Tom D. Heightman

10.0k citations

54 papers · 4.0k indexed · 1 hit paper · h-index 30

Impact in

Organic Chemistry top 1%
- Carbohydrate Chemistry and Synthesis
Biotechnology top 1%
- Enzyme Production and Characterization

Papers in ⓘ

Organic Chemistry 22
- Carbohydrate Chemistry and Synthesis 7
- Click Chemistry and Applications 6
Hematology 8
- Multiple Myeloma Research and Treatments 8

Co-authors: Andrea Vasella (7 shared papers)Christopher N. Johnson (3 shared papers)Honorine Lebraud (6 shared papers)David J. Wright (2 shared papers)O. Fedorov (6 shared papers)Martin Philpott (6 shared papers)Stefan Knapp (6 shared papers)Anthony Tumber (6 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (5 papers)Angewandte Chemie International Edition (4 papers)Journal of Medicinal Chemistry (4 papers)Helvetica Chimica Acta (3 papers)Bioconjugate Chemistry (2 papers)
Partner nations: United Kingdom United States Switzerland

In The Last Decade

Tom D. Heightman

54 papers receiving 3.9k citations

Hit Papers

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Recent Insights into Inhibition, Structure, and Mechanism of Configuration-Retaining Glycosidases 1999 · 494 citations

Peers

Countries citing papers authored by Tom D. Heightman

Since Specialization

Citations

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Fields of papers citing papers by Tom D. Heightman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tom D. Heightman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tom D. Heightman. The network helps show where Tom D. Heightman may publish in the future.

