Lewis C. Cantley

207.4k citations
710 papers · 150.4k indexed · 71 hit papers · h-index 183
Co-authors
Matthew G. Vander HeidenCraig B. ThompsonBrendan D. ManningJi LuoJeffrey A. EngelmanReuben J. ShawAlex TokerZhou Songyang
Topics
PI3K/AKT/mTOR signaling in cancer (148 papers)Protein Kinase Regulation and GTPase Signaling (132 papers)Cancer, Hypoxia, and Metabolism (79 papers)
Cited by
Cancer ResearchMolecular BiologyCell Biology
Journals
NatureScienceNew England Journal of Medicine
Partner nations
United StatesIsraelGermany

In The Last Decade

Lewis C. Cantley

696 papers receiving 147.7k citations

Hit Papers

Understanding the Warburg Eff...1977202619932009200920072002200720094.0k8.0k12.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
    2009 12.1k citations Matthew G. Vander Heiden, Lewis C. Cantley et al. Science profile →
  2. AKT/PKB Signaling: Navigating Downstream
    2007 4.9k citations Brendan D. Manning, Lewis C. Cantley profile →
  3. The Phosphoinositide 3-Kinase Pathway
    2002 4.5k citations Lewis C. Cantley Science profile →
  4. MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
    2007 3.6k citations Jeffrey A. Engelman, Kreshnik Zejnullahu et al. Science profile →
  5. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    2009 3.1k citations Lewis C. Cantley, Matthew G. Vander Heiden et al. profile →
  6. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    2006 2.6k citations Jeffrey A. Engelman, Ji Luo et al. profile →
  7. Oncogenes and signal transduction
    1991 2.5k citations Lewis C. Cantley et al. profile →
  8. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    2008 2.2k citations Matthew G. Vander Heiden, Lewis C. Cantley et al. profile →
  9. The PI3K Pathway in Human Disease
    2017 1.9k citations Lewis C. Cantley et al. profile →
  10. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    1999 1.6k citations Lewis C. Cantley et al. Proceedings of the National Academy of Sciences profile →
  11. Ras, PI(3)K and mTOR signalling controls tumour cell growth
    2006 1.6k citations Reuben J. Shaw, Lewis C. Cantley profile →
  12. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
    2005 1.6k citations Reuben J. Shaw, Nabeel Bardeesy et al. Science profile →
  13. PI3K: Downstream AKTion Blocks Apoptosis
    1997 1.5k citations Lewis C. Cantley et al. profile →
  14. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    2013 1.5k citations Costas A. Lyssiotis, Edouard Mullarky et al. profile →
  15. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    2004 1.5k citations Reuben J. Shaw, Nabeel Bardeesy et al. Proceedings of the National Academy of Sciences profile →
  16. PI3K pathway alterations in cancer: variations on a theme
    2008 1.5k citations Lewis C. Cantley et al. profile →
  17. The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity
    1997 1.4k citations Lewis C. Cantley et al. profile →
  18. Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
    2009 1.4k citations Lewis C. Cantley et al. profile →
  19. Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
    2002 1.3k citations Brendan D. Manning, Andrew R. Tee et al. profile →
  20. Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate
    1997 1.3k citations Lewis C. Cantley, Alex Toker et al. Science profile →
  21. Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
    1997 1.2k citations Lewis C. Cantley et al. Science profile →
  22. PHOSPHOINOSITIDE KINASES
    1998 1.2k citations Lewis C. Cantley et al. profile →
  23. Large-scale characterization of HeLa cell nuclear phosphoproteins
    2004 1.2k citations Sean A. Beausoleil, Mark P. Jedrychowski et al. Proceedings of the National Academy of Sciences profile →
  24. Signalling through the lipid products of phosphoinositide-3-OH kinase
    1997 1.2k citations Alex Toker, Lewis C. Cantley profile →
  25. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    2008 1.1k citations Antonella Papa, Caterina Nardella et al. profile →
  26. Targeting the PI3K-Akt pathway in human cancer
    2003 1.1k citations Ji Luo, Brendan D. Manning et al. profile →
  27. Cancer metabolism: fatty acid oxidation in the limelight
    2013 1.0k citations Lewis C. Cantley, Pier Paolo Pandolfi et al. profile →
  28. Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
    2003 949 citations Andrew R. Tee, Brendan D. Manning et al. profile →
  29. Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
    2011 941 citations John M. Asara, Gary Bellinger et al. Science profile →
  30. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
    1988 872 citations Lewis C. Cantley et al. profile →
  31. The LKB1 tumor suppressor negatively regulates mTOR signaling
    2004 870 citations Reuben J. Shaw, Nabeel Bardeesy et al. profile →
  32. The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function
    1999 826 citations Lucia E. Rameh, Lewis C. Cantley profile →
  33. Pyruvate kinase M2 is a phosphotyrosine-binding protein
    2008 817 citations Matthew G. Vander Heiden, John M. Asara et al. profile →
  34. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
    2016 813 citations John M. Asara, Lewis C. Cantley et al. profile →
  35. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
    1995 812 citations Lewis C. Cantley et al. profile →
  36. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
    1989 809 citations Lewis C. Cantley et al. profile →
  37. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
    1995 805 citations Lewis C. Cantley et al. profile →
  38. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
    1985 724 citations Lewis C. Cantley et al. profile →
  39. A colorectal cancer classification system that associates cellular phenotype and responses to therapy
    2013 721 citations Anguraj Sadanandam, Costas A. Lyssiotis et al. profile →
  40. Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.
    1977 712 citations Lewis C. Cantley et al. profile →
  41. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
    2012 702 citations Costas A. Lyssiotis, Lewis C. Cantley et al. profile →
  42. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
    2015 696 citations Jihye Yun, Edouard Mullarky et al. Science profile →
  43. Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
    2011 672 citations Judit Villén, Lewis C. Cantley et al. Science profile →
  44. Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism
    1997 654 citations Marc W. Kirschner, Lewis C. Cantley et al. Science profile →
  45. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    2002 647 citations Andrew R. Tee, Diane C. Fingar et al. Proceedings of the National Academy of Sciences profile →
  46. Regulation of mTORC1 by PI3K signaling
    2015 623 citations Lewis C. Cantley et al. profile →
  47. Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
    2009 618 citations Matthew G. Vander Heiden, Lewis C. Cantley et al. profile →
  48. The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain
    2003 617 citations Lewis C. Cantley et al. profile →
  49. Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
    2014 613 citations Lewis C. Cantley, Brendan D. Manning et al. profile →
  50. Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
    1987 600 citations Lewis C. Cantley et al. profile →
  51. Phosphatidylinositol 3‐kinase
    1994 567 citations Lewis C. Cantley et al. profile →
  52. Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2
    1996 562 citations Lewis C. Cantley et al. profile →
  53. Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates
    2003 561 citations Lewis C. Cantley et al. Science profile →
  54. Purification and characterization of phosphoinositide 3-kinase from rat liver.
    1990 561 citations Lewis C. Cantley et al. profile →
  55. NRF2 regulates serine biosynthesis in non–small cell lung cancer
    2015 560 citations Edouard Mullarky, John M. Asara et al. profile →
  56. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.
    1994 553 citations Lewis C. Cantley et al. Proceedings of the National Academy of Sciences profile →
  57. Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α
    1999 531 citations Lewis C. Cantley et al. Science profile →
  58. Use of an oriented peptide library to determine the optimal substrates of protein kinases
    1994 530 citations Lewis C. Cantley et al. profile →
  59. AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
    2013 517 citations Gary Bellinger, John M. Asara et al. profile →
  60. A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling
    1994 516 citations Lewis C. Cantley et al. profile →
  61. Evidence for an alternative glycolytic pathway in rapidly proliferating cells
    2010 509 citations Matthew G. Vander Heiden, Jason W. Locasale et al. profile →
  62. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K
    2001 509 citations Seth J. Field, Lewis C. Cantley et al. profile →
  63. Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylation
    2012 506 citations Ng Shyh‐Chang, Jason W. Locasale et al. Science profile →
  64. A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1
    1996 500 citations John Blenis, Lewis C. Cantley et al. profile →
  65. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
    2018 481 citations Lewis C. Cantley et al. profile →
  66. Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.
    1986 465 citations Lewis C. Cantley et al. profile →
  67. A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications.
    1978 458 citations Lewis C. Cantley et al. profile →
  68. The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment
    2018 422 citations Lewis C. Cantley et al. profile →
  69. Targeting cancer vulnerabilities with high-dose vitamin C
    2019 289 citations Lewis C. Cantley, Jihye Yun et al. profile →
  70. Dietary fructose improves intestinal cell survival and nutrient absorption
    2021 194 citations Lukas E. Dow, Lewis C. Cantley et al. profile →
  71. The carbohydrate-insulin model: a physiological perspective on the obesity pandemic
    2021 164 citations Lewis C. Cantley et al. profile →

Peers

Lewis C. Cantley
Comparison fields: 5 of 200
  • Molecular Biology 104.9k
  • Cancer Research 29.7k
  • Oncology 27.4k
  • Cell Biology 19.6k
  • Immunology 16.8k
Replace Craig B. Thompson with:
Craig B. Thompson United States
Matthias Mann Germany
Douglas Hanahan United States
Michael Karin United States
Robert A. Weinberg United States
John C. Reed United States
Bert Vogelstein United States
Douglas R. Green United States
Peter Carmeliet Belgium
Roger J. Davis United States
Lewis C. Cantley relative to Craig B. Thompson United States Craig B. Thompson's profile →
Citations per field
00.5×1.5×2×2.3×
Craig B. Thompson · 1×
Citations per year

Countries citing papers authored by Lewis C. Cantley

Since Specialization
Citations

This map shows the geographic impact of Lewis C. Cantley's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lewis C. Cantley with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lewis C. Cantley more than expected).

