Alexei Degterev

16.6k citations

88 papers · 12.2k indexed · 4 hit papers · h-index 42

Molecular Biology top 0.5%
Immunology top 0.5%
Epidemiology top 1%
Oncology top 2%
Cancer Research top 1%

Co-authors: Junying Yuan Michael Boyce Gregory D. Cuny Timothy J. Mitchison Prakash G. Jagtap Michael A. Moskowitz Noboru Mizushima Yaqiao Li
Topics: Cell death mechanisms and regulation (54 papers)interferon and immune responses (16 papers)Immune Response and Inflammation (11 papers)
Cited by: Immunology Molecular Biology Cancer Research
Journals: Cell Proceedings of the National Academy of Sciences Journal of the American Chemical Society
Partner nations: United States China United Kingdom

In The Last Decade

Alexei Degterev

88 papers receiving 12.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

2005 2.4k citations Alexei Degterev, Gregory D. Cuny et al. profile →
Identification of RIP1 kinase as a specific cellular target of necrostatins

2008 1.6k citations Alexei Degterev, Irene L. Ch’en et al. profile →
A decade of caspases

2003 893 citations Alexei Degterev, Junying Yuan et al. profile →
Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

2008 784 citations Alexei Degterev, Junying Yuan et al. Cell profile →

Peers

Countries citing papers authored by Alexei Degterev

Since Specialization

Citations

This map shows the geographic impact of Alexei Degterev's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alexei Degterev with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alexei Degterev more than expected).

Fields of papers citing papers by Alexei Degterev

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alexei Degterev. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alexei Degterev. The network helps show where Alexei Degterev may publish in the future.

