Frederick W. Alt

95.9k total citations · 31 hit papers
486 papers, 73.8k citations indexed

About

Frederick W. Alt is a scholar working on Immunology, Molecular Biology and Oncology. According to data from OpenAlex, Frederick W. Alt has authored 486 papers receiving a total of 73.8k indexed citations (citations by other indexed papers that have themselves been cited), including 282 papers in Immunology, 239 papers in Molecular Biology and 97 papers in Oncology. Recurrent topics in Frederick W. Alt's work include T-cell and B-cell Immunology (229 papers), Immune Cell Function and Interaction (170 papers) and DNA Repair Mechanisms (115 papers). Frederick W. Alt is often cited by papers focused on T-cell and B-cell Immunology (229 papers), Immune Cell Function and Interaction (170 papers) and DNA Repair Mechanisms (115 papers). Frederick W. Alt collaborates with scholars based in United States, France and Germany. Frederick W. Alt's co-authors include Raúl Mostoslavsky, George D. Yancopoulos, John Manis, Laurie A. Davidson, Craig H. Bassing, T. Keith Blackwell, Jayanta Chaudhuri, Ronald A. DePinho, David O. Ferguson and Katrin F. Chua and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Frederick W. Alt

483 papers receiving 72.5k citations

Hit Papers

Stress-Dependent Regulation of FOXO Trans... 1980 2026 1995 2010 2004 2010 2008 1994 2008 500 1000 1.5k 2.0k 2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
    2004 2.7k citations Anne Brunet, Lora B. Sweeney et al. Science profile →
  2. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
    2010 1.4k citations Frederick W. Alt et al. Nature profile →
  3. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
    2008 1.2k citations Raúl Mostoslavsky, Frederick W. Alt et al. Proceedings of the National Academy of Sciences profile →
  4. An early haematopoietic defect in mice lacking the transcription factor GATA-2
    1994 1.1k citations Frederick W. Alt, Stuart H. Orkin et al. Nature profile →
  5. SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation
    2008 1.1k citations Raúl Mostoslavsky, Frederick W. Alt et al. Cell profile →
  6. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
    2007 1.1k citations Raúl Mostoslavsky, Frederick W. Alt et al. profile →
  7. Plasma cell differentiation requires the transcription factor XBP-1
    2001 1.0k citations John Manis, Frederick W. Alt et al. Nature profile →
  8. Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
    2007 1.0k citations Frederick W. Alt, Raúl Mostoslavsky et al. Molecular and Cellular Biology profile →
  9. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.
    1996 939 citations Frederick W. Alt et al. Proceedings of the National Academy of Sciences profile →
  10. SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
    2006 930 citations Raúl Mostoslavsky, Andrew Murphy et al. Cell profile →
  11. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
    2003 925 citations Hwei-Ling Cheng, Raúl Mostoslavsky et al. Proceedings of the National Academy of Sciences profile →
  12. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
    1995 903 citations Frederick W. Alt et al. profile →
  13. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
    1995 725 citations Frederick W. Alt et al. Cell profile →
  14. DNA Repair, Genome Stability, and Aging
    2005 720 citations Katrin F. Chua, Raúl Mostoslavsky et al. Cell profile →
  15. The Mechanism and Regulation of Chromosomal V(D)J Recombination
    2002 709 citations Craig H. Bassing, Wojciech Swat et al. Cell profile →
  16. SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
    2008 649 citations Raúl Mostoslavsky, Frederick W. Alt et al. Cell profile →
