Craig B. Thompson

205.1k citations

515 papers · 151.3k indexed · 77 hit papers · h-index 182

Molecular Biology top 0.01%
Cancer Research top 0.01%
Immunology top 0.01%
Oncology top 0.01%
Epidemiology top 0.02%

Co-authors: Matthew G. Vander Heiden Lewis C. Cantley Natalya N. Pavlova Ralph J. DeBerardinis Tullia Lindsten Patrick S. Ward Lawrence Boise Julian J. Lum
Topics: T-cell and B-cell Immunology (118 papers)Immune Cell Function and Interaction (103 papers)Cancer, Hypoxia, and Metabolism (93 papers)
Cited by: Cancer Research Immunology Molecular Biology
Journals: Nature Science Cell
Partner nations: United States Canada Slovakia

In The Last Decade

Craig B. Thompson

511 papers receiving 149.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

2009 12.1k citations Matthew G. Vander Heiden, Craig B. Thompson et al. Science profile →
Apoptosis in the Pathogenesis and Treatment of Disease

1995 5.7k citations Craig B. Thompson Science profile →
The Emerging Hallmarks of Cancer Metabolism

2016 4.0k citations Craig B. Thompson et al. profile →
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 3.3k citations Wei‐Xing Zong, Tullia Lindsten et al. Science profile →
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

2008 3.2k citations Ralph J. DeBerardinis, Julian J. Lum et al. profile →
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

2009 3.1k citations Patrick S. Ward, Katharine Yen et al. profile →
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 2.7k citations Tullia Lindsten, Craig B. Thompson et al. profile →
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

2012 2.5k citations Patrick S. Ward, Craig B. Thompson profile →
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

2007 2.0k citations Ralph J. DeBerardinis, Anthony Mancuso et al. Proceedings of the National Academy of Sciences profile →
Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 1.8k citations Craig B. Thompson, Stanley J. Korsmeyer et al. profile →
CTLA-4 can function as a negative regulator of T cell activation

1994 1.8k citations Peter S. Linsley, Craig B. Thompson et al. profile →
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

2009 1.7k citations Kathryn E. Wellen, Georgia Hatzivassiliou et al. Science profile →
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

2005 1.6k citations Craig B. Thompson et al. profile →
Role of Mitochondria in Ferroptosis

2018 1.5k citations Jun-Mei Yi, Jiajun Zhu et al. profile →
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

2005 1.5k citations Richard V. Parry, Jens M. Chemnitz et al. Molecular and Cellular Biology profile →
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

2008 1.5k citations David R. Wise, Ralph J. DeBerardinis et al. Proceedings of the National Academy of Sciences profile →
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

2010 1.5k citations Patrick S. Ward, David R. Wise et al. profile →
IDH mutation impairs histone demethylation and results in a block to cell differentiation

2012 1.5k citations Chao Lü, Patrick S. Ward et al. profile →
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

2012 1.4k citations Chao Lü, Patrick S. Ward et al. profile →
Glutamine addiction: a new therapeutic target in cancer

2010 1.4k citations David R. Wise, Craig B. Thompson profile →
AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint

2005 1.3k citations Russell G. Jones, Monica Buzzai et al. profile →
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

2013 1.3k citations Cosimo Commisso, Jurre J. Kamphorst et al. profile →
Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 1.2k citations Matthew G. Vander Heiden, Craig B. Thompson et al. profile →
Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis

2005 1.2k citations Julian J. Lum, Mei Kong et al. profile →
Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 1.2k citations Craig B. Thompson et al. Science profile →
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 1.2k citations Craig B. Thompson et al. profile →
Akt Stimulates Aerobic Glycolysis in Cancer Cells

2004 1.2k citations Monica Buzzai, Ryan M. Cinalli et al. Cancer Research profile →
The B7 and CD28 receptor families

1994 1.1k citations Craig B. Thompson et al. profile →
The CD28 Signaling Pathway Regulates Glucose Metabolism

2002 1.1k citations Kenneth A. Frauwirth, James L. Riley et al. profile →
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

2004 1.1k citations Craig B. Thompson et al. profile →
Death by design: apoptosis, necrosis and autophagy

2004 1.1k citations Craig B. Thompson et al. profile →
Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 1.1k citations Craig B. Thompson et al. Science profile →
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 1.0k citations Craig B. Thompson et al. profile →
Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation

2010 976 citations Ralph J. DeBerardinis, Justin R. Cross et al. Blood profile →
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

2007 936 citations Ravi K. Amaravadi, Julian J. Lum et al. profile →
Quantitative flux analysis reveals folate-dependent NADPH production

2014 856 citations Jing Fan, Jiangbin Ye et al. profile →
Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

2010 851 citations Thi Bui, Craig B. Thompson et al. profile →
ATP citrate lyase inhibition can suppress tumor cell growth

2005 820 citations Georgia Hatzivassiliou, Fangping Zhao et al. profile →
Tumor suppressors and cell metabolism: a recipe for cancer growth

2009 815 citations Russell G. Jones, Craig B. Thompson profile →
Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 815 citations Craig B. Thompson et al. Science profile →
Brick by brick: metabolism and tumor cell growth

2008 813 citations Ralph J. DeBerardinis, Craig B. Thompson et al. profile →
The hallmarks of cancer metabolism: Still emerging

2022 809 citations Jiajun Zhu, Craig B. Thompson et al. profile →
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

2011 791 citations David R. Wise, Patrick S. Ward et al. Proceedings of the National Academy of Sciences profile →
Metabolic regulation of cell growth and proliferation

2019 757 citations Jiajun Zhu, Craig B. Thompson profile →
Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

2007 756 citations Monica Buzzai, Russell G. Jones et al. Cancer Research profile →
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

2009 737 citations Uma M. Sachdeva, Craig B. Thompson et al. Science profile →
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 731 citations Craig B. Thompson et al. Proceedings of the National Academy of Sciences profile →
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

2014 725 citations Lydia W.S. Finley, Justin R. Cross et al. profile →
Necrotic death as a cell fate

2006 704 citations Wei‐Xing Zong, Craig B. Thompson profile →
T-cell regulation by CD28 and CTLA-4

2001 704 citations Kenneth A. Frauwirth, Craig B. Thompson et al. profile →
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

2020 688 citations Jun-Mei Yi, Jiajun Zhu et al. Proceedings of the National Academy of Sciences profile →
Bcl-xL forms an ion channel in synthetic lipid membranes

1997 682 citations Craig B. Thompson et al. profile →
Fuel feeds function: energy metabolism and the T-cell response

2005 676 citations Casey Fox, Peter S. Hammerman et al. profile →
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 659 citations Wei‐Xing Zong, Tullia Lindsten et al. profile →
Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis

2003 646 citations Craig B. Thompson et al. profile →
Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

2015 644 citations Jurre J. Kamphorst, Michel Nofal et al. Cancer Research profile →
Autophagy in metazoans: cell survival in the land of plenty

2005 635 citations Julian J. Lum, Ralph J. DeBerardinis et al. profile →
Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

2012 628 citations Ralph J. DeBerardinis, Craig B. Thompson profile →
HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation

2007 623 citations Craig B. Thompson et al. profile →
Role of the CD28 receptor in T-cell activation

1990 579 citations Peter S. Linsley, Craig B. Thompson et al. profile →
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 566 citations Craig B. Thompson, Tullia Lindsten et al. Proceedings of the National Academy of Sciences profile →
Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

1999 561 citations Matthew G. Vander Heiden, Craig B. Thompson profile →
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

2013 560 citations Jurre J. Kamphorst, Justin R. Cross et al. Proceedings of the National Academy of Sciences profile →
Molecular Basis of T Cell Inactivation by CTLA-4

1998 557 citations Craig B. Thompson et al. Science profile →
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.

1996 533 citations Colin S. Duckett, Craig B. Thompson et al. The EMBO Journal profile →
The Emerging Role of CTLA-4 as an Immune Attenuator

1997 531 citations Craig B. Thompson et al. profile →
Bcl-2-family proteins: the role of the BH3 domain in apoptosis

1998 525 citations Craig B. Thompson et al. profile →
Hexokinase-Mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak

2004 524 citations Craig B. Thompson et al. profile →
Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 523 citations Craig B. Thompson et al. Proceedings of the National Academy of Sciences profile →
Tumor necrosis factor receptor-associated factors (TRAFs)—a family of adapter proteins that regulates life and death

1998 512 citations Robert H. Arch, Craig B. Thompson et al. profile →
Hypoxia-Induced Energy Stress Regulates mRNA Translation and Cell Growth

