Jonathan N. Pruneda

3.9k citations

48 papers · 2.9k · 1 hit paper · h-index 22

Impact in

Molecular Biology top 5%
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Glycosylation and Glycoproteins Research
Oncology top 5%
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis

Papers in

Molecular Biology 39
- Ubiquitin and proteasome pathways 30
- Protein Degradation and Inhibitors 10
- Glycosylation and Glycoproteins Research 9
Oncology 13
- Cancer-related Molecular Pathways 7
- PARP inhibition in cancer therapy 4

Co-authors: Rachel E. Klevit (10 shared papers)David Komander (13 shared papers)Allan M. Weissman (1 shared paper)Meredith B. Metzger (1 shared paper)Peter S. Brzović (8 shared papers)Kirby N. Swatek (6 shared papers)Christina Gladkova (3 shared papers)Jane L. Wagstaff (3 shared papers)
Journals: Molecular Cell (7 papers)The EMBO Journal (7 papers)eLife (4 papers)FEBS Journal (2 papers)Cell Host & Microbe (2 papers)
Partner nations: United States United Kingdom Netherlands

In The Last Decade

Jonathan N. Pruneda

44 papers receiving 2.8k citations

Jonathan N. Pruneda's Hit Papers

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RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination 2013 · 462 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2013 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Peers

Countries citing papers authored by Jonathan N. Pruneda

Since Specialization

Citations

This map shows the geographic impact of Jonathan N. Pruneda's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jonathan N. Pruneda with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jonathan N. Pruneda more than expected).

Fields of papers citing papers by Jonathan N. Pruneda

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jonathan N. Pruneda. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jonathan N. Pruneda. The network helps show where Jonathan N. Pruneda may publish in the future.

