Frederick W. Alt

95.9k citations

486 papers · 73.8k indexed · 31 hit papers · h-index 153

Impact in

Geriatrics and Gerontology top 0.01%
- Sirtuins and Resveratrol in Medicine
Immunology top 0.01%
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses

Papers in

Immunology 282
- T-cell and B-cell Immunology 229
- Immune Cell Function and Interaction 170
- Immunotherapy and Immune Responses 47
- Immunodeficiency and Autoimmune Disorders 42
Aging 9

Co-authors: Raúl Mostoslavsky George D. Yancopoulos John Manis Laurie A. Davidson Craig H. Bassing T. Keith Blackwell Jayanta Chaudhuri Ronald A. DePinho
Journals: Proceedings of the National Academy of Sciences (74 papers)Nature (45 papers)The Journal of Experimental Medicine (39 papers)Cell (35 papers)Molecular and Cellular Biology (34 papers)
Partner nations: United States Germany France

In The Last Decade

Frederick W. Alt

483 papers receiving 72.5k citations

Hit Papers

15 papers align trajectories log scale

Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies 2022 · 162 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2022 Nature reviews. Immunology
2014 Nature Biotechnology
2010 Nature
2008 Proceedings of the National Academy of Sciences
2008 Cell
2008 Cell
2007 Genes & Development
2007 The EMBO Journal
2007 Molecular and Cellular Biology
2006 Genes & Development
2006 Cell
2005 Cell
2004 Science
2003 Nature
2003 Proceedings of the National Academy of Sciences
2002 Cell
2001 Nature
1999 Science
1996 Cell
1996 Cell
1996 Proceedings of the National Academy of Sciences
1995 Cell
1995 Immunity
1994 Nature
1994 Science
1987 Science
1986 Nature
1984 The EMBO Journal
1984 Nature
1983 Cell
1980 Cell

Peers

Countries citing papers authored by Frederick W. Alt

Since Specialization

Citations

This map shows the geographic impact of Frederick W. Alt's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frederick W. Alt with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frederick W. Alt more than expected).

