Titia K. Sixma

18.6k total citations · 6 hit papers
126 papers, 15.0k citations indexed

About

Titia K. Sixma is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Titia K. Sixma has authored 126 papers receiving a total of 15.0k indexed citations (citations by other indexed papers that have themselves been cited), including 116 papers in Molecular Biology, 34 papers in Oncology and 21 papers in Genetics. Recurrent topics in Titia K. Sixma's work include Ubiquitin and proteasome pathways (57 papers), DNA Repair Mechanisms (28 papers) and Nicotinic Acetylcholine Receptors Study (21 papers). Titia K. Sixma is often cited by papers focused on Ubiquitin and proteasome pathways (57 papers), DNA Repair Mechanisms (28 papers) and Nicotinic Acetylcholine Receptors Study (21 papers). Titia K. Sixma collaborates with scholars based in Netherlands, Germany and United States. Titia K. Sixma's co-authors include Willem J. van Dijk, August B. Smit, Katjuša Brejc, Anastassis Perrakis, Mark P.A. Luna‐Vargas, Annette M.G. Dirac, René Bernards, Remco V. Klaassen, Thijn R. Brummelkamp and Sebastian Nijman and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Titia K. Sixma

125 papers receiving 14.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A Genomic and Functional Inventory of Deubiquitinating Enzymes

2005 1.5k citations Mark P.A. Luna‐Vargas, Titia K. Sixma et al. profile →
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 1.5k citations Willem J. van Dijk, August B. Smit et al. profile →
Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

2004 676 citations Willem J. van Dijk, August B. Smit et al. profile →
Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein

1997 593 citations Titia K. Sixma et al. profile →
The crystal structure of DNA mismatch repair protein MutS binding to a G·T mismatch

2000 520 citations Meindert H. Lamers, H.H.K. Winterwerp et al. profile →
RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

2012 519 citations Francesca Mattiroli, Willem J. van Dijk et al. profile →

Peers

Titia K. Sixma

ONCOL

CMN

GENET

IMMUN

Ning Zheng United States

Anastassis Perrakis Netherlands

Ryuichiro Ishitani Japan

Keith V. Wood United States

John T. Lis United States

James T. Kadonaga United States

Jeremy Thorner United States

Laura W. Murray United States

Mikako Shirouzu Japan

Robert J. Fletterick United States

Ning Zheng United States

Titia K. Sixma

13.5k ×1.0

2.3k ×0.9

ONCOL

1.7k ×1.2

CMN

1.1k ×0.8

GENET

801 ×0.8

IMMUN

Citations per year, relative to Titia K. Sixma Titia K. Sixma (= 1×) peers Ning Zheng

Countries citing papers authored by Titia K. Sixma

Since Specialization

Citations

This map shows the geographic impact of Titia K. Sixma's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Titia K. Sixma with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Titia K. Sixma more than expected).

Fields of papers citing papers by Titia K. Sixma

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Titia K. Sixma. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Titia K. Sixma. The network helps show where Titia K. Sixma may publish in the future.

Co-authorship network of co-authors of Titia K. Sixma

This figure shows the co-authorship network connecting the top 25 collaborators of Titia K. Sixma. A scholar is included among the top collaborators of Titia K. Sixma based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Titia K. Sixma. Titia K. Sixma is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Fish, Alexander, et al.. (2024). Variety in the USP deubiquitinase catalytic mechanism. Life Science Alliance. 7(4). e202302533–e202302533. 14 indexed citations

Zhou, Di, Anita Salmazo, Marjolein van Sluis, et al.. (2024). STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment. Molecular Cell. 84(24). 4740–4757.e12. 13 indexed citations

Fasci, Domenico, Wouter W. Wiegant, Melissa A. Graewert, et al.. (2022). Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF. Science Advances. 8(30). eabo0517–eabo0517. 12 indexed citations

