Tracy M. Handel

16.7k citations

163 papers · 13.4k indexed · 4 hit papers · h-index 61

Molecular Biology top 0.5%
Oncology top 0.5%
Immunology top 0.5%
Radiology, Nuclear Medicine and Imaging top 0.5%
Cell Biology top 0.5%

Co-authors: Samantha J. Allen Amanda E. I. Proudfoot Catherina L. Salanga John R. Desjarlais Zoë Johnson Irina Kufareva Elaine K. Lau William F. DeGrado
Topics: Chemokine receptors and signaling (84 papers)Glycosylation and Glycoproteins Research (46 papers)Monoclonal and Polyclonal Antibodies Research (30 papers)
Cited by: Immunology Oncology Immunology and Allergy
Journals: Nature Science Cell
Partner nations: United States United Kingdom Switzerland

In The Last Decade

Tracy M. Handel

159 papers receiving 13.1k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

2010 1.5k citations Beili Wu, Ellen Y. T. Chien et al. Science profile →
Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines

2003 633 citations Tracy M. Handel, Elaine K. Lau et al. profile →
Chemokine:Receptor Structure, Interactions, and Antagonism

2007 631 citations Tracy M. Handel et al. profile →
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer

2013 428 citations Irina Kufareva, Tracy M. Handel et al. profile →

Peers

Countries citing papers authored by Tracy M. Handel

Since Specialization

Citations

This map shows the geographic impact of Tracy M. Handel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tracy M. Handel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tracy M. Handel more than expected).

Fields of papers citing papers by Tracy M. Handel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tracy M. Handel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tracy M. Handel. The network helps show where Tracy M. Handel may publish in the future.

