Yusuf A. Hannun

74.1k total citations · 22 hit papers
570 papers, 62.0k citations indexed

About

Yusuf A. Hannun is a scholar working on Molecular Biology, Cell Biology and Physiology. According to data from OpenAlex, Yusuf A. Hannun has authored 570 papers receiving a total of 62.0k indexed citations (citations by other indexed papers that have themselves been cited), including 515 papers in Molecular Biology, 184 papers in Cell Biology and 101 papers in Physiology. Recurrent topics in Yusuf A. Hannun's work include Sphingolipid Metabolism and Signaling (405 papers), Lipid Membrane Structure and Behavior (187 papers) and Cellular transport and secretion (94 papers). Yusuf A. Hannun is often cited by papers focused on Sphingolipid Metabolism and Signaling (405 papers), Lipid Membrane Structure and Behavior (187 papers) and Cellular transport and secretion (94 papers). Yusuf A. Hannun collaborates with scholars based in United States, Japan and China. Yusuf A. Hannun's co-authors include Lina M. Obeid, Alicja Bielawska, Robert M. Bell, Chiara Luberto, Jacek Bielawski, Besim Öğretmen, Robert M. Bell, Rick T. Dobrowsky, Carson R. Loomis and Corinne M. Linardic and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Yusuf A. Hannun

563 papers receiving 61.0k citations

Hit Papers

Principles of bioactive lipid signalli... 1986 2026 1999 2012 2008 1993 1996 2017 1989 500 1000 1.5k 2.0k 2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Principles of bioactive lipid signalling: lessons from sphingolipids
    2008 2.7k citations Yusuf A. Hannun, Lina M. Obeid profile →
  2. Programmed Cell Death Induced by Ceramide
    1993 1.6k citations Lina M. Obeid, Yusuf A. Hannun et al. profile →
  3. Functions of Ceramide in Coordinating Cellular Responses to Stress
    1996 1.4k citations Yusuf A. Hannun profile →
  4. Sphingolipids and their metabolism in physiology and disease
    2017 1.4k citations Yusuf A. Hannun, Lina M. Obeid profile →
  5. Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation
    1989 1.1k citations Yusuf A. Hannun, Robert M. Bell profile →
  6. The sphingomyelin cycle and the second messenger function of ceramide.
    1994 1.1k citations Yusuf A. Hannun profile →
  7. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.
    1986 1.0k citations Yusuf A. Hannun, Alfred H. Merrill et al. profile →
  8. Biologically active sphingolipids in cancer pathogenesis and treatment
    2004 1.0k citations Besim Öğretmen, Yusuf A. Hannun profile →
  9. An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown
    2010 861 citations Christopher Gault, Lina M. Obeid et al. Advances in experimental medicine and biology profile →
