Huib Ovaa

23.1k total citations · 3 hit papers
236 papers, 15.3k citations indexed

About

Huib Ovaa is a scholar working on Molecular Biology, Oncology and Immunology. According to data from OpenAlex, Huib Ovaa has authored 236 papers receiving a total of 15.3k indexed citations (citations by other indexed papers that have themselves been cited), including 207 papers in Molecular Biology, 94 papers in Oncology and 46 papers in Immunology. Recurrent topics in Huib Ovaa's work include Ubiquitin and proteasome pathways (148 papers), Peptidase Inhibition and Analysis (71 papers) and Protein Degradation and Inhibitors (43 papers). Huib Ovaa is often cited by papers focused on Ubiquitin and proteasome pathways (148 papers), Peptidase Inhibition and Analysis (71 papers) and Protein Degradation and Inhibitors (43 papers). Huib Ovaa collaborates with scholars based in Netherlands, United States and Germany. Huib Ovaa's co-authors include Hidde L. Ploegh, Celia R. Berkers, Jacques Neefjes, Farid El Oualid, Paul P. Geurink, Reggy Ekkebus, Benedikt M. Kessler, Titia K. Sixma, Boris Rodenko and David Komander and has published in prestigious journals such as Nature, Cell and Chemical Reviews.

In The Last Decade

Huib Ovaa

234 papers receiving 15.1k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

2005 560 citations Huib Ovaa et al. profile →
OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

2013 475 citations Paul P. Geurink, Farid El Oualid et al. profile →
Proteome-wide identification of ubiquitin interactions using UbIA-MS

2018 437 citations Huib Ovaa et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
Huib Ovaa	11.7k	4.4k	2.7k	1.9k	1.9k	236	15.3k
Jun O. Liu	8.9k 0.8×	2.7k 0.6×	1.5k 0.6×	1.3k 0.7×	1.4k 0.8×	210	14.2k
Ronen Marmorstein	12.8k 1.1×	3.8k 0.9×	969 0.4×	800 0.4×	1.6k 0.9×	205	16.1k
Tracy M. Handel	7.5k 0.6×	4.6k 1.1×	4.1k 1.5×	667 0.4×	1000 0.5×	163	13.4k
Laurence H. Pearl	18.0k 1.5×	2.5k 0.6×	2.1k 0.8×	1.1k 0.6×	897 0.5×	217	21.3k
Peter E. Czabotar	8.9k 0.8×	2.1k 0.5×	2.2k 0.8×	621 0.3×	1.2k 0.6×	98	11.8k
Patrick J. Casey	14.8k 1.3×	3.4k 0.8×	1.1k 0.4×	1.0k 0.5×	612 0.3×	247	19.3k
Ulf R. Rapp	18.9k 1.6×	5.1k 1.2×	3.7k 1.4×	657 0.3×	1.2k 0.6×	325	24.8k
Jane B. Trepel	11.8k 1.0×	4.4k 1.0×	2.2k 0.8×	439 0.2×	814 0.4×	290	17.6k
Daniel D. Billadeau	7.5k 0.6×	2.9k 0.7×	4.5k 1.7×	425 0.2×	918 0.5×	215	14.4k
Mark A. Lemmon	18.3k 1.6×	5.7k 1.3×	2.1k 0.8×	807 0.4×	860 0.5×	159	25.5k

Countries citing papers authored by Huib Ovaa

Since Specialization

Citations

This map shows the geographic impact of Huib Ovaa's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Huib Ovaa with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Huib Ovaa more than expected).

Fields of papers citing papers by Huib Ovaa

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Huib Ovaa. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Huib Ovaa. The network helps show where Huib Ovaa may publish in the future.

Co-authorship network of co-authors of Huib Ovaa

This figure shows the co-authorship network connecting the top 25 collaborators of Huib Ovaa. A scholar is included among the top collaborators of Huib Ovaa based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Huib Ovaa. Huib Ovaa is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

1.

Zacarı́as, Natalia V. Ortiz, Sascha Röth, Bo‐Tao Xin, et al.. (2025). Leveraging Targeted Protein Degradation for G Protein-Coupled Receptors: The Development of CCR2 Molecular Degraders. Journal of Medicinal Chemistry. 68(24). 26525–26546.

2.

Jin, Gan, J. de Vries, Jimmy J.L.L. Akkermans, et al.. (2023). Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2. ACS Chemical Biology. 18(9). 2003–2013. 5 indexed citations

3.

