Robert J. Lefkowitz

146.4k total citations · 87 hit papers
715 papers, 118.8k citations indexed

About

Robert J. Lefkowitz is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Animal Science and Zoology. According to data from OpenAlex, Robert J. Lefkowitz has authored 715 papers receiving a total of 118.8k indexed citations (citations by other indexed papers that have themselves been cited), including 643 papers in Molecular Biology, 345 papers in Cellular and Molecular Neuroscience and 128 papers in Animal Science and Zoology. Recurrent topics in Robert J. Lefkowitz's work include Receptor Mechanisms and Signaling (594 papers), Neuropeptides and Animal Physiology (267 papers) and Protein Kinase Regulation and GTPase Signaling (134 papers). Robert J. Lefkowitz is often cited by papers focused on Receptor Mechanisms and Signaling (594 papers), Neuropeptides and Animal Physiology (267 papers) and Protein Kinase Regulation and GTPase Signaling (134 papers). Robert J. Lefkowitz collaborates with scholars based in United States, Canada and France. Robert J. Lefkowitz's co-authors include Marc G. Caron, Louis M. Luttrell, Sudha K. Shenoy, Walter J. Koch, Richard T. Premont, Seungkirl Ahn, Kristen L. Pierce, Yehia Daaka, Jeffrey Benovic and Julie A. Pitcher and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Robert J. Lefkowitz