Fields of papers citing papers by Lewis C. Cantley

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lewis C. Cantley. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lewis C. Cantley. The network helps show where Lewis C. Cantley may publish in the future.

Co-authorship network of co-authors of Lewis C. Cantley

This figure shows the co-authorship network connecting the top 25 collaborators of Lewis C. Cantley. A scholar is included among the top collaborators of Lewis C. Cantley based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lewis C. Cantley. Lewis C. Cantley is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
#WorkIndexed citations
1
PtdIns(3,4,5) P 3-Dependent Activation of the mTORC2 Kinase Complex
2015 ·Cancer Discovery ·Pengda Liu,Wenjian Gan,Y. Rebecca Chin,Kohei Ogura,Jianping Guo,Jinfang Zhang,Bin Wang,John Blenis,Lewis C. Cantley,Alex Toker,Bing Su,Wenyi Wei
307
2
A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics
2015 ·Cancer Discovery ·Anguraj Sadanandam,Stephan Wullschleger,Costas A. Lyssiotis,Carsten Grötzinger,Stefano Barbi,Samantha Bersani,(unknown),(unknown),Andrea Mafficini,Rita T. Lawlor,Michele Simbolo,John M. Asara,Hendrik Bläker,Lewis C. Cantley,Bertram Wiedenmann,Aldo Scarpa,Douglas Hanahan
139
3
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDHbreakdown →
2015 ·Science ·Jihye Yun,Edouard Mullarky,(unknown),Kaitlyn Bosch,Adam Kavalier,Keith Rivera,Jatin Roper,Iok In Christine Chio,Ευγενία Γιαννοπούλου,Carlo Rago,Ashlesha Muley,John M. Asara,Jihye Paik,Olivier Elemento,Zhengming Chen,Darryl Pappin,Lukas E. Dow,Nickolas Papadopoulos,Steven S. Gross,Lewis C. Cantley
696
4
Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain
2014 ·Cancer Research ·Jinyu Chen,Ho-Jeong Lee,Xuefeng Wu,Lei Huo,Sun-Jin Kim,(unknown),Yan Wang,(unknown),Lakshmi Reddy Bollu,Guang Gao,Fei Su,James M. Briggs,Xiaojing Liu,Tamar Melman,John M. Asara,Isaiah J. Fidler,Lewis C. Cantley,Jason W. Locasale,Weihua Zhang
136
5
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9
2013 ·Proceedings of the National Academy of Sciences ·Jennifer L. Gallop,Astrid Walrant,Lewis C. Cantley,Marc W. Kirschner
45
6
A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition
2013 ·Cancer Research ·Hailing Cheng,Pixu Liu,Fan Zhang,Erbo Xu,(unknown),Carolynn E. Ohlson,Roderick T. Bronson,Sauveur-Michel Maira,Emmanuelle di Tomaso,Jane Li,Andrea P. Myers,Lewis C. Cantley,Gordon B. Mills,Jean J. Zhao
45
7
Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism
2013 ·Cancer Research ·Sarah‐Maria Fendt,Eric L. Bell,Mark A. Keibler,Shawn M. Davidson,Grégory J. Wirth,Brian P. Fiske,Jared R. Mayers,Matthias Schwab,Gary Bellinger,(unknown),Akash Patnaik,(unknown),Lewis C. Cantley,Leonard Guarente,John Blenis,Michaël Pollak,Aria F. Olumi,Matthew G. Vander Heiden,Gregory Stephanopoulos
7
8
Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylationbreakdown →
2012 ·Science ·Ng Shyh‐Chang,Jason W. Locasale,Costas A. Lyssiotis,Yu-Xiang Zheng,(unknown),Sutheera Ratanasirintrawoot,Jin Zhang,Tamer T. Önder,Juli Unternaehrer,Hao Zhu,John M. Asara,George Q. Daley,Lewis C. Cantley
506
9
Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
2012 ·Cancer Discovery ·Ashish Juvekar,Laura N. Burga,Hai Hu,Elaine P. Lunsford,Yasir H. Ibrahim,Judith Balmañà,Anbazhagan Rajendran,Antonella Papa,Katherine Spencer,Costas A. Lyssiotis,Caterina Nardella,Pier Paolo Pandolfi,José Baselga,Ralph Scully,John M. Asara,Lewis C. Cantley,Gerburg M. Wulf
336
10
Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI3K in Cancer
2011 ·Cancer Research ·Xuemei Yang,Alexa B. Turke,Jie Qi,Youngchul Song,Brent N. Rexer,Todd W. Miller,Pasi A. Jänne,Carlos L. Arteaga,Lewis C. Cantley,Jeffrey A. Engelman,John M. Asara
9
11
The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling
2010 ·Cancer Research ·Cullen M. Taniguchi,Jonathon N. Winnay,Tatsuya Kondo,Roderick T. Bronson,Alexander R. Guimarães,José O. Alemán,Ji Luo,Gregory Stephanopoulos,Ralph Weissleder,Lewis C. Cantley,C. Ronald Kahn
125
12
Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis
2009 ·Endocrinology ·Jennifer W. Hill,Yong Xu,Frédéric Preitner,Makoto Fukuda,(unknown),Ji Luo,Nina Balthasar,Roberto Coppari,Lewis C. Cantley,Barbara B. Kahn,Jean J. Zhao,Joel K. Elmquist
75
13
Getting Knit-PI3Ky: PIK3CA Mutation Status to Direct Multimodality Therapy?
2009 ·Clinical Cancer Research ·Andrea P. Myers,Jeffrey A. Meyerhardt,Lewis C. Cantley
1
14
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signalingbreakdown →
2007 ·Science ·Jeffrey A. Engelman,Kreshnik Zejnullahu,Tetsuya Mitsudomi,Youngchul Song,Courtney Hyland,Joon Oh Park,Neal I. Lindeman,(unknown),Xiao‐Jun Zhao,James G. Christensen,Takayuki Kosaka,Alison J. Holmes,Andrew M. Rogers,Federico Cappuzzo,Tony Mok,Charles Lee,Bruce E. Johnson,Lewis C. Cantley,Pasi A. Jänne
3570
15
Protein Sequences from Mastodon and Tyrannosaurus Rex Revealed by Mass Spectrometry
2007 ·Science ·John M. Asara,Mary H. Schweitzer,Lisa M. Freimark,Matthew J. Phillips,Lewis C. Cantley
216
16
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast
2004 ·The Journal of Cell Biology ·Prasenjit Mitra,Yingjie Zhang,Lucia E. Rameh,Maria Ivshina,Dannel McCollum,John J. Nunnari,Gregory Hendricks,(unknown),Seth J. Field,Lewis C. Cantley,Alonzo H. Ross
77
17
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressbreakdown →
2004 ·Proceedings of the National Academy of Sciences ·Reuben J. Shaw,(unknown),Nabeel Bardeesy,(unknown),Lee A. Witters,Ronald A. DePinho,Lewis C. Cantley
1484
18
Large-scale characterization of HeLa cell nuclear phosphoproteinsbreakdown →
2004 ·Proceedings of the National Academy of Sciences ·Sean A. Beausoleil,Mark P. Jedrychowski,Daniel Schwartz,Joshua E. Elias,Judit Villén,Jiaxu Li,Martin A. Cohn,Lewis C. Cantley,Steven P. Gygi
1190
19
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation
2003 ·Journal of Cell Science ·Aaron M. Woolsey,(unknown),Christine A. Petersen,Saskia M. Brachmann,Lewis C. Cantley,Barbara A. Burleigh
129
20
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signalingbreakdown →
2002 ·Proceedings of the National Academy of Sciences ·Andrew R. Tee,Diane C. Fingar,Brendan D. Manning,David J. Kwiatkowski,Lewis C. Cantley,John Blenis
647

