Jane B. Trepel

24.6k total citations · 3 hit papers
290 papers, 17.6k citations indexed

About

Jane B. Trepel is a scholar working on Molecular Biology, Oncology and Cancer Research. According to data from OpenAlex, Jane B. Trepel has authored 290 papers receiving a total of 17.6k indexed citations (citations by other indexed papers that have themselves been cited), including 182 papers in Molecular Biology, 105 papers in Oncology and 53 papers in Cancer Research. Recurrent topics in Jane B. Trepel's work include Histone Deacetylase Inhibitors Research (43 papers), Heat shock proteins research (43 papers) and Ubiquitin and proteasome pathways (31 papers). Jane B. Trepel is often cited by papers focused on Histone Deacetylase Inhibitors Research (43 papers), Heat shock proteins research (43 papers) and Ubiquitin and proteasome pathways (31 papers). Jane B. Trepel collaborates with scholars based in United States, United Kingdom and Japan. Jane B. Trepel's co-authors include Len Neckers, Sunmin Lee, Giuseppe Giaccone, Mehdi Mollapour, Jennifer S. Isaacs, Min-Jung Lee, Yunjin Jung, Phuongmai Nguyen, Leonard Μ. Neckers and William D. Figg and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

Jane B. Trepel

288 papers receiving 17.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Targeting the dynamic HSP90 complex in cancer

2010 1.2k citations Jane B. Trepel, Mehdi Mollapour et al. profile →
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

2005 732 citations Yun Jin Jung, Sunmin Lee et al. profile →
IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis

2003 586 citations Sunmin Lee, Jane B. Trepel et al. profile →

Peers

Countries citing papers authored by Jane B. Trepel

Since Specialization

Citations

This map shows the geographic impact of Jane B. Trepel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jane B. Trepel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jane B. Trepel more than expected).

Fields of papers citing papers by Jane B. Trepel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jane B. Trepel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jane B. Trepel. The network helps show where Jane B. Trepel may publish in the future.

