David Komander

31.3k total citations · 16 hit papers
124 papers, 23.0k citations indexed

About

David Komander is a scholar working on Molecular Biology, Oncology and Epidemiology. According to data from OpenAlex, David Komander has authored 124 papers receiving a total of 23.0k indexed citations (citations by other indexed papers that have themselves been cited), including 116 papers in Molecular Biology, 34 papers in Oncology and 29 papers in Epidemiology. Recurrent topics in David Komander's work include Ubiquitin and proteasome pathways (89 papers), Autophagy in Disease and Therapy (28 papers) and Glycosylation and Glycoproteins Research (27 papers). David Komander is often cited by papers focused on Ubiquitin and proteasome pathways (89 papers), Autophagy in Disease and Therapy (28 papers) and Glycosylation and Glycoproteins Research (27 papers). David Komander collaborates with scholars based in United Kingdom, Australia and Germany. David Komander's co-authors include Michael Rapé, Kirby N. Swatek, Michael J. Clague, Sylvie Urbé, Tycho E.T. Mevissen, Dario R. Alessi, Yogesh Kulathu, Laura R. Pearce, Tobias Wauer and Stefan M.V. Freund and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

David Komander

120 papers receiving 22.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Ubiquitin Code

2012 2.7k citations David Komander et al. Annual Review of Biochemistry profile →
Breaking the chains: structure and function of the deubiquitinases

2009 1.7k citations David Komander, Michael J. Clague et al. profile →
Ubiquitin modifications

2016 1.5k citations Kirby N. Swatek, David Komander profile →
The nuts and bolts of AGC protein kinases

2009 1.0k citations David Komander et al. profile →
Mechanisms of Deubiquitinase Specificity and Regulation

2017 771 citations Tycho E.T. Mevissen, David Komander Annual Review of Biochemistry profile →
PDK1, the master regulator of AGC kinase signal transduction

2004 640 citations David Komander et al. profile →
The emerging complexity of protein ubiquitination

2009 630 citations David Komander profile →
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

2009 596 citations Christoph H. Emmerich, David Komander et al. profile →
Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

2009 595 citations Stuart Bloor, David Komander et al. profile →
Breaking the chains: deubiquitylating enzyme specificity begets function

2019 583 citations Michael J. Clague, Sylvie Urbé et al. profile →
Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

2012 538 citations David Komander et al. profile →
OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

2013 475 citations Tycho E.T. Mevissen, Paul P. Geurink et al. profile →
Mechanism of phospho-ubiquitin-induced PARKIN activation

2015 366 citations Tobias Wauer, Alexander F. Schubert et al. Nature profile →
Mechanism of parkin activation by PINK1

2018 293 citations Christina Gladkova, David Komander et al. Nature profile →
Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities

2021 245 citations Zhong Yan Gan, David Komander et al. profile →
Deubiquitinases in cancer

2023 149 citations Grant Dewson, Pieter J.A. Eichhorn et al. Nature reviews. Cancer profile →

Peers

Countries citing papers authored by David Komander

Since Specialization

Citations

This map shows the geographic impact of David Komander's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Komander with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Komander more than expected).

Fields of papers citing papers by David Komander

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Komander. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Komander. The network helps show where David Komander may publish in the future.

Co-authorship network of co-authors of David Komander

This figure shows the co-authorship network connecting the top 25 collaborators of David Komander. A scholar is included among the top collaborators of David Komander based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David Komander. David Komander is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain 2025 ·Scientific Reports ·Haiyin Liu, (unknown), Laura F. Dagley, Simon A. Cobbold, Andrew I. Webb, David Komander, Jóse A. Villadangos, Justine D. Mintern	0
2	Structure of human PINK1 at a mitochondrial TOM-VDAC array 2025 ·Science ·Sylvie Callegari, (unknown), Zhong Yan Gan, Toby A. Dite, Simon A. Cobbold, Andrew Leis, Laura F. Dagley, Alisa Glukhova, David Komander	14
3	Secondary interactions in ubiquitin-binding domains achieve linkage or substrate specificity 2024 ·Cell Reports ·Martin A. Michel, (unknown), David Komander	4
4	Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape 2024 ·Nature Communications ·(unknown), (unknown), (unknown), Nathan W. Kuchel, Bernadine G.C. Lu, (unknown), Kym N. Lowes, Dale J. Calleja, Jeffrey P. Mitchell, Guillaume Lessène, David Komander, Matthew E. Call, Melissa Call	5
5	Reassessing kinetin’s effect on PINK1 and mitophagy 2024 ·Autophagy ·Zhong Yan Gan, David Komander, Sylvie Callegari	4
6	Interaction of PINK1 with nucleotides and kinetin 2024 ·Science Advances ·Zhong Yan Gan, Sylvie Callegari, Thanh Ngoc Nguyen, (unknown), Andrew Leis, Michael Lazarou, Grant Dewson, David Komander	7
7	PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4 2024 ·EMBO Reports ·(unknown), (unknown), Prajakta Gosavi, (unknown), (unknown), (unknown), (unknown), (unknown), Mathew V. Jones, S. Sean Millard, Dominic C.H. Ng, Michele Pagano, Alexis Bonfim‐Melo, (unknown), David Komander, Michael Lazarou, Brett M. Collins, Julia K. Pagan	12
8	Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth 2023 ·eLife ·Daniel Frank, Maria Bergamasco, Michael J. Mlodzianoski, Andrew J. Kueh, (unknown), Cathrine Hall, (unknown), Anne K. Voss, Catriona McLean, Maree C. Faux, Kelly L. Rogers, (unknown), Elizabeth Vincan, David Komander, Grant Dewson, Hoanh Tran	0
9	Deubiquitinases in cancer breakdown → 2023 ·Nature reviews. Cancer ·Grant Dewson, Pieter J.A. Eichhorn, David Komander	149
10	Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes 2023 ·Nature Communications ·(unknown), (unknown), Guinevere S. M. Lageveen‐Kammeijer, Bas C. Jansen, (unknown), (unknown), Ayşegül Sapmaz, Robbert Q. Kim, (unknown), David Komander, Manfred Wuhrer, Gerbrand J. van der Heden van Noort, Huib Ovaa, Paul P. Geurink	9
11	Activation mechanism of PINK1 2021 ·Nature ·Zhong Yan Gan, Sylvie Callegari, Simon A. Cobbold, Thomas R. Cotton, Michael J. Mlodzianoski, Alexander F. Schubert, Niall D. Geoghegan, Kelly L. Rogers, Andrew Leis, Grant Dewson, Alisa Glukhova, David Komander	117
12	Identification and characterization of diverse OTU deubiquitinases in bacteria 2020 ·The EMBO Journal ·Alexander F. Schubert, (unknown), (unknown), Paul P. Geurink, Cameron G. Roberts, (unknown), Lauren N. Miller, Huib Ovaa, Kay Hofmann, Jonathan N. Pruneda, David Komander	43
13	Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression 2020 ·PLoS Pathogens ·Linda J. Visser, (unknown), Kirby N. Swatek, Gisselle N. Medina, K. Olek, Huib H. Rabouw, Raoul J. de Groot, Martijn A. Langereis, Teresa de los Santos, David Komander, Tim Skern, Frank J. M. van Kuppeveld	30
14	A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation 2018 ·Nature Microbiology ·Jonathan N. Pruneda, Robert J. Bastidas, (unknown), Kirby N. Swatek, Balaji Santhanam, Michael J. Clague, Raphael H. Valdivia, Sylvie Urbé, David Komander	49
15	An invisible ubiquitin conformation is required for efficient phosphorylation by PINK 1 2017 ·The EMBO Journal ·Christina Gladkova, Alexander F. Schubert, Jane L. Wagstaff, Jonathan N. Pruneda, Stefan M.V. Freund, David Komander	49
16	Mechanisms of Deubiquitinase Specificity and Regulation breakdown → 2017 ·Annual Review of Biochemistry ·Tycho E.T. Mevissen, David Komander	771
17	Recruitment of TBK 1 to cytosol‐invading Salmonella induces WIPI 2‐dependent antibacterial autophagy 2016 ·The EMBO Journal ·Teresa L. M. Thurston, Keith B. Boyle, Mark D. Allen, Benjamin J. Ravenhill, (unknown), Stuart Bloor, (unknown), (unknown), Ágnes Foeglein, Sophie A. Matthews, David Komander, Mark Bycroft, Felix Randow	96
18	Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis 2014 ·The EMBO Journal ·Tobias Wauer, Kirby N. Swatek, Jane L. Wagstaff, Christina Gladkova, Jonathan N. Pruneda, Martin A. Michel, Malte Gersch, C. Mark Johnson, Stefan M.V. Freund, David Komander	241
19	Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains 2013 ·Proceedings of the National Academy of Sciences ·Christoph H. Emmerich, Alban Ordureau, Sam Strickson, J. Simon C. Arthur, Patrick G. A. Pedrioli, David Komander, Philip Cohen	346
20	Dissection of USPcatalytic domains reveals five common insertion points 2009 ·Molecular BioSystems ·Yu Ye, Hartmut Scheel, Kay Hofmann, David Komander	142

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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