Paul E. Brennan

15.4k total citations · 1 hit paper
114 papers, 4.9k citations indexed

About

Paul E. Brennan is a scholar working on Molecular Biology, Hematology and Organic Chemistry. According to data from OpenAlex, Paul E. Brennan has authored 114 papers receiving a total of 4.9k indexed citations (citations by other indexed papers that have themselves been cited), including 90 papers in Molecular Biology, 27 papers in Hematology and 22 papers in Organic Chemistry. Recurrent topics in Paul E. Brennan's work include Protein Degradation and Inhibitors (40 papers), Multiple Myeloma Research and Treatments (27 papers) and Histone Deacetylase Inhibitors Research (17 papers). Paul E. Brennan is often cited by papers focused on Protein Degradation and Inhibitors (40 papers), Multiple Myeloma Research and Treatments (27 papers) and Histone Deacetylase Inhibitors Research (17 papers). Paul E. Brennan collaborates with scholars based in United Kingdom, United States and Germany. Paul E. Brennan's co-authors include Stefan Knapp, Susanne Müller, O. Fedorov, P. Filippakopoulos, Christopher J. Schofield, S. Picaud, C. Tallant, Martin Philpott, Duncan A. Hay and Octovia Monteiro and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Paul E. Brennan

111 papers receiving 4.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

2022 175 citations Nils Frank, Jeremy Nugent et al. Nature profile →

Peers

Countries citing papers authored by Paul E. Brennan

Since Specialization

Citations

This map shows the geographic impact of Paul E. Brennan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paul E. Brennan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paul E. Brennan more than expected).

Fields of papers citing papers by Paul E. Brennan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paul E. Brennan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paul E. Brennan. The network helps show where Paul E. Brennan may publish in the future.