Co-authorship network of co-authors of Alexei Degterev

This figure shows the co-authorship network connecting the top 25 collaborators of Alexei Degterev. A scholar is included among the top collaborators of Alexei Degterev based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alexei Degterev. Alexei Degterev is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling 2021 ·European Journal of Medicinal Chemistry ·(unknown),(unknown),Lisa Schlicher,(unknown),Mads Gyrd‐Hansen,Alexei Degterev,Gregory D. Cuny	14
2	Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor 2021 ·Cell Death and Disease ·Tom Delanghe,(unknown),(unknown),Dario Priem,Samya Van Coillie,Barbara Gilbert,Sze Men Choi,Peter Vandenabeele,Alexei Degterev,Gregory D. Cuny,Yves Dondelinger,Mathieu J.M. Bertrand	24
3	RIPK protein kinase family: Atypical lives of typical kinases 2020 ·Seminars in Cell and Developmental Biology ·Gregory D. Cuny,Alexei Degterev	59
4	Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors 2018 ·Bioorganic & Medicinal Chemistry Letters ·Chalada Suebsuwong,Daniel M. Pinkas,Soumya S. Ray,Joshua C. Bufton,Bing Dai,Alex N. Bullock,Alexei Degterev,Gregory D. Cuny	18
5	Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis 2017 ·Trends in Pharmacological Sciences ·(unknown),Danish Saleh,Alexei Degterev	144
6	Cytotoxicity of PEGylated liposomes co-loaded with novel pro-apoptotic drug NCL-240 and the MEK inhibitor cobimetinib against colon carcinoma in vitro 2015 ·Journal of Controlled Release ·Shravan Kumar Sriraman,(unknown),Ed Luther,Alexei Degterev,Vladimir P. Torchilin	18
7	Emerging Roles for RIPK1 and RIPK3 in Pathogen-Induced Cell Death and Host Immunity 2015 ·Current topics in microbiology and immunology ·Danish Saleh,Alexei Degterev	15
8	Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases 2013 ·Proceedings of the National Academy of Sciences ·Roshan J. Thapa,Shoko Nogusa,Peirong Chen,Jenny L. Maki,Anthony Lerro,Mark Andrake,Glenn F. Rall,Alexei Degterev,Siddharth Balachandran	280
9	Structural Basis of RIP1 Inhibition by Necrostatins 2013 ·Structure ·Tian Xie,Wei Peng,Yexing Liu,Chuangye Yan,Jenny L. Maki,Alexei Degterev,Junying Yuan,Yigong Shi	185
10	Role of Phosphatidylinositol 3,4,5-Trisphosphate in Cell Signaling 2013 ·Advances in experimental medicine and biology ·(unknown),(unknown),Alexei Degterev	34
11	Activity Assays for Receptor-Interacting Protein Kinase 1:A Key Regulator of Necroptosis 2013 ·Methods in molecular biology ·Jenny L. Maki,Alexei Degterev	2
12	Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability 2012 ·Bioorganic & Medicinal Chemistry Letters ·Sung‐Woon Choi,Heather R. Keys,Richard J. Staples,Junying Yuan,Alexei Degterev,Gregory D. Cuny	17
13	Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models 2012 ·Cell Death and Disease ·Nozomi Takahashi,Linde Duprez,Sasker Grootjans,Anje Cauwels,Wim Nerinckx,James B. DuHadaway,Vera Goossens,Ria Roelandt,Filip Van Hauwermeiren,Claude Libert,Wim Declercq,Nico Callewaert,George C. Prendergast,Alexei Degterev,Junying Yuan,Peter Vandenabeele	369
14	A computational framework for studying neuron morphology from in vitro high content neuron-based screening 2010 ·Journal of Neuroscience Methods ·Yue Huang,Xiaobo Zhou,Benchun Miao,Marta M. Lipinski,Yong Zhang,Fuhai Li,Alexei Degterev,Junying Yuan,Guangshu Hu,Stephen T.C. Wong	10
15	Antigen-mediated T cell expansion regulated by parallel pathways of death 2008 ·Proceedings of the National Academy of Sciences ·Irene L. Ch’en,Daniel R. Beisner,Alexei Degterev,Candace Lynch,Junying Yuan,Alexander Hoffmann,Stephen Μ. Hedrick	117
16	Expansion and evolution of cell death programmes 2008 ·Nature Reviews Molecular Cell Biology ·Alexei Degterev,Junying Yuan	423
17	Structure–activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors 2008 ·Bioorganic & Medicinal Chemistry Letters ·Xin Teng,Heather R. Keys,Junying Yuan,Alexei Degterev,Gregory D. Cuny	25
18	Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G 2007 ·Cell ·Nathan J. Moerke,Hüseyin Aktaş,Han Chen,Sonia Cantel,Mikhail Reibarkh,Amr Fahmy,John D. Gross,Alexei Degterev,Junying Yuan,Michael Chorev,José A. Halperin,Gerhard Wagner	441
19	Structure–activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors 2007 ·Bioorganic & Medicinal Chemistry Letters ·Xin Teng,Heather R. Keys,Arumugasamy Jeevanandam,John A. Porco,Alexei Degterev,Junying Yuan,Gregory D. Cuny	41
20	Automated neurite labeling and analysis in fluorescence microscopy images 2006 ·Cytometry Part A ·Guanglei Xiong,Xiaobo Zhou,Alexei Degterev,Liang Ji,Stephen T.C. Wong	57

About Alexei Degterev

Alexei Degterev is a scholar working on Immunology, Molecular Biology and Biophysics, having authored 88 papers that have together received 12.2k indexed citations. Recurring topics across this work include Cell death mechanisms and regulation (54 papers), interferon and immune responses (16 papers) and Immune Response and Inflammation (11 papers). The work is most often cited by research in Immunology (3.4k citations), Molecular Biology (9.1k citations) and Cancer Research (1.3k citations). Alexei Degterev has collaborated with scholars based in United States, China and United Kingdom. Frequent co-authors include Junying Yuan, Michael Boyce, Gregory D. Cuny, Timothy J. Mitchison, Prakash G. Jagtap, Michael A. Moskowitz, Noboru Mizushima, Yaqiao Li, Zhihong Huang and Gerhard Wagner. Their work appears in journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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