Fields of papers citing papers by Frederick W. Alt

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frederick W. Alt. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frederick W. Alt. The network helps show where Frederick W. Alt may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Frederick W. Alt, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Frederick W. Alt Line = papers co-authored together Frederick W. Alt links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors Proceedings of the National Academy of Sciences ·Sai Luo, Changbin Jing, Adam Yongxin Ye, Sven Kratochvil, Christopher A. Cottrell, Jahyun Koo, Aimee Williams, Luis Giraldo-Alvarado, Himanshu Batra, Kaiyuan Zhao, Oleksandr Kalyuzhniy, Rebecca Stein, Alessandro Barbieri, John Manis, Barton F. Haynes, William R. Schief, Facundo D. Batista, Ming Tian, Frederick W. Alt	2022	11
2	Ku70 suppresses alternative end joining in G1-arrested progenitor B cells Proceedings of the National Academy of Sciences ·Zhuoyi Liang, Vipul Kumar, J. A. Mackintosh, Shabnam Sarah Farivar, Karl, Sherry Lin, Jiangman Lou, Jianqiao Hu, Adam Yongxin Ye, Cristian Boboilă, Frederick W. Alt, Richard L. Frock	2021	21
3	Physiological role of the 3′IgH CBEs super-anchor in antibody class switching Proceedings of the National Academy of Sciences ·Xuefei Zhang, Hye Suk Yoon, Aimee Williams, Nia Kyritsis, Frederick W. Alt	2021	19
4	Parp3 promotes long-range end joining in murine cells Proceedings of the National Academy of Sciences ·Jacob V. Layer, John P. Cleary, Alexander J. Brown, Kristen E. Stevenson, Sara Morrow, Alexandria Van Scoyk, Rafael B. Blasco, Elif Karaca, Fei‐Long Meng, Richard L. Frock, Trevor Tivey, Sunhee S. Kim, Chaiyong Chuchart, Roberto Chiarle, Frederick W. Alt, Steven A. Roberts, David M. Weinstock, Tovah A. Day	2018	12
5	Highly sensitive and unbiased approach for elucidating antibody repertoires Proceedings of the National Academy of Sciences ·Sherry Lin, Zhaoqing Ba, Zhou Du, Yu Zhang, Jiazhi Hu, Frederick W. Alt	2016	42
6	Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development The Journal of Experimental Medicine ·戴良图, Richard L. Frock, Zhou Du, Jiazhi Hu, Liang Chen, Michael S. Krangel, Frederick W. Alt	2016	29
7	A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1 Cancer Immunology Research ·Zhaoqing Ba, Fei‐Long Meng, Monica Gostissa, Arie Israel, Qiang Ke, Zhe Wang, Afilya Hasanbala Gyzy Balayeva, Yuko Fujiwara, Klaus Rajewsky, Baochun Zhang, Frederick W. Alt	2015	3
8	Mechanisms That Can Promote Peripheral B-cell Lymphoma in ATM-Deficient Mice Cancer Immunology Research ·Suprawee Tepsuporn, Jiazhi Hu, Monica Gostissa, Frederick W. Alt	2014	14
9	Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas Proceedings of the National Academy of Sciences ·Monica Gostissa, Carlton J. Spotswood, V. V. Bryuzgin, Jeffery L. Kutok, Scott J. Rodig, Herbert C. Morse, Craig H. Bassing, Frederick W. Alt	2013	25
10	Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells Proceedings of the National Academy of Sciences ·Duane R. Wesemann, Andrew J. Portuguese, Jennifer M. Magee, Michael P. Gallagher, Xiaolong Zhou, Rohit A. Panchakshari, Frederick W. Alt	2012	14
11	Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program Proceedings of the National Academy of Sciences ·Michael R. Green, Stefano Monti, Riccardo Dalla‐Favera, Laura Pasqualucci, Nicole C. Walsh, Marc Schmidt‐Supprian, Jeffery L. Kutok, Scott J. Rodig, Donna Neuberg, Klaus Rajewsky, Todd R. Golub, Frederick W. Alt, Margaret A. Shipp, John Manis	2011	42
12	Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination The Journal of Experimental Medicine ·Duane R. Wesemann, Jennifer M. Magee, Cristian Boboilă, Dinis Pedro Calado, Michael P. Gallagher, Andrew J. Portuguese, John Manis, Xiaolong Zhou, Mike Recher, Klaus Rajewsky, Luigi D. Notarangelo, Frederick W. Alt	2011	84
13	Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination Proceedings of the National Academy of Sciences ·Cosmas Giallourakis, Andrew Franklin, Chunguang Guo, Hwei-Ling Cheng, Hye Suk Yoon, Michael P. Gallagher, Thomas Perlot, Milena M. Andzelm, Andrew Murphy, Lynn E. Macdonald, George D. Yancopoulos, Frederick W. Alt	2010	27
14	DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination The Journal of Experimental Medicine ·Sonia Franco, Michael Murphy, Gang Li, Tiffany M. Borjeson, Cristian Boboilă, Frederick W. Alt	2008	78
15	Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions Proceedings of the National Academy of Sciences ·Thomas Perlot, Gang Li, Frederick W. Alt	2008	51
16	Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching The Journal of Experimental Medicine ·Jing Wang, Frederick W. Alt, Monica Gostissa, Abhishek Datta, Michael Murphy, Marat Alimzhanov, Kristen M. Coakley, Klaus Rajewsky, John Manis, Catherine T. Yan	2008	58
17	Antibody Class Switching Mediated by Yeast Endonuclease-Generated DNA Breaks Science ·Ali A. Zarrin, Catherine Del Vecchio Fitz, 黄家周, Megan Gleason, Payam Zarin, Ming Tian, Frederick W. Alt	2006	78
18	Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer Proceedings of the National Academy of Sciences ·Gustavo Mostoslavsky, Attila J. Fabian, Seán Rooney, Frederick W. Alt, Richard C. Mulligan	2006	129
19	Functional Interaction of H2AX, NBS1, and p53 in ATM-Dependent DNA Damage Responses and Tumor Suppression Molecular and Cellular Biology ·Jian Kang, David O. Ferguson, Hoseok Song, Craig H. Bassing, Mark Eckersdorff, Frederick W. Alt, Yang Xu	2005	104
20	Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase Science ·Anne Brunet, Lora B. Sweeney, James Fitzhugh Sturgill, Katrin F. Chua, Paul L. Greer, Yingxi Lin, Hien Tran, Sarah E. Ross, Raúl Mostoslavsky, Haim Cohen, Linda Hu, Hwei-Ling Cheng, Mark P. Jedrychowski, Steven P. Gygi, David Sinclair, Frederick W. Alt, Michael E. Greenberg Hit paper breakdown →	2004	2730

About Frederick W. Alt

Frederick W. Alt is a scholar working on Immunology, Aging, Geriatrics and Gerontology, Oncology and Molecular Biology, having authored 486 papers that have together received 73.8k indexed citations. Recurring topics across this work include T-cell and B-cell Immunology (229 papers), Immune Cell Function and Interaction (170 papers), DNA Repair Mechanisms (115 papers), Monoclonal and Polyclonal Antibodies Research (73 papers), CRISPR and Genetic Engineering (51 papers), Immunotherapy and Immune Responses (47 papers), Immunodeficiency and Autoimmune Disorders (42 papers) and Cancer-related Molecular Pathways (29 papers). The work is most often cited by research in Geriatrics and Gerontology (7.6k citations), Immunology (26.9k citations), Aging (1.8k citations), Molecular Biology (41.6k citations) and Oncology (12.4k citations). Frederick W. Alt has collaborated with scholars based in United States, Germany and France. Frequent co-authors include Raúl Mostoslavsky, George D. Yancopoulos, John Manis, Laurie A. Davidson, Craig H. Bassing, T. Keith Blackwell, Jayanta Chaudhuri, Ronald A. DePinho, David O. Ferguson and Katrin F. Chua. Their work appears in journals such as Proceedings of the National Academy of Sciences, Nature, The Journal of Experimental Medicine, Cell and Molecular and Cellular Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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