Manolis Pasparakis

44.5k total citations · 10 hit papers
193 papers, 26.6k citations indexed

About

Manolis Pasparakis is a scholar working on Immunology, Molecular Biology and Cancer Research. According to data from OpenAlex, Manolis Pasparakis has authored 193 papers receiving a total of 26.6k indexed citations (citations by other indexed papers that have themselves been cited), including 127 papers in Immunology, 95 papers in Molecular Biology and 80 papers in Cancer Research. Recurrent topics in Manolis Pasparakis's work include NF-κB Signaling Pathways (73 papers), Immune Response and Inflammation (65 papers) and interferon and immune responses (44 papers). Manolis Pasparakis is often cited by papers focused on NF-κB Signaling Pathways (73 papers), Immune Response and Inflammation (65 papers) and interferon and immune responses (44 papers). Manolis Pasparakis collaborates with scholars based in Germany, United States and Italy. Manolis Pasparakis's co-authors include George Kollias, Peter Vandenabeele, Lena Alexopoulou, Geert Loo, Ingo Haase, Klaus Rajewsky, Andy Wullaert, Marc Schmidt‐Supprian, Vasso Episkopou and Dimitris L. Kontoyiannis and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Manolis Pasparakis

191 papers receiving 26.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Necroptosis and its role in inflammation

2015 1.6k citations Manolis Pasparakis et al. Nature profile →
Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1999 1.1k citations Manolis Pasparakis, George Kollias et al. profile →
Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

1996 992 citations Manolis Pasparakis, George Kollias et al. The Journal of Experimental Medicine profile →
Epithelial NEMO links innate immunity to chronic intestinal inflammation

2007 871 citations Andy Wullaert, Geert Loo et al. Nature profile →
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

2019 776 citations Robin Schwarzer, Fabian Schorn et al. Nature profile →
Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

1999 700 citations Manolis Pasparakis, George Kollias et al. profile →
Mechanisms regulating skin immunity and inflammation

2014 631 citations Manolis Pasparakis et al. profile →
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

2011 574 citations Ariadne Androulidaki, Manolis Pasparakis et al. Nature profile →
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

2016 397 citations Laurens Wachsmuth, Manolis Pasparakis et al. Nature profile →
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

2020 333 citations Huipeng Jiao, Laurens Wachsmuth et al. Nature profile →

Peers

Countries citing papers authored by Manolis Pasparakis

Since Specialization

Citations

This map shows the geographic impact of Manolis Pasparakis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Manolis Pasparakis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Manolis Pasparakis more than expected).

Fields of papers citing papers by Manolis Pasparakis

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Manolis Pasparakis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Manolis Pasparakis. The network helps show where Manolis Pasparakis may publish in the future.