Co-authorship network of co-authors of Jane B. Trepel

This figure shows the co-authorship network connecting the top 25 collaborators of Jane B. Trepel. A scholar is included among the top collaborators of Jane B. Trepel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jane B. Trepel. Jane B. Trepel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Tofacitinib to prevent anti-drug antibody formation against LMB-100 immunotoxin in patients with advanced mesothelin-expressing cancers 2024 ·Frontiers in Oncology ·(unknown), Cody J. Peer, Xianyu Zhang, Hyoyoung Choo‐Wosoba, (unknown), Min-Jung Lee, Shraddha Rastogi, N Sato, Yunkai Yu, (unknown), Seth M. Steinberg, (unknown), Liang Cao, William D. Figg, Jane B. Trepel, Ira Pastan, David FitzGerald, Christine Alewine	3
2	A Single-Arm, Open-Label Phase II Study of ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma 2023 ·The Oncologist ·(unknown), Yoshimi Endo Greer, Sarah M. Jenkins, Margaret E. Gatti‐Mays, Nicole Houston, Sunmin Lee, Min-Jung Lee, Shraddha Rastogi, Nahoko Sato, (unknown), Christina M. Annunziata, Jungmin Lee, Kunio Nagashima, Jane B. Trepel, Stanley Lipkowitz, Alexandra S. Zimmer	6
3	CellMinerCDB: NCATS Is a Web-Based Portal Integrating Public Cancer Cell Line Databases for Pharmacogenomic Explorations 2023 ·Cancer Research ·William C. Reinhold, Kelli M. Wilson, Fathi Elloumi, Katie R. Bradwell, Michele Ceribelli, Sudhir Varma, (unknown), Damien Duveau, (unknown), Jane B. Trepel, (unknown), Carleen Klumpp‐Thomas, (unknown), Paul Shinn, Augustin Luna, Craig J. Thomas, Yves Pommier	12
4	Therapeutic Synergy in Esophageal Cancer and Mesothelioma Is Predicted by Dynamic BH3 Profiling 2021 ·Molecular Cancer Therapeutics ·Deborah R. Surman, Yue Xu, Min-Jung Lee, Jane B. Trepel, Kate Brown, Maheshwari Ramineni, (unknown), Laurence P. Diggs, H. Courtney Hodges, Jeremy L. Davis, Hyun‐Sung Lee, Bryan M. Burt, R. Taylor Ripley	4
5	Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults with relapsed refractory disease) acute lymphoblastic leukemia or biphenotypic leukemia 2021 ·Leukemia Research ·Hetty E. Carraway, Yazeed Sawalha, Ivana Gojo, Min-Jung Lee, Sunmin Lee, Yusuke Tomita, Akira Yuno, (unknown), B. Douglas Smith, Keith W. Pratz, Mark J. Levis, Steven D. Gore, Nilanjan Ghosh, Amy E. DeZern, Amanda L. Blackford, Maria R. Baer, Lia Gore, Richard Piekarz, Jane B. Trepel, Judith E. Karp	10
6	Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma 2019 ·Clinical Cancer Research ·Christine Alewine, (unknown), Cody J. Peer, Zishuo I. Hu, Min-Jung Lee, Akira Yuno, (unknown), Anish Thomas, Seth M. Steinberg, Jane B. Trepel, William D. Figg, Raffit Hassan, Ira Pastan	40
7	Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer 2018 ·Cancer Research ·Michael A. Moses, Yeong Sang Kim, (unknown), Nobu Oshima, (unknown), Kristin Beebe, (unknown), Sunmin Lee, Abbey D. Zuehlke, Hao Shao, William E. Bingman, Vineet Kumar, Sanjay V. Malhotra, Nancy L. Weigel, Jason E. Gestwicki, Jane B. Trepel, Leonard Μ. Neckers	97
8	Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 ( SLFN11) Expression with Class I Histone Deacetylase Inhibitors 2018 ·Clinical Cancer Research ·Sai-Wen Tang, Anish Thomas, Junko Murai, Jane B. Trepel, Susan E. Bates, Vinodh N. Rajapakse, Yves Pommier	65
9	Metabolomic and BH3 profiling of esophageal cancers: novel assessment methods for precision therapy 2018 ·BMC Gastroenterology ·R. Taylor Ripley, Deborah R. Surman, Laurence P. Diggs, Jane B. Trepel, Min-Jung Lee, Jeremy Ryan, Jeremy L. Davis, Seth M. Steinberg, Jonathan M. Hernandez, (unknown), (unknown), (unknown), Tricia Kunst, Anthony Letai, David S. Schrump	6
10	Phase I and Preliminary Phase II Study of TRC105 in Combination with Sorafenib in Hepatocellular Carcinoma 2017 ·Clinical Cancer Research ·Austin G. Duffy, Chi Ma, Susanna V. Ulahannan, Osama E. Rahma, Oxana V. Makarova‐Rusher, Liang Cao, Yunkai Yu, David E. Kleiner, Jane B. Trepel, Min-Jung Lee, Yusuke Tomita, Seth M. Steinberg, Theo Heller, Barış Türkbey, Peter L. Choyke, Cody J. Peer, William D. Figg, Bradford J. Wood, Tim F. Greten	68
11	Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies 2016 ·Cancer Research ·Hee-Sheung Lee, Nathan Lee, Natalay Kouprina, Junghyun Kim, (unknown), Susan E. Bates, Jane B. Trepel, Yves Pommier, Dan L. Sackett, Vladimir Larionov	57
12	A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study 2014 ·Clinical Cancer Research ·Anish Thomas, Arun Rajan, Éva Szabó, Yusuke Tomita, Corey A. Carter, Barbara Scepura, Ariel López-Chávez, Min-Jung Lee, Christophe E. Redon, (unknown), Cody J. Peer, Yuanbin Chen, Richard Piekarz, Seth M. Steinberg, Jane B. Trepel, William D. Figg, David S. Schrump, Giuseppe Giaccone	79
13	The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models 2013 ·Cancer Research ·Naoto Miyajima, Shinji Tsutsumi, Carole Sourbier, Kristin Beebe, Mehdi Mollapour, (unknown), Soichiro Yoshida, Jane B. Trepel, Ying Huang, Manabu Tatokoro, Nobuo Shinohara, Katsuya Nonomura, Len Neckers	48
14	Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response 2012 ·Proceedings of the National Academy of Sciences ·Stéphanie Solier, Kurt W. Kohn, Bradley T. Scroggins, Wanping Xu, Jane B. Trepel, Leonard Μ. Neckers, Yves Pommier	74
15	A Phase I Study of PF-04929113 (SNX-5422), an Orally Bioavailable Heat Shock Protein 90 Inhibitor, in Patients with Refractory Solid Tumor Malignancies and Lymphomas 2011 ·Clinical Cancer Research ·Arun Rajan, Ronan J. Kelly, Jane B. Trepel, Yeong Sang Kim, Sylvia V. Alarcon, Shivaani Kummar, Martin Gutierrez, Sonja Crandon, Wadih M. Zein, Lokesh Jain, Baskar Mannargudi, William D. Figg, Brett E. Houk, Michael Shnaidman, Nicoletta Brega, Giuseppe Giaccone	107
16	DNA Methyltransferase 1 and 3B Activate BAG-1 Expression via Recruitment of CTCFL/BORIS and Modulation of Promoter Histone Methylation 2008 ·Cancer Research ·Lunching Sun, Lei Huang, Phuongmai Nguyen, Kheem S. Bisht, Gil Bar‐Sela, Allen S. Ho, C. Matthew Bradbury, Wenqiang Yu, Hengmi Cui, Sun-Min Lee, Jane B. Trepel, Andrew P. Feinberg, David Gius	41
17	The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells. 2003 ·PubMed ·Wanping Xu, Xitong Yuan, Yun Jin Jung, Yongping Yang, Andrea Basso, Neal Rosen, Eun Joo Chung, Jane B. Trepel, Len Neckers	85
18	Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription. 2001 ·PubMed ·Paolo Bonvini, (unknown), A Rosolen, (unknown), Jane B. Trepel, (unknown), Mireia Duñach, L M Neckers	63
19	Metastasis-associated differences in gene expression in a murine model of osteosarcoma. 2001 ·PubMed ·Chand Khanna, Javed Khan, (unknown), (unknown), (unknown), Choh Yeung, Jane B. Trepel, Paul S. Meltzer, Lee J. Helman	229
20	Regulation of actin cytoskeleton in lymphocytes: PKC-? disrupts IL-3-induced membrane ruffles downstream of Rac1 1999 ·Journal of Cellular Physiology ·Larisa Y. Romanova, Ivan A. Alexandrov, Mikhail V. Blagosklonny, Richard P. Nordan, Susan H. Garfield, Péter Ács, Phuongmai Nguyen, Jane B. Trepel, Peter M. Blumberg, J. Frederic Mushinski	20

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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