Co-authorship network of co-authors of Tracy M. Handel

This figure shows the co-authorship network connecting the top 25 collaborators of Tracy M. Handel. A scholar is included among the top collaborators of Tracy M. Handel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tracy M. Handel. Tracy M. Handel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor 2025 ·Nature ·(unknown),(unknown),Somnath Mukherjee,(unknown),Martin Gustavsson,James R. Fuller,(unknown),(unknown),(unknown),(unknown),Genki Terashi,Xin‐Qiu Yao,Daisuke Kihara,Anthony A. Kossiakoff,Tracy M. Handel,J.J.G. Tesmer	3
2	Chemokine-chemokine receptor networks in conventional type I dendritic cells: an opportunity to prime and boost anticancer immunity 2025 ·Journal of Pharmacology and Experimental Therapeutics ·(unknown),Charlotte Shinn,Shiruyeh Schokrpur,Juliana Idoyaga,Tracy M. Handel,J. Silvio Gutkind	0
3	Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes 2025 ·eLife ·(unknown),(unknown),Martin Gustavsson,Tracy M. Handel,David P. Millar	3
4	Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes 2024 ·eLife ·(unknown),(unknown),Martin Gustavsson,Tracy M. Handel,David P. Millar	4
5	Atypical Chemokine Receptor 3 “Senses” CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation 2023 ·Molecular Pharmacology ·(unknown),Qiuyan Chen,J.J.G. Tesmer,Tracy M. Handel	11
6	Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias 2022 ·Science Advances ·(unknown),(unknown),Martin Gustavsson,S.A. Eberle,Pawel K. Dominik,Dawid Deneka,Penglie Zhang,Thomas J. Schall,Anthony A. Kossiakoff,J.J.G. Tesmer,Tracy M. Handel	43
7	Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t 2020 ·Journal of Biological Chemistry ·Richard J. Ward,John D. Pediani,Sara Marsango,Richard Jolly,Michael R. Stoneman,Gabriel Biener,Tracy M. Handel,Valerică Raicu,Graeme Milligan	22
8	CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry 2018 ·Biochemical Pharmacology ·(unknown),A. Klarenbeek,Vladimir Bobkov,Jordi Doijen,Marta Arimont,Chunxia Zhao,Raimond Heukers,(unknown),Chris de Graaf,Theo Verrips,Bas van der Woning,Hans de Haard,Joseph Rucker,Kurt Vermeire,Tracy M. Handel,Tom Van Loy,Martine J. Smit,Dominique Schols	43
9	Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization 2017 ·Open Biology ·Douglas P. Dyer,Elisa Migliorini,Catherina L. Salanga,Dhruv Thakar,Tracy M. Handel,Ralf P. Richter	34
10	Cytokines and growth factors cross-link heparan sulfate 2015 ·Open Biology ·Elisa Migliorini,Dhruv Thakar,(unknown),Rabia Sadir,Douglas P. Dyer,Yong Li,Changye Sun,Brian F. Volkman,Tracy M. Handel,Liliane Coche‐Guérente,David G. Fernig,Hugues Lortat‐Jacob,Ralf P. Richter	54
11	The dependence of chemokine–glycosaminoglycan interactions on chemokine oligomerization 2015 ·Glycobiology ·Douglas P. Dyer,Catherina L. Salanga,Brian F. Volkman,Tetsuya Kawamura,Tracy M. Handel	92
12	A General Method for Site Specific Fluorescent Labeling of Recombinant Chemokines 2014 ·PLoS ONE ·Tetsuya Kawamura,Bryan S. Stephens,Ling Qin,Xin Yin,Michael R. Dores,Thomas H. Smith,Neil Grimsey,Ruben Abagyan,JoAnn Trejo,Irina Kufareva,Mark M. Fuster,Catherina L. Salanga,Tracy M. Handel	22
13	Multiple Glycosaminoglycan-binding Epitopes of Monocyte Chemoattractant Protein-3/CCL7 Enable It to Function as a Non-oligomerizing Chemokine 2014 ·Journal of Biological Chemistry ·Catherina L. Salanga,Douglas P. Dyer,Janna Kiselar,Sayan Gupta,Mark R. Chance,Tracy M. Handel	35
14	Chemokine Receptor Oligomerization and Allostery 2013 ·Progress in molecular biology and translational science ·Bryan S. Stephens,Tracy M. Handel	48
15	Chemokine oligomerization and interactions with receptors and glycosaminoglycans: The role of structural dynamics in function 2011 ·Experimental Cell Research ·Catherina L. Salanga,Tracy M. Handel	134
16	Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonistsbreakdown → 2010 ·Science ·Beili Wu,Ellen Y. T. Chien,Clifford D. Mol,Gustavo Fenalti,Wei Liu,Vsevolod Katritch,Ruben Abagyan,Alexei Brooun,Peter G. Wells,F. Christopher Bi,Damon J. Hamel,Peter Kühn,Tracy M. Handel,Vadim Cherezov,Raymond C. Stevens	1462
17	Chemokine-Glycosaminoglycan Binding 2005 ·Journal of Biological Chemistry ·Yonghao Yu,(unknown),Ola M. Saad,(unknown),Tracy M. Handel,Julie A. Leary	75
18	Examination of MCP-1 (CCL2) partitioning and presentation during transendothelial leukocyte migration 2004 ·Laboratory Investigation ·(unknown),Trevor A. Booth,Elaine K. Lau,Tracy M. Handel,Simi Ali,John A. Kirby	23
19	Structural Basis of Chemokine Sequestration by a Herpesvirus Decoy Receptor 2002 ·Cell ·Jennifer M. Alexander,Christopher A. Nelson,Victor van Berkel,Elaine K. Lau,Joey Studts,Tom J. Brett,Samuel H. Speck,Tracy M. Handel,Herbert W. Virgin,Daved H. Fremont	92
20	Heteronuclear (¹H, ¹³C, ¹⁵N) NMR assignments and secondary structure of the basic region‐helix‐loop‐helix domain of E47 1997 ·Protein Science ·Robert Fairman,(unknown),Tracy M. Handel	21

About Tracy M. Handel

Tracy M. Handel is a scholar working on Immunology and Allergy, Oncology and Immunology, having authored 163 papers that have together received 13.4k indexed citations. Recurring topics across this work include Chemokine receptors and signaling (84 papers), Glycosylation and Glycoproteins Research (46 papers) and Monoclonal and Polyclonal Antibodies Research (30 papers). The work is most often cited by research in Immunology (4.1k citations), Oncology (4.6k citations) and Immunology and Allergy (1.0k citations). Tracy M. Handel has collaborated with scholars based in United States, United Kingdom and Switzerland. Frequent co-authors include Samantha J. Allen, Amanda E. I. Proudfoot, Catherina L. Salanga, John R. Desjarlais, Zoë Johnson, Irina Kufareva, Elaine K. Lau, William F. DeGrado, Ruben Abagyan and Morgan O’Hayre. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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