Randal J. Kaufman

102.5k total citations · 50 hit papers
466 papers, 82.2k citations indexed

About

Randal J. Kaufman is a scholar working on Molecular Biology, Cell Biology and Epidemiology. According to data from OpenAlex, Randal J. Kaufman has authored 466 papers receiving a total of 82.2k indexed citations (citations by other indexed papers that have themselves been cited), including 259 papers in Molecular Biology, 234 papers in Cell Biology and 90 papers in Epidemiology. Recurrent topics in Randal J. Kaufman's work include Endoplasmic Reticulum Stress and Disease (226 papers), RNA regulation and disease (99 papers) and Hemophilia Treatment and Research (75 papers). Randal J. Kaufman is often cited by papers focused on Endoplasmic Reticulum Stress and Disease (226 papers), RNA regulation and disease (99 papers) and Hemophilia Treatment and Research (75 papers). Randal J. Kaufman collaborates with scholars based in United States, Canada and United Kingdom. Randal J. Kaufman's co-authors include Kezhong Zhang, Martin Schröder, Donalyn Scheuner, Jyoti Malhotra, D. Thomas Rutkowski, Miao Wang, Stewart Siyan Cao, Andrew J. Dorner, Jun Wu and Sung Hoon Back and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Randal J. Kaufman

