Richard J. Youle

84.9k total citations · 38 hit papers
239 papers, 63.1k citations indexed

About

Richard J. Youle is a scholar working on Molecular Biology, Immunology and Epidemiology. According to data from OpenAlex, Richard J. Youle has authored 239 papers receiving a total of 63.1k indexed citations (citations by other indexed papers that have themselves been cited), including 164 papers in Molecular Biology, 80 papers in Immunology and 64 papers in Epidemiology. Recurrent topics in Richard J. Youle's work include Mitochondrial Function and Pathology (84 papers), Toxin Mechanisms and Immunotoxins (66 papers) and Autophagy in Disease and Therapy (60 papers). Richard J. Youle is often cited by papers focused on Mitochondrial Function and Pathology (84 papers), Toxin Mechanisms and Immunotoxins (66 papers) and Autophagy in Disease and Therapy (60 papers). Richard J. Youle collaborates with scholars based in United States, United Kingdom and Germany. Richard J. Youle's co-authors include Derek P. Narendra, Andreas Strasser, Chunxin Wang, Mariusz Karbowski, Alexander M. van der Bliek, Atsushi Tanaka, Der‐Fen Suen, Yi‐Te Hsu, Seok Min Jin and Alicia M. Pickrell and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Richard J. Youle

238 papers receiving 62.3k citations

Hit Papers

The BCL-2 protein family: opposing activities that mediat... 1997 2026 2006 2016 2007 2008 2012 2010 2010 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The BCL-2 protein family: opposing activities that mediate cell death
    2007 3.7k citations Richard J. Youle et al. profile →
  2. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    2008 3.2k citations Derek P. Narendra, Atsushi Tanaka et al. The Journal of Cell Biology profile →
  3. Mitochondrial Fission, Fusion, and Stress
    2012 2.7k citations Richard J. Youle et al. profile →
  4. Mechanisms of mitophagy
    2010 2.6k citations Richard J. Youle, Derek P. Narendra profile →
  5. PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
    2010 2.3k citations Derek P. Narendra, Seok Min Jin et al. PLoS Biology profile →
  6. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
    2015 2.1k citations Michael Lazarou, Lesley A. Kane et al. profile →
  7. The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
    2015 1.7k citations Alicia M. Pickrell, Richard J. Youle Neuron profile →
  8. The Role of Mitochondria in Apoptosis
    2009 1.6k citations Chunxin Wang, Richard J. Youle profile →
  9. Movement of Bax from the Cytosol to Mitochondria during Apoptosis
    1997 1.5k citations Carolyn L. Smith, Richard J. Youle et al. The Journal of Cell Biology profile →
  10. Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
    2018 1.5k citations Richard J. Youle et al. profile →
  11. The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis
    2001 1.5k citations Carolyn L. Smith, Richard J. Youle et al. profile →
  12. Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics
    2011 1.2k citations Richard J. Youle et al. profile →
  13. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
    2010 1.1k citations Atsushi Tanaka, Derek P. Narendra et al. The Journal of Cell Biology profile →
  14. Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
    2010 1.1k citations Seok Min Jin, Michael Lazarou et al. The Journal of Cell Biology profile →
  15. Mitochondrial dynamics and apoptosis
    2008 1.0k citations Richard J. Youle et al. profile →
  16. The Mitochondrial Basis of Aging
    2016 1.0k citations Richard J. Youle et al. profile →
  17. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
    2014 991 citations Lesley A. Kane, Michael Lazarou et al. The Journal of Cell Biology profile →
  18. Cytosol-to-membrane redistribution of Bax and Bcl-XLduring apoptosis
    1997 990 citations Richard J. Youle et al. profile →
  19. Structure of Bax
    2000 885 citations Richard J. Youle, Nico Tjandra et al. profile →
  20. Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis
    2004 883 citations Yang-ja Lee, Seon‐Yong Jeong et al. Molecular Biology of the Cell profile →
  21. Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
    2010 865 citations Chunxin Wang, Richard J. Youle et al. The Journal of Cell Biology profile →
  22. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis
    2002 682 citations Mariusz Karbowski, Yang-ja Lee et al. The Journal of Cell Biology profile →
  23. Mitochondrial fission in apoptosis
    2005 642 citations Richard J. Youle, Mariusz Karbowski profile →
  24. Dynamics of mitochondrial morphology in healthy cells and during apoptosis
    2003 638 citations Mariusz Karbowski, Richard J. Youle profile →
  25. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
    2010 629 citations Derek P. Narendra, Lesley A. Kane et al. Autophagy profile →
  26. SLP‐2 is required for stress‐induced mitochondrial hyperfusion
    2009 609 citations Mariusz Karbowski, David C. Chan et al. The EMBO Journal profile →
  27. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
    2016 587 citations Alexandra Stolz, Chunxin Wang et al. profile →
  28. The mechanisms and roles of selective autophagy in mammals
    2022 579 citations Richard J. Youle et al. profile →
  29. Nitric oxide‐induced mitochondrial fission is regulated by dynamin‐related GTPases in neurons
    2006 561 citations Richard J. Youle et al. The EMBO Journal profile →
  30. Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin
    2012 517 citations Michael Lazarou, Seok Min Jin et al. profile →
  31. Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family
    1997 514 citations Richard J. Youle et al. profile →
  32. PINK1 is degraded through the N-end rule pathway
    2013 513 citations Koji Yamano, Richard J. Youle Autophagy profile →
  33. Role of Bax and Bak in mitochondrial morphogenesis
    2006 506 citations Mariusz Karbowski, Seon‐Yong Jeong et al. profile →
  34. PINK1- and Parkin-mediated mitophagy at a glance
    2012 481 citations Seok Min Jin, Richard J. Youle profile →
  35. Mitochondrial fission facilitates the selective mitophagy of protein aggregates
    2017 373 citations Chunxin Wang, Richard J. Youle et al. The Journal of Cell Biology profile →
  36. Mitochondrial Function, Biology, and Role in Disease
    2016 357 citations Richard J. Youle et al. profile →
  37. Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy
    2019 343 citations Chunxin Wang, Eric Bunker et al. profile →
  38. The role of PINK1–Parkin in mitochondrial quality control
    2024 116 citations Derek P. Narendra, Richard J. Youle profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Richard J. Youle United States 103 43.9k 20.3k 7.5k 7.4k 6.7k 239 63.1k
Keiji Tanaka Japan 112 37.9k 0.9× 19.9k 1.0× 4.3k 0.6× 4.8k 0.6× 6.8k 1.0× 428 55.1k
Beth Levine United States 106 38.4k 0.9× 55.2k 2.7× 7.3k 1.0× 3.4k 0.5× 9.4k 1.4× 187 83.7k
Noboru Mizushima Japan 124 42.9k 1.0× 67.1k 3.3× 9.3k 1.2× 5.1k 0.7× 8.9k 1.3× 272 94.2k
Junying Yuan United States 103 36.5k 0.8× 10.9k 0.5× 4.3k 0.6× 2.6k 0.3× 10.4k 1.5× 254 52.9k
Daniel J. Klionsky United States 133 42.5k 1.0× 51.1k 2.5× 6.5k 0.9× 4.3k 0.6× 5.0k 0.7× 519 81.9k
Masaaki Komatsu Japan 89 21.8k 0.5× 29.0k 1.4× 5.8k 0.8× 3.5k 0.5× 3.9k 0.6× 227 45.7k
Ana María Cuervo United States 112 21.1k 0.5× 30.4k 1.5× 12.3k 1.6× 7.3k 1.0× 2.8k 0.4× 252 52.5k
Tamotsu Yoshimori Japan 95 24.4k 0.6× 38.0k 1.9× 5.5k 0.7× 2.6k 0.3× 5.9k 0.9× 246 55.8k
Michael P. Murphy United Kingdom 121 33.6k 0.8× 5.1k 0.2× 12.0k 1.6× 2.2k 0.3× 4.6k 0.7× 535 56.2k
Alfred L. Goldberg United States 138 49.6k 1.1× 10.2k 0.5× 11.9k 1.6× 1.6k 0.2× 6.7k 1.0× 369 67.3k

Countries citing papers authored by Richard J. Youle

Since Specialization
Citations

This map shows the geographic impact of Richard J. Youle's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard J. Youle with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard J. Youle more than expected).