Co-authorship network of co-authors of Paul E. Brennan

This figure shows the co-authorship network connecting the top 25 collaborators of Paul E. Brennan. A scholar is included among the top collaborators of Paul E. Brennan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Paul E. Brennan. Paul E. Brennan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells 2025 ·Nature Communications ·(unknown), (unknown), (unknown), Usha Singh, (unknown), James D. Vasta, Michael Beck, Jennifer Wilkinson, Jennifer Ward, Catherine Rogers, (unknown), (unknown), Jesper S. Hansen, P. Loppnau, Adrian Whitty, Paul E. Brennan, Peter J. Tonge, Matthew B. Robers, K. Huber	0
2	Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor 2025 ·Journal of Proteome Research ·Darragh P. O’Brien, (unknown), Yuqi Shi, (unknown), Iolanda Vendrell, Rosa Viner, Paul E. Brennan, Emma Mead, Tryfon Zarganes‐Tzitzikas, John B. Davis, Adán Pinto-Fernández, Katherine S. England, Emma J. Murphy, A.P. Turnbull, Benedikt M. Kessler	4
3	Luminescence-based complementation assay to assess target engagement and cell permeability of glycolate oxidase (HAO1) inhibitors 2024 ·Biochimie ·(unknown), Tryfon Zarganes‐Tzitzikas, (unknown), Paul E. Brennan, Wyatt W. Yue	1
4	Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease 2023 ·Journal of Biological Chemistry ·Yuhong Du, W.J. Bradshaw, (unknown), (unknown), Kun Qian, (unknown), (unknown), (unknown), Andrei A. Ivanov, Stephen V. Frye, O. Gileadi, Paul E. Brennan, Allan I. Levey, Alison D. Axtman, Kenneth H. Pearce, Haian Fu, V.L. Katis	8
5	Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity 2023 ·Journal of Medicinal Chemistry ·(unknown), Linda Troeberg, Paul E. Brennan, Tonia L. Vincent, Morten Meldal, Ngee Han Lim	4
6	Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane breakdown → 2022 ·Nature ·Nils Frank, Jeremy Nugent, Bethany R. Shire, Helena D. Pickford, Patrick Rabe, Alistair J. Sterling, Tryfon Zarganes‐Tzitzikas, (unknown), Amber L. Thompson, Russell C. Smith, Christopher J. Schofield, Paul E. Brennan, Fernanda Duarte, Edward A. Anderson	175
7	A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation 2021 ·Scientific Reports ·(unknown), Val Millar, (unknown), Tryfon Zarganes‐Tzitzikas, David Brough, Gary Tresadern, Paul E. Brennan, John B. Davis, Daniel Ebner, Elena Di Daniel	10
8	Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia 2021 ·ACS Chemical Biology ·(unknown), T. Krojer, (unknown), L. Diaz Saez, Manshu Tang, K. Huber, F. von Delft, Kent Lai, Paul E. Brennan, G.A. Bezerra, Wyatt W. Yue	9
9	Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death 2020 ·Cancer Research ·Lucia Cottone, Adam P. Cribbs, Garima Khandelwal, Graham Wells, (unknown), Martin Philpott, Anthony Tumber, Patrick Lombard, Edward S. Hookway, Tamás Szommer, C. Johansson, Paul E. Brennan, Nischalan Pillay, Richard G. Jenner, Udo Oppermann, Adrienne M. Flanagan	35
10	Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells 2020 ·Journal of Biological Chemistry ·(unknown), (unknown), (unknown), Roberta Mazzone, (unknown), Irene del Molino del Barrio, Annalidia Donato, (unknown), Fengling Li, Masoud Vedadi, Andrea H. Németh, Paul E. Brennan, Richard Wade‐Martins	9
11	Deliberately Losing Control of C−H Activation Processes in the Design of Small‐Molecule‐Fragment Arrays Targeting Peroxisomal Metabolism 2020 ·ChemMedChem ·(unknown), (unknown), T. Krojer, A.R. Bradley, Srikannathasan Velupillai, R. Talon, M. Fairhead, Iain J. Day, (unknown), Robert Felix, Paul D. Kemmitt, Paul E. Brennan, F. von Delft, L. Diaz Saez, K. Huber, John Spencer	4
12	Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1 2019 ·ACS Medicinal Chemistry Letters ·Xiaomin Ni, David Heidenreich, Thomas Christott, James M. Bennett, Moses Moustakim, Paul E. Brennan, Oleg Fedorov, Stefan Knapp, A. Chaikuad	19
13	Bench-Stable Transfer Reagent Facilitates the Generation of Trifluoromethyl-sulfonimidamides 2018 ·The Journal of Organic Chemistry ·(unknown), (unknown), (unknown), Paul E. Brennan, Andrés A. Trabanco, Daniel Oehlrich	25
14	Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2 2018 ·Bioorganic & Medicinal Chemistry ·Moses Moustakim, Kerstin Riedel, M. Schuller, (unknown), Octovia Monteiro, (unknown), Oleg Fedorov, Jag Heer, Darren J. Dixon, Jonathan M. Elkins, Stefan Knapp, (unknown), Paul E. Brennan	24
15	Discovery of a Highly Selective Cell‐Active Inhibitor of the Histone Lysine Demethylases KDM2/7 2017 ·Angewandte Chemie ·(unknown), Stephen Wolstenhulme, Anthony Tumber, Stephanie B. Hatch, Yijia Zhang, Susanne Müller, Shane A. Chandler, Barbara Mair, Fengling Li, Sebastian Nijman, Rebecca Konietzny, Tamás Szommer, Clarence Yapp, Oleg Fedorov, Justin L. P. Benesch, Masoud Vedadi, Benedikt M. Kessler, Akane Kawamura, Paul E. Brennan, Martin D. Smith	1
16	Discovery of a Highly Selective Cell‐Active Inhibitor of the Histone Lysine Demethylases KDM2/7 2017 ·Angewandte Chemie International Edition ·(unknown), Stephen Wolstenhulme, Anthony Tumber, Stephanie B. Hatch, Yijia Zhang, Susanne Müller, Shane A. Chandler, Barbara Mair, Fengling Li, Sebastian Nijman, Rebecca Konietzny, Tamás Szommer, Clarence Yapp, Oleg Fedorov, Justin L. P. Benesch, Masoud Vedadi, Benedikt M. Kessler, Akane Kawamura, Paul E. Brennan, Martin D. Smith	33
17	CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses 2015 ·Proceedings of the National Academy of Sciences ·Ariane Hammitzsch, C. Tallant, O. Fedorov, Alison O’Mahony, Paul E. Brennan, Duncan A. Hay, Fernando O. Martínez, Hussein Al‐Mossawi, Jelle de Wit, Matteo Vecellio, Christopher Wells, B P Wordsworth, Susanne Müller, Stefan Knapp, Paul Bowness	195
18	K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac 2015 ·Science ·Yin Yao Dong, A.C.W. Pike, Alexandra Mackenzie, Conor McClenaghan, Prafulla Aryal, Liang Dong, Andrew Quigley, Mariana Grieben, S. Goubin, Shubhashish Mukhopadhyay, G.F. Ruda, Michael V. Clausen, Lishuang Cao, Paul E. Brennan, N. Burgess-Brown, Mark S.P. Sansom, Stephen J. Tucker, Elisabeth P. Carpenter	237
19	LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor 2015 ·Angewandte Chemie ·Peter G. K. Clark, Lucas Campos Curcino Vieira, C. Tallant, O. Fedorov, Dean C. Singleton, Catherine Rogers, Octovia Monteiro, James M. Bennett, Roberta Baronio, Susanne Müller, Danette L. Daniels, Jacqui Méndez, Stefan Knapp, Paul E. Brennan, Darren J. Dixon	111
20	New catalysts for olefin metathesis 2001 ·Matthias Scholl, Shan Ding, (unknown), Robert H. Grubbs, Paul E. Brennan, Steven V. Ley, (unknown)	1

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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