Alfred L. Goldberg

85.8k total citations · 26 hit papers
369 papers, 67.3k citations indexed

About

Alfred L. Goldberg is a scholar working on Molecular Biology, Cell Biology and Oncology. According to data from OpenAlex, Alfred L. Goldberg has authored 369 papers receiving a total of 67.3k indexed citations (citations by other indexed papers that have themselves been cited), including 297 papers in Molecular Biology, 119 papers in Cell Biology and 84 papers in Oncology. Recurrent topics in Alfred L. Goldberg's work include Ubiquitin and proteasome pathways (158 papers), Peptidase Inhibition and Analysis (75 papers) and Endoplasmic Reticulum Stress and Disease (65 papers). Alfred L. Goldberg is often cited by papers focused on Ubiquitin and proteasome pathways (158 papers), Peptidase Inhibition and Analysis (75 papers) and Endoplasmic Reticulum Stress and Disease (65 papers). Alfred L. Goldberg collaborates with scholars based in United States, United Kingdom and Germany. Alfred L. Goldberg's co-authors include Kenneth L. Rock, Stewart H. Lecker, Alexei F. Kisselev, Do Hee Lee, William E. Mitch, J. Fred Dice, R. Thomas Jagoe, Marco Sandri, Lloyd Waxman and Jinghui Zhao and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Alfred L. Goldberg

365 papers receiving 65.3k citations

Hit Papers

Foxo Transcription Factors Induce th... 1974 2026 1991 2008 2004 1994 2003 2007 1974 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy
    2004 2.4k citations Marco Sandri, Alfred L. Goldberg et al. Cell profile →
  2. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
    1994 2.2k citations Kenneth L. Rock, Alfred L. Goldberg et al. Cell profile →
  3. Protein degradation and protection against misfolded or damaged proteins
    2003 1.7k citations Alfred L. Goldberg profile →
  4. FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
    2007 1.6k citations Giulia Milan, Jinghui Zhao et al. profile →
  5. Intracellular Protein Degradation in Mammalian and Bacterial Cells
    1974 1.5k citations Alfred L. Goldberg et al. profile →
  6. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
    2001 1.4k citations Ami Navon, Alfred L. Goldberg et al. Proceedings of the National Academy of Sciences profile →
  7. Proteasome inhibitors: valuable new tools for cell biologists
    1998 1.3k citations Do Hee Lee, Alfred L. Goldberg profile →
  8. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
    2004 1.3k citations Vickie E. Baracos, Alfred L. Goldberg et al. profile →
  9. FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells
    2007 1.2k citations Jinghui Zhao, Jeffrey J. Brault et al. profile →
  10. Proteasome inhibitors: from research tools to drug candidates
    2001 962 citations Alexei F. Kisselev, Alfred L. Goldberg profile →
  11. Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States
    2006 959 citations Alfred L. Goldberg et al. profile →
  12. Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway
    1996 917 citations Alfred L. Goldberg et al. profile →
  13. Muscle wasting in disease: molecular mechanisms and promising therapies