2006 506 citations Russell G. Jones, Craig B. Thompson et al. profile →
Alkylating DNA damage stimulates a regulated form of necrotic cell death

2004 504 citations Wei‐Xing Zong, Craig B. Thompson et al. profile →
Metabolic Regulation of Epigenetics

2012 495 citations Chao Lü, Craig B. Thompson profile →
Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine

2017 484 citations Ji Zhang, Craig B. Thompson et al. The EMBO Journal profile →
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

2020 343 citations Justin R. Cross, Craig B. Thompson et al. profile →
Lactate activates the mitochondrial electron transport chain independently of its metabolism

2023 107 citations Tak Shun Fung, Keun Woo Ryu et al. profile →
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria

2024 102 citations Keun Woo Ryu, Tak Shun Fung et al. profile →

Peers

Countries citing papers authored by Craig B. Thompson

Since Specialization

Citations

This map shows the geographic impact of Craig B. Thompson's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Craig B. Thompson with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Craig B. Thompson more than expected).

Fields of papers citing papers by Craig B. Thompson

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Craig B. Thompson. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Craig B. Thompson. The network helps show where Craig B. Thompson may publish in the future.

Co-authorship network of co-authors of Craig B. Thompson

This figure shows the co-authorship network connecting the top 25 collaborators of Craig B. Thompson. A scholar is included among the top collaborators of Craig B. Thompson based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Craig B. Thompson. Craig B. Thompson is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Arginine: at the crossroads of nitrogen metabolism 2025 ·The EMBO Journal ·Tak Shun Fung,Keun Woo Ryu,Craig B. Thompson	13
2	Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesisbreakdown → 2020 ·Proceedings of the National Academy of Sciences ·Jun-Mei Yi,Jiajun Zhu,Jiao Wu,Craig B. Thompson,Xuejun Jiang	688
3	Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism 2020 ·Molecular Cancer Research ·Albert M. Li,Gregory S. Ducker,Yang Li,José A. Seoane,Yiren Xiao,Stavros Melemenidis,(unknown),(unknown),Sakari Vanharanta,Edward E. Graves,Erinn B. Rankin,Christina Curtis,Joan Massagué,Joshua D. Rabinowitz,Craig B. Thompson,Jiangbin Ye	58
4	Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2 - and TET2 -Mutant Acute Myeloid Leukemia 2017 ·Cancer Discovery ·Alan H. Shih,Cem Meydan,Kaitlyn Shank,Francine E. Garrett-Bakelman,Patrick S. Ward,Andrew M. Intlekofer,Abbas Nazir,Eytan M. Stein,Kristina M. Knapp,Jacob L. Glass,Jeremy Travins,(unknown),Camelia Gliser,Christopher E. Mason,Katharine Yen,Craig B. Thompson,Ari Melnick,Ross L. Levine	71
5	Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Proteinbreakdown → 2015 ·Cancer Research ·Jurre J. Kamphorst,Michel Nofal,Cosimo Commisso,Sean R. Hackett,Wenyun Lu,Elda Grabocka,Matthew G. Vander Heiden,George Miller,Jeffrey A. Drebin,Dafna Bar‐Sagi,Craig B. Thompson,Joshua D. Rabinowitz	644
6	Use of Human Papillomavirus 16 (HPV16) Cell Free DNA for Assessment of Response to Chemoradiation in HPV-Associated Oropharyngeal Cancer 2015 ·International Journal of Radiation OncologyBiologyPhysics ·Daniel S. Higginson,Eli D. Scher,(unknown),(unknown),Lindsey Mitrani,Craig B. Thompson,(unknown),Sean M. McBride,Nadeem Riaz,N. Lee	2
7	Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia 2014 ·Cancer Discovery ·Jiangbin Ye,Jing Fan,Sriram Venneti,Ying-Wooi Wan,Bruce Pawel,Ji Zhang,Lydia W.S. Finley,Chao Lü,Tullia Lindsten,Justin R. Cross,Guoliang Qing,Zhandong Liu,M. Celeste Simon,Joshua D. Rabinowitz,Craig B. Thompson	344