  10. The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind
    2002 743 citations Yusuf A. Hannun, Lina M. Obeid profile →
  11. Ceramide in apoptosis: an overview and current perspectives
    2002 668 citations Yusuf A. Hannun et al. profile →
  12. Ceramide in the eukaryotic stress response
    2000 643 citations Yusuf A. Hannun, Chiara Luberto profile →
  13. Ceramide activates heterotrimeric protein phosphatase 2A
    1993 581 citations Yusuf A. Hannun et al. profile →
  14. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.
    1991 564 citations Lina M. Obeid, Yusuf A. Hannun et al. profile →
  15. Bioactive sphingolipids: metabolism and function
    2008 561 citations Yusuf A. Hannun et al. Journal of Lipid Research profile →
  16. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells
    1989 557 citations Robert M. Bell, Yusuf A. Hannun et al. profile →
  17. The complex life of simple sphingolipids
    2004 535 citations Yusuf A. Hannun et al. profile →
  18. Apoptosis and the Dilemma of Cancer Chemotherapy
    1997 526 citations Yusuf A. Hannun profile →
  19. Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses
    1987 519 citations Yusuf A. Hannun, Robert M. Bell profile →
  20. Ceramide: an intracellular signal for apoptosis
    1995 514 citations Yusuf A. Hannun profile →
  21. Many Ceramides
    2011 471 citations Yusuf A. Hannun, Lina M. Obeid profile →
  22. Substantial contribution of extrinsic risk factors to cancer development
    2015 449 citations Yusuf A. Hannun et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Yusuf A. Hannun United States 127 51.4k 13.5k 10.9k 6.2k 4.7k 570 62.0k
Sarah Spiegel United States 113 38.6k 0.7× 14.0k 1.0× 6.8k 0.6× 6.2k 1.0× 2.9k 0.6× 399 44.9k
Shuh Narumiya Japan 125 28.8k 0.6× 12.0k 0.9× 8.6k 0.8× 7.4k 1.2× 1.9k 0.4× 556 60.6k
Philip Cohen United Kingdom 143 67.4k 1.3× 13.5k 1.0× 7.9k 0.7× 8.8k 1.4× 3.2k 0.7× 489 89.2k
Dario R. Alessi United Kingdom 124 50.6k 1.0× 10.1k 0.8× 6.8k 0.6× 4.9k 0.8× 5.1k 1.1× 313 65.6k
Toren Finkel United States 97 30.3k 0.6× 3.5k 0.3× 11.4k 1.0× 6.5k 1.0× 7.8k 1.7× 211 55.4k
Paul Tempst United States 143 62.1k 1.2× 8.7k 0.6× 7.7k 0.7× 9.0k 1.4× 4.9k 1.1× 320 80.8k
Vamsi K. Mootha United States 87 51.6k 1.0× 6.1k 0.5× 10.7k 1.0× 7.3k 1.2× 5.6k 1.2× 199 72.9k
Alan R. Saltiel United States 93 25.3k 0.5× 6.4k 0.5× 11.2k 1.0× 6.4k 1.0× 9.4k 2.0× 280 45.5k
Sten Orrenius Sweden 122 28.6k 0.6× 4.3k 0.3× 4.8k 0.4× 5.1k 0.8× 3.5k 0.7× 455 51.5k
Roger J. Davis United States 146 62.3k 1.2× 11.7k 0.9× 8.3k 0.8× 13.6k 2.2× 7.5k 1.6× 572 92.6k

