Hengming Ke

9.8k citations

107 papers · 8.0k indexed · 3 hit papers · h-index 47

Impact in

Geriatrics and Gerontology top 0.5%
- Sirtuins and Resveratrol in Medicine
Pharmacology top 0.5%
- Cholinesterase and Neurodegenerative Diseases

Papers in

Pharmacology 35
- Cholinesterase and Neurodegenerative Diseases 34
Molecular Biology 90
- Phosphodiesterase function and regulation 57
- Receptor Mechanisms and Signaling 13
- Signaling Pathways in Disease 12

Co-authors: Huanchen Wang Qing Huai William N. Lipscomb Faiyaz Ahmad Jay H. Chung Vincent C. Manganiello Howard Robinson Yingdong Zhao
Journals: Journal of Biological Chemistry (10 papers)Journal of Medicinal Chemistry (10 papers)Proceedings of the National Academy of Sciences (10 papers)Biochemistry (9 papers)Journal of Molecular Biology (6 papers)
Partner nations: United States China Switzerland

In The Last Decade

Hengming Ke

100 papers receiving 7.9k citations

Hit Papers

align trajectories log scale

Advances in targeting cyclic nucleotide phosphodiesterases 2014 · 599 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2014 Nature Reviews Drug Discovery
2012 Cell
2011 Cell

Peers

Countries citing papers authored by Hengming Ke

Since Specialization

Citations

This map shows the geographic impact of Hengming Ke's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hengming Ke with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hengming Ke more than expected).

Fields of papers citing papers by Hengming Ke

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hengming Ke. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hengming Ke. The network helps show where Hengming Ke may publish in the future.

