Derek W. Abbott

9.8k citations

67 papers · 7.4k indexed · 4 hit papers · h-index 36

Impact in

Immunology top 0.5%
- Immune Response and Inflammation
- interferon and immune responses
Molecular Biology top 1%
- Inflammasome and immune disorders
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways

Papers in

Immunology 42
- interferon and immune responses 17
- Immune Response and Inflammation 15
- IL-33, ST2, and ILC Pathways 9
Cancer Research 17
- NF-κB Signaling Pathways 15

Co-authors: Lewis C. Cantley John M. Asara George Dubyak Joseph K. Rathkey Tsan Sam Xiao Junying Yuan Gregory D. Cuny Junichi Hitomi
Journals: Journal of Biological Chemistry (13 papers)The Journal of Immunology (7 papers)Molecular and Cellular Biology (5 papers)Cell Reports (4 papers)Proceedings of the National Academy of Sciences (3 papers)
Partner nations: United States China Greece

In The Last Decade

Derek W. Abbott

65 papers receiving 7.3k citations

Hit Papers

align trajectories log scale

GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis 2022 · 144 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2022 Cell
2020 Nature Communications
2018 Science Immunology
2008 Nature Chemical Biology

Peers

Countries citing papers authored by Derek W. Abbott

Since Specialization

Citations

This map shows the geographic impact of Derek W. Abbott's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Derek W. Abbott with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Derek W. Abbott more than expected).