713 papers receiving 114.6k citations

Hit Papers

Seven-transmembrane receptors 1977 2026 1993 2009 2002 2005 1980 1999 2007 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Seven-transmembrane receptors
    2002 2.1k citations Robert J. Lefkowitz et al. profile →
  2. Transduction of Receptor Signals by ß-Arrestins
    2005 1.4k citations Robert J. Lefkowitz, Sudha K. Shenoy Science profile →
  3. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.
    1980 1.3k citations Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  4. β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
    1999 1.2k citations William E. Miller, Fang‐Tsyr Lin et al. Science profile →
  5. β-Arrestins and Cell Signaling
    2007 1.1k citations Scott M. DeWire, Seungkirl Ahn et al. profile →
  6. G PROTEIN–COUPLED RECEPTOR KINASES
    1998 1.1k citations Julie A. Pitcher, Robert J. Lefkowitz et al. profile →
  7. Turning off the signal: desensitization of β‐adrenergic receptor function
    1990 1.1k citations Marc G. Caron, Robert J. Lefkowitz et al. profile →
  8. A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.
    1993 1.1k citations Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  9. Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
    1997 1.1k citations Robert J. Lefkowitz et al. Nature profile →
  10. International Union of Pharmacology nomenclature of adrenoceptors.
    1994 1.0k citations Robert J. Lefkowitz et al. profile →
  11. Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
    1986 981 citations Brian K. Kobilka, Marc G. Caron et al. Nature profile →
  12. β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
    1990 972 citations Marc G. Caron, Robert J. Lefkowitz et al. Science profile →
  13. G Protein-coupled Receptors
    1998 902 citations Robert J. Lefkowitz Journal of Biological Chemistry profile →
  14. The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
    2002 878 citations Robert J. Lefkowitz et al. profile →
  15. Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
    1999 830 citations Laura Bohn, Robert J. Lefkowitz et al. Science profile →
  16. An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
    2005 796 citations Robert J. Lefkowitz, Raul R. Gainetdinov et al. Cell profile →
  17. μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
    2000 753 citations Laura Bohn, Raul R. Gainetdinov et al. Nature profile →
  18. Seven-transmembrane-spanning receptors and heart function
    2002 715 citations Howard A. Rockman, Walter J. Koch et al. Nature profile →
  19. β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
    2000 699 citations William E. Miller, Fang‐Tsyr Lin et al. Science profile →
  20. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
    1993 696 citations Robert J. Lefkowitz et al. profile →
  21. Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
    2001 688 citations Sudha K. Shenoy, Trudy A. Kohout et al. Science profile →
  22. Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
    2001 682 citations William E. Miller, Robert J. Lefkowitz et al. Proceedings of the National Academy of Sciences profile →
  23. Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor
    1987 677 citations Brian K. Kobilka, Marc G. Caron et al. Science profile →
  24. DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS
    2004 672 citations Raul R. Gainetdinov, Laura Bohn et al. profile →
  25. Teaching old receptors new tricks: biasing seven-transmembrane receptors
    2010 666 citations Sudarshan Rajagopal, Robert J. Lefkowitz et al. profile →
  26. International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update.
    1995 637 citations Robert J. Lefkowitz et al. profile →
  27. Chimeric α 2 -,β 2 -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity
    1988 636 citations Brian K. Kobilka, Marc G. Caron et al. Science profile →
  28. Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model
    1985 633 citations Robert J. Lefkowitz et al. Nature profile →
  29. β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor
    2005 616 citations Sudha K. Shenoy, Matthew T. Drake et al. Journal of Biological Chemistry profile →
  30. Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor
    1994 615 citations Howard A. Rockman, Robert J. Lefkowitz et al. Science profile →
  31. Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
    1995 611 citations Walter J. Koch, Howard A. Rockman et al. Science profile →
  32. Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors
    1992 605 citations Julie A. Pitcher, Marc G. Caron et al. Science profile →
  33. Regulation of tyrosine kinase cascades by G-protein-coupled receptors
    1999 595 citations Robert J. Lefkowitz et al. profile →
