David Sinclair

83.2k total citations · 29 hit papers
382 papers, 47.3k citations indexed

About

David Sinclair is a scholar working on Molecular Biology, Geriatrics and Gerontology and Physiology. According to data from OpenAlex, David Sinclair has authored 382 papers receiving a total of 47.3k indexed citations (citations by other indexed papers that have themselves been cited), including 124 papers in Molecular Biology, 107 papers in Geriatrics and Gerontology and 86 papers in Physiology. Recurrent topics in David Sinclair's work include Sirtuins and Resveratrol in Medicine (102 papers), Genetics, Aging, and Longevity in Model Organisms (53 papers) and Adipose Tissue and Metabolism (50 papers). David Sinclair is often cited by papers focused on Sirtuins and Resveratrol in Medicine (102 papers), Genetics, Aging, and Longevity in Model Organisms (53 papers) and Adipose Tissue and Metabolism (50 papers). David Sinclair collaborates with scholars based in United States, United Kingdom and Australia. David Sinclair's co-authors include Joseph A. Baur, Leonard Guarente, Haim Cohen, Shaday Michán, Marcia C. Haigis, Kevin J. Bitterman, Konrad T. Howitz, Jason G. Wood, Brian J. North and Siva Lavu and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

David Sinclair

369 papers receiving 46.2k citations

Hit Papers

Therapeutic potential of resveratrol: the in vivo evidence 1997 2026 2006 2016 2006 2003 2004 2010 2004 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Therapeutic potential of resveratrol: the in vivo evidence
    2006 3.2k citations Joseph A. Baur, David Sinclair profile →
  2. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    2003 3.0k citations Konrad T. Howitz, Kevin J. Bitterman et al. Nature profile →
  3. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
    2004 2.7k citations Anne Brunet, Lora B. Sweeney et al. Science profile →
  4. Mammalian Sirtuins: Biological Insights and Disease Relevance
    2010 1.7k citations David Sinclair et al. profile →
  5. Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
    2004 1.6k citations Haim Cohen, Christine Miller et al. Science profile →
  6. Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    2004 1.4k citations Konrad T. Howitz, David Sinclair et al. Nature profile →
  7. Sirtuins in mammals: insights into their biological function
    2007 1.4k citations Shaday Michán, David Sinclair profile →
  8. Extrachromosomal rDNA Circles— A Cause of Aging in Yeast
    1997 1.2k citations David Sinclair, Leonard Guarente profile →
  9. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
    2013 1.1k citations Ana P. Gomes, Carlos M. Palmeira et al. profile →
  10. The Intersection Between Aging and Cardiovascular Disease
    2012 1.1k citations Brian J. North, David Sinclair profile →
  11. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
    2007 863 citations Joseph A. Baur, David Sinclair et al. The EMBO Journal profile →
  12. Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1
    2002 832 citations Kevin J. Bitterman, Haim Cohen et al. profile →
  13. Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival
    2007 796 citations Joseph A. Baur, Dudley W. Lamming et al. profile →
  14. The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice
    2014 692 citations Lindsay E. Wu, David Sinclair et al. profile →
  15. Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
    2010 686 citations Joseph A. Baur, Rafael de Cabo et al. The Journals of Gerontology Series A profile →
  16. Why does COVID-19 disproportionately affect older people?
    2020 683 citations David Sinclair et al. Aging profile →
  17. Molecular Biology of Aging
    1999 669 citations David Sinclair, Leonard Guarente et al. profile →
  18. SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
    2008 649 citations Philipp Oberdoerffer, Shaday Michán et al. profile →
  19. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
    2018 616 citations Karolina Chwalek, David Sinclair et al. profile →
  20. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
    2016 615 citations Michael S. Bonkowski, David Sinclair profile →
  21. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
    2003 583 citations Kevin J. Bitterman, Oliver Medvedik et al. Nature profile →
  22. Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
    2012 565 citations David Sinclair et al. profile →
  23. Mitochondrial and metabolic dysfunction in ageing and age-related diseases
    2022 554 citations Carlos M. Palmeira, David Sinclair et al. profile →
  24. NAD+ in Brain Aging and Neurodegenerative Disorders
    2019 509 citations David Sinclair et al. profile →
  25. Small molecule SIRT1 activators for the treatment of aging and age-related diseases
    2014 456 citations David Sinclair et al. profile →
  26. Sirtuin activators and inhibitors: Promises, achievements, and challenges
    2018 359 citations David Sinclair et al. profile →
  27. Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases
    2018 344 citations Alice E. Kane, David Sinclair profile →
  28. The economic value of targeting aging
    2021 130 citations David Sinclair et al. profile →
  29. Human trials exploring anti-aging medicines
    2024 106 citations Leonard Guarente, David Sinclair et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
David Sinclair United States 90 19.5k 17.8k 13.5k 8.4k 6.4k 382 47.3k
Claudio Franceschi Italy 110 23.8k 1.2× 2.8k 0.2× 16.4k 1.2× 7.3k 0.9× 6.8k 1.1× 816 62.5k
Judith Campisi United States 109 33.0k 1.7× 1.9k 0.1× 28.2k 2.1× 5.5k 0.7× 6.7k 1.1× 326 65.9k
Joshua D. Rabinowitz United States 110 30.9k 1.6× 1.1k 0.1× 4.9k 0.4× 7.0k 0.8× 477 0.1× 328 49.1k
Steve Horvath United States 106 44.2k 2.3× 853 0.0× 7.5k 0.6× 3.3k 0.4× 2.7k 0.4× 447 70.9k
Vamsi K. Mootha United States 87 51.6k 2.6× 793 0.0× 10.7k 0.8× 5.6k 0.7× 879 0.1× 199 72.9k
David B. Allison United States 114 7.7k 0.4× 1.3k 0.1× 17.6k 1.3× 4.8k 0.6× 3.2k 0.5× 774 56.8k
Thomas F. Lüscher Switzerland 127 11.6k 0.6× 925 0.1× 16.5k 1.2× 4.4k 0.5× 385 0.1× 1.1k 62.6k
Dean P. Jones United States 109 26.9k 1.4× 521 0.0× 7.5k 0.6× 4.1k 0.5× 687 0.1× 742 54.8k
Douglas R. Green United States 178 80.9k 4.2× 899 0.1× 6.9k 0.5× 18.8k 2.2× 683 0.1× 613 125.1k
Takashi Kadowaki Japan 119 25.1k 1.3× 668 0.0× 16.3k 1.2× 17.1k 2.0× 321 0.1× 869 62.0k