    2014 832 citations Shenhav Cohen, Alfred L. Goldberg et al. profile →
  14. PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
    2006 802 citations Marco Sandri, Alfred L. Goldberg et al. Proceedings of the National Academy of Sciences profile →
  15. Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.
    1975 786 citations Alfred L. Goldberg et al. Journal of Biological Chemistry profile →
  16. Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes
    1986 774 citations Alfred L. Goldberg et al. profile →
  17. Multiple proteolytic systems, including the proteasome, contribute to CFTR processing
    1995 749 citations Alfred L. Goldberg et al. Cell profile →
  18. DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES
    1999 733 citations Kenneth L. Rock, Alfred L. Goldberg profile →
  19. Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
    2010 731 citations Alfred L. Goldberg et al. Cell profile →
  20. The Logic of the 26S Proteasome
    2017 658 citations G. Collins, Alfred L. Goldberg Cell profile →
  21. Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy
    2015 533 citations Giulia Milan, Vanina Romanello et al. Nature Communications profile →
  22. Trehalose Accumulation during Cellular Stress Protects Cells and Cellular Proteins from Damage by Oxygen Radicals
    2001 531 citations Do Hee Lee, Alfred L. Goldberg et al. Journal of Biological Chemistry profile →
  23. Stimulation of Muscle Protein Degradation and Prostaglandin E2Release by Leukocytic Pyrogen (Interleukin-1)
    1983 529 citations Vickie E. Baracos, Alfred L. Goldberg et al. profile →
  24. Proteolysis, proteasomes and antigen presentation
    1992 485 citations Alfred L. Goldberg, Kenneth L. Rock profile →
  25. A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.
    1977 460 citations Alfred L. Goldberg et al. Proceedings of the National Academy of Sciences profile →
  26. Altered peptidase and viral-specific T cell response in LMP2 mutant mice
    1994 366 citations Kenneth L. Rock, Alfred L. Goldberg et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Alfred L. Goldberg United States 138 49.6k 17.3k 11.9k 10.2k 9.1k 369 67.3k
Steven P. Gygi United States 166 88.4k 1.8× 18.1k 1.0× 15.6k 1.3× 14.5k 1.4× 12.4k 1.4× 695 121.5k
Harvey F. Lodish United States 150 49.1k 1.0× 12.2k 0.7× 15.7k 1.3× 11.1k 1.1× 9.4k 1.0× 646 82.0k
Roger J. Davis United States 146 62.3k 1.3× 11.7k 0.7× 8.3k 0.7× 7.5k 0.7× 15.6k 1.7× 572 92.6k
Paul Tempst United States 143 62.1k 1.3× 8.7k 0.5× 7.7k 0.6× 4.9k 0.5× 8.3k 0.9× 320 80.8k
George D. Yancopoulos United States 161 55.1k 1.1× 9.9k 0.6× 12.2k 1.0× 4.5k 0.4× 14.3k 1.6× 430 103.1k
Simon C. Watkins United States 126 28.3k 0.6× 6.0k 0.3× 7.8k 0.7× 6.7k 0.7× 5.8k 0.6× 788 59.2k
Hediye Erdjument‐Bromage United States 125 53.4k 1.1× 7.7k 0.4× 6.7k 0.6× 4.7k 0.5× 7.4k 0.8× 285 68.1k
Kun‐Liang Guan United States 148 57.9k 1.2× 32.0k 1.8× 7.2k 0.6× 14.3k 1.4× 10.0k 1.1× 422 89.1k
D. Grahame Hardie United Kingdom 128 50.5k 1.0× 5.6k 0.3× 15.9k 1.3× 10.2k 1.0× 3.7k 0.4× 450 71.0k
Randal J. Kaufman United States 146 42.0k 0.8× 39.1k 2.3× 6.4k 0.5× 21.4k 2.1× 3.8k 0.4× 466 82.2k