Fields of papers citing papers by Richard J. Youle

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard J. Youle. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard J. Youle. The network helps show where Richard J. Youle may publish in the future.

Co-authorship network of co-authors of Richard J. Youle

This figure shows the co-authorship network connecting the top 25 collaborators of Richard J. Youle. A scholar is included among the top collaborators of Richard J. Youle based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard J. Youle. Richard J. Youle is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Pemberton, Joshua G., Krishnendu Roy, Yeun Ju Kim, et al.. (2025). Acute diacylglycerol production activates critical membrane-shaping proteins leading to mitochondrial tubulation and fission. Nature Communications. 16(1). 2685–2685. 4 indexed citations
2.
Fischer, Tara D., Eric Bunker, Peng-Peng Zhu, et al.. (2024). STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NF-κB signaling. The EMBO Journal. 44(1). 141–165. 6 indexed citations
3.
Bunker, Eric, François Le Guerroué, Chunxin Wang, et al.. (2023). Nix interacts with WIPI2 to induce mitophagy. The EMBO Journal. 42(22). e113491–e113491. 27 indexed citations
4.
Wang, Chunxin & Richard J. Youle. (2022). Mitochondria and peroxisomes are NIXed for clearance. The EMBO Journal. 41(24). e112918–e112918.
5.
Wang, Chunxin, Gil Kanfer, Antonio Velayos‐Baeza, et al.. (2021). VPS13D promotes peroxisome biogenesis. The Journal of Cell Biology. 220(5). 52 indexed citations
6.
Kanfer, Gil, Shireen A. Sarraf, Yaakov Maman, et al.. (2020). Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes. The Journal of Cell Biology. 220(2). 49 indexed citations
7.
Shi, Xiaoshan, Adam L. Yokom, Chunxin Wang, et al.. (2020). ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer. The Journal of Cell Biology. 219(7). 64 indexed citations
8.
Yamano, Koji & Richard J. Youle. (2020). Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy. Autophagy. 16(11). 2105–2107. 35 indexed citations
9.
10.
Yamano, Koji, Chunxin Wang, Shireen A. Sarraf, et al.. (2018). Endosomal Rab cycles regulate Parkin-mediated mitophagy. eLife. 7. 127 indexed citations
11.
Stolz, Alexandra, Mateusz Putyrski, Jessica Huber, et al.. (2016). Fluorescence‐based ATG 8 sensors monitor localization and function of LC 3/ GABARAP proteins. The EMBO Journal. 36(4). 549–564. 36 indexed citations
12.
Pickrell, Alicia M. & Richard J. Youle. (2015). The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease. Neuron. 85(2). 257–273. 1652 indexed citations breakdown →
13.
Kane, Lesley A., Michael Lazarou, Adam I. Fogel, et al.. (2014). PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. The Journal of Cell Biology. 205(2). 143–153. 991 indexed citations breakdown →
14.
Narendra, Derek P., Seok Min Jin, Atsushi Tanaka, et al.. (2010). PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin. PLoS Biology. 8(1). e1000298–e1000298. 2261 indexed citations breakdown →
15.
Jin, Seok Min, Michael Lazarou, Chunxin Wang, et al.. (2010). Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. The Journal of Cell Biology. 191(5). 933–942. 1050 indexed citations breakdown →
16.
Karbowski, Mariusz, Damien Arnoult, Hsiuchen Chen, et al.. (2004). Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. The Journal of Cell Biology. 164(4). 493–499. 357 indexed citations
17.
Lee, Yang-ja, Seon‐Yong Jeong, Mariusz Karbowski, Carolyn L. Smith, & Richard J. Youle. (2004). Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis. Molecular Biology of the Cell. 15(11). 5001–5011. 883 indexed citations breakdown →
18.
Youle, Richard J.. (1988). Toxin selection and modification — Overview. Cancer treatment and research. 37. 93–96. 1 indexed citations
19.
20.
Youle, Richard J. & Anthony H. C. Huang. (1976). Protein Bodies from the Endosperm of Castor Bean. PLANT PHYSIOLOGY. 58(6). 703–709. 87 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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