Co-authors

The 25 scholars most cited alongside Hengming Ke, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Hengming Ke Line = papers co-authored together Hengming Ke links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket Journal of Medicinal Chemistry ·Tianhua Zhang, Zengwei Lai, 楠木, Yi‐You Huang, Guoqiang Dong, Chunquan Sheng, Hengming Ke, Hai‐Bin Luo	2020	30
2	Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer’s disease Bioorganic & Medicinal Chemistry Letters ·Xianfeng Huang, 屈涛, Jinhui Wang, Hengming Ke, Guoqiang Song, Defeng Xu	2020	24
3	Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies Nature Communications ·Cheng Zhu, Elena Dukhovlinova, Li‐Hua Ping, Brizzi Teresa, Eutiche Gbèdolo, E. Lake Potter, 陽子松澤, Guowei Yin, James M. Fay, Laura P. Kincer, Полунин Степан Владимирович, Sharon L. Campbell, S. Rahima Benhabbour, Hengming Ke, Ronald Swanstrom, Nikolay V. Dokholyan	2019	20
4	The neuroprotective and antidepressant‐like effects of Hcyb1, a novel selective PDE2 inhibitor CNS Neuroscience & Therapeutics ·Li Liu, Xiu Zheng, Xianfeng Huang, Xia Zhu, M. Łabęda, Hengming Ke, James M. O’Donnell, Han‐Ting Zhang, Guoqiang Song, Ying Xu	2018	19
5	Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK EBioMedicine ·Sung Jun Park, Faiyaz Ahmad, Laura Campaña‐Martín, Alexandra L. Brown, Xihui Xu, Hyeog Kang, Hengming Ke, Xuesong Feng, James G. Ryall, Andrew Philp, Simon Schenk, Myung K. Kim, Vittorio Sartorelli, Jay H. Chung	2017	31
6	A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation Structure ·James M. Fay, Cheng Zhu, Elizabeth A. Proctor, Yazhong Tao, Wenjun Cui, Hengming Ke, Nikolay V. Dokholyan	2016	36
7	Advances in targeting cyclic nucleotide phosphodiesterases Nature Reviews Drug Discovery ·Donald H. Maurice, Hengming Ke, Faiyaz Ahmad, Yousheng Wang, Jay H. Chung, Vincent C. Manganiello Hit paper breakdown →	2014	599
8	Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases BMC Proceedings ·Sung-Jun Park, Faiyaz Ahmad, Andrew Philp, Keith Baar, Tishan Williams, Hai‐Bin Luo, Hengming Ke, Holger Rehmann, Ronald Taussig, Alexandra L. Brown, Myung K. Kim, Michael A. Beaven, Alex B. Burgin, Vincent C. Manganiello, Jay H. Chung	2012	11
9	Biological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective Inhibitors Journal of Biological Chemistry ·Huanchen Wang, Stefan Kunz, Gong Chen, Thomas Seebeck, Yiqian Wan, Howard Robinson, Sibylla Martinelli, Hengming Ke	2012	20
10	Cyclic GMP from the somatic cells of the mouse ovarian follicle regulates cyclic AMP and meiosis in the oocyte Developmental Biology ·Rachael P. Norris, William J. Ratzan, Marina Freudzon, Lisa M. Mehlmann, Judith Krall, Matthew A. Movsesian, Huanchen Wang, Hengming Ke, Viacheslav O. Nikolaev, Laurinda A. Jaffe	2009	0
11	Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors ChemMedChem ·อนุสรา ต๊ะพรหม, Huanchen Wang, Nuria E. Campillo, Sara Ballester, Coral González‐García, Javier Hernández, Concepción Pérez, Jimena Cuenca, Ana Pérez‐Castillo, Ana Martı́nez, Óscar Huertas, Josep Lluís Gelpí, F. Javier Luque, Hengming Ke, Carmen Gil	2009	57
12	An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies Biochemical Pharmacology ·Gong Chen, Huanchen Wang, Howard Robinson, Jiwen Cai, Yiqian Wan, Hengming Ke	2008	25
13	Computer-Based Redesign of a β Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo β Sheet Design Structure ·Xiaozhen Hu, Huanchen Wang, Hengming Ke, Brian Kuhlman	2008	36
14	High-resolution design of a protein loop Proceedings of the National Academy of Sciences ·Xiaozhen Hu, Huanchen Wang, Hengming Ke, Brian Kuhlman	2007	97
15	Conformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and Sildenafil Molecular Pharmacology ·Huanchen Wang, Mengchun Ye, Howard Robinson, Sharron H. Francis, Hengming Ke	2007	40
16	Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity Journal of Biological Chemistry ·Qing Huai, Yudong Liu, Sharron H. Francis, Jackie D. Corbin, Hengming Ke	2004	103
17	Crystal structure of DJ‐1/RS and implication on familial Parkinson's disease¹ FEBS Letters ·Qing Huai, Yingjie Sun, Huanchen Wang, Lih‐Shen Chin, Lian Li, Howard Robinson, Hengming Ke	2003	110
18	Three-Dimensional Structures of PDE4D in Complex with Roliprams and Implication on Inhibitor Selectivity Structure ·Qing Huai, Huanchen Wang, Yingjie Sun, P. Corazao Tartar, YUKIFLTMI NAKATA, Hengming Ke	2003	97
19	Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes Proceedings of the National Academy of Sciences ·Qing Huai, Hwa-Young Kim, Yudong Liu, Yingdong Zhao, Benedita Lima da Silva Oliveira, Jun O. Liu, Hengming Ke	2002	214
20	Conformational transition of fructose-1,6-bisphosphatase: structure comparison between the AMP complex (T form) and the fructose 6-phosphate complex (R form) Biochemistry ·Hengming Ke, Ghadah A Almujlli, Yiping Zhang, William N. Lipscomb	1991	78

About Hengming Ke

Hengming Ke is a scholar working on Pharmacology, Molecular Biology, Biochemistry, Organic Chemistry and Geriatrics and Gerontology, having authored 107 papers that have together received 8.0k indexed citations. Recurring topics across this work include Phosphodiesterase function and regulation (57 papers), Cholinesterase and Neurodegenerative Diseases (34 papers), Chemical synthesis and alkaloids (24 papers), Enzyme Structure and Function (18 papers), Receptor Mechanisms and Signaling (13 papers), Signaling Pathways in Disease (12 papers), Synthesis and Catalytic Reactions (9 papers) and Amino Acid Enzymes and Metabolism (8 papers). The work is most often cited by research in Geriatrics and Gerontology (617 citations), Pharmacology (1.4k citations), Molecular Biology (5.7k citations), Aging (109 citations) and Physiology (271 citations). Hengming Ke has collaborated with scholars based in United States, China and Switzerland. Frequent co-authors include Huanchen Wang, Qing Huai, William N. Lipscomb, Faiyaz Ahmad, Jay H. Chung, Vincent C. Manganiello, Howard Robinson, Yingdong Zhao, Yousheng Wang and Yudong Liu. Their work appears in journals such as Journal of Biological Chemistry, Journal of Medicinal Chemistry, Proceedings of the National Academy of Sciences, Biochemistry and Journal of Molecular Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact