Manolis Pasparakis

44.5k total citations · 10 hit papers
193 papers, 26.6k citations indexed

About

Manolis Pasparakis is a scholar working on Immunology, Molecular Biology and Cancer Research. According to data from OpenAlex, Manolis Pasparakis has authored 193 papers receiving a total of 26.6k indexed citations (citations by other indexed papers that have themselves been cited), including 127 papers in Immunology, 95 papers in Molecular Biology and 80 papers in Cancer Research. Recurrent topics in Manolis Pasparakis's work include NF-κB Signaling Pathways (73 papers), Immune Response and Inflammation (65 papers) and interferon and immune responses (44 papers). Manolis Pasparakis is often cited by papers focused on NF-κB Signaling Pathways (73 papers), Immune Response and Inflammation (65 papers) and interferon and immune responses (44 papers). Manolis Pasparakis collaborates with scholars based in Germany, United States and Italy. Manolis Pasparakis's co-authors include George Kollias, Peter Vandenabeele, Lena Alexopoulou, Geert Loo, Ingo Haase, Klaus Rajewsky, Andy Wullaert, Marc Schmidt‐Supprian, Vasso Episkopou and Dimitris L. Kontoyiannis and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Manolis Pasparakis

191 papers receiving 26.2k citations

Hit Papers

Necroptosis and its role ... 1996 2026 2006 2016 2015 1999 1996 2007 2019 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Necroptosis and its role in inflammation
    2015 1.6k citations Manolis Pasparakis et al. Nature profile →
  2. Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements
    1999 1.1k citations Manolis Pasparakis, George Kollias et al. profile →
  3. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.
    1996 992 citations Manolis Pasparakis, George Kollias et al. The Journal of Experimental Medicine profile →
  4. Epithelial NEMO links innate immunity to chronic intestinal inflammation
    2007 871 citations Andy Wullaert, Geert Loo et al. Nature profile →
  5. Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
    2019 776 citations Robin Schwarzer, Fabian Schorn et al. Nature profile →
  6. Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis
    1999 700 citations Manolis Pasparakis, George Kollias et al. profile →
  7. Mechanisms regulating skin immunity and inflammation
    2014 631 citations Manolis Pasparakis et al. profile →
  8. SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
    2011 574 citations Manolis Pasparakis et al. Nature profile →
  9. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis
    2016 397 citations Laurens Wachsmuth, Manolis Pasparakis et al. Nature profile →
  10. Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation
    2020 333 citations Huipeng Jiao, Laurens Wachsmuth et al. Nature profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Manolis Pasparakis 13.4k 12.3k 5.8k 4.3k 3.3k 193 26.6k
Erika L. Pearce 8.5k 0.6× 14.2k 1.2× 4.4k 0.7× 4.9k 1.1× 2.8k 0.8× 83 23.1k
Gary S. Firestein 12.1k 0.9× 10.2k 0.8× 5.7k 1.0× 5.9k 1.4× 1.7k 0.5× 308 33.7k
Shao‐Cong Sun 11.2k 0.8× 12.1k 1.0× 8.1k 1.4× 4.3k 1.0× 2.1k 0.6× 188 25.1k
Akihiko Yoshimura 10.6k 0.8× 11.3k 0.9× 3.1k 0.5× 7.0k 1.6× 2.8k 0.8× 349 27.4k
Paul P. Tak 8.6k 0.6× 11.8k 1.0× 3.1k 0.5× 4.5k 1.0× 2.0k 0.6× 459 33.5k
George Kollias 12.1k 0.9× 10.9k 0.9× 3.5k 0.6× 5.6k 1.3× 2.1k 0.6× 306 30.3k
Michael J. Lenardo 14.9k 1.1× 17.6k 1.4× 5.1k 0.9× 6.5k 1.5× 5.2k 1.6× 244 34.1k
Jacques J. Peschon 9.1k 0.7× 11.5k 0.9× 3.2k 0.5× 5.9k 1.4× 2.3k 0.7× 94 24.8k
Jeffrey C. Rathmell 11.1k 0.8× 13.0k 1.1× 6.5k 1.1× 5.6k 1.3× 2.5k 0.8× 202 25.8k
Russell G. Jones 11.2k 0.8× 8.1k 0.7× 5.6k 1.0× 3.8k 0.9× 2.3k 0.7× 112 20.4k

Countries citing papers authored by Manolis Pasparakis

Since Specialization
Citations

This map shows the geographic impact of Manolis Pasparakis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Manolis Pasparakis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Manolis Pasparakis more than expected).

Fields of papers citing papers by Manolis Pasparakis

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Manolis Pasparakis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Manolis Pasparakis. The network helps show where Manolis Pasparakis may publish in the future.

Co-authorship network of co-authors of Manolis Pasparakis

This figure shows the co-authorship network connecting the top 25 collaborators of Manolis Pasparakis. A scholar is included among the top collaborators of Manolis Pasparakis based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Manolis Pasparakis. Manolis Pasparakis is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Li, X., et al.. (2025). RIPK1 autophosphorylation at S161 mediates cell death and inflammation. The Journal of Experimental Medicine. 222(12). 2 indexed citations
2.
Nagata, Masahiro, et al.. (2024). A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses. The EMBO Journal. 43(21). 5037–5056. 9 indexed citations
3.
Berghausen, Eva, Felix S.R. Picard, Apostolos Polykratis, et al.. (2024). Hematopoietic PI3Kδ deficiency aggravates murine atherosclerosis through impairment of Tregs. JCI Insight. 9(22).
4.
Willenborg, Sebastian, et al.. (2023). FADD- and RIPK3-Mediated Cell Death Ensures Clearance of Ly6Chigh Wound Macrophages from Damaged Tissue. Journal of Investigative Dermatology. 144(1). 152–164.e7. 4 indexed citations
5.
Schorn, Fabian, Lars M. Schiffmann, Nieves Peltzer, et al.. (2023). cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation. The EMBO Journal. 42(22). e113614–e113614. 11 indexed citations
6.
Jiao, Huipeng, Laurens Wachsmuth, Masahiro Nagata, et al.. (2022). ADAR1 averts fatal type I interferon induction by ZBP1. Nature. 607(7920). 776–783. 137 indexed citations
7.
Cabeza-Cabrerizo, Mar, Carlos M. Minutti, Mariana Pereira da Costa, et al.. (2021). Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity. Science Immunology. 6(65). eabi9331–eabi9331. 31 indexed citations
8.
Jiao, Huipeng, Laurens Wachsmuth, Snehlata Kumari, et al.. (2020). Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature. 580(7803). 391–395. 333 indexed citations breakdown →
9.
Singer, Stephan, Marietta Armaka, Jesús M. Bañales, et al.. (2019). RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury. Cell Death and Differentiation. 26(12). 2710–2726. 25 indexed citations
10.
Vreka, Malamati, Ioannis Lilis, Georgia A. Giotopoulou, et al.. (2018). IκB Kinase α Is Required for Development and Progression of KRAS -Mutant Lung Adenocarcinoma. Cancer Research. 78(11). 2939–2951. 29 indexed citations
11.
O’Donnell, Joanne A., Justine E. Roderick, Dalia Martinez‐Marin, et al.. (2017). Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity. The Journal of Immunology. 200(2). 737–748. 29 indexed citations
12.
Vlantis, Katerina, Apostolos Polykratis, Patrick-Simon Welz, et al.. (2015). TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice. Gut. 65(6). 935–943. 99 indexed citations
13.
Roderick, Justine E., Nicole Hermance, Matija Zelic, et al.. (2014). Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis. Proceedings of the National Academy of Sciences. 111(40). 14436–14441. 71 indexed citations
14.
Polykratis, Apostolos, Nicole Hermance, Matija Zelic, et al.. (2014). Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo. The Journal of Immunology. 193(4). 1539–1543. 259 indexed citations
15.
Becker, Sven, Tobias A. Oelschlaeger, Andy Wullaert, et al.. (2013). Correction: Bacteria Regulate Intestinal Epithelial Cell Differentiation Factors Both In Vitro and In Vivo. PLoS ONE. 8(5). 12 indexed citations
16.
Maelfait, Jonathan, Kenny Roose, Pieter Bogaert, et al.. (2012). Correction: A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection. PLoS Pathogens. 8(4). 9 indexed citations
17.
Vlantis, Katerina, Andy Wullaert, Yoshiteru Sasaki, et al.. (2011). Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. Journal of Clinical Investigation. 121(7). 2781–2793. 82 indexed citations
18.
Wunderlich, F. Thomas, Tom Luedde, Stephan Singer, et al.. (2008). Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. Proceedings of the National Academy of Sciences. 105(4). 1297–1302. 90 indexed citations
19.
Schmidt‐Supprian, Marc, Jane Tian, Ethan Grant, et al.. (2004). Differential dependence of CD4 + CD25 + regulatory and natural killer-like T cells on signals leading to NF-κB activation. Proceedings of the National Academy of Sciences. 101(13). 4566–4571. 202 indexed citations
20.
Zhang, Yufeng, Manolis Pasparakis, George Kollias, & Michael Simons. (1999). Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression. Journal of Biological Chemistry. 274(21). 14786–14790. 61 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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