Countries citing papers authored by Yusuf A. Hannun

Since Specialization
Citations

This map shows the geographic impact of Yusuf A. Hannun's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Yusuf A. Hannun with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Yusuf A. Hannun more than expected).

Fields of papers citing papers by Yusuf A. Hannun

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Yusuf A. Hannun. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Yusuf A. Hannun. The network helps show where Yusuf A. Hannun may publish in the future.

Co-authorship network of co-authors of Yusuf A. Hannun

This figure shows the co-authorship network connecting the top 25 collaborators of Yusuf A. Hannun. A scholar is included among the top collaborators of Yusuf A. Hannun based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Yusuf A. Hannun. Yusuf A. Hannun is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Al‐Rashed, Fatema, et al.. (2024). IL-6R (trans-signaling) is a key regulator of reverse cholesterol transport in lipid-laden macrophages. Clinical Immunology. 267. 110351–110351. 1 indexed citations
2.
Snider, Justin M., Sitapriya Moorthi, Nicolas Coant, et al.. (2024). A comprehensive measure of Golgi sphingolipid flux using NBD C6-ceramide: evaluation of sphingolipid inhibitors. Journal of Lipid Research. 65(8). 100584–100584. 3 indexed citations
3.
Al‐Rashed, Fatema, Hossein Arefanian, Ashraf Al Madhoun, et al.. (2024). Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation. Cells. 13(5). 463–463.
4.
Coant, Nicolas, John D. Bickel, Ronald J. Rahaim, et al.. (2023). Neutral ceramidase-active site inhibitor chemotypes and binding modes. Bioorganic Chemistry. 139. 106747–106747. 1 indexed citations
5.
Stith, Jeffrey L., et al.. (2023). Targeting sphingosine kinase 1 in p53KO thymic lymphoma. The FASEB Journal. 37(11). e23247–e23247. 1 indexed citations
6.
Clarke, Christopher J., Jeffrey L. Stith, Justin M. Snider, et al.. (2021). Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Cell Death and Disease. 12(1). 27–27. 12 indexed citations
7.
Truman, Jean‐Philip, Christian Ruiz, Emily Montal, et al.. (2021). 1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase. Journal of Lipid Research. 63(1). 100154–100154. 12 indexed citations
8.
Ren, Jihui, Essa M. Saied, Justin M. Snider, et al.. (2018). Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway. Journal of Lipid Research. 59(11). 2126–2139. 13 indexed citations
9.
Lu, Songjian, Chunhui Cai, Gonghong Yan, et al.. (2016). Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations. Cancer Research. 76(23). 6785–6794. 3 indexed citations
10.
Meyers‐Needham, Marisa, Salih Gencer, R. David Sentelle, et al.. (2012). Off-Target Function of the Sonic Hedgehog Inhibitor Cyclopamine in Mediating Apoptosis via Nitric Oxide–Dependent Neutral Sphingomyelinase 2/Ceramide Induction. Molecular Cancer Therapeutics. 11(5). 1092–1102. 33 indexed citations
11.
Salegio, Ernesto A., Lluı́s Samaranch, Russell W. Jenkins, et al.. (2012). Safety Study of Adeno-Associated Virus Serotype 2-Mediated Human Acid Sphingomyelinase Expression in the Nonhuman Primate Brain. Human Gene Therapy. 23(8). 891–902. 19 indexed citations
12.
Canals, Daniel, David M. Perry, Russell W. Jenkins, & Yusuf A. Hannun. (2011). Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. British Journal of Pharmacology. 163(4). 694–712. 144 indexed citations
13.
Gault, Christopher, Lina M. Obeid, & Yusuf A. Hannun. (2010). An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown. Advances in experimental medicine and biology. 688. 1–23. 861 indexed citations breakdown →
14.
Sun, Yunpeng, Huimin Ran, Kazuyuki Kitatani, et al.. (2009). Specific saposin C deficiency: CNS impairment and acid  -glucosidase effects in the mouse. Human Molecular Genetics. 19(4). 634–647. 31 indexed citations
15.
Zeidan, Youssef H., Russell W. Jenkins, & Yusuf A. Hannun. (2008). Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway. The Journal of Cell Biology. 181(2). 335–350. 135 indexed citations
16.
D’Angelo, Giovanni, Elena Polishchuk, Giuseppe Di Tullio, et al.. (2007). Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature. 449(7158). 62–67. 336 indexed citations
17.
Luberto, Chiara, Jacqueline M. Kraveka, & Yusuf A. Hannun. (2002). Ceramide Regulation of Apoptosis versus Differentiation: A Walk on a Fine Line. Lessons from Neurobiology. Neurochemical Research. 27(7-8). 609–617. 44 indexed citations
18.
Idriss, Haitham, Yusuf A. Hannun, Emile L. Boulpaep, & Srisaila Basavappa. (2000). Regulation of volume‐activated chloride channels by P‐glycoprotein: phosphorylation has the final say!. The Journal of Physiology. 524(3). 629–636. 65 indexed citations
19.
Bell, Robert M., Yusuf A. Hannun, & Alfred H. Merrill. (1993). Regulation and function of metabolism. Academic Press eBooks.
20.
Hannun, Yusuf A., Alfred H. Merrill, & Robert M. Bell. (1991). [26] Use of sphingosine as inhibitor of protein kinase C. Methods in enzymology on CD-ROM/Methods in enzymology. 201. 316–328. 57 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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