Lewis C. Cantley

207.4k total citations · 71 hit papers
710 papers, 150.4k citations indexed

About

Lewis C. Cantley is a scholar working on Molecular Biology, Cell Biology and Cancer Research. According to data from OpenAlex, Lewis C. Cantley has authored 710 papers receiving a total of 150.4k indexed citations (citations by other indexed papers that have themselves been cited), including 546 papers in Molecular Biology, 115 papers in Cell Biology and 115 papers in Cancer Research. Recurrent topics in Lewis C. Cantley's work include PI3K/AKT/mTOR signaling in cancer (148 papers), Protein Kinase Regulation and GTPase Signaling (132 papers) and Cancer, Hypoxia, and Metabolism (79 papers). Lewis C. Cantley is often cited by papers focused on PI3K/AKT/mTOR signaling in cancer (148 papers), Protein Kinase Regulation and GTPase Signaling (132 papers) and Cancer, Hypoxia, and Metabolism (79 papers). Lewis C. Cantley collaborates with scholars based in United States, Israel and Germany. Lewis C. Cantley's co-authors include Matthew G. Vander Heiden, Craig B. Thompson, Brendan D. Manning, Ji Luo, Jeffrey A. Engelman, Reuben J. Shaw, Alex Toker, Zhou Songyang, John M. Asara and Stephen P. Soltoff and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Lewis C. Cantley