Co-authors

The 25 scholars most cited alongside Tom D. Heightman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Tom D. Heightman Line = papers co-authored together Tom D. Heightman links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	Recent Insights into Inhibition, Structure, and Mechanism of Configuration-Retaining Glycosidases Angewandte Chemie International Edition ·Tom D. Heightman, Andrea Vasella Hit paper breakdown →	1999	494
2	Recent Insights into Inhibition, Structure, and Mechanism of Configuration-Retaining Glycosidases Angewandte Chemie International Edition ·Tom D. Heightman, Andrea Vasella	1999	485
3	Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras ACS Central Science ·Honorine Lebraud, David J. Wright, Christopher N. Johnson, Tom D. Heightman	2016	310
4	BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones Nature Structural & Molecular Biology ·Tomohiko Kanno, Yuka Kanno, Gary LeRoy, Eric I. Campos, Hong‐Wei Sun, Stephen R. Brooks, Golnaz Vahedi, Tom D. Heightman, Benjamin A. García, Danny Reinberg, Ulrich Siebenlist, John J. O’Shea, Keiko Ozato	2014	239
5	A Structural View of the Action ofEscherichia coli(lacZ) β-Galactosidase^, Biochemistry ·D.H. Juers, Tom D. Heightman, Andrea Vasella, John D. McCarter, Lloyd Mackenzie, Stephen G. Withers, Brian W. Matthews	2001	193
6	Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors PLoS ONE ·Oliver N. F. King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R. Rose, Stanley S. Ng, Amy Quinn, Ganesha Rai, Bryan T. Mott, Paul Beswick, Robert J. Klose, Udo Oppermann, Ajit Jadhav, Tom D. Heightman, David J. Maloney, Christopher J. Schofield, Anton Simeonov	2010	173
7	3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands Journal of Medicinal Chemistry ·David S. Hewings, Minghua Wang, Martin Philpott, O. Fedorov, Sagar Uttarkar, P. Filippakopoulos, S. Picaud, Chaitanya Vuppusetty, Brian D. Marsden, Stefan Knapp, Stuart J. Conway, Tom D. Heightman	2011	172
8	High-resolution native and complex structures of thermostable β-mannanase from Thermomonospora fusca – substrate specificity in glycosyl hydrolase family 5 Structure ·M. Hilge, Sergio M. Gloor, W. Rypniewski, Oliver Sauer, Tom D. Heightman, Wolfgang Zimmermann, Kaspar H. Winterhalter, Klaus Piontek	1998	149
9	BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes Molecular and Cellular Biology ·Mira C. Patel, Maxime Debrosse, Matthew D. Smith, Anup Dey, Walter Huynh, Naoyuki Sarai, Tom D. Heightman, Tomohiko Tamura, Keiko Ozato	2013	136
10	A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases Journal of the American Chemical Society ·Xuelai Luo, Yongxiang Liu, Stefan Kubicek, Johanna Myllyharju, Anthony Tumber, Stanley S. Ng, Ka Hing, Jessica D. Podoll, Tom D. Heightman, Udo Oppermann, Stuart L. Schreiber, Xiang Wang	2011	121
11	Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery Molecular BioSystems ·Martin Philpott, Jing Yang, Tony Tumber, O. Fedorov, Sagar Uttarkar, P. Filippakopoulos, S. Picaud, Tracy Keates, I. Felletar, Alessio Ciulli, Stefan Knapp, Tom D. Heightman	2011	107
12	A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced‐Fit Pocket Stabilized by a Cation–π Interaction Angewandte Chemie International Edition ·Timothy P. C. Rooney, P. Filippakopoulos, O. Fedorov, S. Picaud, Wilian A. Cortopassi, Duncan A. Hay, Sarah Martin, Anthony Tumber, Catherine Rogers, Martin Philpott, Minghua Wang, Amber L. Thompson, Tom D. Heightman, David C. Pryde, Andrew S. Cook, Robert S. Paton, Susanne Müller, Stefan Knapp, Paul E. Brennan, Stuart J. Conway	2014	93
13	Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines Chemical Science ·Rachel Grainger, Tom D. Heightman, Steven V. Ley, Fabio Lima, Christopher N. Johnson	2018	88
14	Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors ACS Medicinal Chemistry Letters ·John Spencer, Jahangir Amin, Minghua Wang, Graham Packham, Sharifah Sakinah Syed Alwi, Graham J. Tizzard, Simon J. Coles, Ronald M. Paranal, James E. Bradner, Tom D. Heightman	2011	80
15	Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain Journal of Medicinal Chemistry ·Fleur M. Ferguson, O. Fedorov, A. Chaikuad, Martin Philpott, J.R.C. Muniz, I. Felletar, F. von Delft, Tom D. Heightman, Stefan Knapp, Chris Abell, Alessio Ciulli	2013	71
16	Neue Erkenntnisse über Hemmung, Struktur und Mechanismus konfigurationserhaltender Glycosidasen Angewandte Chemie ·Tom D. Heightman, Andrea Vasella	1999	62
17	Inhibition of Histone Demethylases by 4‐Carboxy‐2,2′‐Bipyridyl Compounds ChemMedChem ·Kai‐Hsuan Chang, Oliver N. F. King, Anthony Tumber, Esther C. Y. Woon, Tom D. Heightman, M.A. McDonough, Christopher J. Schofield, Nathan R. Rose	2011	61
18	Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP) Journal of Medicinal Chemistry ·Emiliano Tamanini, Ildiko M. Buck, Gianni Chessari, Elisabetta Chiarparin, James E. H. Day, Martyn Frederickson, Charlotte Griffiths-Jones, Keisha Hearn, Tom D. Heightman, Aman Iqbal, Christopher N. Johnson, Edward J. Lewis, Vanessa Martins, Torren M. Peakman, Michael Reader, Sharna J. Rich, George A. Ward, Pamela A. Williams, Nicola E. Wilsher	2017	57
19	The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains MedChemComm ·Duncan A. Hay, O. Fedorov, P. Filippakopoulos, Sarah Martin, Martin Philpott, S. Picaud, David S. Hewings, Sagar Uttakar, Tom D. Heightman, Stuart J. Conway, Stefan Knapp, Paul E. Brennan	2012	54
20	Development of homogeneous luminescence assays for histone demethylase catalysis and binding Analytical Biochemistry ·Akane Kawamura, Anthony Tumber, Nathan R. Rose, Oliver N. F. King, Michelle Daniel, Udo Oppermann, Tom D. Heightman, Christopher J. Schofield	2010	51

About Tom D. Heightman

Tom D. Heightman is a scholar working on Organic Chemistry, Hematology, Molecular Biology, Biotechnology and Endocrine and Autonomic Systems, having authored 54 papers that have together received 4.0k indexed citations. Recurring topics across this work include Protein Degradation and Inhibitors (14 papers), Histone Deacetylase Inhibitors Research (13 papers), Epigenetics and DNA Methylation (9 papers), Multiple Myeloma Research and Treatments (8 papers), Carbohydrate Chemistry and Synthesis (7 papers), Click Chemistry and Applications (6 papers), Chemical Synthesis and Analysis (5 papers) and Cancer-related gene regulation (5 papers). The work is most often cited by research in Organic Chemistry (1.7k citations), Biotechnology (441 citations), Molecular Biology (3.0k citations), Hematology (427 citations) and Oncology (408 citations). Tom D. Heightman has collaborated with scholars based in United Kingdom, United States and Switzerland. Frequent co-authors include Andrea Vasella, Christopher N. Johnson, Honorine Lebraud, David J. Wright, O. Fedorov, Martin Philpott, Stefan Knapp, Anthony Tumber, David J. Procter and P. Filippakopoulos. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Angewandte Chemie International Edition, Journal of Medicinal Chemistry, Helvetica Chimica Acta and Bioconjugate Chemistry.

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