Co-authors

The 25 scholars most cited alongside Jonathan N. Pruneda, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Jonathan N. Pruneda Line = papers co-authored together Jonathan N. Pruneda links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Meredith B. Metzger, Jonathan N. Pruneda, Rachel E. Klevit, Allan M. Weissman Hit paper breakdown →	2013	462
2	Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases Molecular Cell ·Jonathan N. Pruneda, Peter Littlefield, Sarah E. Soss, Kyle A. Nordquist, Walter Chazin, Peter S. Brzović, Rachel E. Klevit	2012	260
3	Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis The EMBO Journal ·Tobias Wauer, Kirby N. Swatek, Jane L. Wagstaff, Christina Gladkova, Jonathan N. Pruneda, Martin A. Michel, Malte Gersch, C. Mark Johnson, Stefan M.V. Freund, David Komander	2014	241
4	Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal Nature ·Paul A. DaRosa, Zhizhi Wang, Xiaomo Jiang, Jonathan N. Pruneda, Feng Cong, Rachel E. Klevit, Wenqing Xu	2014	183
5	Insights into ubiquitin chain architecture using Ub-clipping Nature ·Kirby N. Swatek, Joanne L. Usher, Anja F. Kueck, Christina Gladkova, Tycho E.T. Mevissen, Jonathan N. Pruneda, Tim Skern, David Komander	2019	183
6	Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin Molecular Cell ·Martin A. Michel, P.R. Elliott, Kirby N. Swatek, Michal Šimíček, Jonathan N. Pruneda, Jane L. Wagstaff, Stefan M.V. Freund, David Komander	2015	165
7	OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function Molecular Cell ·Yu‐Chi Juang, Marie-Claude Landry, Mário Sanches, Vinayak Vittal, Charles Chung Yun Leung, Derek F. Ceccarelli, Abigail-Rachele F. Mateo, Jonathan N. Pruneda, Daniel Y.L. Mao, Rachel K. Szilard, Stephen Orlicky, Meagan Munro, Peter S. Brzović, Rachel E. Klevit, Frank Sicheri, Daniel Durocher	2012	162
8	Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis Proceedings of the National Academy of Sciences ·Lea M. Starita, Jonathan N. Pruneda, Russell S. Lo, Douglas M. Fowler, Helen J. Kim, Joseph B. Hiatt, Jay Shendure, Peter S. Brzović, Stanley Fields, Rachel E. Klevit	2013	127
9	A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes Nature Chemical Biology ·Monique P. C. Mulder, Katharina F. Witting, Ilana Berlin, Jonathan N. Pruneda, Kuen‐Phon Wu, Jer-Gung Chang, Remco Merkx, Johanna Bialas, Marcus Groettrup, Alfred C.O. Vertegaal, Brenda A. Schulman, David Komander, Jacques Neefjes, Farid El Oualid, Huib Ovaa	2016	120
10	Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate Biochemistry ·Jonathan N. Pruneda, Kate E. Stoll, Laura J. Bolton, Peter S. Brzović, Rachel E. Klevit	2011	119
11	The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases Molecular Cell ·Jonathan N. Pruneda, Charlotte H. Durkin, Paul P. Geurink, Huib Ovaa, Balaji Santhanam, David W. Holden, David Komander	2016	110
12	Structural and Functional Studies on the Interaction of GspC and GspD in the Type II Secretion System PLoS Pathogens ·Konstantin V. Korotkov, Tanya L. Johnson, Michael G. Jobling, Jonathan N. Pruneda, Els Pardon, A. Héroux, S. Turley, Jan Steyaert, Randall K. Holmes, Maria Sandkvist, Wim G. J. Hol	2011	78
13	Structural Insights into the Conformation and Oligomerization of E2∼Ubiquitin Conjugates Biochemistry ·Richard C. Page, Jonathan N. Pruneda, Joseph Amick, Rachel E. Klevit, Saurav Misra	2012	72
14	E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis The EMBO Journal ·Jonathan N. Pruneda, F. Donelson Smith, Angela Daurie, Danielle L. Swaney, Judit Villén, John D. Scott, Andrew W. Stadnyk, Isolde Le Trong, Ronald E. Stenkamp, Rachel E. Klevit, John R. Rohde, Peter S. Brzović	2014	58
15	Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies Proceedings of the National Academy of Sciences ·Kirby N. Swatek, Martina Aumayr, Jonathan N. Pruneda, Linda J. Visser, Stephen Berryman, Anja F. Kueck, Paul P. Geurink, Huib Ovaa, Frank J. M. van Kuppeveld, Tobias J. Tuthill, Tim Skern, David Komander	2018	56
16	An invisible ubiquitin conformation is required for efficient phosphorylation by PINK 1 The EMBO Journal ·Christina Gladkova, Alexander F. Schubert, Jane L. Wagstaff, Jonathan N. Pruneda, Stefan M.V. Freund, David Komander	2017	49
17	A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation Nature Microbiology ·Jonathan N. Pruneda, Robert J. Bastidas, Erithelgi Bertsoulaki, Kirby N. Swatek, Balaji Santhanam, Michael J. Clague, Raphael H. Valdivia, Sylvie Urbé, David Komander	2018	49
18	Development of Diubiquitin‐Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes ChemBioChem ·Paul P. Geurink, Bianca D. M. van Tol, Duco van Dalen, Paul J. G. Brundel, Tycho E.T. Mevissen, Jonathan N. Pruneda, P.R. Elliott, Gabriëlle B. A. van Tilburg, David Komander, Huib Ovaa	2016	48
19	The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence Journal of Biological Chemistry ·Grzegorz J. Grabe, Yue Zhang, Michal Przydacz, Nathalie Rolhion, Yi Yang, Jonathan N. Pruneda, David Komander, David W. Holden, S. Hare	2016	44
20	Identification and characterization of diverse OTU deubiquitinases in bacteria The EMBO Journal ·Alexander F. Schubert, Justine Nguyen, Tyler G. Franklin, Paul P. Geurink, Cameron G. Roberts, Daniel J. Sanderson, Lauren N. Miller, Huib Ovaa, Kay Hofmann, Jonathan N. Pruneda, David Komander	2020	43

About Jonathan N. Pruneda

Jonathan N. Pruneda is a scholar working on Molecular Biology, Oncology, Epidemiology, Biotechnology and Parasitology, having authored 48 papers that have together received 2.9k indexed citations. Recurring topics across this work include Ubiquitin and proteasome pathways (30 papers), Protein Degradation and Inhibitors (10 papers), Glycosylation and Glycoproteins Research (9 papers), Cancer Research and Treatments (8 papers), Autophagy in Disease and Therapy (8 papers), Cancer-related Molecular Pathways (7 papers), Toxoplasma gondii Research Studies (6 papers) and PARP inhibition in cancer therapy (4 papers). The work is most often cited by research in Molecular Biology (2.4k citations), Oncology (836 citations), Endocrinology (142 citations), Parasitology (123 citations) and Cell Biology (303 citations). Jonathan N. Pruneda has collaborated with scholars based in United States, United Kingdom and Netherlands. Frequent co-authors include Rachel E. Klevit, David Komander, Allan M. Weissman, Meredith B. Metzger, Peter S. Brzović, Kirby N. Swatek, Christina Gladkova, Jane L. Wagstaff, Stefan M.V. Freund and Martin A. Michel. Their work appears in journals such as Molecular Cell, The EMBO Journal, eLife, FEBS Journal and Cell Host & Microbe.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Jonathan N. Pruneda

Jonathan N. Pruneda's Hit Papers

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About Jonathan N. Pruneda

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