Countries citing papers authored by Alfred L. Goldberg

Since Specialization
Citations

This map shows the geographic impact of Alfred L. Goldberg's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfred L. Goldberg with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfred L. Goldberg more than expected).

Fields of papers citing papers by Alfred L. Goldberg

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfred L. Goldberg. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfred L. Goldberg. The network helps show where Alfred L. Goldberg may publish in the future.

Co-authorship network of co-authors of Alfred L. Goldberg

This figure shows the co-authorship network connecting the top 25 collaborators of Alfred L. Goldberg. A scholar is included among the top collaborators of Alfred L. Goldberg based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alfred L. Goldberg. Alfred L. Goldberg is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Dear, Alexander J., Gonzalo Garcia, Georg Meisl, et al.. (2024). Maximum entropy determination of mammalian proteome dynamics. Proceedings of the National Academy of Sciences. 121(18). e2313107121–e2313107121.
2.
Vahidi, Siavash, Zev A. Ripstein, Enrico Rennella, et al.. (2020). An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR. Proceedings of the National Academy of Sciences. 117(11). 5895–5906. 44 indexed citations
3.
Li, Mi, Olga Kandror, Tatos Akopian, et al.. (2016). Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis. Journal of Biological Chemistry. 291(14). 7465–7476. 38 indexed citations
4.
Milan, Giulia, Vanina Romanello, Francesca Pescatore, et al.. (2015). Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy. Nature Communications. 6(1). 6670–6670. 533 indexed citations breakdown →
5.
Raju, Ravikiran M., Meera Unnikrishnan, Daniel H. F. Rubin, et al.. (2012). Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection. PLoS Pathogens. 8(2). e1002511–e1002511. 141 indexed citations
6.
Nijhawan, Deepak, Travis Zack, Yin Ren, et al.. (2012). Cancer Vulnerabilities Unveiled by Genomic Loss. Cell. 150(4). 842–854. 161 indexed citations
7.
Smith, David M., Hugo Fraga, Christian Robson de Souza Reis, Galit Kafri, & Alfred L. Goldberg. (2011). ATP Binds to Proteasomal ATPases in Pairs with Distinct Functional Effects, Implying an Ordered Reaction Cycle. Cell. 144(4). 526–538. 158 indexed citations
8.
Peth, Andreas, Tomoaki Uchiki, & Alfred L. Goldberg. (2010). ATP-Dependent Steps in the Binding of Ubiquitin Conjugates to the 26S Proteasome that Commit to Degradation. Molecular Cell. 40(4). 671–681. 136 indexed citations
9.
Cohen, Shenhav, Jeffrey J. Brault, Steven P. Gygi, et al.. (2009). During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. The Journal of Cell Biology. 185(6). 1083–1095. 472 indexed citations
10.
Kim, Hyoung Tae, Kwang Pyo Kim, Tomoaki Uchiki, Steven P. Gygi, & Alfred L. Goldberg. (2009). S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains. The EMBO Journal. 28(13). 1867–1877. 67 indexed citations
11.
Kisselev, Alexei F., Alice Callard, & Alfred L. Goldberg. (2006). Importance of the Different Proteolytic Sites of the Proteasome and the Efficacy of Inhibitors Varies with the Protein Substrate. Journal of Biological Chemistry. 281(13). 8582–8590. 342 indexed citations
12.
York, Ian A., et al.. (2006). Tripeptidyl Peptidase II Is the Major Peptidase Needed to Trim Long Antigenic Precursors, but Is Not Required for Most MHC Class I Antigen Presentation. The Journal of Immunology. 177(3). 1434–1443. 74 indexed citations
13.
Chang, Shih‐Chung, Frank Momburg, Nidhi Bhutani, & Alfred L. Goldberg. (2005). The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a “molecular ruler” mechanism. Proceedings of the National Academy of Sciences. 102(47). 17107–17112. 259 indexed citations
14.
Kandror, Olga, et al.. (2002). Trehalose synthesis is induced upon exposure of Escherichia coli to cold and is essential for viability at low temperatures. Proceedings of the National Academy of Sciences. 99(15). 9727–9732. 320 indexed citations
15.
Navon, Ami & Alfred L. Goldberg. (2001). Proteins Are Unfolded on the Surface of the ATPase Ring before Transport into the Proteasome. Molecular Cell. 8(6). 1339–1349. 173 indexed citations
16.
Kandror, Olga, Michael Y. Sherman, & Alfred L. Goldberg. (1999). Rapid Degradation of an Abnormal Protein in Escherichia coli Proceeds through Repeated Cycles of Association with GroEL. Journal of Biological Chemistry. 274(53). 37743–37749. 35 indexed citations
17.
Chain, Daniel G., Andrea Casadio, Samuel Schacher, et al.. (1999). Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia. Neuron. 22(1). 147–156. 144 indexed citations
18.
Lee, Do Hee & Alfred L. Goldberg. (1998). Proteasome Inhibitors Cause Induction of Heat Shock Proteins and Trehalose, Which Together Confer Thermotolerance in Saccharomyces cerevisiae. Molecular and Cellular Biology. 18(1). 30–38. 190 indexed citations
19.
Solomon, Vered & Alfred L. Goldberg. (1996). Importance of the ATP-Ubiquitin-Proteasome Pathway in the Degradation of Soluble and Myofibrillar Proteins in Rabbit Muscle Extracts. Journal of Biological Chemistry. 271(43). 26690–26697. 340 indexed citations
20.
Goldberg, Alfred L., Ísis do Carmo Kettelhut, K. Furuno, Julie M. Fagan, & Vickie E. Baracos. (1988). Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines.. Journal of Clinical Investigation. 81(5). 1378–1383. 108 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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