Xie, Feng, Xiaoxue Zhou, Heyu Li, et al.. (2022). USP8 promotes cancer progression and extracellular vesicle‐mediated CD8 + T cell exhaustion by deubiquitinating the TGF ‐β receptor TβRII. The EMBO Journal. 41(16). e108791–e108791. 54 indexed citations

4.

Horn‐Ghetko, Daniel, David T. Krist, J. Rajan Prabu, et al.. (2021). Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly. Nature. 590(7847). 671–676. 126 indexed citations

5.

Gangaev, Anastasia, Steven L. C. Ketelaars, Olga I. Isaeva, et al.. (2021). Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features. Nature Communications. 12(1). 2593–2593. 69 indexed citations

6.

Krist, David T., Gerbrand J. van der Heden van Noort, Fynn M. Hansen, et al.. (2020). Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. Nature Chemical Biology. 17(3). 272–279. 32 indexed citations

7.

Shin, Dong Hyuk, Anshu Bhattacharya, Ahmad Reza Mehdipour, et al.. (2020). Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection. eLife. 9. 30 indexed citations

8.

Schubert, Alexander F., Paul P. Geurink, Cameron G. Roberts, et al.. (2020). Identification and characterization of diverse OTU deubiquitinases in bacteria. The EMBO Journal. 39(15). e105127–e105127. 43 indexed citations

9.

Sapmaz, Ayşegül, et al.. (2019). Development of a DUB-selective fluorogenic substrate. Chemical Science. 10(44). 10290–10296. 16 indexed citations

10.

Liu, Sijia, Román González‐Prieto, Mengdi Zhang, et al.. (2019). Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis. Clinical Cancer Research. 26(6). 1460–1473. 106 indexed citations

11.

Vertegaal, Alfred C.O., et al.. (2019). Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs). ACS Chemical Biology. 14(11). 2389–2395. 19 indexed citations

12.

Narasimhan, Siddarth, Alessandra Lucini Paioni, Johan van der Zwan, et al.. (2019). DNP‐Supported Solid‐State NMR Spectroscopy of Proteins Inside Mammalian Cells. Angewandte Chemie International Edition. 58(37). 12969–12973. 89 indexed citations

13.

Narasimhan, Siddarth, Alessandra Lucini Paioni, Johan van der Zwan, et al.. (2019). DNP‐Supported Solid‐State NMR Spectroscopy of Proteins Inside Mammalian Cells. Angewandte Chemie. 131(37). 13103–13107. 22 indexed citations

14.

Hameed, Dharjath S., et al.. (2019). Development of Ubiquitin‐Based Probe for Metalloprotease Deubiquitinases. Angewandte Chemie International Edition. 58(41). 14477–14482. 17 indexed citations

15.

Teunisse, Amina F.A.S., et al.. (2018). Selective PKCδ Inhibitor B106 Elicits Uveal Melanoma Growth Inhibitory Effects Independent of Activated PKC Isoforms. ACS Chemical Biology. 14(1). 132–136. 4 indexed citations

16.

Kasteren, Sander I. van, Jacques Neefjes, & Huib Ovaa. (2018). Creating molecules that modulate immune responses. Nature Reviews Chemistry. 2(8). 184–193. 17 indexed citations

17.

Jong, Annemieke de, Katharina F. Witting, Raymond Kooij, Dennis Flierman, & Huib Ovaa. (2017). Release of Enzymatically Active Deubiquitinating Enzymes upon Reversible Capture by Disulfide Ubiquitin Reagents. Angewandte Chemie International Edition. 56(42). 12967–12970. 25 indexed citations

18.

Garstka, Malgorzata, Alexander Fish, Patrick H. N. Celie, et al.. (2015). The first step of peptide selection in antigen presentation by MHC class I molecules. Proceedings of the National Academy of Sciences. 112(5). 1505–1510. 66 indexed citations

19.

Basters, Anja, Paul P. Geurink, Farid El Oualid, et al.. (2014). Molecular characterization of ubiquitin‐specific protease 18 reveals substrate specificity for interferon‐stimulated gene 15. FEBS Journal. 281(7). 1918–1928. 43 indexed citations

20.

Schmidt‐Supprian, Marc, Jane Tian, Ethan Grant, et al.. (2004). Differential dependence of CD4 ⁺ CD25 ⁺ regulatory and natural killer-like T cells on signals leading to NF-κB activation. Proceedings of the National Academy of Sciences. 101(13). 4566–4571. 202 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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