Medema Netherlands 88 24.0k 8.9k 8.2k 3.4k 1.9k 235 29.6k
Channing J. Der United States 111 36.2k 1.5× 10.6k 1.2× 12.7k 1.6× 6.1k 1.8× 2.4k 1.3× 406 48.3k
Junjie Chen United States 93 26.9k 1.1× 4.5k 0.5× 9.8k 1.2× 6.6k 2.0× 4.0k 2.1× 387 32.5k
Lynda Chin United States 82 20.4k 0.8× 2.9k 0.3× 9.3k 1.1× 6.7k 2.0× 2.6k 1.4× 160 29.4k
Steven I. Reed United States 83 22.7k 0.9× 7.8k 0.9× 11.3k 1.4× 1.8k 0.5× 2.4k 1.2× 208 27.3k
Johannes L. Bos Netherlands 92 25.6k 1.1× 4.8k 0.5× 11.1k 1.4× 5.2k 1.5× 3.5k 1.8× 246 39.6k
Brendan D. Manning United States 62 22.0k 0.9× 3.5k 0.4× 3.9k 0.5× 4.9k 1.5× 1.6k 0.8× 118 30.9k
Michael B. Kastan United States 77 30.5k 1.3× 4.0k 0.5× 18.4k 2.3× 8.3k 2.5× 2.6k 1.4× 156 39.1k
Julian Downward United Kingdom 101 30.1k 1.3× 5.9k 0.7× 11.4k 1.4× 4.9k 1.5× 2.2k 1.2× 292 41.7k
Nabeel Bardeesy United States 84 19.1k 0.8× 3.7k 0.4× 12.0k 1.5× 7.4k 2.2× 1.5k 0.8× 182 30.8k
J. Alan Diehl United States 73 13.6k 0.6× 6.0k 0.7× 5.6k 0.7× 3.4k 1.0× 1.0k 0.5× 175 20.9k

Countries citing papers authored by René H. Medema

Since Specialization
Citations

This map shows the geographic impact of René H. Medema's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by René H. Medema with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites René H. Medema more than expected).

Fields of papers citing papers by René H. Medema

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by René H. Medema. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by René H. Medema. The network helps show where René H. Medema may publish in the future.

Co-authorship network of co-authors of René H. Medema

This figure shows the co-authorship network connecting the top 25 collaborators of René H. Medema. A scholar is included among the top collaborators of René H. Medema based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with René H. Medema. René H. Medema is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Schubert, Michaël, et al.. (2024). Reduction of chromosomal instability and inflammation is a common aspect of adaptation to aneuploidy. EMBO Reports. 25(11). 5169–5193. 3 indexed citations
2.
Boutros, Michael, Michaël Baumann, Anna Bigas, et al.. (2024). UNCAN.eu: Toward a European Federated Cancer Research Data Hub. Cancer Discovery. 14(1). 30–35. 2 indexed citations
3.
Solary, Éric, P. Blanc, Michael Boutros, et al.. (2022). UNCAN.eu, a European Initiative to UNderstand CANcer. Cancer Discovery. 12(11). 2504–2508. 2 indexed citations
4.
Pogacar, Ziva, Jackie Johnson, Lenno Krenning, et al.. (2022). Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity. PLoS ONE. 17(9). e0273182–e0273182. 12 indexed citations
5.
Burdová, Kamila, et al.. (2021). A novel assay for screening WIP1 phosphatase substrates in nuclear extracts. FEBS Journal. 288(20). 6035–6051. 4 indexed citations
6.
García‐Santisteban, Iraia, et al.. (2021). Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells. BMC Biology. 19(1). 35–35. 12 indexed citations
7.
Menegakis, Apostolos, Rob Klompmaker, Claire Vennin, et al.. (2021). Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence. Cells. 10(3). 610–610. 30 indexed citations
8.
Sharma, Samanta, Tian Zhang, Wojciech Michowski, et al.. (2020). Targeting the cyclin-dependent kinase 5 in metastatic melanoma. Proceedings of the National Academy of Sciences. 117(14). 8001–8012. 17 indexed citations
9.
Velden, Lieke M. van der, René H. Medema, Arno Siebes, et al.. (2020). Combining Supervised and Unsupervised Machine Learning Methods for Phenotypic Functional Genomics Screening. SLAS DISCOVERY. 25(6). 655–664. 15 indexed citations
10.
Maia, Ana, Simon Linder, Ji‐Ying Song, et al.. (2018). Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division. British Journal of Cancer. 118(12). 1586–1595. 33 indexed citations
11.
Jaiswal, Himjyot, Jan Benada, Erik Müllers, et al.. (2017). ATM /Wip1 activities at chromatin control Plk1 re‐activation to determine G2 checkpoint duration. The EMBO Journal. 36(14). 2161–2176. 31 indexed citations
12.
Sansregret, Laurent, James O. Patterson, Sally M. Dewhurst, et al.. (2017). APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. Cancer Discovery. 7(2). 218–233. 80 indexed citations
13.
Pagliero, Romina J., Lieke M. van der Velden, Daphne Lelieveld, et al.. (2016). HC StratoMineR: A Web-Based Tool for the Rapid Analysis of High-Content Datasets. Assay and Drug Development Technologies. 14(8). 439–452. 12 indexed citations
14.
Feringa, Femke M., Lenno Krenning, André Koch, et al.. (2016). Hypersensitivity to DNA damage in antephase as a safeguard for genome stability. Nature Communications. 7(1). 12618–12618. 23 indexed citations
15.
Kongsema, Mesayamas, Stefania Zona, Ellen P.S. Man, et al.. (2016). RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment. Oncogenesis. 5(8). e252–e252. 31 indexed citations
16.
Xue, Jianfei, Xia Lin, Wen‐Tai Chiu, et al.. (2014). Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β–dependent cancer metastasis. Journal of Clinical Investigation. 124(2). 564–579. 146 indexed citations
17.
Eggermont, Alexander M.M., Carlos Caldas, Ulrik Ringborg, et al.. (2014). Cancer Core Europe: A consortium to address the cancer care – Cancer research continuum challenge. European Journal of Cancer. 50(16). 2745–2746. 17 indexed citations
18.
Ståhl, Marie, Pascale F. Dijkers, Geert J.P.L. Kops, et al.. (2002). The Forkhead Transcription Factor FoxO Regulates Transcription of p27 Kip1 and Bim in Response to IL-2. The Journal of Immunology. 168(10). 5024–5031. 499 indexed citations
19.
Verdonck, Leo F., et al.. (1999). CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes. European Journal of Immunology. 29(3). 789–798. 61 indexed citations
20.
Smits, Veronique A. J., et al.. (1999). Inhibition of cell proliferation by lithium is associated with interference in cdc2 activation. FEBS Letters. 457(1). 23–27. 24 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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