Countries citing papers authored by David Sinclair

Since Specialization
Citations

This map shows the geographic impact of David Sinclair's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Sinclair with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Sinclair more than expected).

Fields of papers citing papers by David Sinclair

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Sinclair. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Sinclair. The network helps show where David Sinclair may publish in the future.

Co-authorship network of co-authors of David Sinclair

This figure shows the co-authorship network connecting the top 25 collaborators of David Sinclair. A scholar is included among the top collaborators of David Sinclair based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David Sinclair. David Sinclair is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Vera, Daniel L., Patrick Griffin, Don Leigh, et al.. (2025). Multiomic clocks to predict phenotypic age in mice. The Journals of Gerontology Series A. 80(11).
2.
O’Donovan, Sinead M., David Sinclair, Kathleen A. Grant, et al.. (2024). Extracellular matrix abnormalities in the hippocampus of subjects with substance use disorder. Translational Psychiatry. 14(1). 115–115. 8 indexed citations
3.
Sinclair, David. (2024). A bile acid could explain how calorie restriction slows ageing. Nature. 643(8070). 38–40. 1 indexed citations
4.
Kim, Lynn‐Jee, Greg C. Smith, Catherine Li, et al.. (2023). Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation. FEBS Letters. 597(17). 2196–2220. 15 indexed citations
5.
Karg, Margarete M., Yuancheng Ryan Lu, James R. Cameron, et al.. (2023). Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma. Cellular Reprogramming. 25(6). 288–299. 12 indexed citations
6.
Bosch, Justin A., Berrak Uğur, Zhongyuan Zuo, et al.. (2022). Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila. eLife. 11. 6 indexed citations
7.
Schultz, Michael, Alice E. Kane, Sarah J. Mitchell, et al.. (2020). Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty. Nature Communications. 11(1). 5143–5143. 3 indexed citations
8.
Schultz, Michael, Alice E. Kane, Sarah J. Mitchell, et al.. (2020). Age and life expectancy clocks based on machine learning analysis of mouse frailty. Nature Communications. 11(1). 4618–4618. 83 indexed citations
9.
Kliner, Merav, A. Keenan, David Sinclair, Sam Ghebrehewet, & Paul Garner. (2016). Influenza vaccination for healthcare workers in the UK: appraisal of systematic reviews and policy options. BMJ Open. 6(9). e012149–e012149. 24 indexed citations
10.
North, Brian J., Michael A. Rosenberg, Karthik B. Jeganathan, et al.. (2014). SIRT 2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO Journal. 33(13). 1438–1453. 192 indexed citations
11.
Sinclair, David, et al.. (2014). The “Metabolic Winter” Hypothesis: A Cause of the Current Epidemics of Obesity and Cardiometabolic Disease. Metabolic Syndrome and Related Disorders. 12(7). 355–361. 13 indexed citations
12.
Michán, Shaday, Yan Li, Edoardo Parrella, et al.. (2010). SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity. Journal of Neuroscience. 30(29). 9695–9707. 446 indexed citations
13.
Hafner, Angela, Jing Dai, Ana P. Gomes, et al.. (2010). Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging. 2(12). 914–923. 437 indexed citations
14.
Baur, Joseph A. & David Sinclair. (2008). What is Xenohormesis?. American Journal of Pharmacology and Toxicology. 3(1). 152–159. 24 indexed citations
15.
Firestein, Ron, Gil Blander, Shaday Michán, et al.. (2008). The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth. PLoS ONE. 3(4). e2020–e2020. 477 indexed citations
16.
Lamming, Dudley W., Magda Latorre‐Esteves, Oliver Medvedik, et al.. (2005). HST2 Mediates SIR2 -Independent Life-Span Extension by Calorie Restriction. Science. 309(5742). 1861–1864. 185 indexed citations
17.
Cohen, Haim, Christine Miller, Kevin J. Bitterman, et al.. (2004). Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase. Science. 305(5682). 390–392. 1587 indexed citations breakdown →
18.
Brunet, Anne, Lora B. Sweeney, James Fitzhugh Sturgill, et al.. (2004). Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase. Science. 303(5666). 2011–2015. 2730 indexed citations breakdown →
19.
Kouchnarenko, Olga, et al.. (2003). Automatic Approximation for the Verification of Cryptographic Protocols. HAL (Le Centre pour la Communication Scientifique Directe). 1 indexed citations
20.
Sinclair, David. (1973). The Heart and the Vascular System in Ancient Greek Medicine from Alcmaeon to Galen. Journal of Anatomy. 115. 134–134. 95 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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