About Lewis C. Cantley

Lewis C. Cantley is a scholar working on Molecular Biology, Cancer Research and Cell Biology, having authored 710 papers that have together received 150.4k indexed citations. Recurring topics across this work include PI3K/AKT/mTOR signaling in cancer (148 papers), Protein Kinase Regulation and GTPase Signaling (132 papers) and Cancer, Hypoxia, and Metabolism (79 papers). The work is most often cited by research in Cancer Research (29.7k citations), Molecular Biology (104.9k citations) and Cell Biology (19.6k citations). Lewis C. Cantley has collaborated with scholars based in United States, Israel and Germany. Frequent co-authors include Matthew G. Vander Heiden, Craig B. Thompson, Brendan D. Manning, Ji Luo, Jeffrey A. Engelman, Reuben J. Shaw, Alex Toker, Zhou Songyang, John M. Asara and Stephen P. Soltoff. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Craig B. ThompsonBreakdown of academic impact, for papers by Matthias MannBreakdown of academic impact, for papers by Douglas HanahanBreakdown of academic impact, for papers by Michael KarinBreakdown of academic impact, for papers by Robert A. WeinbergBreakdown of academic impact, for papers by John C. ReedBreakdown of academic impact, for papers by Bert VogelsteinBreakdown of academic impact, for papers by Douglas R. GreenBreakdown of academic impact, for papers by Peter CarmelietBreakdown of academic impact, for papers by Roger J. Davis
Rankless by CCL
2026