696 papers receiving 147.7k citations

Hit Papers

Understanding the Warburg... 1977 2026 1993 2009 2009 2007 2002 2007 2009 4.0k 8.0k 12.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
    2009 12.1k citations Matthew G. Vander Heiden, Lewis C. Cantley et al. Science profile →
  2. AKT/PKB Signaling: Navigating Downstream
    2007 4.9k citations Brendan D. Manning, Lewis C. Cantley profile →
  3. The Phosphoinositide 3-Kinase Pathway
    2002 4.5k citations Lewis C. Cantley Science profile →
  4. MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
    2007 3.6k citations Lewis C. Cantley et al. Science profile →
  5. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    2009 3.1k citations Joshua D. Rabinowitz, Lewis C. Cantley et al. profile →
  6. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    2006 2.6k citations Ji Luo, Lewis C. Cantley et al. profile →
  7. Oncogenes and signal transduction
    1991 2.5k citations Lewis C. Cantley, Stephen P. Soltoff et al. profile →
  8. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    2008 2.2k citations Heather R. Christofk, Matthew G. Vander Heiden et al. profile →
  9. The PI3K Pathway in Human Disease
    2017 1.9k citations Lewis C. Cantley et al. profile →
  10. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    1999 1.6k citations Lewis C. Cantley et al. Proceedings of the National Academy of Sciences profile →
  11. Ras, PI(3)K and mTOR signalling controls tumour cell growth
    2006 1.6k citations Reuben J. Shaw, Lewis C. Cantley profile →
  12. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
    2005 1.6k citations Reuben J. Shaw, Katja Lamia et al. Science profile →
  13. PI3K: Downstream AKTion Blocks Apoptosis
    1997 1.5k citations Lewis C. Cantley et al. profile →
  14. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    2013 1.5k citations Costas A. Lyssiotis, Edouard Mullarky et al. profile →
  15. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    2004 1.5k citations Reuben J. Shaw, Nabeel Bardeesy et al. Proceedings of the National Academy of Sciences profile →
  16. PI3K pathway alterations in cancer: variations on a theme
    2008 1.5k citations Lewis C. Cantley et al. profile →
  17. The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity
    1997 1.4k citations Lewis C. Cantley et al. profile →
  18. Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
    2009 1.4k citations Lewis C. Cantley et al. profile →
  19. Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
    2002 1.3k citations Brendan D. Manning, John Blenis et al. profile →
  20. Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate
    1997 1.3k citations Lewis C. Cantley, Alex Toker et al. Science profile →
  21. Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
    1997 1.2k citations Lewis C. Cantley et al. Science profile →
  22. PHOSPHOINOSITIDE KINASES
    1998 1.2k citations Lewis C. Cantley et al. profile →
  23. Large-scale characterization of HeLa cell nuclear phosphoproteins
    2004 1.2k citations Lewis C. Cantley et al. Proceedings of the National Academy of Sciences profile →
  24. Signalling through the lipid products of phosphoinositide-3-OH kinase
    1997 1.2k citations Alex Toker, Lewis C. Cantley profile →
  25. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    2008 1.1k citations Antonella Papa, Caterina Nardella et al. profile →
  26. Targeting the PI3K-Akt pathway in human cancer
    2003 1.1k citations Ji Luo, Brendan D. Manning et al. profile →
  27. Cancer metabolism: fatty acid oxidation in the limelight
    2013 1.0k citations Lewis C. Cantley, Pier Paolo Pandolfi et al. profile →
  28. Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
    2003 949 citations Brendan D. Manning, Lewis C. Cantley et al. profile →
  29. Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
    2011 941 citations George Poulogiannis, John M. Asara et al. Science profile →
  30. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
    1988 872 citations Lewis C. Cantley et al. profile →
  31. The LKB1 tumor suppressor negatively regulates mTOR signaling
    2004 870 citations Reuben J. Shaw, Nabeel Bardeesy et al. profile →
  32. The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function
    1999 826 citations Lewis C. Cantley et al. profile →
  33. Pyruvate kinase M2 is a phosphotyrosine-binding protein
    2008 817 citations Heather R. Christofk, Matthew G. Vander Heiden et al. profile →
  34. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
    2016 813 citations Daniel M. Kremer, John M. Asara et al. profile →
  35. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
    1995 812 citations Lewis C. Cantley et al. profile →
  36. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
    1989 809 citations Stephen P. Soltoff, Lewis C. Cantley et al. profile →
  37. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
    1995 805 citations Lewis C. Cantley et al. profile →
  38. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
    1985 724 citations Lewis C. Cantley, Thomas M. Roberts et al. profile →
  39. A colorectal cancer classification system that associates cellular phenotype and responses to therapy
    2013 721 citations Costas A. Lyssiotis, Lewis C. Cantley et al. profile →
  40. Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.
    1977 712 citations Lewis C. Cantley et al. profile →
  41. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
    2012 702 citations Costas A. Lyssiotis, Lewis C. Cantley et al. profile →
  42. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
    2015 696 citations Edouard Mullarky, John M. Asara et al. Science profile →
  43. Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
    2011 672 citations George Poulogiannis, Lewis C. Cantley et al. Science profile →
  44. Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism
    1997 654 citations Lewis C. Cantley et al. Science profile →
  45. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    2002 647 citations Brendan D. Manning, Lewis C. Cantley et al. Proceedings of the National Academy of Sciences profile →
  46. Regulation of mTORC1 by PI3K signaling
    2015 623 citations Lewis C. Cantley et al. profile →
  47. Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
    2009 618 citations Matthew G. Vander Heiden, Lewis C. Cantley et al. profile →
  48. The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain
    2003 617 citations Lewis C. Cantley et al. profile →
  49. Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
    2014 613 citations Lewis C. Cantley, Brendan D. Manning et al. profile →
  50. Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
    1987 600 citations Lewis C. Cantley, Thomas M. Roberts et al. profile →
  51. Phosphatidylinositol 3‐kinase
    1994 567 citations Lewis C. Cantley et al. profile →
  52. Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2
    1996 562 citations Lewis C. Cantley et al. profile →
  53. Purification and characterization of phosphoinositide 3-kinase from rat liver.
    1990 561 citations Lewis C. Cantley et al. profile →
  54. Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates
    2003 561 citations Lewis C. Cantley et al. Science profile →
  55. NRF2 regulates serine biosynthesis in non–small cell lung cancer
    2015 560 citations Edouard Mullarky, John M. Asara et al. profile →
  56. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.
    1994 553 citations Lewis C. Cantley et al. Proceedings of the National Academy of Sciences profile →
  57. Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α
    1999 531 citations Lewis C. Cantley et al. Science profile →
  58. Use of an oriented peptide library to determine the optimal substrates of protein kinases
    1994 530 citations Lewis C. Cantley et al. profile →
  59. AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
    2013 517 citations Gary Bellinger, John M. Asara et al. profile →
  60. A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling
    1994 516 citations Lewis C. Cantley et al. profile →
  61. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K
    2001 509 citations Lewis C. Cantley et al. profile →
  62. Evidence for an alternative glycolytic pathway in rapidly proliferating cells
    2010 509 citations Matthew G. Vander Heiden, Jason W. Locasale et al. profile →
  63. Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylation
    2012 506 citations Jason W. Locasale, Costas A. Lyssiotis et al. Science profile →
  64. A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1
    1996 500 citations John Blenis, Lewis C. Cantley et al. profile →
  65. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
    2018 481 citations Lewis C. Cantley et al. profile →
  66. Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.
    1986 465 citations Lewis C. Cantley et al. profile →
  67. A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications.
    1978 458 citations Lewis C. Cantley, Lewis C. Cantley et al. profile →
  68. The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment
    2018 422 citations Lewis C. Cantley et al. profile →
  69. Targeting cancer vulnerabilities with high-dose vitamin C
    2019 289 citations Lewis C. Cantley et al. profile →
  70. Dietary fructose improves intestinal cell survival and nutrient absorption
    2021 194 citations Lewis C. Cantley et al. profile →
  71. The carbohydrate-insulin model: a physiological perspective on the obesity pandemic
    2021 164 citations Lewis C. Cantley et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Lewis C. Cantley United States 183 104.9k 29.7k 27.4k 19.6k 16.8k 710 150.4k
Craig B. Thompson United States 182 91.8k 0.9× 44.6k 1.5× 25.3k 0.9× 8.6k 0.4× 36.7k 2.2× 515 151.3k
Douglas Hanahan United States 109 79.7k 0.8× 36.5k 1.2× 43.8k 1.6× 9.5k 0.5× 19.2k 1.1× 230 137.2k
Rakesh K. Jain United States 170 56.7k 0.5× 27.5k 0.9× 34.7k 1.3× 9.6k 0.5× 14.2k 0.8× 862 134.8k
Peter Carmeliet Belgium 151 53.1k 0.5× 27.4k 0.9× 15.0k 0.5× 7.7k 0.4× 11.7k 0.7× 729 100.0k
Matthias Mann Germany 214 150.8k 1.4× 14.3k 0.5× 17.3k 0.6× 24.0k 1.2× 18.1k 1.1× 845 215.4k
Zena Werb United States 151 45.6k 0.4× 33.6k 1.1× 35.3k 1.3× 11.5k 0.6× 18.5k 1.1× 416 110.4k
Joan Massagué United States 184 95.5k 0.9× 22.6k 0.8× 47.2k 1.7× 12.7k 0.6× 12.3k 0.7× 362 137.5k
Robert A. Weinberg United States 176 135.1k 1.3× 56.3k 1.9× 95.3k 3.5× 20.7k 1.1× 25.8k 1.5× 382 223.8k
Bert Vogelstein United States 204 134.2k 1.3× 56.8k 1.9× 91.6k 3.3× 15.1k 0.8× 15.1k 0.9× 553 229.5k
Kenneth W. Kinzler United States 163 79.7k 0.8× 37.4k 1.3× 49.2k 1.8× 9.5k 0.5× 8.0k 0.5× 381 131.7k

