Fred van Leeuwen

6.1k citations

93 papers · 4.7k indexed · 2 hit papers · h-index 36

Molecular Biology top 2%
Epidemiology top 5%
Plant Science top 5%
Public Health, Environmental and Occupational Health top 5%
Immunology top 10%

Co-authors: Daniel E. Gottschling Philip R. Gafken Piet Borst Tibor van Welsem Romeo Caffé Rudo Kieft Dirk Schübeler David M. MacAlpine
Topics: Genomics and Chromatin Dynamics (36 papers)Epigenetics and DNA Methylation (25 papers)Cancer-related gene regulation (15 papers)
Cited by: Molecular Biology Aging Behavioral Neuroscience
Journals: Cell Proceedings of the National Academy of Sciences Nucleic Acids Research
Partner nations: Netherlands United States United Kingdom

In The Last Decade

Fred van Leeuwen

90 papers receiving 4.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Dot1p Modulates Silencing in Yeast by Methylation of the Nucleosome Core

2002 661 citations Fred van Leeuwen, Daniel E. Gottschling et al. Cell profile →
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

2004 634 citations Fred van Leeuwen, Daniel E. Gottschling et al. profile →

Peers

Countries citing papers authored by Fred van Leeuwen

Since Specialization

Citations

This map shows the geographic impact of Fred van Leeuwen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Fred van Leeuwen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Fred van Leeuwen more than expected).

Fields of papers citing papers by Fred van Leeuwen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Fred van Leeuwen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Fred van Leeuwen. The network helps show where Fred van Leeuwen may publish in the future.