Fields of papers citing papers by Derek W. Abbott

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Derek W. Abbott. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Derek W. Abbott. The network helps show where Derek W. Abbott may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Derek W. Abbott, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Derek W. Abbott Line = papers co-authored together Derek W. Abbott links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP Cell Reports ·壽子井川, Hannah Kondolf, Stefania De Santis, Theresa T. Pizarro, Derek W. Abbott	2025	2
2	Gasdermins, Executors of Pyroptosis: A Decade in Perspective Annual Review of Pathology Mechanisms of Disease ·Bowen Zhou, Derek W. Abbott	2025	0
3	Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface Life Science Alliance ·Mathilde Lethier, Karine Huard, Michael Hons, Adrien Favier, Bernhard Brutscher, Elisabetta Boeri Erba, Derek W. Abbott, S. Cusack, Erika Pellegrini	2023	2
4	GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis Cell ·Nitish Rana, Giuseppe Privitera, Hannah Kondolf, Katarzyna Bulek, Susana Lechuga, Carlo De Salvo, Daniele Corridoni, Agne Antanaviciute, Rebecca L. Maywald, J. Miksova, Junjie Zhao, Emina H. Huang, Xiaoxia Li, E. Ricky Chan, Alison Simmons, Giorgos Bamias, Derek W. Abbott, Jason D. Heaney, Andrei I. Ivanov, Theresa T. Pizarro Hit paper breakdown →	2022	144
5	TH17 cells promote CNS inflammation by sensing danger signals via Mincle Nature Communications ·安晓萍, Weiwei Liu, Han Wang, Hao Zhou, Katarzyna Bulek, Xing Chen, Cun‐Jin Zhang, Junjie Zhao, Renliang Zhang, Caini Liu, Zizhen Kang, Robert A Bermel, George Dubyak, Derek W. Abbott, Tsan Sam Xiao, Laura E. Nagy, Xiaoxia Li	2022	17
6	Discovery of a Redox Thiol Switch: Implications for Cellular Energy Metabolism Molecular & Cellular Proteomics ·Xing‐Huang Gao, Ling Li, Marc Parisien, Jing Wu, Ilya Bederman, Zhaofeng Gao, Dawid Krokowski, Steven M. Chirieleison, Derek W. Abbott, Benlian Wang, Peter Arvan, Mark J. Cameron, Mark R. Chance, Belinda Willard, Maria Hatzoglou	2020	37
7	Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage Immunity ·Zhonghua Liu, Chuanping Wang, Jie Yang, Yinghua Chen, Bowen Zhou, Derek W. Abbott, Tsan Sam Xiao	2020	152
8	Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization Immunity ·Zhonghua Liu, Chuanping Wang, Jie Yang, Bowen Zhou, Rui Yang, Rajesh Ramachandran, Derek W. Abbott, Tsan Sam Xiao	2019	200
9	Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor Proceedings of the National Academy of Sciences ·Jie Yang, Liu Z, Chuanping Wang, Rui Yang, Joseph K. Rathkey, Otis Pinkard, Wuxian Shi, Yinghua Chen, George Dubyak, Derek W. Abbott, Tsan Sam Xiao	2018	150
10	Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis Science Immunology ·Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah Kondolf, Bryan L. Benson, Steven M. Chirieleison, Alex Y. Huang, George Dubyak, Tsan Sam Xiao, Xiaoxia Li, Derek W. Abbott Hit paper breakdown →	2018	460
11	Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition Structure ·Zhonghua Liu, Chuanping Wang, Joseph K. Rathkey, Jie Yang, George Dubyak, Derek W. Abbott, Tsan Sam Xiao	2018	75
12	Live-cell visualization of gasdermin D-driven pyroptotic cell death Journal of Biological Chemistry ·Joseph K. Rathkey, Bryan L. Benson, Steven M. Chirieleison, Jie Yang, Tsan Sam Xiao, George Dubyak, Alex Y. Huang, Derek W. Abbott	2017	53
13	IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis American Journal Of Pathology ·Carlo De Salvo, F. Leonarski, Luca Pastorelli, Benedetta Mattioli, Sara Omenetti, Ashma Taqiyyah, Guodong Lv, Rekha Garg, Wendy A. Goodman, Alexander Rodriguez‐Palacios, Dirk E. Smith, Derek W. Abbott, Fabio Cominelli, Giorgos Bamias, Wei Xin, James J. Lee, Maurizio Vecchi, Theresa T. Pizarro	2016	66
14	An IκB Kinase-Regulated Feedforward Circuit Prolongs Inflammation Cell Reports ·Jessica M. Perez, Steven M. Chirieleison, Derek W. Abbott	2015	13
15	Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Justine T. Tigno-Aranjuez, Derek W. Abbott	2012	45
16	CpG-B Oligodeoxynucleotides Inhibit TLR-Dependent and -Independent Induction of Type I IFN in Dendritic Cells The Journal of Immunology ·Yichun Liu, Nuria B. Cajamarca-Tene, Gareth Hardy, John Kuchtey, Derek W. Abbott, Steven N. Emancipator, Clifford V. Harding	2010	18
17	Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses Genes & Development ·Justine T. Tigno-Aranjuez, John M. Asara, Derek W. Abbott	2010	161
18	A Novel Motif in the Crohn's Disease Susceptibility Protein, NOD2, Allows TRAF4 to Down-regulate Innate Immune Responses Journal of Biological Chemistry ·Jill M. Marinis, Craig R. Homer, Christine McDonald, Derek W. Abbott	2010	55
19	NOD2 Pathway Activation by MDP or Mycobacterium tuberculosis Infection Involves the Stable Polyubiquitination of Rip2 Journal of Biological Chemistry ·Yibin Yang, Catherine Yin, Amit Kumar Pandey, Derek W. Abbott, Christopher M. Sassetti, Michelle A. Kelliher	2007	186
20	The Crohn's Disease Protein, NOD2, Requires RIP2 in Order to Induce Ubiquitinylation of a Novel Site on NEMO Current Biology ·Derek W. Abbott, Andrew Wilkins, John M. Asara, Lewis C. Cantley	2004	312

About Derek W. Abbott

Derek W. Abbott is a scholar working on Immunology, Cancer Research, Structural Biology, Nephrology and Hematology, having authored 67 papers that have together received 7.4k indexed citations. Recurring topics across this work include Inflammasome and immune disorders (24 papers), interferon and immune responses (17 papers), Immune Response and Inflammation (15 papers), NF-κB Signaling Pathways (15 papers), IL-33, ST2, and ILC Pathways (9 papers), Autoimmune and Inflammatory Disorders Research (7 papers), Inflammatory Bowel Disease (6 papers) and Cell death mechanisms and regulation (5 papers). The work is most often cited by research in Immunology (2.9k citations), Molecular Biology (5.2k citations), Cancer Research (1.1k citations), Nephrology (484 citations) and Oncology (938 citations). Derek W. Abbott has collaborated with scholars based in United States, China and Greece. Frequent co-authors include Lewis C. Cantley, John M. Asara, George Dubyak, Joseph K. Rathkey, Tsan Sam Xiao, Junying Yuan, Gregory D. Cuny, Junichi Hitomi, Chengye Yuan and Alexey A. Lugovskoy. Their work appears in journals such as Journal of Biological Chemistry, The Journal of Immunology, Molecular and Cellular Biology, Cell Reports and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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