Paul Säftig

61.9k citations

333 papers · 39.2k indexed · 14 hit papers · h-index 104

Impact in

Physiology top 0.02%
- Alzheimer's disease research and treatments
- Lysosomal Storage Disorders Research
- Calcium signaling and nucleotide metabolism
Immunology and Allergy top 0.05%
- Cell Adhesion Molecules Research

Papers in

Physiology 43
- Lysosomal Storage Disorders Research 77
- Alzheimer's disease research and treatments 51
- Calcium signaling and nucleotide metabolism 39
Immunology and Allergy 46
- Cell Adhesion Molecules Research 45

Co-authors: Eeva‐Liisa Eskelinen Bart De Strooper Karina Reiß Dieter Hartmann Kurt Von Figura Judith Klumperman Wim Annaert Katleen Craessaerts
Journals: Journal of Biological Chemistry (29 papers)Proceedings of the National Academy of Sciences (13 papers)Journal of Cell Science (11 papers)Journal of Neuroscience (10 papers)Molecular and Cellular Biology (8 papers)
Partner nations: Germany United States Belgium

In The Last Decade

Paul Säftig

329 papers receiving 38.7k citations

Hit Papers

14 papers align trajectories log scale

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis 2011 · 734 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2011 Developmental Cell
2009 Nature Reviews Molecular Cell Biology
2008 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
2007 The EMBO Journal
2006 Science
2005 Proceedings of the National Academy of Sciences
2004 The Journal of Cell Biology
2004 Journal of Cell Science
2003 Blood
2003 Trends in Cell Biology
2000 Nature
1999 Nature
1998 Nature
1998 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by Paul Säftig

Since Specialization

Citations

This map shows the geographic impact of Paul Säftig's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paul Säftig with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paul Säftig more than expected).

