Junying Yuan

80.9k total citations · 32 hit papers
254 papers, 52.9k citations indexed

About

Junying Yuan is a scholar working on Molecular Biology, Immunology and Epidemiology. According to data from OpenAlex, Junying Yuan has authored 254 papers receiving a total of 52.9k indexed citations (citations by other indexed papers that have themselves been cited), including 204 papers in Molecular Biology, 57 papers in Immunology and 54 papers in Epidemiology. Recurrent topics in Junying Yuan's work include Cell death mechanisms and regulation (121 papers), Autophagy in Disease and Therapy (49 papers) and interferon and immune responses (33 papers). Junying Yuan is often cited by papers focused on Cell death mechanisms and regulation (121 papers), Autophagy in Disease and Therapy (49 papers) and interferon and immune responses (33 papers). Junying Yuan collaborates with scholars based in United States, China and Japan. Junying Yuan's co-authors include Hong Zhu, Alexei Degterev, Bruce A. Yankner, Honglin Li, Michael Boyce, Dimitry Ofengeim, Toshiyuki Nakagawa, Vincent L. Cryns, Bénédicte F. Py and Dana E. Christofferson and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Junying Yuan

249 papers receiving 52.2k citations

Hit Papers

Cleavage of BID by Caspase 8 Mediates the Mitochondrial D... 1990 2026 2002 2014 1998 2000 2008 2005 2008 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
    1998 3.7k citations Hong Zhu, Junying Yuan et al. Cell profile →
  2. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
    2000 2.8k citations Hong Zhu, Junying Yuan et al. profile →
  3. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
    2008 2.4k citations Bénédicte F. Py, Junying Yuan et al. profile →
  4. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    2005 2.4k citations Alexei Degterev, Gregory D. Cuny et al. profile →
  5. Identification of RIP1 kinase as a specific cellular target of necrostatins
    2008 1.6k citations Alexei Degterev, Irene L. Ch’en et al. profile →
  6. Apoptosis in the nervous system
    2000 1.5k citations Junying Yuan et al. profile →
  7. A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress
    2005 1.2k citations Junying Yuan et al. profile →
  8. Proteases to die for
    1998 1.1k citations Junying Yuan et al. profile →
  9. Cross-Talk between Two Cysteine Protease Families
    2000 990 citations Junying Yuan et al. profile →
  10. A decade of caspases
    2003 893 citations Alexei Degterev, Junying Yuan et al. profile →
  11. Caspases in apoptosis and beyond
    2008 831 citations Junying Yuan et al. profile →
  12. Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway
    2008 784 citations Dana E. Christofferson, Aylwin Ng et al. Cell profile →
  13. Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia
    1998 780 citations Junying Yuan et al. Journal of Neuroscience profile →
  14. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
    1994 747 citations Hong Zhu, Junying Yuan et al. Cell profile →
  15. Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
    1997 704 citations Robert M. Friedlander, Junying Yuan et al. Proceedings of the National Academy of Sciences profile →
  16. Mechanisms of pre‐apoptotic calreticulin exposure in immunogenic cell death
    2009 688 citations Junying Yuan et al. profile →
  17. Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
    2018 685 citations Junying Yuan, Palak Amin et al. profile →
  18. Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13
    2011 659 citations Hongguang Xia, Ying Li et al. Cell profile →
  19. Necroptosis as an alternative form of programmed cell death
    2010 635 citations Dana E. Christofferson, Junying Yuan Current Opinion in Cell Biology profile →
  20. Cellular response to endoplasmic reticulum stress: a matter of life or death
    2006 585 citations Junying Yuan et al. profile →
  21. Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE
    1998 575 citations Hong Zhu, Junying Yuan et al. Cell profile →
  22. Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
    2012 563 citations Bénédicte F. Py, Mi-Sung Kim et al. Molecular Cell profile →
  23. Defects in regulation of apoptosis in caspase-2-deficient mice
    1998 560 citations Junying Yuan et al. profile →
  24. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
    2010 550 citations Marta M. Lipinski, Bénédicte F. Py et al. Proceedings of the National Academy of Sciences profile →
  25. Prevention of Vertebrate Neuronal Death by the crmA Gene
    1994 528 citations Junying Yuan et al. profile →
  26. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
    1999 504 citations Junying Yuan, Robert M. Friedlander et al. profile →
  27. Chaperone-mediated autophagy is involved in the execution of ferroptosis
    2019 456 citations Guowei Wu, Bing Shan et al. Proceedings of the National Academy of Sciences profile →
  28. Cell death assays for drug discovery
    2011 446 citations Marta M. Lipinski, Junying Yuan et al. profile →
  29. A guide to cell death pathways
    2023 443 citations Junying Yuan, Dimitry Ofengeim profile →
  30. The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death
    1990 422 citations Junying Yuan, H. Robert Horvitz Developmental Biology profile →
  31. Activation of Necroptosis in Multiple Sclerosis
    2015 419 citations Dimitry Ofengeim, Yasushi Ito et al. profile →
  32. Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
    2020 310 citations Lauren Mifflin, Dimitry Ofengeim et al. profile →

Peers

Junying Yuan
Comparison fields: 5 of 171
  • Molecular Biology 36.5k
  • Epidemiology 10.9k
  • Immunology 10.4k
  • Cell Biology 8.1k
  • Oncology 5.1k
Replace Keiji Tanaka with:
Keiji Tanaka Japan
Richard J. Youle United States
Xiaodong Wang China
Guy S. Salvesen United States
Dario R. Alessi United Kingdom
Paul Säftig Germany
Paul Tempst United States
Stanley J. Korsmeyer United States
Ivan Đikić Germany
Hediye Erdjument‐Bromage United States
Keiji Tanaka Japan View profile →
Citations per field, relative to Junying Yuan
Junying Yuan · 1×
Citations per year, relative to Junying Yuan
Junying Yuan · 1×

Countries citing papers authored by Junying Yuan

Since Specialization
Citations

This map shows the geographic impact of Junying Yuan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Junying Yuan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Junying Yuan more than expected).

Fields of papers citing papers by Junying Yuan

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Junying Yuan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Junying Yuan. The network helps show where Junying Yuan may publish in the future.

Co-authorship network of co-authors of Junying Yuan

This figure shows the co-authorship network connecting the top 25 collaborators of Junying Yuan. A scholar is included among the top collaborators of Junying Yuan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Junying Yuan. Junying Yuan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
# Work Indexed citations
1
Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis
2025 ·Nature Communications ·(unknown), (unknown), Wei Jia Sun, Libo Jiang, Bing Shan, (unknown), (unknown), Wanjin Li, Jianping Liu, Hongyang Jing, (unknown), Min Hou, Cen Xie, Rongling Wu, Heling Pan, Junying Yuan
8
2
Development and validation of a nomogram for predicting intellectual disability in children with cerebral palsy
2024 ·International Journal of Clinical and Health Psychology ·Junying Yuan, (unknown), Mengyue Li, Lingling Zhang, (unknown), Yiran Xu, Dengna Zhu, Zhen Yang, (unknown), (unknown), Wei Zhang, Li Li, Xiaoli Zhang, Changlian Zhu
1
3
RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT
2024 ·Proceedings of the National Academy of Sciences ·(unknown), Min Xia, Xingxing Xie, (unknown), (unknown), Weimin Sun, Guifang Xu, Miao He, Kaiwen He, Ying Li, Junying Yuan
11
4
Discovery of a cooperative mode of inhibiting RIPK1 kinase
2021 ·Cell Discovery ·Huyan Meng, Guowei Wu, (unknown), Anhui Wang, Dekang Li, Yilun Tong, Taijie Jin, Ye Cao, Bing Shan, Shichen Hu, Ying Li, Lifeng Pan, Xiaoxu Tian, Ping Wu, Chao Peng, Junying Yuan, Guohui Li, Li Tan, Zhaoyin Wang
16
5
PINK1 mediates neuronal survival in monkey
2021 ·Protein & Cell ·Z. Sun, Jiangyu Ye, Junying Yuan
10
6
RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
2020 ·Molecular Cell ·Ayaz Najafov, (unknown), Adnan K. Mookhtiar, Lauren Mifflin, Hongguang Xia, Palak Amin, Alban Ordureau, Huibing Wang, Junying Yuan
29
7
Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
2018 ·Proceedings of the National Academy of Sciences ·Palak Amin, Marcus A. Florez, Ayaz Najafov, Heling Pan, Jiefei Geng, Dimitry Ofengeim, (unknown), Huibing Wang, (unknown), Yasushi Ito, Matthew J. LaVoie, Junying Yuan
120
8
Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis
2018 ·Proceedings of the National Academy of Sciences ·Huyan Meng, Zhen Liu, Xingyan Li, Huibing Wang, Taijie Jin, Guowei Wu, Bing Shan, Dana E. Christofferson, Chunting Qi, Qiang Yu, Ying Li, Junying Yuan
109
9
Structural Basis of RIP1 Inhibition by Necrostatins
2013 ·Structure ·Tian Xie, Wei Peng, Yexing Liu, Chuangye Yan, Jenny L. Maki, Alexei Degterev, Junying Yuan, Yigong Shi
185
10
Inhibition of Cellular Autophagy Deranges Dengue Virion Maturation
2012 ·Journal of Virology ·Roberto Mateo, Claude M. Nagamine, Jeannie F. Spagnolo, Ernesto Méndez, Michael P. Murtaugh, Michael Gale, Junying Yuan, Karla Kirkegaard
127
11
Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability
2012 ·Bioorganic & Medicinal Chemistry Letters ·Sung‐Woon Choi, Heather R. Keys, Richard J. Staples, Junying Yuan, Alexei Degterev, Gregory D. Cuny
17
12
Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity breakdown →
2012 ·Molecular Cell ·Bénédicte F. Py, Mi-Sung Kim, Helin Vakifahmetoglu-Norberg, Junying Yuan
563
13
A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions
2010 ·Developmental Cell ·Marta M. Lipinski, Greg Hoffman, Aylwin Ng, Wen Zhou, Bénédicte F. Py, Emily Hsu, Xuxin Liu, (unknown), Jun S. Liu, John Blenis, Ramnik J. Xavier, Junying Yuan
182
14
Antigen-mediated T cell expansion regulated by parallel pathways of death
2008 ·Proceedings of the National Academy of Sciences ·Irene L. Ch’en, Daniel R. Beisner, Alexei Degterev, Candace Lynch, Junying Yuan, Alexander Hoffmann, Stephen Μ. Hedrick
117
15
Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G
2007 ·Cell ·Nathan J. Moerke, Hüseyin Aktaş, Han Chen, Sonia Cantel, Mikhail Reibarkh, Amr Fahmy, John D. Gross, Alexei Degterev, Junying Yuan, Michael Chorev, José A. Halperin, Gerhard Wagner
441
16
Caspase-11 Is Not Necessary for Chemotherapy-Induced Intestinal Mucositis
2004 ·DNA and Cell Biology ·(unknown), (unknown), (unknown), (unknown), (unknown), Junying Yuan, Stephen T. Sonis
9
17
Caspase Cascades in Human Immunodeficiency Virus-Associated Neurodegeneration
2002 ·Journal of Neuroscience ·Gwenn A. Garden, Samantha L. Budd, Elena Tsai, Lisa Hanson, Marcus Kaul, (unknown), Robert M. Friedlander, Junying Yuan, Eliezer Masliah, Stuart A. Lipton
189
18
The Peutz-Jegher Gene Product LKB1 Is a Mediator of p53-Dependent Cell Death
2001 ·Molecular Cell ·(unknown), Or Gozani, Robert D. Odze, Xun Zhou, Hong Zhu, Reuben J. Shaw, (unknown), (unknown), (unknown), Lewis C. Cantley, Junying Yuan
256
19
Molecular control of life and death
1995 ·Current Opinion in Cell Biology ·Junying Yuan
81
20
The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death breakdown →
1990 ·Developmental Biology ·Junying Yuan, H. Robert Horvitz
422

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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