463 papers receiving 80.3k citations

Hit Papers

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE 1984 2026 1998 2012 2005 1999 2020 2008 2004 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
    2005 2.5k citations Martin Schröder, Randal J. Kaufman profile →
  2. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
    1999 1.9k citations Randal J. Kaufman profile →
  3. Mechanisms, regulation and functions of the unfolded protein response
    2020 1.7k citations Kezhong Zhang, Randal J. Kaufman et al. Nature Reviews Molecular Cell Biology profile →
  4. From endoplasmic-reticulum stress to the inflammatory response
    2008 1.7k citations Kezhong Zhang, Randal J. Kaufman profile →
  5. ER stress and the unfolded protein response
    2004 1.4k citations Martin Schröder, Randal J. Kaufman profile →
  6. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
    2013 1.3k citations Jaeseok Han, Sung Hoon Back et al. profile →
  7. Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?
    2007 1.3k citations Jyoti Malhotra, Randal J. Kaufman profile →
  8. Protein misfolding in the endoplasmic reticulum as a conduit to human disease
    2016 1.2k citations Randal J. Kaufman et al. profile →
  9. A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress
    2005 1.2k citations Donalyn Scheuner, Randal J. Kaufman et al. profile →
  10. A trip to the ER: coping with stress
    2003 1.2k citations Randal J. Kaufman et al. profile →
  11. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling
    2005 1.2k citations Donalyn Scheuner, Randal J. Kaufman et al. profile →
  12. Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
    2001 1.1k citations Donalyn Scheuner, Randal J. Kaufman et al. profile →
  13. Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease
    2014 1.1k citations Randal J. Kaufman et al. profile →
  14. Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins
    1985 1.1k citations Randal J. Kaufman et al. profile →
  15. Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival
    2003 1.0k citations Randal J. Kaufman et al. profile →
  16. Orchestrating the unfolded protein response in health and disease
    2002 999 citations Randal J. Kaufman Journal of Clinical Investigation profile →
  17. Endoplasmic reticulum stress in liver disease
    2010 961 citations Randal J. Kaufman et al. profile →
  18. Orchestrating the unfolded protein response in health and disease
    2002 886 citations Randal J. Kaufman Journal of Clinical Investigation profile →
  19. The impact of the endoplasmic reticulum protein-folding environment on cancer development
    2014 854 citations Randal J. Kaufman et al. profile →
  20. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
    2002 852 citations Kyung‐Ho Lee, Witoon Tirasophon et al. profile →
  21. Isolation and characterization of genomic and cDNA clones of human erythropoietin
    1985 829 citations Randal J. Kaufman et al. profile →
  22. The endoplasmic reticulum and the unfolded protein response
    2007 812 citations Jyoti Malhotra, Randal J. Kaufman profile →
  23. The impact of the unfolded protein response on human disease
    2012 787 citations Shiyu Wang, Randal J. Kaufman profile →
  24. ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
    2006 774 citations Randal J. Kaufman et al. profile →
  25. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
    1998 744 citations Witoon Tirasophon, Randal J. Kaufman et al. profile →
  26. Molecular cloning of a cDNA encoding human antihaemophilic factor
    1984 731 citations Debra D. Pittman, Randal J. Kaufman et al. profile →
  27. From acute ER stress to physiological roles of the Unfolded Protein Response
    2006 726 citations Randal J. Kaufman et al. profile →
  28. Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins
    2006 672 citations Stacey Arnold, Kazutoshi Mori et al. profile →
  29. Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response
    2006 672 citations Kezhong Zhang, Xiaohua Shen et al. profile →
  30. Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression
    2006 626 citations Randal J. Kaufman et al. profile →
  31. Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors
    2003 611 citations Randal J. Kaufman et al. Journal of Biological Chemistry profile →
  32. Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway
    2001 608 citations Zsolt Tallóczy, Wenxia Jiang et al. Proceedings of the National Academy of Sciences profile →
  33. Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development
    2001 590 citations Xiaohua Shen, Kyung‐Ho Lee et al. profile →
  34. Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes
    2008 581 citations Donalyn Scheuner, Randal J. Kaufman et al. Journal of Clinical Investigation profile →
  35. The unfolded protein response in immunity and inflammation
    2016 577 citations Randal J. Kaufman et al. profile →
  36. Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome
    2012 576 citations Randal J. Kaufman et al. profile →
  37. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion
    2008 576 citations Jyoti Malhotra, Kezhong Zhang et al. Proceedings of the National Academy of Sciences profile →
  38. ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
    2005 574 citations Donalyn Scheuner, Randal J. Kaufman et al. The EMBO Journal profile →
  39. ATF6α Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress
    2007 566 citations Randal J. Kaufman et al. profile →
  40. A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response
    2003 562 citations Nobuko Hosokawa, Randal J. Kaufman et al. profile →
  41. Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2
    2004 540 citations Donalyn Scheuner, Randal J. Kaufman et al. profile →
  42. The unfolded protein response in nutrient sensing and differentiation
    2002 502 citations Randal J. Kaufman, Donalyn Scheuner et al. Nature Reviews Molecular Cell Biology profile →
  43. The role of ER stress in lipid metabolism and lipotoxicity
    2016 486 citations Jaeseok Han, Randal J. Kaufman profile →
  44. UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators
    2008 480 citations Robert L. Clark, Michael G. Katze et al. profile →
  45. Endoplasmic Reticulum Stress and Type 2 Diabetes
    2012 478 citations Sung Hoon Back, Randal J. Kaufman profile →
  46. ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development
    2014 396 citations Randal J. Kaufman et al. profile →
  47. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P
    2018 246 citations Randal J. Kaufman et al. profile →
  48. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis
    2023 228 citations Randal J. Kaufman et al. profile →
  49. Endoplasmic reticulum stress in liver diseases
    2022 224 citations Randal J. Kaufman et al. profile →
  50. Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus
    2021 155 citations Jing Yong, Peter Arvan et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Randal J. Kaufman United States 146 42.0k 39.1k 21.4k 10.3k 9.1k 466 82.2k
David Ron United States 118 40.5k 1.0× 45.4k 1.2× 22.2k 1.0× 10.2k 1.0× 7.9k 0.9× 266 74.6k
Kun‐Liang Guan United States 148 57.9k 1.4× 32.0k 0.8× 14.3k 0.7× 4.9k 0.5× 7.3k 0.8× 422 89.1k
Noboru Mizushima Japan 124 42.9k 1.0× 20.1k 0.5× 67.1k 3.1× 4.5k 0.4× 8.9k 1.0× 272 94.2k
Steven P. Gygi United States 166 88.4k 2.1× 18.1k 0.5× 14.5k 0.7× 3.5k 0.3× 7.9k 0.9× 695 121.5k
Alfred L. Goldberg United States 138 49.6k 1.2× 17.3k 0.4× 10.2k 0.5× 2.0k 0.2× 6.7k 0.7× 369 67.3k
Beth Levine United States 106 38.4k 0.9× 13.3k 0.3× 55.2k 2.6× 4.0k 0.4× 9.4k 1.0× 187 83.7k
John C. Reed United States 161 73.3k 1.7× 10.1k 0.3× 10.6k 0.5× 4.6k 0.4× 20.4k 2.2× 799 107.5k
George D. Yancopoulos United States 161 55.1k 1.3× 9.9k 0.3× 4.5k 0.2× 7.9k 0.8× 16.0k 1.7× 430 103.1k
Keiji Tanaka Japan 112 37.9k 0.9× 11.5k 0.3× 19.9k 0.9× 2.4k 0.2× 6.8k 0.7× 428 55.1k
Dario R. Alessi United Kingdom 124 50.6k 1.2× 10.1k 0.3× 5.1k 0.2× 6.2k 0.6× 4.9k 0.5× 313 65.6k

Countries citing papers authored by Randal J. Kaufman

Since Specialization
Citations

This map shows the geographic impact of Randal J. Kaufman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Randal J. Kaufman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Randal J. Kaufman more than expected).

Fields of papers citing papers by Randal J. Kaufman

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Randal J. Kaufman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Randal J. Kaufman. The network helps show where Randal J. Kaufman may publish in the future.