Countries citing papers authored by Lewis C. Cantley

Since Specialization
Citations

This map shows the geographic impact of Lewis C. Cantley's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lewis C. Cantley with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lewis C. Cantley more than expected).

Fields of papers citing papers by Lewis C. Cantley

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lewis C. Cantley. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lewis C. Cantley. The network helps show where Lewis C. Cantley may publish in the future.

Co-authorship network of co-authors of Lewis C. Cantley

This figure shows the co-authorship network connecting the top 25 collaborators of Lewis C. Cantley. A scholar is included among the top collaborators of Lewis C. Cantley based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lewis C. Cantley. Lewis C. Cantley is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Anderson, Kenneth C., Lewis C. Cantley, Riccardo Dalla‐Favera, et al.. (2022). The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Cancer Discovery. 12(11). 2475–2481.
2.
Liu, Hui, Marcia N. Paddock, Haibin Wang, et al.. (2020). The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer. Cancer Discovery. 10(8). 1226–1239. 42 indexed citations
3.
Holt, Melissa C., Reza Beheshti Zavareh, Lin Lin, et al.. (2018). Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. 57(47). 6604–6614. 27 indexed citations
4.
Thorpe, Lauren M., Jennifer M. Spangle, Carolynn E. Ohlson, et al.. (2017). PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α. Proceedings of the National Academy of Sciences. 114(27). 7095–7100. 81 indexed citations
5.
Croessmann, Sarah, Jonathan H. Sheehan, Kyung‐min Lee, et al.. (2017). PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3K α Inhibitors. Clinical Cancer Research. 24(6). 1426–1435. 27 indexed citations
6.
Liu, Hui, Charles J. Murphy, Florian A. Karreth, et al.. (2017). Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. Cancer Discovery. 8(3). 354–369. 49 indexed citations
7.
Mathur, Deepti, Ηλίας Στρατικόπουλος, Sait Öztürk, et al.. (2017). PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition. Cancer Discovery. 7(4). 380–390. 89 indexed citations
8.
Chen, Jinyu, Ho-Jeong Lee, Xuefeng Wu, et al.. (2014). Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain. Cancer Research. 75(3). 554–565. 136 indexed citations
9.
González‐Billalabeitia, Enrique, Nina Seitzer, Su Jung Song, et al.. (2014). Vulnerabilities of PTEN – TP53 -Deficient Prostate Cancers to Compound PARP–PI3K Inhibition. Cancer Discovery. 4(8). 896–904. 80 indexed citations
10.
Emerling, Brooke M., Cyril H. Benes, George Poulogiannis, et al.. (2013). Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proceedings of the National Academy of Sciences. 110(9). 3483–3488. 49 indexed citations
11.
Cheng, Hailing, Pixu Liu, Fan Zhang, et al.. (2013). A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition. Cancer Research. 74(1). 15–23. 45 indexed citations
12.
Fendt, Sarah‐Maria, Eric L. Bell, Mark A. Keibler, et al.. (2013). Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism. Cancer Research. 73(14). 4429–4438. 7 indexed citations
13.
Cheung, Lydia W.T., Bryan T. Hennessy, Jie Li, et al.. (2011). High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability. Cancer Discovery. 1(2). 170–185. 352 indexed citations
14.
Taniguchi, Cullen M., Jonathon N. Winnay, Tatsuya Kondo, et al.. (2010). The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling. Cancer Research. 70(13). 5305–5315. 125 indexed citations
15.
Heiden, Matthew G. Vander, Jason W. Locasale, Kenneth D. Swanson, et al.. (2010). Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells. Science. 329(5998). 1492–1499. 31 indexed citations
16.
Asara, John M., Mary H. Schweitzer, Lisa M. Freimark, Matthew J. Phillips, & Lewis C. Cantley. (2007). Protein Sequences from Mastodon and Tyrannosaurus Rex Revealed by Mass Spectrometry. Science. 316(5822). 280–285. 216 indexed citations
17.
Togawa, Akashi, Sandra Maday, Marc Pypaert, et al.. (2007). Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells. The Journal of Cell Biology. 179(6). 1133–1140. 74 indexed citations
18.
Shaw, Reuben J., Katja Lamia, Debbie S. Vasquez, et al.. (2005). The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin. Science. 310(5754). 1642–1646. 1580 indexed citations breakdown →
19.
Woolsey, Aaron M., et al.. (2003). Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation. Journal of Cell Science. 116(17). 3611–3622. 129 indexed citations
20.
Manning, Brendan D. & Lewis C. Cantley. (2002). Hitting the Target: Emerging Technologies in the Search for Kinase Substrates. Science s STKE. 2002(162). pe49–pe49. 85 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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