8	Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipidsbreakdown → 2013 ·Proceedings of the National Academy of Sciences ·Jurre J. Kamphorst,Justin R. Cross,Jing Fan,Elisa de Stanchina,Robin Mathew,Eileen White,Craig B. Thompson,Joshua D. Rabinowitz	560
9	The Proteasome Activator PA200 Regulates Tumor Cell Responsiveness to Glutamine and Resistance to Ionizing Radiation 2012 ·Molecular Cancer Research ·(unknown),Scott H. Olejniczak,Ryan Cummings,(unknown),Ana Mantilla,Asher Chanan‐Khan,Tej K. Pandita,Marion Schmidt,Craig B. Thompson,Naveen Bangia	27
10	Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation 2010 ·Science ·David Bungard,(unknown),Ping-Yao Zeng,Brandon Faubert,Nancy L. Maas,Benoı̂t Viollet,David Carling,Craig B. Thompson,Russell G. Jones,Shelley L. Berger	290
11	ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylationbreakdown → 2009 ·Science ·Kathryn E. Wellen,Georgia Hatzivassiliou,Uma M. Sachdeva,Thi Bui,Justin R. Cross,Craig B. Thompson	1698
12	Execution of Superoxide-Induced Cell Death by the Proapoptotic Bcl-2-Related Proteins Bid and Bak 2009 ·Molecular and Cellular Biology ·Muniswamy Madesh,Wei‐Xing Zong,Brian J. Hawkins,Subbiah Ramasamy,(unknown),Partha Mukhopadhyay,Patrick J. Doonan,Krishna M. Irrinki,Mohanraj Rajesh,Pál Pacher,Craig B. Thompson	44
13	Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addictionbreakdown → 2008 ·Proceedings of the National Academy of Sciences ·David R. Wise,Ralph J. DeBerardinis,Anthony Mancuso,(unknown),(unknown),(unknown),Ilana Nissim,Evgueni Daikhin,Marc Yudkoff,Steven B. McMahon,Craig B. Thompson	1532
14	Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growthbreakdown → 2007 ·Cancer Research ·Monica Buzzai,Russell G. Jones,Ravi K. Amaravadi,Julian J. Lum,Ralph J. DeBerardinis,Fangping Zhao,Benoı̂t Viollet,Craig B. Thompson	756
15	Multiple signaling pathways promote B lymphocyte stimulator–dependent B-cell growth and survival 2007 ·Blood ·Robert T. Woodland,Casey Fox,Madelyn R. Schmidt,Peter S. Hammerman,Joseph T. Opferman,Stanley J. Korsmeyer,David M. Hilbert,Craig B. Thompson	152
16	CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanismsbreakdown → 2005 ·Molecular and Cellular Biology ·Richard V. Parry,Jens M. Chemnitz,Kenneth A. Frauwirth,Anthony R. Lanfranco,Inbal Braunstein,Sumire Kobayashi,Peter S. Linsley,Craig B. Thompson,James L. Riley	1541
17	The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis 2004 ·Science ·Mei Kong,Casey Fox,James Mu,Laura A. Solt,(unknown),Ryan M. Cinalli,Morris J. Birnbaum,Tullia Lindsten,Craig B. Thompson	125
18	Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis 2003 ·The Journal of Cell Biology ·Patrick Ryan Potts,Shweta Singh,(unknown),Craig B. Thompson,Mohanish Deshmukh	119
19	Human IAP-Like Protein Regulates Programmed Cell Death Downstream of Bcl-x _L and Cytochrome c 1998 ·Molecular and Cellular Biology ·Colin S. Duckett,Feng Li,Yu Wang,Kevin J. Tomaselli,Craig B. Thompson,Robert C. Armstrong	185
20	4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor κB 1998 ·Molecular and Cellular Biology ·Robert H. Arch,Craig B. Thompson	308

About Craig B. Thompson

Craig B. Thompson is a scholar working on Cancer Research, Immunology and Molecular Biology, having authored 515 papers that have together received 151.3k indexed citations. Recurring topics across this work include T-cell and B-cell Immunology (118 papers), Immune Cell Function and Interaction (103 papers) and Cancer, Hypoxia, and Metabolism (93 papers). The work is most often cited by research in Cancer Research (44.6k citations), Immunology (36.7k citations) and Molecular Biology (91.8k citations). Craig B. Thompson has collaborated with scholars based in United States, Canada and Slovakia. Frequent co-authors include Matthew G. Vander Heiden, Lewis C. Cantley, Natalya N. Pavlova, Ralph J. DeBerardinis, Tullia Lindsten, Patrick S. Ward, Lawrence Boise, Julian J. Lum, Georgia Hatzivassiliou and Carl H. June. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact