David Ron

95.7k total citations · 37 hit papers
266 papers, 74.6k citations indexed

About

David Ron is a scholar working on Cell Biology, Molecular Biology and Epidemiology. According to data from OpenAlex, David Ron has authored 266 papers receiving a total of 74.6k indexed citations (citations by other indexed papers that have themselves been cited), including 196 papers in Cell Biology, 169 papers in Molecular Biology and 57 papers in Epidemiology. Recurrent topics in David Ron's work include Endoplasmic Reticulum Stress and Disease (187 papers), RNA regulation and disease (65 papers) and Autophagy in Disease and Therapy (56 papers). David Ron is often cited by papers focused on Endoplasmic Reticulum Stress and Disease (187 papers), RNA regulation and disease (65 papers) and Autophagy in Disease and Therapy (56 papers). David Ron collaborates with scholars based in United States, United Kingdom and France. David Ron's co-authors include Heather P. Harding, Peter Walter, Yuhong Zhang, Huiqing Zeng, Anne Bertolotti, Isabel Novoa, Ira Tabas, Fumihiko Urano, Stefan J. Marciniak and Marcella A. Calfon and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

David Ron

263 papers receiving 73.8k citations

Hit Papers

Signal integration in the endoplasmic reticulum ... 1992 2026 2003 2014 2007 2011 1999 2003 2000 1000 2.0k 3.0k 4.0k 5.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Signal integration in the endoplasmic reticulum unfolded protein response
    2007 5.2k citations David Ron et al. profile →
  2. The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
    2011 4.5k citations David Ron et al. Science profile →
  3. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    1999 2.7k citations Heather P. Harding, Yuhong Zhang et al. profile →
  4. An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
    2003 2.6k citations Heather P. Harding, Yuhong Zhang et al. profile →
  5. Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
    2000 2.6k citations Heather P. Harding, Yuhong Zhang et al. profile →
  6. Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1
    2000 2.4k citations Anne Bertolotti, Yuhong Zhang et al. Science profile →
  7. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    2002 2.3k citations Heather P. Harding, David Ron et al. profile →
  8. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
    2000 2.3k citations Anne Bertolotti, Yuhong Zhang et al. profile →
  9. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
    2011 2.2k citations David Ron et al. profile →
  10. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
    1998 1.7k citations Hélène Zinszner, David Ron et al. profile →
  11. Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response
    2000 1.6k citations Heather P. Harding, Yuhong Zhang et al. profile →
  12. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
    2004 1.6k citations Yuhong Zhang, Heather P. Harding et al. profile →
  13. A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress
    2005 1.2k citations Heather P. Harding, Donalyn Scheuner et al. Science profile →
  14. Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α
    2001 1.1k citations Heather P. Harding, David Ron et al. profile →
  15. Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival
    2001 1.0k citations Heather P. Harding, David Ron et al. profile →
  16. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.
    1992 1.0k citations David Ron et al. profile →
  17. GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase
    2005 974 citations Heather P. Harding, Yuhong Zhang et al. profile →
  18. Transcriptional and Translational Control in the Mammalian Unfolded Protein Response
    2002 786 citations Heather P. Harding, David Ron et al. profile →
  19. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
    2004 784 citations David Ron et al. profile →
  20. Endoplasmic Reticulum Stress Signaling in Disease
    2006 782 citations David Ron et al. profile →
  21. Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase
    1996 764 citations David Ron et al. Science profile →
  22. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
    2004 750 citations Phoebe D. Lu, Heather P. Harding et al. profile →
  23. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
    2003 735 citations Heather P. Harding, David Ron et al. profile →
  24. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
    1993 731 citations David Ron et al. profile →
  25. Translational control in the endoplasmic reticulum stress response
    2002 687 citations David Ron profile →
  26. Translational control in the endoplasmic reticulum stress response
    2002 638 citations David Ron profile →
  27. Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)
    1996 606 citations Hélène Zinszner, David Ron et al. Molecular and Cellular Biology profile →
  28. Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes
    2008 581 citations Donalyn Scheuner, David Ron et al. profile →
  29. ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
    2005 574 citations Meixia Bi, Jaime D. Blais et al. profile →
  30. Linking of Autophagy to Ubiquitin-Proteasome System Is Important for the Regulation of Endoplasmic Reticulum Stress and Cell Viability
    2007 565 citations David Ron et al. American Journal Of Pathology profile →
  31. The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
    2010 552 citations David Ron, Constantinos Koumenis et al. profile →
  32. Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2
    2004 540 citations Jing Deng, Phoebe D. Lu et al. Molecular and Cellular Biology profile →
  33. Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
    2013 505 citations David Ron et al. Proceedings of the National Academy of Sciences profile →
  34. Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis
    2009 503 citations Heather P. Harding, David Ron et al. profile →
  35. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
    2012 452 citations Benedict C. S. Cross, Peter J. Bond et al. Proceedings of the National Academy of Sciences profile →
  36. The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.
    1994 430 citations David Ron et al. Molecular and Cellular Biology profile →
  37. Pharmacological targeting of endoplasmic reticulum stress in disease
    2021 341 citations David Ron et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
David Ron United States 118 45.4k 40.5k 22.2k 10.2k 7.9k 266 74.6k
Randal J. Kaufman United States 146 39.1k 0.9× 42.0k 1.0× 21.4k 1.0× 10.3k 1.0× 9.1k 1.2× 466 82.2k
Kun‐Liang Guan United States 148 32.0k 0.7× 57.9k 1.4× 14.3k 0.6× 4.9k 0.5× 7.3k 0.9× 422 89.1k
Heather P. Harding United States 75 25.8k 0.6× 22.4k 0.6× 12.6k 0.6× 5.8k 0.6× 4.3k 0.5× 125 41.0k
Noboru Mizushima Japan 124 20.1k 0.4× 42.9k 1.1× 67.1k 3.0× 4.5k 0.4× 8.9k 1.1× 272 94.2k
Peter Walter United States 106 24.8k 0.5× 34.3k 0.8× 10.8k 0.5× 3.8k 0.4× 4.1k 0.5× 354 50.4k
Beth Levine United States 106 13.3k 0.3× 38.4k 0.9× 55.2k 2.5× 4.0k 0.4× 9.4k 1.2× 187 83.7k
Daniel J. Klionsky United States 133 21.3k 0.5× 42.5k 1.1× 51.1k 2.3× 3.0k 0.3× 5.0k 0.6× 519 81.9k
Keiji Tanaka Japan 112 11.5k 0.3× 37.9k 0.9× 19.9k 0.9× 2.4k 0.2× 6.8k 0.9× 428 55.1k
Tamotsu Yoshimori Japan 95 14.1k 0.3× 24.4k 0.6× 38.0k 1.7× 2.6k 0.3× 5.9k 0.7× 246 55.8k
Philipp E. Scherer United States 135 12.8k 0.3× 26.9k 0.7× 32.5k 1.5× 7.3k 0.7× 5.9k 0.7× 503 74.4k

Countries citing papers authored by David Ron

Since Specialization
Citations

This map shows the geographic impact of David Ron's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Ron with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Ron more than expected).

Fields of papers citing papers by David Ron

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Ron. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Ron. The network helps show where David Ron may publish in the future.

Co-authorship network of co-authors of David Ron

This figure shows the co-authorship network connecting the top 25 collaborators of David Ron. A scholar is included among the top collaborators of David Ron based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David Ron. David Ron is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Yan, Yahui, Heather P. Harding, Alisa Zyryanova, et al.. (2024). Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response. Proceedings of the National Academy of Sciences. 121(14). e2320013121–e2320013121. 1 indexed citations
2.
Perera, Luke A., Andrew T. Hattersley, Heather P. Harding, et al.. (2023). Infancy‐onset diabetes caused by de‐regulated AMPylation of the human endoplasmic reticulum chaperone BiP. EMBO Molecular Medicine. 15(3). e16491–e16491. 15 indexed citations
3.
Zyryanova, Alisa, Félix Weis, Alexandre Faille, et al.. (2018). Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B. Science. 359(6383). 1533–1536. 135 indexed citations
4.
Kono, Nozomu, Niko Amin-Wetzel, & David Ron. (2017). Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy. Molecular Biology of the Cell. 28(17). 2318–2332. 42 indexed citations
5.
Zeng, Xiaomei, et al.. (2017). The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development. Journal of Cell Science. 130(18). 3040–3049. 33 indexed citations
6.
Tsuru, Akio, Naoko Fujimoto, Michiko Saito, et al.. (2013). Negative feedback by IRE1β optimizes mucin production in goblet cells. Proceedings of the National Academy of Sciences. 110(8). 2864–2869. 133 indexed citations
7.
Ravindran, Rajesh, Nooruddin Khan, Helder I. Nakaya, et al.. (2013). Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation. Science. 343(6168). 313–317. 161 indexed citations
8.
Cunha, Daniel A., Mariana Igoillo‐Esteve, Esteban N. Gurzov, et al.. (2012). Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis. Diabetes. 61(11). 2763–2775. 111 indexed citations
9.
Cross, Benedict C. S., Peter J. Bond, Paweł Sadowski, et al.. (2012). The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. 9 indexed citations
10.
Jones, Lyle V., Brian K. Brighton, Camille Ehré, et al.. (2012). The ER stress transducer IRE1β is required for airway epithelial mucin production. Mucosal Immunology. 6(3). 639–654. 150 indexed citations
11.
Tsaytler, Pavel, Heather P. Harding, David Ron, & Anne Bertolotti. (2011). Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis. Science. 332(6025). 91–94. 429 indexed citations
12.
Tao, Jiahui, Kseniya Petrova, David Ron, & Bingdong Sha. (2010). Crystal Structure of P58(IPK) TPR Fragment Reveals the Mechanism for its Molecular Chaperone Activity in UPR. Journal of Molecular Biology. 397(5). 1307–1315. 22 indexed citations
13.
Cobbold, Stephen, Elizabeth Adams, Kathleen F. Nolan, et al.. (2009). Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proceedings of the National Academy of Sciences. 106(29). 12055–12060. 264 indexed citations
14.
Ron, David & Heather P. Harding. (2007). 13 eIF2α Phosphorylation in Cellular Stress Responses and Disease. Cold Spring Harbor Monograph Archive. 48. 345–368. 58 indexed citations
15.
Dimcheff, Derek E., Cynthia Favara, David W. Dorward, et al.. (2006). Oligodendrocytes Are a Major Target of the Toxicity of Spongiogenic Murine Retroviruses. American Journal Of Pathology. 169(3). 1026–1038. 18 indexed citations
16.
Deng, Jing, Phoebe D. Lu, Yuhong Zhang, et al.. (2004). Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2. Molecular and Cellular Biology. 24(23). 10161–10168. 540 indexed citations breakdown →
17.
Wek, Sheree A., Barbara C. McGrath, Dan Lü, et al.. (2004). Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response. Molecular and Cellular Biology. 24(3). 1365–1377. 409 indexed citations
18.
Blais, Jaime D., Meixia Bi, Heather P. Harding, et al.. (2004). Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress. Molecular and Cellular Biology. 24(17). 7469–7482. 359 indexed citations
19.
Ron, David & Heather P. Harding. (2000). 15 PERK and Translational Control by Stress in the Endoplasmic Reticulum. Cold Spring Harbor Monograph Archive. 39. 547–560. 52 indexed citations
20.
Immanuel, David, Hélène Zinszner, & David Ron. (1995). Association of SARFH (Sarcoma-Associated RNA-Binding Fly Homolog) with Regions of Chromatin Transcribed by RNA Polymerase II. Molecular and Cellular Biology. 15(8). 4562–4571. 50 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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