  17. Ordered rearrangement of immunoglobulin heavy chain variable region segments.
    1984 610 citations Frederick W. Alt, George D. Yancopoulos et al. profile →
  18. Transposition and amplification of oncogene-related sequences in human neuroblastomas
    1983 607 citations Frederick W. Alt et al. Cell profile →
  19. Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    2003 605 citations Ming Tian, Katrin F. Chua et al. Nature profile →
  20. The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages
    1996 591 citations Catherine Porcher, Wojciech Swat et al. Cell profile →
  21. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination
    1994 555 citations Frederick W. Alt et al. Science profile →
  22. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines
    1984 549 citations George D. Yancopoulos, Frederick W. Alt et al. Nature profile →
  23. The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo
    1996 532 citations Frederick W. Alt et al. Cell profile →
  24. Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α
    1999 531 citations Frederick W. Alt et al. Science profile →
  25. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
    2014 529 citations Richard L. Frock, Jiazhi Hu et al. profile →
  26. Development of the Primary Antibody Repertoire
    1987 518 citations Frederick W. Alt, George D. Yancopoulos et al. Science profile →
  27. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
    2006 509 citations Hwei-Ling Cheng, Frederick W. Alt et al. profile →
  28. SIRT1 controls endothelial angiogenic functions during vascular growth
    2007 508 citations Raúl Mostoslavsky, Frederick W. Alt et al. profile →
  29. Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends
    1980 483 citations Frederick W. Alt Cell profile →
  30. Differential expression of myc family genes during murine development
    1986 480 citations George D. Yancopoulos, Frederick W. Alt et al. Nature profile →
  31. Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
    2022 162 citations Barton F. Haynes, Frederick W. Alt et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Frederick W. Alt United States 153 41.6k 26.9k 12.4k 7.9k 7.6k 486 73.8k
Roderick T. Bronson United States 139 46.0k 1.1× 11.5k 0.4× 23.2k 1.9× 5.8k 0.7× 1.7k 0.2× 544 77.8k
Ronald A. DePinho United States 149 56.0k 1.3× 9.8k 0.4× 23.0k 1.9× 16.5k 2.1× 1.8k 0.2× 417 86.1k
Paul Tempst United States 143 62.1k 1.5× 9.0k 0.3× 8.3k 0.7× 7.7k 1.0× 1.0k 0.1× 320 80.8k
Kun‐Liang Guan United States 148 57.9k 1.4× 7.3k 0.3× 10.0k 0.8× 7.2k 0.9× 3.0k 0.4× 422 89.1k
Pier Paolo Pandolfi United States 139 61.9k 1.5× 10.6k 0.4× 13.1k 1.1× 4.8k 0.6× 837 0.1× 449 80.3k
Chu‐Xia Deng United States 119 31.1k 0.7× 2.7k 0.1× 9.0k 0.7× 5.3k 0.7× 5.1k 0.7× 414 47.2k
Nahum Sonenberg Canada 160 77.5k 1.9× 9.1k 0.3× 7.1k 0.6× 4.9k 0.6× 494 0.1× 673 97.8k
Hediye Erdjument‐Bromage United States 125 53.4k 1.3× 6.9k 0.3× 7.4k 0.6× 6.7k 0.8× 987 0.1× 285 68.1k
John Blenis United States 101 39.2k 0.9× 6.5k 0.2× 8.2k 0.7× 4.7k 0.6× 705 0.1× 222 51.9k
Richard G. Pestell United States 124 33.3k 0.8× 4.7k 0.2× 15.2k 1.2× 3.7k 0.5× 894 0.1× 465 49.9k

Countries citing papers authored by Frederick W. Alt

Since Specialization
Citations

This map shows the geographic impact of Frederick W. Alt's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frederick W. Alt with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frederick W. Alt more than expected).

Fields of papers citing papers by Frederick W. Alt

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frederick W. Alt. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frederick W. Alt. The network helps show where Frederick W. Alt may publish in the future.