Co-authorship network of co-authors of Manolis Pasparakis

This figure shows the co-authorship network connecting the top 25 collaborators of Manolis Pasparakis. A scholar is included among the top collaborators of Manolis Pasparakis based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Manolis Pasparakis. Manolis Pasparakis is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	RIPK1 autophosphorylation at S161 mediates cell death and inflammation 2025 ·The Journal of Experimental Medicine ·(unknown), X. Li, (unknown), (unknown), Manolis Pasparakis	2
2	A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses 2024 ·The EMBO Journal ·Masahiro Nagata, (unknown), Laurens Wachsmuth, Manolis Pasparakis	9
3	Hematopoietic PI3Kδ deficiency aggravates murine atherosclerosis through impairment of Tregs 2024 ·JCI Insight ·(unknown), Eva Berghausen, (unknown), (unknown), Felix S.R. Picard, (unknown), (unknown), Apostolos Polykratis, (unknown), (unknown), Manolis Pasparakis, Stephan Baldus, Chanil Valasarajan, Soni Savai Pullamsetti, Holger Winkels, Marius Vantler, Stephan Rosenkranz	0
4	cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation 2023 ·The EMBO Journal ·Fabian Schorn, (unknown), (unknown), (unknown), (unknown), Lars M. Schiffmann, (unknown), (unknown), Nieves Peltzer, Alexander Quaas, Domagoj Vucic, John Silke, Manolis Pasparakis, Hamid Kashkar	11
5	FADD- and RIPK3-Mediated Cell Death Ensures Clearance of Ly6Chigh Wound Macrophages from Damaged Tissue 2023 ·Journal of Investigative Dermatology ·(unknown), Sebastian Willenborg, (unknown), David E. Sanin, Manolis Pasparakis, Hamid Kashkar, Sabine A. Eming	4
6	ADAR1 averts fatal type I interferon induction by ZBP1 2022 ·Nature ·Huipeng Jiao, Laurens Wachsmuth, (unknown), (unknown), Masahiro Nagata, (unknown), Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold, Simon E. Tröder, Branko Zevnik, Marco Prinz, Christoph Schell, George R. Young, George Kassiotis, Manolis Pasparakis	137
7	Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity 2021 ·Science Immunology ·Mar Cabeza-Cabrerizo, Carlos M. Minutti, Mariana Pereira da Costa, Ana Cardoso, Robert P. Jenkins, (unknown), Michael D. Buck, Cécile Piot, Neil C. Rogers, Stefania Crotta, Lynne Whittaker, Hector Huerga Encabo, John W. McCauley, Judith E. Allen, Manolis Pasparakis, Andreas Wack, Erik Sahai, Caetano Reis e Sousa	31
8	Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation 2021 ·Mucosal Immunology ·Nikos Oikonomou, Martijn J. Schuijs, Antonis Chatzigiagkos, Ariadne Androulidaki, Vassilis Aidinis, Hamida Hammad, Bart N. Lambrecht, Manolis Pasparakis	33
9	NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation 2021 ·Life Science Alliance ·Snehlata Kumari, Trieu-My Van, (unknown), (unknown), Marijana Basic, André Bleich, Ulf Klein, Manolis Pasparakis	23
10	Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation breakdown → 2020 ·Nature ·Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser, Manolis Pasparakis	333
11	RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury 2019 ·Cell Death and Differentiation ·(unknown), Stephan Singer, Marietta Armaka, Jesús M. Bañales, Kerstin Hölzer, Peter Schirmacher, Henning Walczak, George Kollias, Manolis Pasparakis, Vangelis Kondylis	25
12	IκB Kinase α Is Required for Development and Progression of KRAS -Mutant Lung Adenocarcinoma 2018 ·Cancer Research ·Malamati Vreka, Ioannis Lilis, (unknown), Georgia A. Giotopoulou, (unknown), Ioanna Giopanou, Nikolaos I. Kanellakis, Μάγδα Σπέλλα, Theodora Agalioti, (unknown), Torsten Goldmann, Sebastian Marwitz, Fiona E. Yull, Timothy S. Blackwell, Manolis Pasparakis, Antonia Marazioti, Georgios T. Stathopoulos	29
13	Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity 2017 ·The Journal of Immunology ·Joanne A. O’Donnell, (unknown), Justine E. Roderick, Dalia Martinez‐Marin, Matija Zelic, (unknown), Nicole Hermance, Stephen Lyle, Manolis Pasparakis, Katherine A. Fitzgerald, Ann Marshak‐Rothstein, Michelle A. Kelliher	29
14	TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice 2015 ·Gut ·Katerina Vlantis, Apostolos Polykratis, Patrick-Simon Welz, Geert Loo, Manolis Pasparakis, Andy Wullaert	99
15	Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis 2014 ·Proceedings of the National Academy of Sciences ·Justine E. Roderick, Nicole Hermance, Matija Zelic, Matthew J. Simmons, Apostolos Polykratis, Manolis Pasparakis, Michelle A. Kelliher	71
16	Correction: Bacteria Regulate Intestinal Epithelial Cell Differentiation Factors Both In Vitro and In Vivo 2013 ·PLoS ONE ·Sven Becker, Tobias A. Oelschlaeger, Andy Wullaert, Katerina Vlantis, Manolis Pasparakis, Jan Wehkamp, Eduard F. Stange, Michael Gersemann	12
17	Correction: A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection 2012 ·PLoS Pathogens ·Jonathan Maelfait, Kenny Roose, Pieter Bogaert, Mozes Sze, Xavier Saelens, Manolis Pasparakis, Isabelle Carpentier, Geert Loo, Rudi Beyaert	9
18	Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice 2011 ·Journal of Clinical Investigation ·Katerina Vlantis, Andy Wullaert, Yoshiteru Sasaki, Marc Schmidt‐Supprian, Klaus Rajewsky, Tania Roskams, Manolis Pasparakis	82
19	Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis 2008 ·Proceedings of the National Academy of Sciences ·F. Thomas Wunderlich, Tom Luedde, Stephan Singer, Marc Schmidt‐Supprian, (unknown), Peter Schirmacher, Manolis Pasparakis, Jens C. Brüning	90
20	Differential dependence of CD4 ⁺ CD25 ⁺ regulatory and natural killer-like T cells on signals leading to NF-κB activation 2004 ·Proceedings of the National Academy of Sciences ·Marc Schmidt‐Supprian, Jane Tian, Ethan Grant, Manolis Pasparakis, René Maehr, Huib Ovaa, Hidde L. Ploegh, Anthony J. Coyle, Klaus Rajewsky	202

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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