Co-authorship network of co-authors of Fred van Leeuwen

This figure shows the co-authorship network connecting the top 25 collaborators of Fred van Leeuwen. A scholar is included among the top collaborators of Fred van Leeuwen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Fred van Leeuwen. Fred van Leeuwen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells 2025 ·Science Advances ·(unknown),(unknown),Muhammad Assad Aslam,(unknown),Teun van den Brand,Bram van den Broek,(unknown),Liesbeth Hoekman,Natalie Proost,Tibor van Welsem,Nikolina Bąbała,(unknown),Elzo de Wit,Jannie Borst,Heinz Jacobs,Fred van Leeuwen	0
2	Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphoma 2025 ·Blood ·(unknown),(unknown),Marnix H. P. de Groot,(unknown),Joleen J.H. Traets,Daan J. Kloosterman,(unknown),Ben Morris,Maaike Kreft,Ji‐Ying Song,(unknown),(unknown),(unknown),(unknown),Liesbeth Hoekman,Onno B. Bleijerveld,Marie José Kersten,Muhammad Assad Aslam,Fred van Leeuwen,Heinz Jacobs	2
3	Should I stay or should I go: TFIIIC as assembly factor and barrier in RNA polymerase III transcription 2025 ·Biochemical Society Transactions ·(unknown),(unknown),Fred van Leeuwen,Christoph W. Müller	0
4	The choreography of chromatin in RNA polymerase III regulation 2024 ·Biochemical Society Transactions ·(unknown),Alan Gerber,Fred van Leeuwen	3
5	Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting 2023 ·Nature Structural & Molecular Biology ·Ineke Brouwer,(unknown),Fred van Leeuwen,Tineke L. Lenstra	19
6	The histone methyltransferase SETD2 negatively regulates cell size 2022 ·Journal of Cell Science ·(unknown),(unknown),Joana Silva,Ning Qing Liu,Judith H.I. Haarhuis,Christina M. Ambrosi,(unknown),Tibor van Welsem,Tuncay Baubec,William J. Faller,Fred van Leeuwen	2
7	SETD2: from chromatin modifier to multipronged regulator of the genome and beyond 2022 ·Cellular and Molecular Life Sciences ·(unknown),Fred van Leeuwen	30
8	DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors in vitro 2022 ·Frontiers in Genetics ·(unknown),(unknown),Tibor van Welsem,Remco van Doorn,Maarten H. Vermeer,Hanneke Vlaming,Heinz Jacobs,Fred van Leeuwen	2
9	The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8 ⁺ T cells 2020 ·Proceedings of the National Academy of Sciences ·(unknown),Muhammad Assad Aslam,Mir Farshid Alemdehy,Teun van den Brand,Chelsea McLean,Hanneke Vlaming,Tibor van Welsem,(unknown),Cesare Lancini,(unknown),Tomasz Ahrends,(unknown),Joke M. M. den Haan,Jannie Borst,Elzo de Wit,Fred van Leeuwen,Heinz Jacobs	32
10	Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes 2020 ·Genome Research ·(unknown),(unknown),Christine E. Cucinotta,Ila van Kruijsbergen,Tibor van Welsem,Dris El Atmioui,Huib Ovaa,Toshio Tsukiyama,Fred van Leeuwen	7
11	Strategy for Development of Site-Specific Ubiquitin Antibodies 2020 ·Frontiers in Chemistry ·Ila van Kruijsbergen,Monique P. C. Mulder,Michael Uckelmann,Tibor van Welsem,John de Widt,Aldo Spanjaard,Heinz Jacobs,Farid El Oualid,Huib Ovaa,Fred van Leeuwen	9
12	Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism 2018 ·Nucleic Acids Research ·Tibor van Welsem,(unknown),Reggy Ekkebus,(unknown),(unknown),(unknown),(unknown),Su Ming Sun,Tineke L. Lenstra,Rohith Srivas,Trey Ideker,Frank C. P. Holstege,Haico van Attikum,Farid El Oualid,Huib Ovaa,I.J.E. Stulemeijer,Hanneke Vlaming,Fred van Leeuwen	26
13	The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae 2017 ·PLoS ONE ·Angelina Huseinovic,Jolanda van Leeuwen,Tibor van Welsem,I.J.E. Stulemeijer,Fred van Leeuwen,Nico Vermeulen,Jan M. Kooter,J. Chris Vos	6
14	Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae 2009 ·BMC Molecular Biology ·Kitty F. Verzijlbergen,Alex W. Faber,I.J.E. Stulemeijer,Fred van Leeuwen	25
15	Synthetic Lethal Screens Identify Gene Silencing Processes in Yeast and Implicate the Acetylated Amino Terminus of Sir3 in Recognition of the Nucleosome Core 2008 ·Molecular and Cellular Biology ·Tibor van Welsem,Floor Frederiks,Kitty F. Verzijlbergen,Alex W. Faber,(unknown),David A. Egan,Daniel E. Gottschling,Fred van Leeuwen	49
16	Chemical Biology Approaches to Probe the Proteome 2008 ·ChemBioChem ·Huib Ovaa,Fred van Leeuwen	10
17	Dynamic region-dependent changes in oxytocin receptor expression in the rat brain at parturition 2007 ·Proceedings of The Physiological Society ·Simone Meddle,Valerie Bishop,(unknown),Fred van Leeuwen,Alison J. Douglas	0
18	Assays for gene silencing in yeast 2002 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Fred van Leeuwen,Daniel E. Gottschling	63
19	Aggresome Formation in Liver Cells in Response to Different Toxic Mechanisms: Role of the Ubiquitin-Proteasome Pathway and the Frameshift Mutant of Ubiquitin 2001 ·Experimental and Molecular Pathology ·Barbara A. French,Fred van Leeuwen,Nora E. Riley,(unknown),Fawzia Bardag‐Gorce,Karl Gaal,Yanhe Lue,(unknown),Samuel W. French	65
20	β-d-glucosyl-hydroxymethyluracil: A novel modified base present in the DNA of the parasitic protozoan T. brucei 1993 ·Cell ·Janet Gommers-Ampt,Fred van Leeuwen,(unknown),(unknown),Miral Dizdaroglu,Jeffrey A. Kowalak,Pamela F. Crain,(unknown)	168

About Fred van Leeuwen

Fred van Leeuwen is a scholar working on Molecular Biology, Aging and Behavioral Neuroscience, having authored 93 papers that have together received 4.7k indexed citations. Recurring topics across this work include Genomics and Chromatin Dynamics (36 papers), Epigenetics and DNA Methylation (25 papers) and Cancer-related gene regulation (15 papers). The work is most often cited by research in Molecular Biology (3.7k citations), Aging (61 citations) and Behavioral Neuroscience (78 citations). Fred van Leeuwen has collaborated with scholars based in Netherlands, United States and United Kingdom. Frequent co-authors include Daniel E. Gottschling, Philip R. Gafken, Piet Borst, Tibor van Welsem, Romeo Caffé, Rudo Kieft, Dirk Schübeler, David M. MacAlpine, C Wirbelauer and Stephen P. Bell. Their work appears in journals such as Cell, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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