Co-authorship network of co-authors of Frederick W. Alt

This figure shows the co-authorship network connecting the top 25 collaborators of Frederick W. Alt. A scholar is included among the top collaborators of Frederick W. Alt based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Frederick W. Alt. Frederick W. Alt is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Zhang, Yiwen, Zhaoqing Ba, Jiangman Lou, et al.. (2024). Molecular basis for differential Igk versus Igh V(D)J joining mechanisms. Nature. 630(8015). 189–197. 5 indexed citations
2.
Luo, Sai, Changbin Jing, Adam Yongxin Ye, et al.. (2022). Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors. Proceedings of the National Academy of Sciences. 120(1). e2217883120–e2217883120. 11 indexed citations
3.
Liang, Zhuoyi, Vipul Kumar, Sherry Lin, et al.. (2021). Ku70 suppresses alternative end joining in G1-arrested progenitor B cells. Proceedings of the National Academy of Sciences. 118(21). 21 indexed citations
4.
Zhang, Xuefei, Hye Suk Yoon, Aimee Williams, Nia Kyritsis, & Frederick W. Alt. (2021). Physiological role of the 3′IgH CBEs super-anchor in antibody class switching. Proceedings of the National Academy of Sciences. 118(3). 19 indexed citations
5.
Tena, Aseda, et al.. (2020). Induction of recurrent break cluster genes in neural progenitor cells differentiated from embryonic stem cells in culture. Proceedings of the National Academy of Sciences. 117(19). 10541–10546. 11 indexed citations
6.
Frock, Richard L., Zhou Du, Jiazhi Hu, et al.. (2016). Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. The Journal of Experimental Medicine. 213(9). 1921–1936. 29 indexed citations
7.
Ba, Zhaoqing, Fei‐Long Meng, Monica Gostissa, et al.. (2015). A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1. Cancer Immunology Research. 3(6). 641–649. 3 indexed citations
8.
Tepsuporn, Suprawee, Jiazhi Hu, Monica Gostissa, & Frederick W. Alt. (2014). Mechanisms That Can Promote Peripheral B-cell Lymphoma in ATM-Deficient Mice. Cancer Immunology Research. 2(9). 857–866. 14 indexed citations
9.
Gostissa, Monica, Jeffery L. Kutok, Scott J. Rodig, et al.. (2013). Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas. Proceedings of the National Academy of Sciences. 110(8). 2934–2939. 25 indexed citations
10.
Wesemann, Duane R., Andrew J. Portuguese, Jennifer M. Magee, et al.. (2012). Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells. Proceedings of the National Academy of Sciences. 109(34). 13745–13750. 14 indexed citations
11.
Wesemann, Duane R., Jennifer M. Magee, Cristian Boboilă, et al.. (2011). Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. The Journal of Experimental Medicine. 208(13). 2733–2746. 84 indexed citations
12.
Giallourakis, Cosmas, Andrew Franklin, Chunguang Guo, et al.. (2010). Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proceedings of the National Academy of Sciences. 107(51). 22207–22212. 27 indexed citations
13.
Franco, Sonia, et al.. (2008). DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. The Journal of Experimental Medicine. 205(3). 557–564. 78 indexed citations
14.
Zarrin, Ali A., Catherine Del Vecchio Fitz, Megan Gleason, et al.. (2006). Antibody Class Switching Mediated by Yeast Endonuclease-Generated DNA Breaks. Science. 315(5810). 377–381. 78 indexed citations
15.
Kang, Jian, David O. Ferguson, Hoseok Song, et al.. (2005). Functional Interaction of H2AX, NBS1, and p53 in ATM-Dependent DNA Damage Responses and Tumor Suppression. Molecular and Cellular Biology. 25(2). 661–670. 104 indexed citations
16.
Zarrin, Ali A., et al.. (2005). Influence of switch region length on immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences. 102(7). 2466–2470. 43 indexed citations
17.
O’Neil, Jennifer, Jennifer A. Calvo, Keith McKenna, et al.. (2005). Activating Notch1 mutations in mouse models of T-ALL. Blood. 107(2). 781–785. 177 indexed citations
18.
Brunet, Anne, Lora B. Sweeney, James Fitzhugh Sturgill, et al.. (2004). Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase. Science. 303(5666). 2011–2015. 2730 indexed citations breakdown →
19.
Porcher, Catherine, Wojciech Swat, Karen Rockwell, et al.. (1996). The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages. Cell. 86(1). 47–57. 591 indexed citations breakdown →
20.
Yancopoulos, George D., et al.. (1990). Methods for cloning and analysis of eukaryotic genes. 63 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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