Fields of papers citing papers by Paul Säftig

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paul Säftig. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paul Säftig. The network helps show where Paul Säftig may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Paul Säftig, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Paul Säftig Line = papers co-authored together Paul Säftig links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Sphingosine-1-phosphate signalling activates E-Syt1 to facilitate HDL-derived cholesterol transport Nature Cell Biology ·Christopher Houtkamp, Ying Meng, 史维东, Harun Kazancı, Wang Xun-fu, Saskia Heybrock, Qiang Zhao, 傅永聚, M. P. Manglick, Richard F. Collins, Hu Hu, Quan Zhou, Qiming Sun, Pinglong Xu, Wei Liu, Paul Säftig, Brian Raught, Gregory D. Fairn, Dante Neculai	2025	0
2	Inhibition of BACE1 affected both its Aβ producing and degrading activities and increased Aβ42 and Aβ40 levels at high-level BACE1 expression Journal of Biological Chemistry ·田中俊子, Merav Carmeli, MAREK PAWUK, Hao Qu, Adeola Shobo, Paul Säftig, Mark A. Hancock, O Shibata, Marc Garnica	2024	10
3	Non-canonical function of ADAM10 in presynaptic plasticity Cellular and Molecular Life Sciences ·Julia Bär, Tomas Fanutza, L. L. SILVA, Lisa Seipold, Biying Song, Guiboke Seong, Andréia da Silva Magaton, Michael Bucher, Christine E. Gee, Michaela Schweizer, Paul Säftig, Marina Mikhaylova	2024	0
4	Rab GTPase regulation of phagosome–lysosome fusion is bypassed in the presence of micromolar Ca2+ Journal of Cell Science ·須藤隆紀, 太一脇屋, Yuichi Sakurai, JohnA. Luetscher, Paul Säftig, LI Wenguan, Albert Haas	2023	1
5	Tetraspanin 15 depletion impairs extracellular vesicle docking at target neurons SHILAP Revista de lepidopterología ·Falitha Elian, Franco L. Lombino, Michaela Schweizer, Markus Glatzel, Paul Säftig, Kira V. Gromova, Matthias Kneussel	2023	5
6	Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes Cell Reports ·太一脇屋, 田中艳, Tal Keren‐Kaplan, Jing Pu, Paul Säftig, Juan S. Bonifacino, Albert Haas, LI Wenguan	2023	29
7	LAMP3 deficiency affects surfactant homeostasis in mice PLoS Genetics ·Lars Lunding, Donald L. Summers, Guido Stichtenoth, Cordula Stamme, 정인태, Jan Hegermann, Matthias Ochs, Björn Schuster, Radislav Sedláček, Paul Säftig, Dominik Schwudke, Michael Wegmann, Markus Daμμe	2021	9
8	S-palmitoylation determines TMEM55B-dependent positioning of lysosomes Journal of Cell Science ·Kaan Icer, Saskia Heybrock, Paul Säftig, Markus Daμμe	2021	6
9	The intramembrane protease SPPL 2c promotes male germ cell development by cleaving phospholamban EMBO Reports ·Cefalu Sj, Torben Mentrup, Imants Plūme, Stephan A. Müller, Leif Erik Simonsen, W. Knowsley Sibley, Alexander Pfefferle, Verena Dederer, Martina Haug‐Kröper, Sharda S. Gavande, Renate Lüllmann‐Rauch, Martin Bergmann, Artur Mayerhofer, Paul Säftig, Gunther Wennemuth, Rolf Jessberger, Regina Fluhrer, Stefan F. Lichtenthaler, Marius K. Lemberg, Bernd Schröder	2019	29
10	The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments The Journal of Immunology ·Janna Schneppenheim, Toshikazu Nomura, Carsten Stroud, Michaela Schweizer, Renate Lüllmann‐Rauch, Hans‐Heinrich Oberg, Philipp Arnold, Christian H.K. Lehmann, Diana Dudziak, Dieter Kabelitz, Ralph Lucius, Ana‐Maria Lennon‐Duménil, Paul Säftig, Bernd Schröder	2017	11
11	Parkinson's disease: acid‐glucocerebrosidase activity and alpha‐synuclein clearance Journal of Neurochemistry ·Judith Blanz, Paul Säftig	2016	51
12	Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver Gastroenterology ·Barbara T. Grünwald, Robert Davies, Susanne Schaten, Dmitrii A. Gurianov, Naruhisa Matsuda, Bastian Höchst, Luis A Barranco Olivera, Pamela Pasian, Mert Erkan, Olga Prokopchuk, Marc E. Martignoni, Iréne Esposito, Mathias Heikenwälder, Aayush Gupta, Jens T. Siveke, Paul Säftig, Percy A. Knolle, Dirk Wohlleber, Achim Krüger	2016	104
13	Mannose 6‐phosphate‐independent Lysosomal Sorting of LIMP‐2 Traffic ·Judith Blanz, Friederike Zunke, D Thibault, Markus Daμμe, Thomas Braulke, Paul Säftig, Michael Schwake	2015	26
14	Lysosomal Membrane Proteins and Their Central Role in Physiology Traffic ·Michael Schwake, Bernd Schröder, Paul Säftig	2013	185
15	Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles The EMBO Journal ·Cyril Chéret, Michael Willem, Florence R. Fricker, Hagen Wende, Annika Wulf-Goldenberg, Sabina Tahirović, Klaus‐Armin Nave, Paul Säftig, Christian Haass, Alistair N. Garratt, David Bennett, Carmen Birchmeier	2013	106
16	Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis Science ·Masataka Asagiri, Toshitake Hirai, Toshihiro Kunigami, DA Schon, Hans-Jürgen Gober, Kazuo Okamoto, Keizo Nishikawa, Eicke Latz, Douglas T. Golenbock, Kazuhiro Aoki, Keiichi Ohya, Yuuki Imai, Yasuyuki Morishita, Kohei Miyazono, Shigeaki Kato, Paul Säftig, Hiroshi Takayanagi	2008	290
17	Deficiency of the Tetraspanin CD63 Associated with Kidney Pathology but Normal Lysosomal Function Molecular and Cellular Biology ·J Schröder, Renate Lüllmann‐Rauch, Nina Himmerkus, Irina Pleines, Bernhard Nieswandt, Zane Orinska, Friedrich Koch‐Nolte, Bernd Schröder, Markus Bleich, Paul Säftig	2008	83
18	Control of Peripheral Nerve Myelination by the ß-Secretase BACE1 Science ·Michael Willem, Alistair N. Garratt, Božidar Novak, Martin Citron, Vikha Rianti Amalia, Andrea Rittger, Bart De Strooper, Paul Säftig, Carmen Birchmeier, Christian Haass Hit paper breakdown →	2006	527
19	Disruption of the Cathepsin K Gene Reduces Atherosclerosis Progression and Induces Plaque Fibrosis but Accelerates Macrophage Foam Cell Formation Circulation ·Esther Lutgens, Suzanne P. M. Lutgens, Birgit Faber, Sylvia Heeneman, Marion Gijbels, Menno P.J. de Winther, Peter M. Frederik, Ingeborg van der Made, Alan Daugherty, Anneke M. Sijbers, Andrew J. Fisher, Clive Long, Paul Säftig, D.A.K. Black, Mat J.A.P. Daemen, Kitty B.J.M. Cleutjens	2005	178
20	Participation of Autophagy in Storage of Lysosomes in Neurons from Mouse Models of Neuronal Ceroid-Lipofuscinoses (Batten Disease) American Journal Of Pathology ·Masato Koike, Masahiro Shibata, Satoshi Waguri, Kentaro Yoshimura, Isei Tanida, Eiki Kominami, Takahiro Gotow, Christoph Peters, Kurt Von Figura, Noboru Mizushima, Paul Säftig, Yasuo Uchiyama	2005	264

About Paul Säftig

Paul Säftig is a scholar working on Physiology, Immunology and Allergy, Cell Biology, Physiology and Molecular Biology, having authored 333 papers that have together received 39.2k indexed citations. Recurring topics across this work include Lysosomal Storage Disorders Research (77 papers), Cellular transport and secretion (68 papers), Alzheimer's disease research and treatments (51 papers), Cell Adhesion Molecules Research (45 papers), Calcium signaling and nucleotide metabolism (39 papers), Autophagy in Disease and Therapy (34 papers), Protease and Inhibitor Mechanisms (22 papers) and Peptidase Inhibition and Analysis (21 papers). The work is most often cited by research in Physiology (2.7k citations), Immunology and Allergy (3.2k citations), Cell Biology (7.9k citations), Physiology (11.5k citations) and Molecular Biology (18.9k citations). Paul Säftig has collaborated with scholars based in Germany, United States and Belgium. Frequent co-authors include Eeva‐Liisa Eskelinen, Bart De Strooper, Karina Reiß, Dieter Hartmann, Kurt Von Figura, Judith Klumperman, Wim Annaert, Katleen Craessaerts, Andreas Ludwig and Carl Blobel. Their work appears in journals such as Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, Journal of Cell Science, Journal of Neuroscience and Molecular and Cellular Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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