Fernández-Leiro, Rafael, Charlie Laffeber, H.H.K. Winterwerp, et al.. (2021). The selection process of licensing a DNA mismatch for repair. Nature Structural & Molecular Biology. 28(4). 373–381. 27 indexed citations

Laffeber, Charlie, H.H.K. Winterwerp, Titia K. Sixma, et al.. (2019). The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair. Nucleic Acids Research. 47(22). 11667–11680. 22 indexed citations

Kim, Robbert Q., et al.. (2019). Quantitative analysis of USP activity in vitro. Methods in enzymology on CD-ROM/Methods in enzymology. 618. 281–319. 8 indexed citations

Haahr, Peter, Dimitris Typas, Saskia Hoffmann, et al.. (2018). ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability. Molecular Cell. 70(1). 165–174.e6. 70 indexed citations

Zhou, Fangfang, Feng Xie, Ke Jin, et al.. (2017). USP 4 inhibits SMAD 4 monoubiquitination and promotes activin and BMP signaling. The EMBO Journal. 36(11). 1623–1639. 46 indexed citations

Friedhoff, Peter, et al.. (2017). Use of Single-Cysteine Variants for Trapping Transient States in DNA Mismatch Repair. Methods in enzymology on CD-ROM/Methods in enzymology. 592. 77–101. 4 indexed citations

10.

Speranzini, Valentina, Simona Pilotto, Titia K. Sixma, & Andrea Mattevi. (2016). Touch, act and go: landing and operating on nucleosomes. The EMBO Journal. 35(4). 376–388. 19 indexed citations

11.

Smit, Judith J., Willem J. van Dijk, Dris El Atmioui, et al.. (2013). Target Specificity of the E3 Ligase LUBAC for Ubiquitin and NEMO Relies on Different Minimal Requirements. Journal of Biological Chemistry. 288(44). 31728–31737. 43 indexed citations

12.

Faesen, Alex C., Mark P.A. Luna‐Vargas, Paul P. Geurink, et al.. (2011). The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types. Chemistry & Biology. 18(12). 1550–1561. 171 indexed citations

13.

Kasheverov, Igor E., М. Н. Жмак, Alexander Fish, et al.. (2009). Interaction of α‐conotoxin ImII and its analogs with nicotinic receptors and acetylcholine‐binding proteins: additional binding sites on Torpedo receptor. Journal of Neurochemistry. 111(4). 934–944. 19 indexed citations

14.

Rucktooa, Prakash, August B. Smit, & Titia K. Sixma. (2009). Insight in nAChR subtype selectivity from AChBP crystal structures. Biochemical Pharmacology. 78(7). 777–787. 106 indexed citations

15.

Knipscheer, Puck, Willem J. van Dijk, Jesper V. Olsen, Matthias Mann, & Titia K. Sixma. (2007). Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation. The EMBO Journal. 26(11). 2797–2807. 167 indexed citations

16.

Sixma, Titia K.. (2001). DNA mismatch repair: MutS structures bound to mismatches. Current Opinion in Structural Biology. 11(1). 47–52. 68 indexed citations

17.

Merritt, E.A., et al.. (1994). Structure of partially‐activated E. coli heat‐labile enterotoxin (LT) at 2.6 Å resolution. FEBS Letters. 337(1). 88–92. 30 indexed citations

18.

Merritt, E.A., et al.. (1994). Galactose‐binding site in Escherichia coli heat‐labile enterotoxin (LT) and cholera toxin (CT). Molecular Microbiology. 13(4). 745–753. 110 indexed citations

19.

Sixma, Titia K., Ángel Aguirre, Anke C. Terwisscha van Scheltinga, et al.. (1992). Heat‐labile enterotoxin crystal forms with variable A/B₅ orientation Analysis of conformational flexibility. FEBS Letters. 305(2). 81–85. 9 indexed citations

20.

Sixma, Titia K., et al.. (1992). X‐Ray studies reveal lanthanide binding sites at the A/B₅ interface of E. coli heat labile enterotoxin. FEBS Letters. 297(1-2). 179–182. 4 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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