Co-authorship network of co-authors of Randal J. Kaufman

This figure shows the co-authorship network connecting the top 25 collaborators of Randal J. Kaufman. A scholar is included among the top collaborators of Randal J. Kaufman based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Randal J. Kaufman. Randal J. Kaufman is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Chen, Zhouji, Roland W. Herzog, & Randal J. Kaufman. (2023). Cellular stress and coagulation factor production: when more is not necessarily better. Journal of Thrombosis and Haemostasis. 21(12). 3329–3341. 7 indexed citations
2.
Liu, Ming, Yumeng Huang, Xiaoxi Xu, et al.. (2021). Normal and defective pathways in biogenesis and maintenance of the insulin storage pool. Journal of Clinical Investigation. 131(2). 46 indexed citations
3.
Li, Hainan, Megan M. O’Meara, Xiang Zhang, et al.. (2019). Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes. Diabetes. 68(6). 1287–1302. 32 indexed citations
4.
Arunagiri, Anoop, Leena Haataja, Anita Pottekat, et al.. (2019). Proinsulin misfolding is an early event in the progression to type 2 diabetes. eLife. 8. 100 indexed citations
5.
Liu, Ming, Michael A. Weiss, Anoop Arunagiri, et al.. (2018). Biosynthesis, structure, and folding of the insulin precursor protein. Diabetes Obesity and Metabolism. 20(S2). 28–50. 144 indexed citations
6.
Genereux, Joseph C., Song Qu, Minghai Zhou, et al.. (2014). Unfolded protein response‐induced ER dj3 secretion links ER stress to extracellular proteostasis. The EMBO Journal. 34(1). 4–19. 99 indexed citations
7.
Prisco, Gonzalo Viana Di, Wei‐Chien Huang, Shelly A. Buffington, et al.. (2014). Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nature Neuroscience. 17(8). 1073–1082. 153 indexed citations
8.
Javeed, Naureen, Gunisha Sagar, Shamit K. Dutta, et al.. (2014). Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction. Clinical Cancer Research. 21(7). 1722–1733. 150 indexed citations
9.
Sakaki, Kenjiro, Sawako Yoshina, Xiaohua Shen, et al.. (2012). RNA surveillance is required for endoplasmic reticulum homeostasis. Proceedings of the National Academy of Sciences. 109(21). 8079–8084. 67 indexed citations
10.
Malhotra, Jyoti & Randal J. Kaufman. (2011). ER Stress and Its Functional Link to Mitochondria: Role in Cell Survival and Death. Cold Spring Harbor Perspectives in Biology. 3(9). a004424–a004424. 316 indexed citations
11.
Sopha, Pattarawut, et al.. (2010). Domain compatibility in Ire1 kinase is critical for the unfolded protein response. FEBS Letters. 584(14). 3203–3208. 8 indexed citations
12.
Nagasawa, Koji, Toshio Higashi, Nobuko Hosokawa, Randal J. Kaufman, & Kazuhiro Nagata. (2007). Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation. EMBO Reports. 8(5). 483–489. 54 indexed citations
13.
Drogat, Benjamin, Patrick Auguste, Duc Thang Nguyên, et al.. (2007). IRE1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth In vivo. Cancer Research. 67(14). 6700–6707. 176 indexed citations
14.
Zhou, Jiahai, Chuan Yin Liu, Sung Hoon Back, et al.. (2006). The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proceedings of the National Academy of Sciences. 103(39). 14343–14348. 285 indexed citations
15.
Tardif, Keith D., Kazutoshi Mori, Randal J. Kaufman, & Aleem Siddiqui. (2004). Hepatitis C Virus Suppresses the IRE1-XBP1 Pathway of the Unfolded Protein Response. Journal of Biological Chemistry. 279(17). 17158–17164. 192 indexed citations
16.
Kaufman, Randal J., Donalyn Scheuner, Martin Schröder, et al.. (2002). The unfolded protein response in nutrient sensing and differentiation. Nature Reviews Molecular Cell Biology. 3(6). 411–421. 502 indexed citations breakdown →
17.
Tallóczy, Zsolt, Wenxia Jiang, Herbert W. Virgin, et al.. (2001). Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway. Proceedings of the National Academy of Sciences. 99(1). 190–195. 608 indexed citations breakdown →
18.
Kaufman, Randal J., Steven W. Pipe, Luigina Tagliavacca, Manju Swaroop, & Micheline J. Moussalli. (1997). Biosynthesis, assembly and secretion of coagulation factor VIII.. PubMed. 8 Suppl 2(1). S3–14. 70 indexed citations
19.
Marquette, Kimberly, Debra D. Pittman, & Randal J. Kaufman. (1995). A 110-amino Acid Region within the A1-domain of Coagulation Factor VIII Inhibits Secretion from Mammalian Cells. Journal of Biological Chemistry. 270(17). 10297–10303. 58 indexed citations
20.
Clemens, Michael J., John W.B. Hershey, Michael G. Katze, et al.. (1993). PKR: Proposed Nomenclature for the RNA-Dependent Protein Kinase Induced by Interferon. Journal of Interferon Research. 13(3). 241–241. 44 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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