  34. Regulation of transmembrane signaling by receptor phosphorylation
    1987 579 citations Marc G. Caron, Robert J. Lefkowitz et al. Cell profile →
  35. β-arrestin-mediated receptor trafficking and signal transduction
    2011 575 citations Sudha K. Shenoy, Robert J. Lefkowitz profile →
  36. cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
    1987 554 citations Brian K. Kobilka, Marc G. Caron et al. Proceedings of the National Academy of Sciences profile →
  37. Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.
    1982 552 citations Robert J. Lefkowitz et al. profile →
  38. Beta-adrenergic receptors: biochemical mechanisms of physiological regulation
    1984 548 citations Marc G. Caron, Robert J. Lefkowitz et al. profile →
  39. Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
    2003 547 citations Seungkirl Ahn, Sudha K. Shenoy et al. Proceedings of the National Academy of Sciences profile →
  40. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.
    1986 524 citations Robert J. Lefkowitz et al. Proceedings of the National Academy of Sciences profile →
  41. GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling
    2006 521 citations Robert J. Lefkowitz et al. profile →
  42. Biased signalling: from simple switches to allosteric microprocessors
    2018 514 citations Robert J. Lefkowitz, Sudarshan Rajagopal et al. profile →
  43. Palmitoylation of the human β2-adrenergic receptor
    1989 511 citations Marc G. Caron, Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  44. A family of receptors coupled to guanine nucleotide regulatory proteins
    1987 507 citations Marc G. Caron, Robert J. Lefkowitz et al. profile →
  45. Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
    1995 497 citations Brian E. Hawes, Kazushige Touhara et al. Nature profile →
  46. Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
    1988 497 citations Robert J. Lefkowitz, Brian K. Kobilka et al. Proceedings of the National Academy of Sciences profile →
  47. Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin
    2011 497 citations Kunhong Xiao, Seungkirl Ahn et al. Science Signaling profile →
  48. The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
    1998 495 citations Julie A. Pitcher, Larry S. Barak et al. Nature profile →
  49. Cloning of the cDNA for the human beta 1-adrenergic receptor.
    1987 492 citations Robert J. Lefkowitz, Brian K. Kobilka et al. Proceedings of the National Academy of Sciences profile →
  50. Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.
    1992 489 citations Marc G. Caron, Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  51. Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases
    1996 485 citations Brian E. Hawes, Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  52. The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor
    1988 484 citations Brian K. Kobilka, Marc G. Caron et al. Nature profile →
  53. Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase
    1998 481 citations Seungkirl Ahn, Marc G. Caron et al. Journal of Biological Chemistry profile →
  54. β-Arrestin-biased ligands at seven-transmembrane receptors
    2007 481 citations Jonathan D. Violin, Robert J. Lefkowitz profile →
  55. A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
    2007 477 citations James W. Wisler, Scott M. DeWire et al. Proceedings of the National Academy of Sciences profile →
  56. Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes.
    1977 474 citations Robert J. Lefkowitz et al. Proceedings of the National Academy of Sciences profile →
  57. Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.
    1992 470 citations Marc G. Caron, Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  58. β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
    2009 469 citations Sudarshan Rajagopal, Ji‐Hee Kim et al. Proceedings of the National Academy of Sciences profile →
  59. Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation
    1987 457 citations Robert J. Lefkowitz, Marc G. Caron et al. Nature profile →
  60. Protein kinases that phosphorylate activated G protein‐coupled receptors
    1995 456 citations Robert J. Lefkowitz et al. profile →
  61. A Quantitative Analysis of Beta-Adrenergic Receptor Interactions: Resolution of High and Low Affinity States of the Receptor by Computer Modeling of Ligand Binding Data
    1980 454 citations Robert J. Lefkowitz et al. profile →
  62. Thyroid hormone regulation of beta-adrenergic receptor number.
    1977 445 citations Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  63. Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor
    2004 433 citations Seungkirl Ahn, Sudha K. Shenoy et al. Journal of Biological Chemistry profile →
  64. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins
    1987 425 citations Brian K. Kobilka, Robert J. Lefkowitz et al. Nature profile →
  65. Therapeutic potential of β-arrestin- and G protein-biased agonists
    2010 419 citations Erin J. Whalen, Sudarshan Rajagopal et al. profile →
  66. Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor
    1997 416 citations Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  67. The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.
    1993 415 citations Walter J. Koch, Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  68. Binding of G protein beta gamma-subunits to pleckstrin homology domains.
    1994 413 citations Kazushige Touhara, Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  69. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
    2016 410 citations Arun K. Shukla, Alem W. Kahsai et al. Cell profile →
  70. Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors
    1997 408 citations Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  71. Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
    1998 405 citations Howard A. Rockman, Robert J. Lefkowitz et al. Proceedings of the National Academy of Sciences profile →
  72. Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation
    1995 405 citations Brian E. Hawes, Walter J. Koch et al. Journal of Biological Chemistry profile →
  73. Activation of the cloned muscarinic potassium channel by G protein βγ subunits
    1994 403 citations Robert J. Lefkowitz et al. Nature profile →
  74. Structure and mechanism of the G protein-coupled receptor kinases.
    1993 398 citations Walter J. Koch, Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  75. Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
    2002 390 citations Stephen J. Perry, George S. Baillie et al. Science profile →
  76. ADENYLATE CYCLASE-COUPLED BETA-ADRENERGIC RECEPTORS: Structure and Mechanisms of Activation and Desensitization
    1983 387 citations Robert J. Lefkowitz, Marc G. Caron et al. profile →
  77. G protein—coupled receptor kinases
    1993 380 citations Robert J. Lefkowitz Cell profile →
  78. β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
    1989 377 citations Marc G. Caron, Robert J. Lefkowitz et al. Science profile →
  79. Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
    1994 376 citations Walter J. Koch, Brian E. Hawes et al. Proceedings of the National Academy of Sciences profile →
  80. Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.
    1994 376 citations Walter J. Koch, Brian E. Hawes et al. Journal of Biological Chemistry profile →
  81. Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization
    1988 370 citations Brian K. Kobilka, Marc G. Caron et al. Nature profile →
  82. Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor
    1995 366 citations Howard A. Rockman, Robert J. Lefkowitz et al. Nature profile →
  83. Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.
    1988 365 citations Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  84. Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
    2011 350 citations Arun K. Shukla, Kunhong Xiao et al. profile →
  85. Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release.
    1978 309 citations Marc G. Caron, Robert J. Lefkowitz et al. Journal of Biological Chemistry profile →
  86. Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
    1985 292 citations Robert J. Lefkowitz, Marc G. Caron et al. Proceedings of the National Academy of Sciences profile →
  87. Multiple ligand-specific conformations of the β2-adrenergic receptor
    2011 206 citations Alem W. Kahsai, Kunhong Xiao et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Robert J. Lefkowitz United States 190 96.0k 52.5k 13.4k 12.2k 8.5k 715 118.8k
Solomon H. Snyder United States 200 74.9k 0.8× 59.1k 1.1× 29.9k 2.2× 6.5k 0.5× 10.3k 1.2× 1.0k 143.6k
Marc G. Caron United States 158 54.9k 0.6× 45.8k 0.9× 7.7k 0.6× 3.4k 0.3× 5.2k 0.6× 596 80.1k
Kenji Kangawa Japan 133 26.1k 0.3× 21.6k 0.4× 24.6k 1.8× 13.2k 1.1× 2.8k 0.3× 992 84.3k
Paul Greengard United States 182 69.9k 0.7× 52.0k 1.0× 19.5k 1.5× 2.8k 0.2× 22.4k 2.6× 961 112.1k
Ronald M. Evans United States 187 96.0k 1.0× 18.7k 0.4× 20.1k 1.5× 3.1k 0.3× 6.0k 0.7× 629 148.1k
Brian K. Kobilka United States 128 51.2k 0.5× 29.9k 0.6× 4.4k 0.3× 4.2k 0.3× 2.0k 0.2× 363 61.3k
Michael J. Berridge United Kingdom 96 42.2k 0.4× 19.2k 0.4× 7.8k 0.6× 4.2k 0.3× 9.8k 1.1× 210 65.7k
Nahum Sonenberg Canada 160 77.5k 0.8× 5.5k 0.1× 4.9k 0.4× 10.2k 0.8× 7.9k 0.9× 673 97.8k
Alfred G. Gilman United States 121 41.2k 0.4× 13.0k 0.2× 5.1k 0.4× 2.6k 0.2× 9.4k 1.1× 240 54.7k
Philip Cohen United Kingdom 143 67.4k 0.7× 7.6k 0.1× 7.9k 0.6× 3.0k 0.2× 13.5k 1.6× 489 89.2k

Countries citing papers authored by Robert J. Lefkowitz

Since Specialization
Citations

This map shows the geographic impact of Robert J. Lefkowitz's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Robert J. Lefkowitz with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Robert J. Lefkowitz more than expected).

Fields of papers citing papers by Robert J. Lefkowitz

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Robert J. Lefkowitz. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Robert J. Lefkowitz. The network helps show where Robert J. Lefkowitz may publish in the future.

Co-authorship network of co-authors of Robert J. Lefkowitz

This figure shows the co-authorship network connecting the top 25 collaborators of Robert J. Lefkowitz. A scholar is included among the top collaborators of Robert J. Lefkowitz based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Robert J. Lefkowitz. Robert J. Lefkowitz is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Liu, Samuel, Preston J. Anderson, Sudarshan Rajagopal, Robert J. Lefkowitz, & Howard A. Rockman. (2024). G Protein-Coupled Receptors: A Century of Research and Discovery. Circulation Research. 135(1). 174–197. 40 indexed citations
2.
Asher, Wesley B., Daniel S. Terry, G. Glenn Gregorio, et al.. (2022). GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. Cell. 185(10). 1661–1675.e16. 57 indexed citations
3.
Suomivuori, Carl‐Mikael, Naomi R. Latorraca, Laura M. Wingler, et al.. (2020). Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor. Science. 367(6480). 881–887. 167 indexed citations
4.
McMahon, Conor, Dean P. Staus, Laura M. Wingler, et al.. (2020). Synthetic nanobodies as angiotensin receptor blockers. Proceedings of the National Academy of Sciences. 117(33). 20284–20291. 38 indexed citations
5.
Liu, Xiangyu, Ali Masoudi, Alem W. Kahsai, et al.. (2019). Mechanism of β 2 AR regulation by an intracellular positive allosteric modulator. Science. 364(6447). 1283–1287. 90 indexed citations
6.
Xiao, Kunhong, Seungkirl Ahn, Arun K. Shukla, et al.. (2011). Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin. Science Signaling. 4(185). ra51–ra51. 497 indexed citations breakdown →
7.
Xiao, Kunhong, Jin‐Peng Sun, Ji‐Hee Kim, et al.. (2010). Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR). Proceedings of the National Academy of Sciences. 107(34). 15299–15304. 164 indexed citations
8.
Xie, Liang, Kunhong Xiao, Erin J. Whalen, et al.. (2009). Oxygen-Regulated β 2 -Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL. Science Signaling. 2(78). ra33–ra33. 125 indexed citations
9.
Shenoy, Sudha K., Arun K. Shukla, Kunhong Xiao, et al.. (2009). β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proceedings of the National Academy of Sciences. 106(16). 6650–6655. 125 indexed citations
10.
Nelson, Christopher, Stephen J. Perry, Debra S. Regier, et al.. (2007). Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins. Science. 315(5812). 663–666. 117 indexed citations
11.
Xiao, Kunhong, Daniel B. McClatchy, Arun K. Shukla, et al.. (2007). Functional specialization of β-arrestin interactions revealed by proteomic analysis. Proceedings of the National Academy of Sciences. 104(29). 12011–12016. 327 indexed citations breakdown →
12.
Wisler, James W., Scott M. DeWire, Erin J. Whalen, et al.. (2007). A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling. Proceedings of the National Academy of Sciences. 104(42). 16657–16662. 477 indexed citations breakdown →
13.
Chen, Wei, Xiu-Rong Ren, Christopher Nelson, et al.. (2004). Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2. Science. 306(5705). 2257–2260. 221 indexed citations
14.
Wang, Qin, Jiali Zhao, Ashley E. Brady, et al.. (2004). Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors. Science. 304(5679). 1940–1944. 118 indexed citations
15.
Lodowski, David T., Julie A. Pitcher, W. Darrell Capel, Robert J. Lefkowitz, & J.J.G. Tesmer. (2003). Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ. Science. 300(5623). 1256–1262. 315 indexed citations
16.
Chen, Wei, Derk ten Berge, Seungkirl Ahn, et al.. (2003). Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4. Science. 301(5638). 1391–1394. 281 indexed citations
17.
Perry, Stephen J., George S. Baillie, Trudy A. Kohout, et al.. (2002). Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins. Science. 298(5594). 834–836. 390 indexed citations breakdown →
18.
Bohn, Laura, Raul R. Gainetdinov, Fang‐Tsyr Lin, Robert J. Lefkowitz, & Marc G. Caron. (2000). μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence. Nature. 408(6813). 720–723. 753 indexed citations breakdown →
19.
Pitcher, Julie A., et al.. (1999). Feedback Inhibition of G Protein-coupled Receptor Kinase 2 (GRK2) Activity by Extracellular Signal-regulated Kinases. Journal of Biological Chemistry. 274(49). 34531–34534. 155 indexed citations
20.
Touhara, Kazushige, Walter J. Koch, Brian E. Hawes, & Robert J. Lefkowitz. (1995). Mutational Analysis of the Pleckstrin Homology Domain of the β-Adrenergic Receptor Kinase.. Journal of Biological Chemistry. 270(28). 17000–17005. 95 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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